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1 ne a signaling pathway from chloride channel calcium-activated 1 (CLCA1) to MAPK13 that is responsibl
2 ctrometry identified murine chloride channel calcium-activated 1 (mCLCA1) as the 10.1.1 Ag, a 90-kDa
3 s, Western blot analysis of chloride channel calcium activated 3 (CLCA3) expression in lung homogenat
4 Lowering the activity of Gelsolin, a known calcium-activated actin filament-severing protein, also
5 chment), which regulates voltage-independent calcium-activated action potentials at the neuronal syna
6 w that the functional expression of the slow calcium-activated afterhyperpolarizing current in pyrami
9 significantly from caspases because they are calcium-activated, arginine-specific peptidases that do
10 tress axis-regulated exon (STREX)-containing calcium-activated big potassium (BKCa) channel splice va
12 an-neurexin deletion reduced the function of calcium-activated BK potassium channels, whose activatio
15 emonstrated that the increase in cytoplasmic calcium activated Ca(2+) dependent potassium currents an
17 shots of ryanodine receptor type 1 (RyR1), a calcium-activated calcium channel engaged in the binding
18 ha-mediated Ser648 phosphorylation abrogated calcium-activated calmodulin (CaM) binding to the regula
23 One candidate subpopulation expresses the calcium activated cation channel TRPM5 (transient recept
26 ial cells (PDECs) have been shown to express calcium activated chloride channels (CaCCs) and there is
28 eins with unknown function 16 (TMEM16A) is a calcium-activated chloride channel (CaCC) important for
29 ver, the molecular identity of the olfactory calcium-activated chloride channel (CaCC) is unknown.
30 Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is exp
32 te that TMEM16A, an evolutionarily conserved calcium-activated chloride channel (CaCC), regulates cyt
33 inhibit self-cleavage prevent activation of calcium-activated chloride channel (CaCC)-mediated chlor
35 ugmentation in iPSC-RPE fully restored BEST1 calcium-activated chloride channel activity and improved
38 To date, only five mutations in the proposed calcium-activated chloride channel ANO5/TMEM16E gene hav
39 sought to investigate the involvement of the calcium-activated chloride channel anoctamin 1 (ANO1) in
41 s in the ANO5 gene, which encodes a putative calcium-activated chloride channel belonging to the Anoc
42 EM16A), also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mamm
44 16A is the major constituent of the vascular calcium-activated chloride channel in rat pulmonary arte
45 characterized the expression of the TMEM16B calcium-activated chloride channel in the LS and showed
46 inhibited the expression of Gob5, a putative calcium-activated chloride channel involved in the regul
49 nes, including IL13, IL5, periostin (POSTN), calcium-activated chloride channel regulator 1 (CLCA1),
50 ), which revealed an increased expression of calcium-activated chloride channel regulator 1 (CLCA1).
53 Inducible expression of either CFTR or the calcium-activated chloride channel TMEM16A attenuated th
61 igated the physiological contribution of the calcium-activated chloride channel to LS neuronal signal
62 terstitial cells of Cajal, which express the calcium-activated chloride channel transmembrane member
64 we determined the expression pattern of the calcium-activated chloride channel, TMEM16B, in the LS o
72 r components of the physiologically relevant calcium-activated chloride channels (CaCCs) present in m
78 n absence of expression/activity of reported calcium-activated chloride channels (TMEM16A, Bestrophin
79 an intrinsic property observed in endogenous calcium-activated chloride channels and could be relevan
80 ng pathway in the VNO and the requirement of calcium-activated chloride channels currents to mediate
83 r the analyses of physiological functions of calcium-activated chloride channels that contain TMEM16A
85 In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has b
86 gative effect through interaction with other calcium-activated chloride channels, such as hBest2, 3,
87 ffects of calcium signaling on CFTR or other calcium-activated chloride channels; here, we investigat
89 vertebrate olfactory signal transduction, a calcium-activated chloride conductance serves as a major
91 re, our analysis suggests that activation of calcium-activated chloride conductances by intracellular
95 lso found to strongly inhibit the intestinal calcium-activated Cl(-) channel TMEM16A by a voltage-ind
96 ost two decades, it has been postulated that calcium-activated Cl(-) channels (CaCCs) play a role in
99 a potential feed-forward mechanism in which calcium-activated CPK32 activates CNGC18, further promot
100 the mean intracellular activity of calpains, calcium-activated cysteine proteases that are known to c
104 force of diaphragm strips, absolute maximal calcium activated force, and maximal specific calcium-ac
106 alcium activated force, and maximal specific calcium-activated force of permeabilized diaphragm fiber
107 ss spectrometric analysis of the products of calcium-activated hydrolysis of endogenous mitochondrial
109 ium influx accompanying such signaling opens calcium-activated ion channels for feedback regulation.
