ライフサイエンスコーパス: calmodulin kinase

1 in MC pretreated with inhibitors of calcium calmodulin kinase.

2 d in part by increases in cell [Ca2+] and Ca-calmodulin kinase.

3 tivation of protein kinase C but not calcium calmodulin kinase.

4 Intracellular Ca2+ ions may activate AMPK by calmodulin kinase 1 kinase-mediated phosphorylation.

5 tinocyte cultures with KN93, an inhibitor of calmodulin kinase 2, known to phosphorylate Ser-325 in C

6 bited more than 100-fold selectivity against calmodulin kinase 2; casein kinase-1 and -2; CDK1 and -4

7 hibiting either [Ca2+]i elevation or calcium calmodulin kinase activation.

8 tely preventing the pathological increase of calmodulin kinase activity in treated mice.

9 tained reduction of intracellular Ca(2+) and calmodulin kinase activity, ranolazine prevented the dev

10 nstrate an important role for the calmodulin/calmodulin kinase and cAMP/protein kinase A pathways in

11 ulin involve downstream signaling via Ca(2+)/calmodulin kinase and gene transcription.

12 avium, activate Ca(2+)-dependent calmodulin/calmodulin kinase and MAPK pathways in murine macrophage

13 anner that is dependent on Ca(2+) and Ca(2+)/calmodulin kinases and independent of ERKs, p38 MAPK, an

14 Both KN-62, an inhibitor of calcium/calmodulin kinase, and calpain inhibitor III, a calpain

15 38 and p42/44 MAP kinases, protein kinase C, calmodulin kinase, and tyrosine kinase, showing that HGF

16 evation of [Ca2+]i and activation of calcium calmodulin kinases are upstream mediators of ET-1-induce

17 ted to cAMP response element (CREB), calcium/calmodulin kinases, bassoon, and glutamatergic signaling

18 Signaling by the Ca(2+)/calmodulin kinase (CaMK) cascade has been implicated in

19 Calmodulin kinase (CaMK) has characteristics suitable fo

20 Calmodulin kinase (CaMK) II is linked to arrhythmia mech

21 MKIV) is the nuclear effector of the Ca(2+) /calmodulin kinase (CaMK) pathway where it coordinates tr

22 2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade inv

23 Because H(2)O(2) activates Ca(2+)/calmodulin kinase (CaMK)II, which also impairs I(Na) ina

24 meiotic maturation is dependent upon calcium calmodulin kinase (CamKII) activity.

25 Autonomous activation of calcium-calmodulin kinase (CaMKII) has been proposed as a molecu

26 ermine the role of PPT intracellular calcium/calmodulin kinase (CaMKII) signaling in the regulation o

27 exhibit attenuated calcium release, reduced calmodulin kinase (CaMKII) signaling, and impaired muscl

28 ily distinguish DCLKs from all other calcium calmodulin kinases (CAMKs), and a 'Swiss Army' assembly

29 voltage-sensitive Ca2+ channel and the Ca2+/calmodulin kinase cascade.

30 t, trifluoperazine, an antagonist of calcium/calmodulin kinases, completely blocked H(2)O(2)-induced

31 ependence, and is clearly different from the calmodulin kinase-dependent mechanism by which AngII mod

32 omologous to a CNS protein containing a Ca2+/calmodulin kinase domain, suggesting that the DCX protei

33 ved binding site for the peptide on the CASK calmodulin kinase domain.

34 omain protein composed of an N-terminal Ca2+/calmodulin-kinase domain, central PDZ and SH3 domains, a

35 Inhibition of calcineurin or calcium-calmodulin kinase greatly attenuates ionophore-induced a

36 contrast, inhibitors of protein kinase A and calmodulin kinases had no effect on CREB phosphorylation

37 pendent protein kinase, protein kinase C and calmodulin kinases have been implicated in calcium-signa

38 C (PKC) activity and not protein kinase A or calmodulin kinase; however, the identity and role of the

39 We identified a new calmodulin kinase I (CaMKI) substrate, cytidyltransferas

40 ase (CaMKK) and its downstream target Ca(2+)/calmodulin kinase I (CaMKI).

