ライフサイエンスコーパス: calmodulin

1 in a process depending on Ca binding to CaM (calmodulin).

2 o what is observed in the presence of barium-calmodulin.

3 of the channels by phosphorylating SK-bound calmodulin.

4 on; these are important for the functions of calmodulin.

5 mbrane via a peripheral protein complex with calmodulin.

6 e and reveal that the enzyme is regulated by calmodulin.

7 inase A (PKA)-independent CFTR activation by calmodulin.

8 d increases eNOS decoupling compared with WT calmodulin.

9 y interactive "hubs" such as parvalbumin and calmodulin.

10 otein of the primary calcium-sensing protein calmodulin.

11 on rate is slower in the presence of calcium-calmodulin.

12 its LTP by precluding binding of CaMKII with calmodulin.

13 ic oxide and did so more efficiently than WT calmodulin.

14 Our results indicate that calmodulin 1a (calm1a), expressed specifically in the MH

15 Under low calcium, calcium-free calmodulin 2 (Apo-CaM2) interacts with CNGC18-CNGC8 comp

16 els (CNGC18, CNGC8, and CNGC7) together with calmodulin 2 (CaM2) constitute a molecular switch that e

17 nctional roles enhanced by interactions with calmodulin, accessory proteins, or CaMKII that modulate

18 initiation in both sexes; similarly, Ca(2+)/calmodulin-activated kinase II is required for expressio

19 gation factor 2 kinase (eEF-2K), an atypical calmodulin-activated protein kinase, regulates translati

20 s onto layer 5 SOM neurons can be induced by calmodulin activation, suggesting that synaptic function

21 ylation of Ser(495) directly impairs calcium-calmodulin activation, whereas phosphorylation of Ser(10

22 ide by studying Ca(2+) and Mg(2+) binding of calmodulin, an EF-hand protein.

23 rized by cooperative Ca(2+) binding, such as calmodulin and calretinin.

24 scle channel isoform (RyR1) interaction with calmodulin and FK506 binding protein 12.6.

25 r decreased local cytosolic [Ca(2+)], Ca(2+)-calmodulin and FKBP12.

26 rogranin binds to the closed conformation of calmodulin and its impact on synaptic plasticity is less

27 s of these alterations on calcium binding by calmodulin and on binding and activation of eNOS.

28 We also found that calmodulin and phosphodiesterase 6 delta (PDE6delta), bu

29 This study identifies a new role for calmodulin and sheds new light on the intriguing CaM-bin

30 s disassembled after the addition of calcium-calmodulin and were then spaced within 3 min into compac

31 ction with the eukaryotic-specific co-factor calmodulin, and can be regulated by intracellular change

32 intracellular calcium, protein kinase C, and calmodulin, and downstream signaling regulated the relea

33 the actin regulatory proteins, caldesmon (a calmodulin- and actin-binding protein) and calpain 1 and

34 6-1,664) bound to alpha-actinin-1 and to apo-calmodulin (apoCaM).

35 Although calmodulins are well-known to regulate catalytic propert

36 We identified calmodulin as a partner for NCKX4 and confirmed the inte

37 e applied this novel approach to variants in calmodulin associated with two distinct arrhythmias as w

38 code expansion to site-specifically nitrate calmodulin at its two tyrosine residues, we assessed the

39 s, glyceraldehyde-3-phosphate dehydrogenase, calmodulin, ATP synthase, sperm equatorial segment prote

40 motif (amino acids 29-58) results in loss of calmodulin binding and a significant increase in the in

41 These observations show that calmodulin binding contributes to SPB mechanical integri

42 tures of a set of short IDPs, that mimic the calmodulin binding domain of calcium/calmodulin-dependen

43 Calmodulin binding enhanced TRPA1 sensitivity and Ca(2+)

44 unctional significance of calcium-dependent, calmodulin binding on OHC function.

45 inding transcription activators (CAMTA)3 and calmodulin binding protein 60g (CBP60g) together amplify

46 Because our previous work showed that a calmodulin binding site (CBS) was located in prestin's C

47 S recapitulates via one approach the calcium-calmodulin binding that required decades of sophisticate

48 Calmodulin binding to NCKX4 was demonstrated in extracts

49 Although CDI is mediated by calmodulin binding to the constitutive GluN1 subunit, pr

50 s a conserved hydrophobic pocket in CMI1 and calmodulin binding-like domain in ICR1.

51 d R553L mutations at distal helix B decrease calmodulin-binding and axonal enrichment.

