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4 he costameric protein plasma membrane Ca(2+)/calmodulin-dependent ATPase (PMCA), and that its deletio
5 er, they were associated with reduced Ca(2+)/calmodulin-dependent auto-phosphorylation of eEF2 kinase
6 ave characterized two common forms of Ca(2+)/calmodulin-dependent endocytosis, i.e., slow clathrin-de
8 sible for dBest1 activation is likely Ca(2+)/calmodulin dependent kinase II (CaMKII), because specifi
9 ymbioses using three candidate genes: Ca(2+)/Calmodulin-Dependent Kinase (CCaMK), which plays a centr
10 autophosphorylation (activation) of calcium/calmodulin-dependent kinase 2 (CaMKII) and also that inh
11 The Ca(2+) and redox-sensing enzyme Ca(2+) /calmodulin-dependent kinase 2 (CaMKII) is a crucial and
14 actors promoted the activation of the Ca(2+)/calmodulin-dependent kinase II (CaMKII) and the phosphor
15 dynamin-related protein 1 (Drp1), by Ca(2+)/calmodulin-dependent kinase II (CaMKII) at a serine 616
17 diseases, we have targeted the host calcium/calmodulin-dependent kinase II (CaMKII) for inhibition.
21 onses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from
23 glucagon-induced calcium signaling, calcium/calmodulin-dependent kinase II (CaMKII) phosphorylates O
24 rum show that synapsin is a target of Ca(2+) calmodulin-dependent kinase II (CaMKII) phosphorylation
26 a putative regulator of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) signaling, exclu
29 )JPH2 overexpressing myocytes caused calcium/calmodulin-dependent kinase II activation and altered my
30 NK1 in vitro Inhibiting PKC, JNK, or calcium/calmodulin-dependent kinase II activity prevented the ef
31 y-dependent phosphorylation event on calcium-calmodulin-dependent kinase II alpha (CaMKIIalpha) at se
32 horylation directly through JNK1 and calcium/calmodulin-dependent kinase II and also by inducing expr
33 the extrasynaptic cell surface, in a calcium/calmodulin-dependent kinase II and protein kinase G-depe
34 ed RyRs have a distinct modulation by Ca(2+)/calmodulin-dependent kinase II and reactive oxygen speci
36 a substrate for protein kinase D and Ca(2+)/calmodulin-dependent kinase II in vitro and identified S
37 ng protein phosphorylated at Ser133, calcium-calmodulin-dependent kinase II phosphorylated at Thr286,
38 m signaling, autoinhibition is reinforced by calmodulin-dependent kinase II phosphorylation of serine
39 FIP2 expression also increases alpha-calcium/calmodulin-dependent kinase II protein expression, and t
40 ts Nav1.5 and its regulatory protein calcium/calmodulin-dependent kinase II to the intercalated disc.
43 ude local synthesis of APP and alpha-calcium/calmodulin-dependent kinase II, a kinase that can phosph
44 e for ankyrin-dependent targeting of calcium/calmodulin-dependent kinase II-delta; however, betaIV-sp
46 lele with a cre mouse line driven by calcium/calmodulin-dependent kinase IIalpha promoter also elimin
51 utophagy via a pathway that included calcium/calmodulin-dependent kinase kinase beta (CaMKKbeta), AMP
53 ns of the excitatory neuron-specific Ca(2+) /calmodulin-dependent kinase subunit alpha (CaMKIIalpha)
54 ongation factor 2 kinase (eEF2K) is a Ca(2+)/calmodulin-dependent kinase that regulates translation e
55 ese cells, and in cells where calmodulin and calmodulin-dependent kinase were blocked pharmacological
58 ctivated phosphatase calcineurin in a Ca(2+)/calmodulin-dependent manner, preventing beta-arrestin re
59 denylyl cyclase synthesizes cAMP in a Ca(2+)/calmodulin-dependent manner, serving as a coincidence de
63 endent on the relative activities of Ca(2+) /calmodulin-dependent myosin light chain kinase (MLCK) an
64 pendent on the relative activities of Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) an
65 ght chain (RLC) is phosphorylated by Ca(2+) /calmodulin-dependent myosin light chain kinase and depho
66 ends on the respective activities of Ca(2+) /calmodulin-dependent myosin light chain kinase and myosi
67 del predicted new crosstalks between calcium/calmodulin-dependent pathways and upstream signaling of
69 These observations show that calcium- and calmodulin-dependent PDEs (PDE1A and PDE1C) and PDE3A mo
73 esults also provide evidence that the Ca(2+)/calmodulin-dependent phosphatase calcineurin plays a rol