41 binding of the calmodulin-binding domain of calmodulin kinase I on the fast internal dynamics of cal

42 ion (Ca(2+))-dependent activation of Ca(2+)/calmodulin kinase-I (CaMKI), which triggers cAMP respons

43 ozygous for a null mutation of alpha-calcium-calmodulin kinase II (alpha-CaMKII+/-) show normal learn

44 Autophosphorylation of alpha-Ca2+/calmodulin kinase II (alphaCaMKII) at Thr286 is thought

45 The molecule alpha calcium calmodulin kinase II (alphaCaMKII) is known to play a fu

46 ion 286 mutated to alanine (A)] in the alpha calmodulin kinase II (alphaCaMKIIT286A) than in mice def

47 ctivation of the calmodulin-dependent enzyme calmodulin kinase II (CaM kinase II) was studied in PC12

48 ylated by protein kinase C (PKC) and calcium/calmodulin kinase II (CaMK II) after stimulation with ag

49 L-type Ca(2+) channel (LTCC) C terminus and calmodulin kinase II (CaMK) both signal increases in LTC

50 diator of cAMP-protein kinase (PKA) and Ca2+-calmodulin kinase II (CAMK-II) activation, we tested whe

51 otein (alphakap), encoded within the calcium/calmodulin kinase II (camk2) alpha gene, was recently fo

52 -C and TnI phosphorylation using the calcium/calmodulin kinase II (CaMK2) inhibitor autocamtide-2 rel

53 ompanied by changes in protein expression of calmodulin kinase II (CaMKII) (P<0.05) and calmodulin ki

54 Silencing or inhibiting Ca/calmodulin kinase II (CaMKII) abolished the p.P888L-indu

55 Here, we report increased mitochondrial calmodulin kinase II (CaMKII) activation and left ventri

56 tivated protein kinase (MAPK/ERK) and Ca(2+)/calmodulin kinase II (CaMKII) activation.

57 Such changes were related to enhanced Ca(2+)/calmodulin kinase II (CaMKII) activity and increased pho

58 cortex (PFC) via the dual control of calcium/calmodulin kinase II (CaMKII) activity.

59 s, protein kinase C (PKC) betaII, or calcium-calmodulin kinase II (CaMKII) and inhibition by Galphai/

60 Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and hea

61 In order to study the role of calcium/calmodulin kinase II (CaMKII) in T cells, we generated t

62 GT-1 DNA binding, phosphorylation by calcium/calmodulin kinase II (CaMKII) increased the binding acti

63 [Ca(2+)]i-activated calmodulin kinase II (CaMKII) inhibition with KN-93 (1 m

64 Both the calmodulin kinase II (CaMKII) inhibitor KN-62 and the PK

65 Pretreatment with the Ca-calmodulin kinase II (CaMKII) inhibitor KN-93, but not i

66 The inclusion of Ca2+-calmodulin kinase II (CaMKII) inhibitor peptides in the

67 Calmodulin Kinase II (CamKII) inhibits the transcription

68 (OGN) are increased in diabetic hearts, and calmodulin kinase II (CaMKII) is a proarrhythmic signal

69 Calcium/calmodulin kinase II (CaMKII) is required for LTP and ex

70 we investigated the role of the WNT/Calcium Calmodulin Kinase II (CaMKII) pathway in osteoarthritis.

71 ctivation and inhibited by Ca2+ through Ca2+/calmodulin kinase II (CaMKII) phosphorylation at Ser-107

72 51-300) of mouse Emi2 that also contained a calmodulin kinase II (CaMKII) phosphorylation motif and

73 ted increase in calcium (Ca(2+)) levels, via calmodulin kinase II (CaMKII) phosphorylation, inhibits

74 Ca(2+)/calmodulin kinase II (CaMKII) plays an important role in

75 everses LTS, and specific inhibitors of Ca2+/calmodulin kinase II (CaMKII) prevent induction and inhi

76 k-out mice (C3KO), Ca(2+) release and Ca(2+)/calmodulin kinase II (CaMKII) signaling are attenuated.

77 Ca2+-Calmodulin kinase II (CaMKII) was also required since it

78 ac myocyte apoptosis by activation of Ca(2+)/calmodulin kinase II (CaMKII), independently of PKA sign

79 a second Ca2+-activated signaling molecule, calmodulin kinase II (CaMKII), were increased in hearts

80 Calmodulin kinase II (CaMKII), which is not activated di

81 reases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII)-mediated enhancement of Ca

82 ses dependent on synaptic activity or Ca(2+)/calmodulin kinase II (CaMKII).

83 We show that the mLin-2/CASK calmodulin kinase II (CKII) domain directly binds to a 6

84 s mediated by direct interaction between the Calmodulin Kinase II (CKII)-like domain of mLin-2 and th

85 ease, which was reduced (50%) by blocking of calmodulin kinase II (KN-62).

86 Here, we show that oxidized calmodulin kinase II (ox-CaMKII) is a biomarker for SND

87 ontrast, currents were not attenuated by the calmodulin kinase II 281-309 peptide (10 micrometer), an

88 the autoactivated calcium-dependent kinase (calmodulin kinase II [CaMKII]) via the AC3I peptide and

89 out inhibition of calcium elevation, calcium-calmodulin kinase II activation, or cystic fibrosis tran

90 l relationship between a decrease in calcium/calmodulin kinase II activity and the development of sei

91 The data suggest that decreased calmodulin kinase II activity may play a role in epilept

92 of LCC activity (possibly mediated by Ca(2+)-calmodulin kinase II activity).