52 WT and N53I CaM in complex with the primary calmodulin-binding domain (CaMBD2) from RyR2 at 1.84-2.1

53 and S6 in the pore domain, and intracellular calmodulin-binding helix B and helix B-C linker.

54 nt signal amplification via an intracellular calmodulin-binding motif.

55 centriole loss and showed that the conserved calmodulin-binding region of Pcp1/pericentrin is critica

56 ansient membrane-interactions, it contains a calmodulin-binding region, suggesting that in vivo FaEO

57 TIC32, was also shown to be dependent on its calmodulin-binding site for retention in the cytosol.

58 uctase, was analyzed in more detail, and its calmodulin-binding site was identified by specific mutat

59 The calmodulin-binding tetraleucine motif of KCNE4 is respon

60 The Arabidopsis thaliana Calmodulin-binding Transcription Activator (CAMTA) trans

61 e role of Arabidopsis (Arabidopsis thaliana) CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 6 (CAMTA6) in

62 The Arabidopsis (Arabidopsis thaliana) calmodulin-binding transcription activator3 (CAMTA3) is

63 Calcium, calmodulin, calmodulin-binding transcription activators (CAMTA)3 and

64 stream of the jasmonate receptor complex and calmodulin-binding transcription activators are nuclear

65 Calmodulin bound in a Ca(2+)-dependent manner to a motif

66 When cotransfected in HEK293 cells, calmodulin bound to NCKX4 under basal conditions and ind

67 ation through a process mediated by resident calmodulin bound to the intracellular C-terminal segment

68 While neurogranin might act as a calmodulin buffer, it does not significantly preclude th

69 ed in these cells, coexpression of wild-type calmodulin, but not a Ca(2+) binding-deficient calmoduli

70 AFM and then measuring the stabilization of calmodulin by myosin light chain kinase at dramatically

71 CaMKII is activated by calcium-bound calmodulin (Ca(2+)/CaM) through a direct binding mechani

72 s revealed that extinction recruited calcium/calmodulin (Ca(2+)/CaMK)-dependent protein kinase II (Ca

73 Ca(v)3 channels appears to be independent of calmodulin, calcineurin and endocytic pathways.

74 ion, including genes for calcium management (calmodulin, calcium-binding proteins), pH regulation (V-

75 Calcium, calmodulin, calmodulin-binding transcription activators

76 The calcium-sensor calmodulin (CaM) acts as a common activator of the netwo

77 How calmodulin (CaM) acts in KRAS-driven cancers is a vastly

78 als are decoded by the Ca(2+)-sensor protein calmodulin (CaM) and are transduced to Ca(2+)/CaM-bindin

79 The proximal Kv7.1 C terminus (CT) binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphospha

80 regulated by Ca(2+)-binding proteins such as calmodulin (CaM) and recoverin, the molecular mechanisms

81 in the intracellular Ca(2+)-sensing protein calmodulin (CaM) are arrhythmogenic, yet their underlyin

82 the highly conserved Ca(2+)-sensing protein calmodulin (CaM) cause severe cardiac arrhythmias, inclu

83 Calmodulin (CaM) conveys intracellular Ca(2+) signals to

84 eraction was associated with dissociation of calmodulin (CaM) from the IQ motif in Myo1c.

85 The Ca(2+) -sensing protein calmodulin (CaM) has a central role in tuning Na(V) func

86 Calmodulin (CaM) has been suggested to selectively bind

87 logical membrane potentials and modulated by calmodulin (CaM) in a calcium-dependent manner.

88 increased the current density of BdALMT12, a calmodulin (CaM) inhibitor reduced the Ca(2+)-dependent

89 Calmodulin (CaM) is proposed to modulate activity of the

90 +) channel (Na(V)1.4) activity is subject to calmodulin (CaM) mediated Ca(2+)-dependent inactivation;

91 Calmodulin (CaM) mediates a wide range of biological res

92 Among various modulators, calmodulin (CaM) regulates RyR2 in a Ca(2+)-dependent ma

93 Calmodulin (CaM) regulation of voltage-gated calcium (Ca

94 ding of a regulatory calcium-binding protein calmodulin (CaM) to the proximal C-terminus leads to the

95 ifs in their C termini, which associate with calmodulin (CaM), a universal calcium sensor.

