ライフサイエンスコーパス: calm

1 l probe to the mitochondrial inner membrane (CALM).

2 P180 and the presumed non-neuronal homologue CALM.

3 heavy chain is the major binding partner of CALM.

4 % difference in traffic calming (0.07, 95%CI: -0.07 to 0.20); proportion of scho

5 it, the calcium and integrin binding protein CALM-1 and the transmembrane inner ear protein TMIE.

6 g TMC-1 subunit, the calcium-binding protein CALM-1 and the transmembrane inner ear protein TMIE.

7 CALM-1 makes extensive contacts with the cytoplasmic fac

8 arrestin domain protein (ARRD-6), bound to a CALM-1 subunit.

9 CALM-1, the calcium and integrin binding protein ortholo

10 r, and centromeric to the calmodulin-2 gene (CALM-2; 2p22-21) and son-of-sevenless gene (SOS; 2p22-21

11 We also found that CALM adaptors associated with clathrin plaques form clus

12 airborne infections in vitro, we generated a calm-aerosol settling chamber system designed to examine

13 Fusions of the CALM NES (NES(CALM)-AF10) or NES motifs from heterologous proteins (AB

14 ansformation by preventing nuclear export of CALM-AF10 and by upregulating the Hoxa5 gene through H3K

15 S) that mediates cytoplasmic localization of CALM-AF10 and is necessary for CALM-AF10-dependent trans

16 AF10(PZP) promotes nuclear localization of CALM-AF10 and is required for association with chromatin

17 ) driven by the most common AF10 FPs, PICALM/CALM-AF10 and KMT2A/MLL-AF10, and performed comprehensiv

18 Thus, our study establishes CALM-AF10 fusion as a cause of leukaemia and reveals tha

19 the disruption of AF10(PZP) function in the CALM-AF10 fusion directly leads to transformation, where

20 chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggr

21 The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients.

22 To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo

23 e generated transgenic mice that expressed a CALM-AF10 fusion gene.

24 We demonstrate that CALM-AF10 fusion is both necessary and sufficient for le

25 f functional AF10(PZP) into the leukemogenic CALM-AF10 fusion prevents the transforming activity of t

26 erlying mechanism behind leukaemia caused by CALM-AF10 fusion.

27 nance energy transfer analysis, we show that CALM-AF10 has a propensity to homo-oligomerize, raising

28 b2 activation promotes the transformation of CALM-AF10 hematopoietic precursors toward B-lineage leuk

29 Finally, we observed that CALM-AF10 leukemia cells are selectively sensitive to in

30 tors as therapeutic agents for patients with CALM-AF10 leukemias.

31 ras, Kras, and Ptpn11 point mutations in the CALM-AF10 leukemic mice.

32 In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent ef

33 CALM-AF10 mice infected with the MOL4070LTR retrovirus d

34 es from both clinically healthy and leukemic CALM-AF10 mice showed up-regulation of Hoxa cluster gene

35 genetic events are needed to complement the CALM-AF10 transgene and complete the process of leukemic

36 Expression of a CALM-AF10 transgene results in leukemia, with prolonged

37 6 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leuke

38 We developed a mouse model of CALM-AF10(+) leukemia to examine the hypothesis that dis

39 integrations, suggesting cooperativity among CALM-AF10, Zeb2, and Ras pathway mutations.

40 The CALM NES is essential for CALM-AF10-dependent Hoxa gene up-regulation and aberrant

41 calization of CALM-AF10 and is necessary for CALM-AF10-dependent transformation.

42 CALM-AF10-driven leukemias are characterized by HOXA gen

43 hDOT1L contributes to CALM-AF10-mediated leukaemic transformation by preventin

44 tor cells in vitro and in vivo and abrogates CALM-AF10-mediated leukemogenesis in vivo.

45 suggest a model for the AF10(PZP)-dependent CALM-AF10-mediated leukemogenesis.

46 een shown to be necessary and sufficient for CALM-AF10-mediated transformation.