93 on the bi-directional regulation of calcium/calmodulin kinase II activity.

94 Neither p38 nor Ca2+/calmodulin kinase II agents exert significant influences

95 a(2+) disturbances, this results from Ca(2+)-calmodulin kinase II and reactive oxygen species-mediate

96 dependent Ca(2+) entry, activation of Ca(2+)/calmodulin kinase II and subsequent gating of CLC-3 link

97 tion with the protein effector alpha calcium-calmodulin kinase II and the regulation of the mTOR path

98 ffects of this indolamine on the activity of calmodulin kinase II as an inhibitor and as stimulator o

99 mice were bred with mice expressing an alpha-calmodulin kinase II Cre to selectively inactivate Dicer

100 e via S-nitrosylation of CaMKIIdelta (Ca(2+)/calmodulin kinase II delta) is emerging.

101 MCU expression through activation of Ca(2+)/calmodulin kinase II deltaB (CaMKIIdeltaB) and promotion

102 tion of protein kinase C isoforms or calcium calmodulin kinase II did not alter the BzATP-induced inc

103 re observed after a significant reduction in calmodulin kinase II expression.

104 fluorescent images of COS1 cells expressing calmodulin kinase II fused with enhanced yellow fluoresc

105 xpression of a constitutively active form of calmodulin kinase II in neurons.

106 n), completely inhibited by KN-62, a calcium-calmodulin kinase II inhibitor, and only partially repre

107 e I, calphostin C, and Ro31-8220 but not the calmodulin kinase II inhibitor, Kn-93, suggesting a role

108 Moreover, Ca(2+)/calmodulin kinase II is mechanistically involved in modu

109 to play a role in targeting multiple calcium/calmodulin kinase II isoforms to specific subcellular lo

110 Overexpression of activated calmodulin kinase II mimics the effect of Wnt5a, suggest

111 al LTP-mice heterozygous for a alpha-calcium calmodulin kinase II mutation (alpha CaMKII +/-) have lo

112 casein kinase (CK) I or II, but not calcium-calmodulin kinase II or protein kinase A, inhibited DNA

113 tion was dependent on the calcium/calmodulin/calmodulin kinase II pathway in both M. smegmatis- and M

114 sing a decoy peptide representing the Ca(2+)/calmodulin kinase II phosphorylation site on CLC-3, we s

115 on was driven by a forebrain-specific Ca(2+) calmodulin kinase II promoter system resulting in high l

116 (MAPK 1/2) substrate site), and serine 603 (calmodulin kinase II site).

117 antidepressant-like effects in mice through calmodulin kinase II stimulation of downstream melatonin

118 eta(IV)-spectrin, to bind and recruit Ca(2+)/calmodulin kinase II to the channel at a cellular locati

119 s inhibited by intracellular calcium through calmodulin kinase II, AC3 may serve as an important inte

120 te, or the calcium-responsive kinase calcium calmodulin kinase II, CpG-induced TNFalpha secretion was

121 dual effect of melatonin on the activity of calmodulin kinase II, the possible mechanisms involved,

122 ecific phosphorylation events on Erk 1/2 and calmodulin kinase II, two proteins required for CA1 hipp

123 chanistically, this regulation appears to be calmodulin kinase II-dependent and mediated through the

124 ivated by PGE(2) in human arterial SMCs is a calmodulin kinase II-inhibited AC with characteristics s

125 en probability was linked to enhance calcium-calmodulin kinase II-mediated phosphorylation in non-nat

126 Esophageal acid exposure induced calcium calmodulin kinase II-mediated phosphorylation of the sub

127 otein kinase C, MEK1/2, p38 kinase, and Ca2+/calmodulin kinase II.

128 309 peptide (10 micrometer), an inhibitor of calmodulin kinase II.

129 fluenced when channels are phosphorylated by calmodulin kinase II.

130 m IP3-sensitive internal stores, and calcium/calmodulin kinase II.

131 8 and protein kinase A but not on ERK 1/2 or calmodulin kinase II.

132 l inhibitors of calmodulin kinase kinase and calmodulin kinases II and III do not inhibit EGF-induced

133 the hippocampus requires activation of Ca2+/calmodulin-kinase II (CaM-KII), which phosphorylates Ser

134 Similarly, when the Ca(2+)/calmodulin-kinase II (CaMKII) inhibitory peptide was pre

135 tracellular calcium, elevated calmodulin and calmodulin-kinase II expression, whereas calcium chelati

136 eviously to be contingent upon modulation by calmodulin kinase IIalpha (alphaCaMKII).