96 ropyridine receptor (DHPR), FKBP12/12.6, and calmodulin (CaM), as well as ions and small molecules in

97 ncentration, limits the availability of free calmodulin (CaM), the protein which activates CaMKII in

98 ructural and dynamic effects of oxidation on calmodulin (CaM), using peroxide and the Met to Gln oxim

99 nd calcium channels (Ca(V)) form targets for calmodulin (CaM), which affects channel inactivation pro

100 tly inhibited by the calcium-sensing protein calmodulin (CaM), which leads to nuclear translocation o

101 Ca(2+) inhibits TRPV6 via binding to calmodulin (CaM), which mediates Ca(2+) -dependent inact

102 question, we found that the large number of calmodulin (CaM)-binding TFs or proteins in plant cells

103 nel P2X4 regulates lysosome fusion through a calmodulin (CaM)-dependent mechanism.

104 The Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) wa

105 In calmodulin (CaM)-rich environments, oncogenic KRAS plays

106 ith the eukaryotic Ca(2+)-binding regulator, calmodulin (CaM).

107 vity requires the eukaryote-specific protein calmodulin (CaM).

108 ition that requires intracellular Ca(2+) and calmodulin (CaM).

109 olled by ER-alpha is modulated by Ca(2+) via calmodulin (CaM).

110 In cells, the channels are regulated by calmodulin (CaM).

111 n in plants has long been known to involve a calmodulin (CaM)/Ca(2+)-dependent NAD(+) kinase, the nat

112 The model suggests that calmodulin can act as a protein cross-linker and Spc29 i

113 e of the SPB by binding to Spc42, Spc29, and calmodulin (Cmd1).

114 eraction platform, in which Kv1.3 and Ca(2+)/calmodulin compete for the KCNE4 interaction.

115 Crystal structures of the SidJ-calmodulin complex reveal a protein kinase fold that cat

116 Calcium-calmodulin dependent protein kinase II (CaMKII) regulate

117 CaMKII (Ca(2+)-Calmodulin dependent protein kinase) deltaC activation i

118 autophosphorylation (activation) of calcium/calmodulin-dependent kinase 2 (CaMKII) and also that inh

119 actors promoted the activation of the Ca(2+)/calmodulin-dependent kinase II (CaMKII) and the phosphor

120 diseases, we have targeted the host calcium/calmodulin-dependent kinase II (CaMKII) for inhibition.

121 Calcium-calmodulin-dependent kinase II (CaMKII) has an important

122 Calmodulin-dependent kinase II (CaMKII) has long been kn

123 Calcium/calmodulin-dependent kinase II (CaMKII) plays a key role

124 )JPH2 overexpressing myocytes caused calcium/calmodulin-dependent kinase II activation and altered my

125 the extrasynaptic cell surface, in a calcium/calmodulin-dependent kinase II and protein kinase G-depe

126 arbors a phosphorylation site for the Ca(2+)/calmodulin-dependent kinase II at serine 315.

127 ng protein phosphorylated at Ser133, calcium-calmodulin-dependent kinase II phosphorylated at Thr286,

128 CaMKII (Ca(2+)/calmodulin-dependent kinase II) enhances I(Na,L) in resp

129 Unlike the CaMKII (Ca(2+)/calmodulin-dependent kinase II)-dependent JNK2 action in

130 lele with a cre mouse line driven by calcium/calmodulin-dependent kinase IIalpha promoter also elimin

131 Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are

132 Calcium/calmodulin-dependent kinase kinase (CaMKK) and AMP-activ

133 Here we find calcium/calmodulin-dependent kinase kinase (CaMKK2) to be highly

134 Ca(2+)/calmodulin-dependent kinase kinase beta (CaMKKbeta) emer

135 he Aurora kinases, Polo kinases, and calcium/calmodulin-dependent kinase kinases.

136 ctivated phosphatase calcineurin in a Ca(2+)/calmodulin-dependent manner, preventing beta-arrestin re

137 denylyl cyclase synthesizes cAMP in a Ca(2+)/calmodulin-dependent manner, serving as a coincidence de

138 sponse to hypoxia-induced cell swelling in a calmodulin-dependent manner.

139 ke Legionella effector, SidJ, in an ATP- and calmodulin-dependent manner.

140 del predicted new crosstalks between calcium/calmodulin-dependent pathways and upstream signaling of

141 Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin)

142 The ubiquitous Ca(2+) /calmodulin-dependent phosphatase calcineurin is a key re

143 The Ca(2+)/calmodulin-dependent phosphatase calcineurin is a key re

144 ion by inhibiting the activity of the Ca(2+)/calmodulin-dependent phosphatase calcineurin toward nucl

145 ndent phosphorylation by members of the Ca2+/calmodulin-dependent protein kinase (CaMK) group.

