ライフサイエンスコーパス: calcium-activated potassium channel

1 g protein) modulates the Drosophila SLOWPOKE calcium-activated potassium channel.

2 um efflux from RBCs is the Gardos channel, a calcium-activated potassium channel.

3 e Drosophila slowpoke gene encodes a BK-type calcium-activated potassium channel.

4 legans SHN-1/Shank promotes CaV1 coupling to calcium activated potassium channels.

5 ither large- (BK) or small- (SK) conductance calcium-activated potassium channels.

6 o mediate efferent inhibition via associated calcium-activated potassium channels.

7 current, and higher concentrations activated calcium-activated potassium channels.

8 ivity of small- and intermediate-conductance calcium-activated potassium channels.

9 ropic acetylcholine receptors and associated calcium-activated potassium channels.

10 enced by the activation of small-conductance calcium-activated potassium channels.

11 ue to an increase in the open probability of calcium-activated potassium channels.

12 ation of small- and intermediate-conductance calcium-activated potassium channels.

13 cellular calcium that gated surface-membrane calcium-activated potassium channels.

14 ncreases the expression of small-conductance calcium-activated potassium channels.

15 ated by calcium-dependent processes, such as calcium-activated potassium channels.

16 I(AHP) was occluded by previous blockade of calcium-activated potassium channels.

17 urkinje neurons via decreased recruitment of calcium-activated potassium channels.

18 paradoxically mimics the effects of blocking calcium-activated potassium channels.

19 nels is to provide calcium for activation of calcium-activated potassium channels.

20 ium influx couples to large conductance (BK) calcium-activated potassium channels.

21 Small-conductance calcium-activated potassium channel 2 (SK2) serves a var

22 KCNN2 encodes the small conductance calcium-activated potassium channel 2 (SK2).

23 Using the cannabinoid-like large-conductance calcium-activated potassium channel activator VSN16R we

24 FMR protein causes reduced large-conductance calcium-activated potassium channel activity leading to

25 inding and also normalized large-conductance calcium-activated potassium channel activity.

26 ized protein levels of the large conductance calcium-activated potassium channel and the water channe

27 e established by the interactions between BK calcium-activated potassium channels and an L-type calci

28 mechanisms underlying seizure generation (BK calcium-activated potassium channels and interneuron-exp

29 d after acute dissociation, we found that BK calcium-activated potassium channels and Kv2 channels bo

30 This work shows that BK calcium-activated potassium channels and Kv2 voltage-act

31 results in the opening of large-conductance, calcium-activated potassium channels, and an attendant h

32 Here we demonstrate that calcium-activated potassium channels are activated exclu

33 ymorphisms and variants in large-conductance calcium-activated potassium channels are increasingly li

34 P/Q-type voltage-gated calcium channels and calcium-activated potassium channels are required for no

35 ls to burst firing.SIGNIFICANCE STATEMENT BK calcium-activated potassium channels are widely expresse

36 he cloning and characterization of two novel calcium-activated potassium channel beta subunits, hKCNM

37 nique splice variant of a large conductance, calcium-activated potassium channel (BK channel).

38 A high-conductance calcium-activated potassium channel (BK KCa) was charact

39 ET-cGMP-S (50 muM), and the high-conductance calcium-activated potassium channel (BK(Ca) channel) inh

40 the function of both the large conductance, calcium-activated potassium channel (BK) and specific me

41 and while the large conductance voltage and calcium-activated potassium channel (BK) is widely expre

42 Large-conductance calcium-activated potassium channels (BK channels) are a

43 he presence of functional large-conductance, calcium-activated potassium channels (BK channels) on th

44 Large conductance, calcium-activated potassium channels (BK(Ca) or maxi-K)

45 RATIONALE: Large-conductance calcium-activated potassium channels (BK) are composed o

46 Voltage- and calcium-activated potassium channels (BK) are important

47 Large-conductance calcium-activated potassium channels (BK) are potent neg

48 fects of ethanol (EtOH) on large-conductance calcium-activated potassium channels (BK) in cell bodies

49 Mammalian large-conductance, voltage- and calcium-activated potassium channels (BK, K(Ca)1.1) are

50 Large conductance calcium-activated potassium channels (BK, MaxiK, Slo) ha

51 as recombinant cell lines (large-conductance calcium-activated potassium channel, BK(Ca)).