137 stablished within the context of full-length calmodulin kinase IIalpha (CaM KIIalpha).

138 lar signaling molecules calcineurin, calcium calmodulin kinase IIalpha (CAMKIIalpha) and the receptor

139 signaling molecules calcineurin and calcium calmodulin kinase IIalpha (CAMKIIalpha); and the recepto

140 e myosin light chain kinase but not with the calmodulin kinase IIalpha peptide.

141 construct containing SUR cDNA and a calcium-calmodulin kinase IIalpha promoter.

142 tested this hypothesis in mice with calcium calmodulin kinase IIalpha-Cre-mediated forebrain GR dele

143 ctively, whereas the mutants fully activated calmodulin kinase IIalpha.

144 Calmodulin kinase IID (CaMKIID) was selected as a candid

145 ce of calcium, CaM binds endothelial calcium/calmodulin kinase IId (CaMKIId).

146 tein expression of Orai1, STIM1, and calcium-calmodulin kinase IIdelta2 (CamKIIdelta2); increased pro

147 cells, but neither protein phosphatase-1 nor calmodulin kinase III (EF-2 kinase) activity was affecte

148 Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that i

149 itor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III, abrogated the up-regulation at bo

150 rt that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage

151 ell [Ca2+] low with BAPTA, and by KN62, a Ca-calmodulin kinase inhibitor.

152 hancing glycolysis, and upregulating calcium/calmodulin kinase IV (CaMK4), which resulted in suppress

153 preceded by increased expression of calcium/calmodulin kinase IV (CAMK4).

154 f calmodulin kinase II (CaMKII) (P<0.05) and calmodulin kinase IV (CaMKIV) (P<0.05).

155 )-dependent CREB/c-fos activation via Ca(2+)-calmodulin kinase IV (CaMKIV) induces transcriptional re

156 can bind to T cells and activate the Ca(2+)-calmodulin kinase IV (CaMKIV) signaling cascade, resulti

157 iologic synaptic stimulation recruits a fast calmodulin kinase IV (CaMKIV)-dependent pathway that dom

158 y co-transfection with constitutively active calmodulin kinase IV and protein kinase A, and binding o

159 Constitutively active Ca(2+)-dependent calmodulin kinase IV enhanced Glis1-mediated transcripti

160 ampal neurons demonstrates a role for Ca(2+)/calmodulin kinase kinase (CaMKK) and its downstream targ

161 Pharmacological inhibitors of calmodulin kinase kinase and calmodulin kinases II and I

162 LKB1, upstream kinases for AMPK; STO-609, a calmodulin kinase kinase beta inhibitor, had the same ef

163 K phosphorylation was inhibited by siRNA for calmodulin kinase kinase beta, but not LKB1, upstream ki

164 AMPK phosphorylation by stimulating calcium-calmodulin kinase kinase beta.

165 e corresponding to the CaM-binding domain of calmodulin kinase kinase, along with the thermodynamic u

166 Here we report the identification of 'calmodulin kinase-like vesicle-associated' (CaMKv), a ps

167 ular signaling pathways involving Ca2+, Ca2+/calmodulin kinase, mitogen-activated protein kinase, cyc

168 t activation is mediated directly by neither calmodulin kinases nor phosphatidylinositol 3-kinase (PI

169 les, including histone deacetylases, calcium calmodulin kinase, or CK1.

170 We also report that signaling via the Ca(2+)/calmodulin kinase pathway functions upstream of the MAPK

171 duction was also dependent on the calmodulin/calmodulin kinase pathway.

172 Inhibition of Ca(2+)/calmodulin kinase, protein kinases A and C, tyrosine kin

173 Evaluation of these calcium calmodulin kinase superfamily members as candidate Ser(2

174 as used to identify a broad range of calcium calmodulin kinase superfamily members, including CHK2, C

175 f kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinas

176 The molecule alpha calcium-calmodulin kinase type II (alphaCaMKII) is known to play

177 el (CaV1.1) facilitates activation of Ca(2+)/calmodulin kinase type II (CaMKII) and Ca(2+) store refi

178 Calcium/calmodulin kinase type II (CaMKII) is a major postsynapt

179 e of Ca2+ and the absence of endogenous Ca2+/calmodulin kinase type II or protein kinase C activity,

180 tein kinase A specific and S2814 as a Ca(2+)/calmodulin kinase type-2-specific site.

181 pecific for the alpha subunit of the calcium/calmodulin kinase were used to decrease the expression o