146 ral root development in Populus in a calcium/calmodulin-dependent protein kinase (CCaMK)-dependent ma

147 am kinase liver kinase B1 (LKB1) and calcium/calmodulin-dependent protein kinase 2 (CaMKK2).

148 tion by the liver kinase B1 or by the Ca(2+)/calmodulin-dependent protein kinase 2 (CaMKK2).

149 Mechanistically, calmodulin-dependent protein kinase I phosphorylates a R

150 Ca(2+)/calmodulin-dependent protein kinase II (CAMK2) is a key

151 Ca2+/calmodulin-dependent protein kinase II (CaMKII) accounts

152 Ca(2+) oscillations and consequent Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati

153 Calcium/calmodulin-dependent protein kinase II (CaMKII) and calc

154 phorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot

155 tein kinase A (PKA) at Ser(16) and by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at Thr(1

156 The many variants of human Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) differ i

157 The calcium calmodulin-dependent protein kinase II (CaMKII) is a dod

158 Calcium/calmodulin-dependent protein kinase II (CaMKII) is a mul

159 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an ol

160 nhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphor

161 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a

162 Here, we show that activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) strongly

163 In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was bloc

164 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an adre

165 In addition, calcium/calmodulin-dependent protein kinase II (CaMKII), protein

166 d for activation of a MAPK cascade utilizing calmodulin-dependent protein kinase II (CaMKII), Raf, an

167 ts depends on their interaction with calcium/calmodulin-dependent protein kinase II (CaMKII), which i

168 ators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependen

169 reased intracellular Ca(2+) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated

170 to principal or local-circuit cells, calcium/calmodulin-dependent protein kinase II (CAMKIIalpha) imm

171 Activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKIIdelta) is

172 , PKA regulatory subunit type II, and Ca(2+)/calmodulin-dependent protein kinase II across cardiomyoc

173 increase in oxidation-dependent calcium and calmodulin-dependent protein kinase II activity, which c

174 t mice devoid of IFNAR1 signaling in calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph

175 ) currents were dependent in part on calcium/calmodulin-dependent protein kinase II and IP(3) pathway

176 mic the calmodulin binding domain of calcium/calmodulin-dependent protein kinase II and its 1-amino-a

177 It is also acknowledged that calcium/calmodulin-dependent protein kinase II and protein kinas

178 , cardiac stress protein biomarkers, such as calmodulin-dependent protein kinase II and the transcrip

179 Calcium/calmodulin-dependent protein kinase II gamma knockout mi

180 tracellular signal-regulated kinase, calcium/calmodulin-dependent protein kinase II gamma, and CREB2,

181 eam signaling protein, PKC-alpha, and Ca(2+)/calmodulin-dependent protein kinase II in endothelial ce

182 xygen species signaling, and oxidized Ca(2+)/calmodulin-dependent protein kinase II signaling were in

183 mellitus and counteracts pathological Ca(2+)/calmodulin-dependent protein kinase II signaling.

184 Pharmacologic inhibition of calcium and calmodulin-dependent protein kinase II with 2.5 microM o

185 Increased CaMKII (Ca/calmodulin-dependent protein kinase II) activity has bee

186 kinases, including protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and extracellula

187 turn, led to the phosphorylation of calcium/calmodulin-dependent protein kinase II, which promoted b

188 l fragment of HDAC4 but also promoted Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphor

189 ent of HDAC4, which was attenuated by Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphor

190 used 1 Hz optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive principa

191 lease channel-ryanodine receptor-2, PKA, and calmodulin-dependent protein kinase II-were activated in

192 ning of GABA(A) receptor synapses via Ca(2+)/calmodulin-dependent protein kinase II.

193 dent on calcium influx and linked to calcium/calmodulin-dependent protein kinase II.

194 by calcium influx and activation of calcium/calmodulin-dependent protein kinase II.

195 control (dependent largely on CaMKII [Ca(2+)/calmodulin-dependent protein kinase II] activity).

196 rotein (alphakap) encoded within the calcium/calmodulin-dependent protein kinase IIalpha (CAMK2A) gen

197 ization of beta-actin mRNA but not of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

198 essing Cre-recombinase driven by the calcium/calmodulin-dependent protein kinase IIalpha promoter.