74 ion by inhibiting the activity of the Ca(2+)/calmodulin-dependent phosphatase calcineurin toward nucl
75 k1 signaling negatively regulates the Ca(2+)/calmodulin-dependent phosphatase, calcineurin, to enable
76 BAA signaling by calcineurin, a calcium- and calmodulin-dependent phosphatase, enables homeostatic ba
78 ranslational control mechanism is the Ca(2+)/calmodulin-dependent phosphorylation of eukaryotic elong
80 er brain regions, using Thy1-Cre and calcium/calmodulin dependent protein kinase II alpha-Cre for abl
81 A protein with similarities to the Ca(2+)/ calmodulin dependent protein kinase II_association domai
86 Psi Here, we characterize a role for calcium/calmodulin-dependent protein kinase (CaMK) I in the regu
87 +)-dependent binding of S100B to the calcium/calmodulin-dependent protein kinase (CaMK)-type domain o
88 ore than 20 years, we have known that Ca(2+)/calmodulin-dependent protein kinase (CaMKII) activation
91 prevent the arrhythmias induced by a Ca(2+) -calmodulin-dependent protein kinase (CaMKII)-dependent l
92 ral root development in Populus in a calcium/calmodulin-dependent protein kinase (CCaMK)-dependent ma
93 crease its activity in BTICs, whereas Ca(2+)-calmodulin-dependent protein kinase 2 (CAMK2) inhibited
96 hanistically, CaMKK2 signals through Ca(2+) /calmodulin-dependent protein kinase 4 (CaMKIV) to contro
98 d dysregulation of Na and Ca handling and Ca/calmodulin-dependent protein kinase and are especially p
99 ined increase in cytosolic Ca(2+), activated calmodulin-dependent protein kinase and the calpain-casp
100 cannabinoid type 1 (CB1) receptor and Ca(2+)/calmodulin-dependent protein kinase beta, activates AMP-
102 plex dephosphorylates and inactivates Ca2(+)/calmodulin-dependent protein kinase I (CaMKI), an upstre
105 is critically regulated by the alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII), a
111 tate (NMDA) receptor activation, and Calcium/calmodulin-dependent protein kinase II (CaMKII) activati
112 Ca(2+) oscillations and consequent Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati
113 y (SOCE) and sequential activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and Ca(2
116 phorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot
117 hibitory peptide (mAIP) selective for Ca2+ / calmodulin-dependent protein kinase II (CaMKII) and U012
118 cription factor DeltaFosB and protein kinase calmodulin-dependent protein kinase II (CaMKII) are co-r
120 tein kinase A (PKA) at Ser(16) and by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at Thr(1
123 ulation; (5) inhibiting either PKA or Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) during b
124 imulation; (5) inhibiting either PKA or Ca2+/calmodulin-dependent protein kinase II (CaMKII) during b
131 e heart; however, the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is also
134 Here we show that the activity of calcium/calmodulin-dependent protein kinase II (CaMKII) is incre
135 Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overacti
137 nhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphor
141 nel activity reduced EGF receptor (EGFR) and calmodulin-dependent protein kinase II (CAMKII) signalin
142 treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific
145 esulted in compromised signaling from Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to myosi
146 which in turn requires binding of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to the N
147 protein GW182 increases expression of a Ca2+/calmodulin-dependent protein kinase II (CaMKII) translat
150 CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key s
151 reduces FRET between the NMDARcd and calcium/calmodulin-dependent protein kinase II (CaMKII), a proce
153 triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an olig
154 embranes, synGAP is phosphorylated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), another
155 ono pentanoic acid; the inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII), autocam
156 vented by pharmacological blockade of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), it was
157 tream effector of WNT/Ca(2+) pathway, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), led to