47 eage leukemic transformation in concert with CALM-AF10.

48 he molecular mechanism of leukaemogenesis by CALM-AF10.

49 The identification of the CALM/AF10 fusion gene in the widely used U937 cell line

50 Ultrastructural analysis shows that CALM affiliates with a wider range of intracellular traf

51 e mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperact

52 Aloof/Predatory", "Reactive/Assertive", and "Calm/Agreeable".

53 CALM allowed choice of cognitive behavioral therapy (CBT

54 t ignition in hand-spread pine needles under calm ambient wind conditions are analysed in this study.

55 the two cargo-selecting, clathrin adaptors, CALM and AP2.

56 nerator, which regulates the balance between calm and arousal behaviors.

57 et was "sedated" or "very sedated" for 59%, "calm and cooperative" for 25%, and "unarousable" for 16%

58 n addition, patients were significantly less calm and happy and more anxious.

59 ries, such as feeling depressed, social, and calm and hearing voices.

60 M, we engineered chimeric fusion proteins of CALM and its fragments with the green fluorescent protei

61 F1:F0 treatment interaction patterns (e.g., Calm and Myd88).

62 r masks as conveying more positive emotions (calm and pleasure).

63 They must elicit information, calm and reassure, instruct, check procedures, ask for a

64 Our data identify CALM and related ANTH domain-containing proteins as the

65 iagnosis, to reassuring our patients, to the calm and sterility of an operating theatre, and to the w

66 ate, temperature and water viscosity, winter calm and summer (iceberg and storm) disturbance and reso

67 ex (SWR) by changing the environment between calm and turbulent.

68 All patients had a clinical diagnosis of CALM and were treated with a Q-switched or picosecond la

69 grasping and loss of ground contact trigger calming and postural adjustments for parental transport

70 about the operation of the viscera provide a calming and relaxing influence?

71 h actual suicide attempt, while 'feelings of calm' and 'positive feelings towards self' associated ne

72 ers in which patient behavior (irritable vs. calm) and mental illness (present vs. absent) were exper

73 itation Sedation Scale score of 0 (alert and calm) and requires failure of intermittent sedative dosi

74 assembly lymphoid myeloid leukemia protein (CALM) and the heterotetrameric complex AP2.

75 "Cafe-au-lait" macules (CALMs) and overall skin hyperpigmentation are early hall

76 11 transcription factor (SOX11), calmodulin (CALM), and estrogen receptor 2 (ESR2A), all with a signi

77 otein (Bip), calpactin I (CalP), calmodulin (CalM), and Sik similar protein (Sik-SP) genes in ovariec

78 as been used for centuries to promote mental calming, and it is used clinically to suppress excessive

79 rminal halves of their SNARE motifs bind the CALM(ANTH) domain as helices in a manner that mimics SNA

80 re initiated when Yap1801 and Yap1802 (yeast CALM/AP180) and Syp1 (yeast FCHo1/2) coordinate with ani

81 rofessionals may wish to encourage alternate calming approaches.

82 Bip, CalP, and CalM are calcium-binding proteins and implicated in calc

83 interference (RNAi) indicate that AP180 and CALM are dispensable for some aspects of embryonic neuro

84 Epsin and AP180/CALM are endocytotic accessory proteins that have been i

85 assembly lymphoid myeloid leukemia protein (CALM) are clathrin accessory proteins that promote the f

86 assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important

87 These results suggest the potential of CALM as a new tool to study mitophagy.

88 iogram abnormalities of previously described CALM-associated disease, suggesting the variant causes p

89 Among the boys, the use of devices to calm at T2 was associated with higher emotional reactivi

90 emperamental surgency, the use of devices to calm at T2 was associated with increased emotional react

91 nt association with increased device use for calming at T3 (r = 0.10; 95% CI, -0.01 to 0.21).

92 was associated with increased device use for calming at T3 (r = 0.13; 95% CI, 0.02-0.24).