199 d cardiomyocyte apoptosis, fibrosis, calcium/calmodulin-dependent protein kinase IIdelta phosphorylat

200 as a direct inhibitor of CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, a

201 Because SN inhibits CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, w

202 Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activati

203 Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) ac

204 The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is

205 Calcium/calmodulin-dependent protein kinase regulates the PINK1/

206 Calcium/calmodulin-dependent protein kinase type II delta (CaMKI

207 Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is

208 gh saturated fat diet activates CaMK (Ca(2+)/calmodulin-dependent protein kinase) in the heart, which

209 CaMKII (Ca(2+)/calmodulin-dependent protein kinase-II) protein-expressi

210 ms like those associated with CaMKII (Ca(2+)/calmodulin-dependent protein kinase-II), NLRP3 (NACHT, L

211 cations, MEF2D is an effector for the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin (Ca

212 including transcripts encoding Cask (calcium/calmodulin-dependent serine protein kinase) and Madd (MA

213 d protein from yeast to humans, is a calcium-calmodulin-dependent serine-threonine-specific phosphata

214 Calmodulin directly binds the AQP4 carboxyl terminus, ca

215 n the presence of calcium and stabilizes the calmodulin-dissociated, nonmotile myosin.

216 cium-calmodulin, persists autonomously after calmodulin dissociation.

217 tic allosteric ON switches by insertion of a calmodulin domain into rationally selected sites.

218 Evidence of CFTR binding to isolated calmodulin domains/lobes suggests a mechanism for the ro

219 Activation with Ca2(+)/calmodulin engages additional interactive surfaces and c

220 ery damage) and can be mitigated by reducing calmodulin expression.

221 CaMKII) and calcineurin (CaN) both bind open calmodulin, favoring Long-Term Potentiation (LTP) or Dep

222 nistic role of this modification in altering calmodulin function and eNOS activation has not been inv

223 y which SidE ligases are inhibited by a SidJ-calmodulin glutamylase, and opens avenues for exploring

224 Inhibition of calmodulin in a rat spinal cord injury model with the li

225 unctional calcium channel that is blocked by calmodulin in the resting state.

226 site-specific gain or loss of functions for calmodulin-induced eNOS activation.

227 ese interactions renders Eag1 insensitive to calmodulin inhibition.

228 Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic

229 The structure of the calmodulin insensitive mutant in a pre-open conformation

230 Calmodulin is a calcium binding protein with two lobes,

231 Calmodulin is often modified by the main biomarker of ni

232 and reverse genetics) demonstrated that the calmodulin isoform CAM5 is specifically involved in the

233 Silencing or inhibiting Ca/calmodulin kinase II (CaMKII) abolished the p.P888L-indu

234 Here, we report increased mitochondrial calmodulin kinase II (CaMKII) activation and left ventri

235 s, protein kinase C (PKC) betaII, or calcium-calmodulin kinase II (CaMKII) and inhibition by Galphai/

236 the autoactivated calcium-dependent kinase (calmodulin kinase II [CaMKII]) via the AC3I peptide and

237 Moreover, Ca(2+)/calmodulin kinase II is mechanistically involved in modu

238 preceded by increased expression of calcium/calmodulin kinase IV (CAMK4).

239 The peptidic nature of the calmodulin ligand enables incorporation of such syntheti

240 rmational changes within the soluble protein calmodulin, ligand binding to a G protein-coupled recept

241 nteractions between Myo1 and its associating calmodulin light chains.

242 Calmodulin-like (CML) proteins are major EF-hand-contain

243 a(2+)-free and Ca(2+)-bound EhActn2 reveal a calmodulin-like domain (CaMD) uniquely inserted within t

244 Ser/Thr and Tyr) kinase domain tethered to a calmodulin-like domain (CLD) via an autoinhibitory junct

245 The calmodulin-like domain of alpha-actinin binds to the Z-r

246 regulation of the gene encoding doublecortin calmodulin-like kinase 1 (DCLK1), a marker of cancer ste

247 we have identified the small EF-hand protein calmodulin-like protein 4 (CALML4) as an IMAC component.

248 t a largely uncharacterized protein known as calmodulin-like protein 4 (CALML4) is a component of thi

249 sis and signalling, including those encoding calmodulin-like proteins and Ca transporters.