158 athway is a kinase cascade involving calcium/calmodulin-dependent protein kinase II (CaMKII), p38alph
160 d for activation of a MAPK cascade utilizing calmodulin-dependent protein kinase II (CaMKII), Raf, an
161 tors of transient spine expansion, including calmodulin-dependent protein kinase II (CaMKII), RhoA, a
162 ts depends on their interaction with calcium/calmodulin-dependent protein kinase II (CaMKII), which i
163 scular smooth muscle (VSM) expresses calcium/calmodulin-dependent protein kinase II (CaMKII)-delta an
164 ators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependen
165 reased intracellular Ca(2+) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated
166 he hypotheses that (1) inhibition of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated
167 o the model reveal that inclusion of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated
168 lism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated
169 Although many studies have focused on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated
177 to principal or local-circuit cells, calcium/calmodulin-dependent protein kinase II (CAMKIIalpha) imm
179 ites by protein kinase A (Ser-7) and calcium-calmodulin-dependent protein kinase II (Ser-13) and at m
180 , PKA regulatory subunit type II, and Ca(2+)/calmodulin-dependent protein kinase II across cardiomyoc
182 id) receptor activation, calcium and calcium/calmodulin-dependent protein kinase II activity, but not
183 increase in oxidation-dependent calcium and calmodulin-dependent protein kinase II activity, which c
185 Alcohol-sensitive proteins included calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph
187 t mice devoid of IFNAR1 signaling in calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph
188 ling molecules, calcineurin, Ras, and Ca(2+)/calmodulin-dependent protein kinase II and implicates Ca
189 ) currents were dependent in part on calcium/calmodulin-dependent protein kinase II and IP(3) pathway
190 mic the calmodulin binding domain of calcium/calmodulin-dependent protein kinase II and its 1-amino-a
191 itive deficits via altered levels of calcium/calmodulin-dependent protein kinase II and N-methyl-D-as
192 lated to higher activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and nuclear expor
194 rrhythmic manifestations, related to Ca(2+) /calmodulin-dependent protein kinase II and ryanodine rec
195 , cardiac stress protein biomarkers, such as calmodulin-dependent protein kinase II and the transcrip
196 es and Thr-287 autophosphorylation of Ca(2+)/calmodulin-dependent protein kinase II beta (CaMKIIbeta)
198 nt and function, including Titin and calcium/calmodulin-dependent protein kinase II delta (Camk2d).
199 he mechanical effects of the kinases calcium/calmodulin-dependent protein kinase II delta (CaMKIIdelt
201 myocytes from arrhythmia-susceptible calcium calmodulin-dependent protein kinase II delta C (CaMKIIde
203 the LTP kinase dependency from PKA to Ca2(+)/calmodulin-dependent protein kinase II during synapse ma
207 tracellular signal-regulated kinase, calcium/calmodulin-dependent protein kinase II gamma, and CREB2,
208 A null mutation of the Drosophila calcium/calmodulin-dependent protein kinase II gene (CaMKII) was
209 ion and subsequent activation of calcium and calmodulin-dependent protein kinase II has a causal role
210 eam signaling protein, PKC-alpha, and Ca(2+)/calmodulin-dependent protein kinase II in endothelial ce
211 2B, also referred to as Pyk2) and of calcium/calmodulin-dependent protein kinase II in wild-type brai
212 rolled firing rate adaptation whereas Ca(2+)/Calmodulin-dependent protein kinase II induced a delayed
213 Development of organ-specific calcium and calmodulin-dependent protein kinase II inhibitors may re
215 rom transgenic mice expressing a calcium and calmodulin-dependent protein kinase II inhibitory peptid
218 on synapsin I, two of which are known Ca(2+)/calmodulin-dependent protein kinase II phosphorylation s
219 xygen species signaling, and oxidized Ca(2+)/calmodulin-dependent protein kinase II signaling were in
221 ignaling kinases protein kinase C and Ca(2+)/Calmodulin-dependent protein kinase II to AngII-mediated
223 as phosphorylation of substrates for calcium/calmodulin-dependent protein kinase II was unchanged.