93 al and spatial resolution under low wind and calm atmospheric conditions.

94 presenting mainly with cafe au lait macules (CALMs), axillary freckling, and macrocephaly.

95 the substratum even in conditions mimicking calm back-reef flow environments.

96 calm) behavior and omit specific clinical information (e

97 calm) behavior as more likely to exaggerate their pain a

98 ult mice left breathing intact but increased calm behaviors and decreased time in aroused states.

99 ikely to recover than patients who displayed calm behaviour.

100 The C-terminal part of CALM binds clathrin heavy chain, although the full-lengt

101 in-individual changes in body temperature in calm birds and then in response to an experimental incre

102 body temperature within minutes of shifting calm birds to active flight, with strong evidence for a

103 onsolation of distressed parties by means of calming body contact.

104 the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5- bisphosphate [Pt

105 Calm buntings exhibited a modal body temperature range f

106 Effect sizes favored CALM but were not statistically significant for other co

107 ften used to keep young children occupied or calm, but it is not known whether this practice influenc

108 can be rescued by re-expression of wild-type CALM, but not with CALM that lacks a functional N-termin

109 ing Q-switched or picosecond lasers to treat CALMs can use morphologic characteristics to help predic

110 Here we demonstrate that depletion of CALM causes a substantial increase in the ratio of "open

111 ported frequency of use of mobile devices to calm children when upset (5-point Likert scale).

112 CALM circumvents the expense, labor, and time required f

113 AF10 is fused to a novel gene that we named CALM (Clathrin Assembly Lymphoid Myeloid leukemia gene)

114 elated clathrin assembly proteins, AP180 and CALM (clathrin assembly lymphoid myeloid leukemia protei

115 The clathrin assembly proteins AP180 and CALM (clathrin assembly lymphoid myeloid protein) are kn

116 MLL, AF10 has also been reported to fuse to CALM (clathrin-assembly protein-like lymphoid-myeloid) i

117 whereas shared resilience supports included calm clinician behavior and redundant intraoperative res

118 g and driving roles of CALM, we propose that CALM clusters may increase the strain on clathrin lattic

119 CALM (cognitive behavior therapy and pharmacotherapy med

120 CALM (cognitive behavior therapy and pharmacotherapy rec

121 y disorders treated in primary care clinics, CALM compared with UC resulted in greater improvement in

122 Coordinated Anxiety Learning and Management (CALM) compared with UC in 17 primary care clinics in 4 U

123 These aircraft can fly in calm conditions but avoid operations in gusty environmen

124 e around a closed circuit in both stress and calm conditions.

125 Here, we show that CALM contains a nuclear export signal (NES) that mediate

126 ort that the Alzheimer's disease risk factor CALM controls the surface levels of CP-AMPARs and thereb

127 CALM-LQTS and CALM-CPVT are the prevalent phenotypes.

128 ect navigation with current-driven drift: in calm currents, they maintained precise line-of-sight hea

129 bsolute NH(3) inequalities for all groups on calm days and for Black and African Americans and Hispan

130 Additionally, CALM-deficient neurons show disrupted secretory transpor

131 tosis is reduced in both AP180-deficient and CALM-deficient neurons.

132 The phenotypic effects of CALM depletion can be rescued by re-expression of wild-t

133 -assembly lymphoid myeloid leukemia protein, CALM, did not influence transferrin endocytosis but cons

134 Since the expression of adaptors, including CALM, differs among cells, our data support a model in w

135 and the subsequent socializing they seek to calm down.

136 formation flow between circuits, probably by calming down the overactive cells.

137 ACE-induced abnormal emotional behaviors by "calming down" the whole PrL.

138 uenceswhat distressed youngsters learn about calming down.

139 ) in paediatric patients requires them to be calm during the procedure to avoid motion artefacts in t

140 agged associations of the use of devices for calming, EF, and emotional reactivity, testing for moder

141 ernal signal that attracts piglets and has a calming effect at weaning.