250 a rotation of the intracellular domains and calmodulin may prevent this rotation by stabilizing inte

251 We propose that targeting the mechanism of calmodulin-mediated cell-surface localization of AQP4 is

252 Thus, calmodulin-mediated gating modulation, an evolutionarily

253 alcium machinery and impairing signaling via calmodulin, melanin drives an immunometabolic signaling

254 lmodulin, but not a Ca(2+) binding-deficient calmodulin mutant, suppressed NCKX4 activation in a time

255 spectrum of calmodulinopathies with 2 novel calmodulin mutations and to investigate mosaicism in 2 a

256 CaM (calmodulin) mutations are associated with congenital arr

257 We reveal that the calcium-calmodulin-myosin light chain kinase pathway controls sh

258 In contrast, calmodulin nitrated at Tyr-138 produced more nitric oxid

259 Results from in vitro eNOS assays with calmodulin nitrated at Tyr-99 revealed that this nitrati

260 ffer, it does not significantly preclude the calmodulin opening by calcium.

261 regulatory domain of CaMKII may bind either calmodulin or F-actin, but not both.

262 activation, triggered by binding of calcium-calmodulin, persists autonomously after calmodulin disso

263 We propose that Ca(2+) binding to calmodulin prepositioned on NCKX4 induces a slow conform

264 In turn, fluxed Ca(2+) ions bind to calmodulin-primed receptors and reduce further entry, th

265 , CALM1, CALM2 and CALM3 (encoding identical calmodulin protein).

266 nits, the constitutively bound Ca(2+) sensor calmodulin, protein kinase CK2, and protein phosphatase

267 arrhythmias produced by exacerbated Ca(2+) /calmodulin-protein kinase (CaMKII) activity, ryanodine r

268 Furthermore, the MAPKKK YDA and two calcium/calmodulin-regulated receptor-like kinases, CRLK1 and CR

269 he microtubule minus-end protein Patronin, a calmodulin-regulated spectrin-associated protein (CAMSAP

270 kdown mouse model for MT minus-end regulator calmodulin-regulated spectrin-associated protein 3 (CAMS

271 ck eNOS interaction with CCR10, but not with calmodulin, resulting in upregulation of eNOS activity.

272 We found that nitroTyr-calmodulin retains affinity for eNOS under resting physi

273 structure of SidJ in complex with human apo-calmodulin revealed the architecture of this heterodimer

274 e-level LITPOMS applied to Ca(2+) binding to calmodulin reveals binding order and site-specific affin

275 As reported previously, calmodulin's response to binding four Ca(2+) can be dete

276 ary, neurogranin synchronizes the opening of calmodulin's two lobes and promotes their activation at

277 n, like tyrosine phosphorylation, can impact calmodulin sensitivity for calcium and reveal Tyr site-s

278 These two lobes of calmodulin show subtle differences in calcium binding an

279 Calmodulin sits at the center of molecular mechanisms un

280 l based on allosteric principles to simulate calmodulin state transitions and its interactions with c

281 ons, we show that in the presence of calcium-calmodulin, the distance across the two GluN1 subunits a

282 on between the regulatory region of CFTR and calmodulin, the major calcium signaling molecule, and re

283 abundant post-translational modification on calmodulin, the mechanistic role of this modification in

284 Calcium signals cause calcium-calmodulin to activate CaMKII, which leads to remodeling

285 ediates calcium influx in LECs and activates calmodulin to facilitate a physical interaction between

286 vealed that FGF13 potentiates the binding of calmodulin to NaV1.5 and that phosphomimetic mutations a

287 SidJ is activated by host-cell calmodulin to polyglutamylate the SidE family of ubiquit

288 al NO synthase (nNOS) is activated by Ca(2+)/calmodulin to produce NO, which causes smooth muscle rel

289 ese results show that the binding of calcium-calmodulin to the C-terminus has long-range allosteric e

290 tite nature of the binding interface, allows calmodulin transiently to strip CaMKII from actin assemb

291 stimulation, CaMKII is disengaged by calcium-calmodulin, triggering network disassembly, expansion, a

292 er's biological utility by first resolving a calmodulin unfolding intermediate previously undetected

293 We analyzed the structure of calmodulin using molecular dynamics and found difference

294 Signaling proteins exemplified by calmodulin usually bind cooperatively to multiple ligand

295 We also discovered that UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ)

296 of CaMKII from F-actin, triggered by calcium-calmodulin, was too rapid to measure with flow-cell exch

297 tivates the channel via constitutively-bound calmodulin, whereas higher [Ca(2+) ] exerts inhibitory e

298 we show that Ca(2+) regulates TRPA1 through calmodulin, which binds to TRPA1 in a Ca(2+)-dependent m

299 ed by other NOSs but does not require Ca(2+)-calmodulin, which regulates NOS(red)-mediated NOS(ox) re

300 e interaction of FGF13 and, consequently, of calmodulin with NaV1.5.