113 ses of ion channels, including examples from calcium-activated K(+) (BK(Ca)), voltage-activated K(+)
114 idal neurons revealed that large-conductance calcium-activated K(+) (BK) channel open probability was
117 ons, FMRP interaction with large-conductance calcium-activated K(+) (BK) channels, specifically their
121 tigated two candidate ethanol effectors, the calcium-activated K(+) channel SLO-1 and gap junctions,
123 1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K(+) channels are critically involved
124 ctance (KCa3.1) and small-conductance (KCa2) calcium-activated K(+) channels are gated by calcium bin
125 (KCa2) and intermediate-conductance (KCa3.1) calcium-activated K(+) channels are voltage-independent
126 mediated by activation of small conductance calcium-activated K(+) channels in PDGFRalpha(+) cells,
127 Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact ve
129 goal of this study was to determine whether calcium-activated kinases such as calcium/calmodulin-dep
131 n synaptic transmission properties, LTD, and calcium-activated membrane channels of hippocampal CA1 p
132 id, an antagonist of a previously identified calcium activated non-selective cation channel (I(CAN)).
133 while flufenamic acid, an antagonist for the calcium-activated non-selective cation conductance (ICAN
134 ity, while flufenamic acid, a blocker of the calcium-activated non-selective cation conductance, abol
135 ion further excites the cell by recruiting a calcium-activated non-selective cation current (ICAN) ca
136 t sodium current ([Formula: see text]) and a calcium-activated non-selective cationic current ([Formu
138 d synaptic efficacy, and a small-conductance calcium-activated nonselective cation channel, TMEM16F,
139 carinic afterdepolarization is mediated by a calcium-activated nonselective cation current, suggestin
140 ained responses were found to be mediated by calcium-activated nonselective cationic current induced
142 tinguished DBQD type 1 and identified CANT1 (calcium activated nucleotidase 1) mutations as responsib
144 sponses to herbivory can be separated into a calcium-activated oxidative response and a K(+) -depende
146 ibits AT1R phosphorylation by activating the calcium-activated phosphatase calcineurin in a Ca(2+)/ca
147 cium channels but not on the activity of the calcium-activated phosphatase calcineurin, and was oppos
153 ulting from a reduction in large-conductance calcium-activated potassium (BK) and subthreshold-activa
154 lcium channel CaV1.3 and the big conductance calcium-activated potassium (BK) channel are preferentia
157 ract with the auxiliary beta4 subunit of the calcium-activated potassium (BK) channel; this interacti
158 ction in the expression of large-conductance calcium-activated potassium (BK) channels and Kv3.3 volt
159 ncreases in cytoplasmic Ca(2+), voltage- and calcium-activated potassium (BK) channels and their modu
162 xon domain of large conductance voltage- and calcium-activated potassium (BK) channels inhibiting cha
163 MRP's interaction with the large-conductance calcium-activated potassium (BK) channels that modulate
164 h nonmammals and mammals, large-conductance, calcium-activated potassium (BK) channels underlie a pri
165 spines act by suppressing large-conductance calcium-activated potassium (BK) channels, and this effe
170 larization potential, a voltage signature of calcium-activated potassium (Kca) channel activity.
171 ting through nitric oxide synthase (NOS) and calcium-activated potassium (KCa) channels in young adul
177 are occluded by apamin, a small-conductance calcium-activated potassium (SK(Ca)) channel blocker.
178 vivo, and were mediated by small-conductance calcium-activated potassium (SK) channel and CB1 cannabi
180 um conductance mediated by small-conductance calcium-activated potassium (SK) channels in rat MNTB pr
181 +) conductance mediated by small-conductance calcium-activated potassium (SK) channels in the MNTB ne
189 t that voltage-independent small conductance calcium-activated potassium (SK)-channel dysfunction cau
192 ET-cGMP-S (50 muM), and the high-conductance calcium-activated potassium channel (BK(Ca) channel) inh
194 e gene encoding the intermediate conductance calcium-activated potassium channel (IKCa) was termed SK
196 is associated with reduced small-conductance calcium-activated potassium channel (SK) currents and de
200 ized protein levels of the large conductance calcium-activated potassium channel and the water channe
201 fication of a role for the large conductance calcium-activated potassium channel brings new thinking
202 nergic neuron burst firing by decreasing the calcium-activated potassium channel current (SK), as wel
203 dent activation of MthK, a two transmembrane calcium-activated potassium channel from thermophilic ar
204 rther demonstrate that the activation of the calcium-activated potassium channel is sufficient to ind
209 Among the altered genes, an increase of the calcium-activated potassium channel Kcnn2 in the motor c
210 staining to determine small conductance (SK) calcium-activated potassium channel protein levels.