142 Psychostimulants have a paradoxical calming effect in the treatment of attention deficit hyp

143 We assessed the calming effect of doppel, a wearable device that deliver

144 This paradoxical calming effect of psychostimulants depended on serotoner

145 KO) mice have suggested that the paradoxical calming effect of psychostimulants might occur through a

146 animal behavioral changes as a result of the calming effect of the lockdowns on human actions (COVID-

147 r, but not with non-nutritive sweetener, has calming effect on consumers with acute stress, suggestin

148 st holding - by human mothers has a specific calming effect on crying infants, inducing a coordinated

149 delivered through doppel, had a significant calming effect on physiological arousal and subjective e

150 ested whether the use of doppel would have a calming effect on physiological arousal and subjective r

151 ntic Ocean, Franklin observed that oil had a calming effect on waves when poured into rough ocean wat

152 cortex (PFC) might explain this paradoxical calming effect.

153 xiety levels, suggesting the occurrence of a calming effect.

154 displayed a marked reduction in locomotion ("calming" effect) in response to the same dose of ampheta

155 These results may be relevant to GFC's calming effects in attention deficit hyperactivity disor

156 tral nervous system (CNS), thereby producing calming effects.

157 robes to dissipate from stressed organelles, CALM enables signal-on fluorescence imaging of mitophagy

158 lting coding sequences are encoded using the CaLM encoder to generate codon-aware embeddings, which a

159 um management should also include ensuring a calming environment and adequate pain control, minimizin

160 CALM expands the applications of SM imaging techniques b

161 dentify the developmental stage of AP180 and CALM expression and suggest that each protein has distin

162 Furthermore, altered CALM expression exacerbates tau-mediated toxicity in zeb

163 d to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed

164 Amygdala response to fearful and calm faces was predicted to differentiate groups, with t

165 face emotion perception task of fearful and calm faces.

166 buildings, bus stops, street trash, traffic calming features, and warning signs.

167 CALM-FIM_EUR was a prospective, first-in-human, open-lab

168 complementation-activated light microscopy (CALM) for subresolution imaging of individual membrane p

169 ncreased in calm saline water compared to in calm freshwater.

170 Exclusion of the C-terminal portion of CALM from the fusion protein, which is required for opti

171 We propose that both AP180 and CALM function as endocytic accessory proteins at synapse

172 mponent suppression and replacement (SupRep) CALM gene therapy (CALM-SupRep) was created by cloning i

173 clathrin assembly lymphoid myeloid leukemia (CALM) gene encodes a putative homologue of the clathrin

174 The PICALM (CALM) gene, whose product is involved in clathrin-mediat

175 onversely, neurons that overexpress AP180 or CALM generate multiple axons.

176 nopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia

177 ase-causing variants in 1 of the 3 identical CALM genes cause severe forms of long QT syndrome, catec

178 achieve selective knockdown of any of the 3 CALM genes, making it a generalizable therapeutic strate

179 Indeed, all 3 calmodulin (CALM) genes are among the most constrained genes in the

180 CALM has a very high homology in its N-terminal third to

181 ponents of the endocytic machinery including CALM, HIP1R, and Sla2 bind Ub via their N-terminal ANTH

182 dents and other altricial mammals react with calming, immobility, and postural modifications to paren

183 we found high expression levels of AP180 and CALM in hippocampal tissues as early as embryonic day 18

184 e previously unknown functions for AP180 and CALM in intracellular trafficking that are essential in

185 However, the precise role of CALM in leukemogenesis remains unclear.

186 We found AP180 and CALM in synapses at all developmental stages and in nons

187 y to establish the distribution of AP180 and CALM in the developing hippocampal synapses.

188 h as healing illness, explaining misfortune, calming infants, and inducing others to cooperate.

189 most important during the resolution phase, calming inflammation and the activation state of dendrit

190 Long thought to be potassium channels with calming influence quietly working away in the background

191 CALM influences autophagy by regulating the endocytosis

192 Clathrin-CALM interaction seems to be regulated by multiple conta

193 n by restricting their release of gametes to calm intervals.