52 o elevated activity of the large conductance calcium-activated potassium channel BKCa downstream of c

53 The large-conductance calcium-activated potassium channel (BKCa, KCa1.1) is al

54 rt through cGMP-mediated activation of large calcium-activated potassium channels (BKCa).

55 as limited by activation of putative BK-type calcium-activated potassium channels (blocked by 250 mic

56 reductions in the sensitivity to the BK-type calcium-activated potassium channel blocker iberiotoxin.

57 y the CYP inhibitor, SKF525A, but not by the calcium-activated potassium channel blocker, charybdotox

58 ely prolonged by small-conductance (SK-type) calcium-activated potassium channel blockers in normally

59 fication of a role for the large conductance calcium-activated potassium channel brings new thinking

60 Inhibiting calcium-activated potassium channels by charybdotoxin or

61 vessels to adenosine; however, inhibition of calcium-activated potassium channels by iberiotoxin had

62 o identify the molecular gating mechanism in calcium-activated potassium channels by obtaining struct

63 owed that slowpoke mutations, which affect a calcium-activated potassium channel, cause severe song a

64 mino acid level with three small conductance calcium-activated potassium channels cloned from brain.

65 nergic neuron burst firing by decreasing the calcium-activated potassium channel current (SK), as wel

66 ntial (AP) repolarization; small-conductance calcium-activated potassium channel currents generate an

67 For large-conductance calcium-activated potassium channels, data are satisfact

68 The Drosophila large-conductance calcium-activated potassium channel (dSlo) binds to and

69 ates the fibroblast intermediate conductance calcium-activated potassium channel, FIK, a positive reg

70 hKCa4, encoding an intermediate conductance, calcium-activated potassium channel from a human lymph n

71 dent activation of MthK, a two transmembrane calcium-activated potassium channel from thermophilic ar

72 f RYR-mediated calcium release, and thereby, calcium-activated potassium channel function in the mamm

73 tional regulation of the Drosophila slowpoke calcium-activated potassium channel gene is complex.

74 a2, Myl3, and Myom1, myofibril proteins; and calcium-activated potassium-channel gene activity (KCNMB

75 howed several significant results, including calcium-activated potassium channels (GO:0016286; P=2.30

76 BK calcium-activated potassium channels have complex kineti

77 An intermediate conductance calcium-activated potassium channel, hIK1, was cloned fr

78 ctifier channels (I(KV)) and noninactivating calcium-activated potassium channels (I(BK,steady)), and

79 e gene encoding the intermediate conductance calcium-activated potassium channel (IKCa) was termed SK

80 co-localization of intermediate-conductance calcium-activated potassium channels (IKCa) and IP3 rece

81 e colocalization of intermediate-conductance calcium-activated potassium channels (IKCa) and TRPV4 ch

82 ane blockers of the intermediate conductance calcium-activated potassium channel, IKCa1, have therape

83 f N-type voltage-gated calcium channels with calcium-activated potassium channels in DCN neurons.

84 f calcium-calmodulin-dependent kinase II and calcium-activated potassium channels in mediating these

85 The role of calcium-activated potassium channels in the regulation o

86 sistent with native intermediate conductance calcium-activated potassium channels, including the eryt

87 In addition, the activity of calcium-activated potassium channels increased markedly.

88 es distension-induced Ca(2+) elevations, and calcium-activated potassium channel inhibition restores

89 nel inhibitor), and iberiotoxin (100 nmol/L, calcium-activated potassium channel inhibitor).

90 rther demonstrate that the activation of the calcium-activated potassium channel is sufficient to ind

91 The opening of large-conductance calcium-activated potassium channels is a common endogen

92 voltage-gated potassium channels (K(v)) and calcium-activated potassium channels (K(Ca)).