224 Pharmacologic inhibition of calcium and calmodulin-dependent protein kinase II with 2.5 microM o
226 stabilization of postsynaptic CaMKII (Ca(2+)/calmodulin-dependent protein kinase II) at inhibitory sy
227 1 pathway, phospho-alphaCaMKII (alpha Ca2(+)/calmodulin-dependent protein kinase II) level in the hip
228 mitochondrial recruitment of CaMKII (Ca(2+)/calmodulin-dependent protein kinase II), which decreases
229 phosphorylation at Ser16 and CaMKII (Ca(2+)/calmodulin-dependent protein kinase II)-dependent phosph
231 ng protein, but not the activation of Ca(2+)/calmodulin-dependent protein kinase II, Akt or mitogen-a
232 kinases, including protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and extracellula
233 ellular protein mediators Homer1b/c, calcium/calmodulin-dependent protein kinase II, and the Alzheime
234 a(2+) must first mobilize actin-bound Ca(2+)/calmodulin-dependent protein kinase II, freeing it for s
236 turn, led to the phosphorylation of calcium/calmodulin-dependent protein kinase II, which promoted b
237 at have the ryanodine receptor 2 calcium and calmodulin-dependent protein kinase II-dependent phospho
238 l fragment of HDAC4 but also promoted Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphor
239 ent of HDAC4, which was attenuated by Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphor
241 used 1 Hz optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive principa
242 lease channel-ryanodine receptor-2, PKA, and calmodulin-dependent protein kinase II-were activated in
248 FTO interacts with three isoforms of calcium/calmodulin-dependent protein kinase II: alpha, beta and
250 rotein (alphakap) encoded within the calcium/calmodulin-dependent protein kinase IIalpha (CAMK2A) gen
251 is study, we investigated the role of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha
252 ization of beta-actin mRNA but not of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha
254 ceptors, p600 associates with the calmodulin.calmodulin-dependent protein kinase IIalpha complex.
255 essing Cre-recombinase driven by the calcium/calmodulin-dependent protein kinase IIalpha promoter.
256 d cardiomyocyte apoptosis, fibrosis, calcium/calmodulin-dependent protein kinase IIdelta phosphorylat
257 as a direct inhibitor of CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, a
258 Because SN inhibits CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, w
259 Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increa
260 ive oxygen species (ROS) production, calcium/calmodulin-dependent protein kinase IV (CaMKIV) activati
262 describe a novel mechanism in which calcium/calmodulin-dependent protein kinase IV (CaMKIV), through
264 KN93, a small-molecule inhibitor of calcium/calmodulin-dependent protein kinase IV, targeted to CD4(
265 is regulated by the classical nuclear Ca(2+)/calmodulin-dependent protein kinase IV-CREB/CREB-binding
267 re, we report that the expression of Ca(2+) /calmodulin-dependent protein kinase kinase 2 (CaMKK2) is
268 ally reduced by the application of a calcium/calmodulin-dependent protein kinase kinase 2 inhibitor (
269 istic target of rapamycin complex 1, calcium/calmodulin-dependent protein kinase kinase 2, and protei
270 e expression of constitutively active Ca(2+)/calmodulin-dependent protein kinase kinase alpha (caCaMK
271 PK kinases liver kinase B1 (LKB1) and Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe
272 AMPK activation by aa is mediated by Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe
274 events were blocked by inhibition of Ca(2+)/calmodulin-dependent protein kinase kinase beta, an upst
277 alcineurin, Akt/protein kinase B, and Ca(2+)/calmodulin-dependent protein kinase signaling pathways i
279 ger, phospholamban, calcineurin, and calcium/calmodulin-dependent protein kinase type II (CaMKII) wer
281 to remodeling pathways (e.g., Akt and Ca(2+)/calmodulin-dependent protein kinase type II) and develop
283 gh saturated fat diet activates CaMK (Ca(2+)/calmodulin-dependent protein kinase) in the heart, which
285 ngation factor 2 kinase (eEF2K), an atypical calmodulin-dependent protein kinase, phosphorylates and
287 ms like those associated with CaMKII (Ca(2+)/calmodulin-dependent protein kinase-II), NLRP3 (NACHT, L
289 r new protein synthesis and required calcium/calmodulin-dependent protein kinases and the nuclear cal
291 cations, MEF2D is an effector for the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin (Ca
293 pines, (3) required activation of the Ca(2+)/calmodulin-dependent protein-kinase II, (4) was restrict
294 or somatostatin-positive interneurons and of calmodulin-dependent, protein kinase-positive, principal
295 h GluN2B and with the adaptor protein Ca(2+)/calmodulin-dependent serine protein kinase and kinesin K
296 including transcripts encoding Cask (calcium/calmodulin-dependent serine protein kinase) and Madd (MA
297 ; membrane protein, palmitoylated 3; calcium/calmodulin-dependent serine protein kinase; membrane-ass
298 d protein from yeast to humans, is a calcium-calmodulin-dependent serine-threonine-specific phosphata
299 ere we provide evidence that the calcium and calmodulin-dependent serine/threonine protein kinase typ