194 Altogether, the data suggest that CALM is an important component of coated pit internaliza

195 docytosis is tissue specific and explain why CALM is essential during embryogenesis and red blood cel

196 edominantly in presynaptic profiles, whereas CALM is found nonselectively in pre- and postsynaptic pr

197 e probe with acidity-triggered fluorescence, CALM is operated via Wm-promoted probe accumulation in m

198 INTERPRETATION: CALM is the first study to show that timely escalation w

199 Thus, CALM is the second protein besides Grb2 that appears to

200 CALM is thus a major factor in controlling CCV size and

201 to laser treatment for cafe au lait macules (CALMs) is inconsistent and difficult to predict.

202 tern beaches of Lake Michigan on a sunny and calm July 4, 2003, hours after a fast-moving convective

203 impairs axonal development, whereas reducing CALM levels results in dendritic dystrophy.

204 CALM-LQTS and CALM-CPVT are the prevalent phenotypes.

205 ects, are present in 30% of patients, mainly CALM-LQTS, and lethal cases of heart failure have occurr

206 Traffic-calming measures (TCMs) are physical modifications of th

207 , street furnishings, and safety and traffic calming measures.

208 e feel, such as during the slow breathing of calming meditation and anxiety-inducing hyperventilation

209 Interaction analyses suggest 'calm' moderates the association of 'love' with suicide a

210 Here we show that CALM modulates autophagy and alters clearance of tau, a

211 udy suggests that the AD genetic risk factor CALM modulates autophagy, and this may affect disease in

212 Fusions of the CALM NES (NES(CALM)-AF10) or NES motifs from heterologou

213 The CALM NES is essential for CALM-AF10-dependent Hoxa gene

214 cold-start online learning setting, Branched CALM-Net outperforms other models, attaining an average

215 nges, we developed a platform named Branched CALM-Net that aims to predict students' stress levels th

216 and have risen as much on windy nights as on calm nights, indicating that the observed overall warmin

217 est the hypothesis that irregularly bordered CALMs of the "coast of Maine" subtype respond better to

218 ne, we also report the presence of AP180 and CALM on other types of membrane structures.

219 CALM, on the other hand, is expressed as early as E12, b

220 l effects of psychostimulants, including the calming ones, in attention deficit hyperactivity disorde

221 High levels of expression of GFP-CALM or its fragments with clathrin-binding activity inh

222 rly in the absence of protective feelings of calm or positive self-view associated with current attem

223 In addition, GFP-CALM overexpression caused the loss of clathrin accumula

224 Rocking motion therapy has been shown to calm people with dementia but has never been investigate

225 one brought by convective mixing between the calm periods, caused unprecedented high concentrations o

226 lved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly pro

227 may provide insight into the association of CALM/PICALM mutations with growth retardation, cognitive

228 s4,5P(2)-binding, endocytic clathrin adaptor CALM/PICALM.

229 Here we provide evidence that AP180 and CALM play critical roles in establishing the polarity an

230 g and analysing clinical and genetic data on CALM-positive patients.

231 Our results demonstrate that CALM promotes vesicle completion upon membrane tension i

232 calization, and the role in endocytosis of a CALM protein were studied.

233 and Yap1801/2 (homologues of epsin and AP180/CALM proteins), with a plasmid encoding Ent1 or Yap1802

234 nean plant used in traditional medicine for "calming purposes", pointing at a possible antidepressant

235 Thus, CALM:R-SNARE interactions ensure that R-SNAREs, required

236 dge live-cell microscopy approaches to study CALM recruitment at forming CCVs.

237 s were often interpreted as omens, while the calm regularity of the astronomical cycles must have bee

238 CALM's role in directing the endocytosis of small R-SNAR

239 tors of all the MPs under study increased in calm saline water compared to in calm freshwater.

240 e anxious or agitated (SAS 5 to 7), 26% were calm (SAS 4), and 29% were sedated (SAS 1 to 3).