93 muscle, we investigated the contribution of calcium-activated potassium channels (KCa) and endotheli

94 Large-conductance calcium-activated potassium channel (KCa1.1; BK, Slo1, M

95 The intermediate conductance calcium-activated potassium channel KCa3.1 contributes t

96 The calcium-activated potassium channel KCa3.1 controls diff

97 The calcium-activated potassium channel KCa3.1 is critically

98 The intermediate-conductance calcium-activated potassium channel KCa3.1 is expressed

99 hanism involving arginine methylation of the calcium-activated potassium channel KCa3.1.

100 Among the altered genes, an increase of the calcium-activated potassium channel Kcnn2 in the motor c

101 Small conductance calcium-activated potassium channels link elevations of

102 Thus, voltage-gated and calcium-activated potassium channels located in the spin

103 Large-conductance calcium-activated potassium channels (maxi-K channels) h

104 Large conductance voltage- and calcium-activated potassium channels (MaxiK, BK(Ca)) are

105 ctivating A-current or the large conductance calcium-activated potassium channel-mediated fast spike

106 Because the large conductance calcium-activated potassium channel mSlo is sensitive to

107 The X-ray structure of the calcium-activated potassium channel MthK, which was crys

108 ne for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has

109 hese findings suggest that the maturation of calcium-activated potassium channels, particularly the a

110 staining to determine small conductance (SK) calcium-activated potassium channel protein levels.

111 members of the small-intermediate family of calcium-activated potassium channel proteins.

112 Cloned SK channels (small conductance calcium-activated potassium channel) recapitulate these

113 Calcium-activated potassium channels regulate AHP and ex

114 ated potassium channel and large-conductance calcium-activated potassium channel, respectively).

115 which selectively block the small and large calcium-activated potassium channels, respectively, resu

116 BK large conductance voltage- and calcium-activated potassium channels respond to elevatio

117 Small conductance calcium-activated potassium channels show a distinct pha

118 is associated with reduced small-conductance calcium-activated potassium channel (SK) currents and de

119 Three small conductance calcium-activated potassium channel (SK) subunits have b

120 Small conductance calcium-activated potassium channels (SK channels) are p

121 t of the activation of the small conductance calcium-activated potassium channels (SK channels) by ch

122 investigate the impact of small conductance calcium-activated potassium channels (SK channels) on de

123 rated by the activation of small-conductance calcium-activated potassium channels (SK channels).

124 The activation of small-conductance calcium-activated potassium channels (SK) has a profound

125 s were analyzed in native (small-conductance calcium-activated potassium channel, SK(Ca)) as well as

126 ing peptide (GRP) and the small conductance, calcium-activated potassium channel, SK2.

127 releasing peptide and the small conductance, calcium-activated potassium channel, SK2.

128 We found that the calcium-activated potassium channel SK3 and the G protei

129 Administration of an activator of calcium-activated potassium channels, SKA-31, partially

130 Apamin-sensitive small conductance calcium-activated potassium channels (SKCa1-3) mediate t

131 triarylmethane-insensitive small conductance calcium-activated potassium channel SKCa3 into IKCa1 ren

132 (HVA) (N- and P/Q-type) calcium channels and calcium-activated potassium channels (SKKCa).

133 eterminant of its anthelmintic effect is the calcium-activated potassium channel SLO-1.

134 e found that Magi-1 bound to sequence like a calcium-activated potassium channel sodium-activated (Sl

135 is downregulation reversed a decrease of the calcium-activated potassium channel subfamily N member 1

136 to, but distinct from, the small conductance calcium-activated potassium channel subfamily, which is

137 egulating voltage-gated calcium channels and calcium-activated potassium channels that together contr

138 ium was similar to that of small conductance calcium-activated potassium channels, the slope factor d

139 he contribution of the SK (small-conductance calcium-activated potassium) channel to neuronal functio

140 botropic glutamate receptors or postsynaptic calcium-activated potassium channels, two conditions tha

141 Calcium-activated potassium channels were analyzed in na

142 tent with the SK class of small-conductance, calcium-activated potassium channels, which contribute t

143 d is abolished by blocking small conductance calcium-activated potassium channels with apamin.

144 ent is reduced by blocking large conductance calcium-activated potassium channels with iberiotoxin, a