214 e found that Magi-1 bound to sequence like a calcium-activated potassium channel sodium-activated (Sl
220 he presence of functional large-conductance, calcium-activated potassium channels (BK channels) on th
224 Mammalian large-conductance, voltage- and calcium-activated potassium channels (BK, K(Ca)1.1) are
225 howed several significant results, including calcium-activated potassium channels (GO:0016286; P=2.30
226 ctifier channels (I(KV)) and noninactivating calcium-activated potassium channels (I(BK,steady)), and
227 co-localization of intermediate-conductance calcium-activated potassium channels (IKCa) and IP3 rece
228 e colocalization of intermediate-conductance calcium-activated potassium channels (IKCa) and TRPV4 ch
232 investigate the impact of small conductance calcium-activated potassium channels (SK channels) on de
233 d after acute dissociation, we found that BK calcium-activated potassium channels and Kv2 channels bo
235 o identify the molecular gating mechanism in calcium-activated potassium channels by obtaining struct
236 f N-type voltage-gated calcium channels with calcium-activated potassium channels in DCN neurons.
237 f calcium-calmodulin-dependent kinase II and calcium-activated potassium channels in mediating these
239 ent is reduced by blocking large conductance calcium-activated potassium channels with iberiotoxin, a
250 d by a nonselective cation conductance and a calcium-activated potassium conductance (SK), respective
251 , we show that the excessive activation of a calcium-activated potassium conductance disrupts the ace
252 The slow afterhyperpolarization (sAHP) is a calcium-activated potassium conductance with critical ro
253 Elevation of [K(+) ](c) occurs through a calcium-activated potassium conductance, G(BK) , and a l
254 to calcium influx and activation of a large calcium-activated potassium conductance, G(BK) , that ca
258 -clamp) that changes in the leak, sodium and calcium-activated potassium currents are central to thes
259 plasticity mediated by reductions in BK-type calcium-activated potassium currents in spontaneously fi
262 he contribution of the SK (small-conductance calcium-activated potassium) channel to neuronal functio
263 r firing range, and of SK (small-conductance calcium-activated potassium) currents, which were essent
264 ovary cells' plasma membrane gave rise to a calcium-activated, potassium-selective activity in patch
265 Length-tension relationships in maximally calcium activated preparations are relatively shallow an
266 tic cleavage of p35 to a p25 fragment by the calcium-activated protease calpain or by phosphorylation
269 We report that calpastatin, an inhibitor of calcium-activated proteases of the calpain family, funct
270 animal models, the dysregulated activity of calcium-activated proteases, calpains, contributes direc
273 ction of the carboxypeptidase EGL-21 and the calcium-activated protein for secretion (CAPS) UNC-31, s
274 Additionally, the synaptic protein UNC-31 [calcium-activated protein for secretion (CAPS)] acts thr
279 suggest CXCL12 regulates restitution through calcium-activated Pyk2 localized to active focal adhesio
280 Together, these results demonstrate that calcium-activated removal of RNA from membranes by Xendo
281 we identified type 5 NADPH oxidase (NOX5), a calcium-activated, ROS-forming enzyme, as the missing li
284 entify a unique mechanism of virus-mediated, calcium-activated signaling that initiates autophagy and
286 yed rectifier, A-type, and small-conductance calcium-activated (SK) potassium and HCN) and two recept
287 ntaining ionotropic receptors and associated calcium-activated (SK2) potassium channels, providing th
289 eartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward
291 t KCNQ channels might partially underlie the calcium-activated slow afterhyperpolarization (sAHP), a
293 ndependent NETosis is fast and mediated by a calcium-activated small conductance potassium (SK) chann
295 holinergic receptors functionally coupled to calcium-activated, small conductance (SK2) potassium cha
296 nge likely used during flight), stretch- and calcium-activated tension contributed 80% and 20%, respe
297 V domain-caged protease cleavage site, and a calcium-activated TEV protease that we designed through
300 Our study links calpain and dysferlin in the calcium-activated vesicle fusion of membrane repair, pla