241 We show that CALM selectively facilitates the endocytosis of ubiquiti

242 Mutation of residues in the CALM:SNARE interface inhibits binding in vitro and preve

243 ecovery time, triggers, and effectiveness of calming strategies.

244 The single CALM-SupRep construct may be able to treat all calmoduli

245 The CALM-SupRep gene therapy shortened the pathologically pr

246 Additionally, transfection with CALM-SupRep shortened the APD90 of CALM1-F142L (665+/-9

247 Transfection with CALM-SupRep shortened the average APD90 of CALM2-D130G t

248 and replacement (SupRep) CALM gene therapy (CALM-SupRep) was created by cloning into a single constr

249 e-expression of wild-type CALM, but not with CALM that lacks a functional N-terminal, membrane-insert

250 tween loss of heterozygosity and the typical CALMs that appear over the general hyperpigmentation.

251 The assembly protein CALM, the ubiquitously expressed homolog of AP180, also

252 ullabies as the songs that they would use to calm their fussy infant, despite their unfamiliarity.

253 23 mothers (92.2%) and 2923 fathers (88.9%), calming their infant, 11396 mothers (94.6%) and 3035 fat

254 96 mothers (94.6%) and 3035 fathers (91.9%), calming themselves; 10060 mothers (85.1%) and 2688 fathe

255 The ability of the GFP-tagged fragments of CALM to affect clathrin-mediated processes correlated wi

256 re observed, eliciting perceptions from very calm to chaotic.

257 rents, changing the nearshore condition from calm to hazardous in just a few minutes and lasting for

258 Our observations link AP180 and CALM to multiple vesicular organelles and raise the poss

259 nt during CCV formation has been hampered by CALM toxicity upon overexpression.

260 gs from the codon adaptation language model (CaLM), trained on protein-coding DNA sequences.

261 The CALM trial is a first-in-human study evaluating the safe

262 Not surprisingly, CALM variants are poorly tolerated and accompany signifi

263 A significantly greater improvement for CALM vs UC in global anxiety symptoms was found (BSI-12

264 At 12 months, response and remission rates (CALM vs UC) were 63.66% (95% CI, 58.95%-68.37%) vs 44.68

265 CALM was an open-label, randomised, controlled phase 3 s

266 The bulk of cellular CALM was associated with the membrane fractions of the c

267 In the membrane fraction, CALM was present at near stoichiometric amounts relative

268 CALM was superior to UC for comorbid SAD at 6-month (-4.

269 CALM was superior to UC for principal GAD at 6-month (-1

270 GFP-CALM was targeted to the plasma membrane-coated pits and

271 We found the headspace above calm water provides an excellent environment for NP depo

272 The desiccation phase took place in calm waters of the lake.

273 To perform structure-function analysis of CALM, we engineered chimeric fusion proteins of CALM and

274 g the curvature sensing and driving roles of CALM, we propose that CALM clusters may increase the str

275 mode remains < - 15 dB for a 1-km link under calm weather, when we transmit OAM + 4 at 0.5 THz with a

276 t lead to power leakage to other modes under calm weather, while it tends to be unobtrusive under bad

277 R adaptation-mediated library manufacturing (CALM), which turns bacterial cells into "factories" for

278 es; P < .001), and were more often awake and calm while intubated (median, 86% [IQR, 67%-100%] of day

279 a C-terminal-attached fluorescent version of CALM, while preserving its endogenous expression levels,

280 CALMs with jagged or ill-defined borders of the coast of

281 Of 94 probands with familial CALMs with or without freckling and no other NF1 feature

282 lies with an autosomal dominant phenotype of CALMs with or without freckling and no other NF1 feature

283 riteria based on the presence of more than 5 CALMs with or without freckling or an NF1-compatible fam

284 examination, the patient was fully alert and calm without any signs of distress and had bilateral sub

285 that the frequent use of mobile devices for calming young children may displace their opportunities