ライフサイエンスコーパス: caloric restriction

1 nduced by dietary restriction (also known as caloric restriction).

2 uenced by the energy expenditure response to caloric restriction.

3 armacologic agents that mimic the effects of caloric restriction.

4 n in different species by mechanisms akin to caloric restriction.

5 ons, but also lowered BW and adiposity under caloric restriction.

6 (r = 0.79), and was decreased in response to caloric restriction.

7 ptive decreases of metabolic rate induced by caloric restriction.

8 remodeling, to cardioprotection arising from caloric restriction.

9 d metabolism were both increased, even under caloric restriction.

10 tween IDH2 and SIRT3 under acute and chronic caloric restriction.

11 betes and regulated by feeding, fasting, and caloric restriction.

12 volved in life-span extension in response to caloric restriction.

13 bserved in controls matched for adiposity by caloric restriction.

14 odulated by environmental challenges such as caloric restriction.

15 neither has the correction that occurs upon caloric restriction.

16 ats were subjected to 0, 2, 4, or 6 weeks of caloric restriction.

17 tensity aerobic exercise is performed during caloric restriction.

18 ed to the beneficial effects of exercise and caloric restriction.

19 gevity through pathways common to effects of caloric restriction.

20 e in the antiaging cardiovascular effects of caloric restriction.

21 ling pathway, mitochondrial dysfunction, and caloric restriction.

22 yeast and promotes lifespan extension during caloric restriction.

23 oposed to underlie the beneficial effects of caloric restriction.

24 plicated in the lifespan-enhancing effect of caloric restriction.

25 stimuli as pharmacological interventions or caloric restriction.

26 cted by MsrA or MsrB, and further reduced by caloric restriction.

27 pendent of the lifespan extension offered by caloric restriction.

28 be predicted to increase weight loss during caloric restriction.

29 ageing by mechanisms that may be related to caloric restriction.

30 -old ob/ob mice either by leptin infusion or caloric restriction.

31 tabolic potential and a mechanism resembling caloric restriction.

32 rfeeding and resistant to weight loss during caloric restriction.

33 fitness benefits of lifespan extension under caloric restriction.

34 nisms promotes longevity in a manner akin to caloric restriction.

35 accumulation through a mechanism resembling caloric restriction.

36 own and delays age-related kidney disease is caloric restriction.

37 se and the changes in their capacities after caloric restriction.

38 ance to H(2)O(2) and extending lifespan upon caloric restriction.

39 glycemia and prevalent mortality upon severe caloric restriction.

40 e metabolite profile is mainly attributed to caloric restriction.

41 groups followed a Mediterranean diet without caloric restriction.

42 Volunteers then underwent 6 weeks of 50% caloric restriction.

43 isms and may underlie the health benefits of caloric restriction, a diet that delays aging and neurod

44 Caloric restriction, a near-universal lifespan extending

45 Caloric restriction activates SIRT3 expression in both w

46 It is possible that caloric restriction acts by improving insulin sensitivit

47 of Molecular Cell, Molin et al. reveal that caloric restriction alleviates PKA-dependent inhibition

48 Caloric restriction alone also led to significant decrea

49 ve caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or us

50 tion to one of the following 2 diets without caloric restriction: an HP diet (>40% of energy from pro

51 for potential factors that are regulated by caloric restriction and act as caloric restriction mimet

52 tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and

53 ts consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restri

54 , and finally we discuss the role of Sir2 in caloric restriction and aging.

55 l nutrient uptake and thus causes functional caloric restriction and allows improved anti-tumor immun

56 models of longevity are related primarily to caloric restriction and alterations in metabolism.

57 fy the molecular pathways responsive to both caloric restriction and dietary composition within adipo

58 to the idea that prevention of obesity, and caloric restriction and exercise could reduce the predis

59 the beneficial effects on neural function of caloric restriction and exercise, which are among the mo

60 has also been proposed to mimic benefits of caloric restriction and exercise.

61 Diet can greatly impact health, while caloric restriction and fasting have putative benefits f

62 s using preconditioning protocols, including caloric restriction and hypoxic preconditioning, have be

63 ing strategies shows overlapping patterns in caloric restriction and hypoxic preconditioning, pointin

64 To identify genes and pathways shared by caloric restriction and hypoxic preconditioning, we used

65 he airway hyperresponsiveness preventable by caloric restriction and IL-1beta blockade.

66 L-1beta mechanism, which can be prevented by caloric restriction and IL-1beta blockade.

67 Caloric restriction and intermittent fasting are emergin

68 issue mass in obese humans in the absence of caloric restriction and markedly accelerate weight and b

69 provided by the in vivo efficacy of dietary caloric restriction and natural product-based energy res

70 Caloric restriction and periodic fasting can extend adul

71 ed in the beneficial effects of exercise and caloric restriction and putative anti-inflammatory effec

72 g histone deacetylase, which is increased by caloric restriction and reduced by overfeeding.

73 trations and reduced HDL is improved by both caloric restriction and reduced carbohydrate consumption

74 eeminence for their roles in the response to caloric restriction and the regulation of aging and life

75 lycemia and promoting survival during severe caloric restriction and the requirement for ghrelin cell

76 In rodents, caloric restriction and young blood-induced revitalizati

77 the weight-loss program included nutrition (caloric restriction) and psychological therapies.

78 potential regulation of pathways mediated by caloric restriction, and growing links to human disease

79 en shown to decrease with age, increase with caloric restriction, and influence stress resistance.

80 lifespan, reproduction, and the response to caloric restriction, and investigate maternal investment

81 t stimulate AMPK and PGC1alpha via exercise, caloric restriction, and medications result in stimulati

82 ttenuated in the kidney, ovary, and heart by caloric restriction, and this decrease correlates with d

83 ently in young and old rats after 6 weeks of caloric restriction ( approximately decrease 53%; P = 0.

84 Disturbed eating and severe caloric restriction are characteristic features of patie

85 ) localized to ghrelin cells is required for caloric restriction-associated ghrelin release and the e

86 Previous reports indicate that caloric restriction attenuates anxiety and other behavio

87 We propose that caloric restriction attenuates behavioral and physiologi

88 Glycemic control improves in part because of caloric restriction but also because gut peptide secreti

89 n (TFCA) was measured at baseline and during caloric restriction by using a dual-stable calcium isoto

90 Caloric restriction (by 33% of energy intake) for 4 wk d

91 rat model to a greater extent than moderate caloric restriction (by comparison to the WM group).

92 Caloric restriction can ameliorate celsr1a aging phenoty

93 Thus, a reduction of fat mass without caloric restriction can be associated with increased lon

94 by environmental modification; for example, caloric restriction can increase life span.

95 Even moderate exercise or caloric restriction can lead to lower progesterone level

96 Six weeks of caloric restriction caused a similar reduction in body w

97 Caloric restriction causes many changes in glucose metab

98 ew study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC

99 lerate weight and body fat loss secondary to caloric restriction compared with diets low in dairy pro

100 rwent either 2 wk of eTRF (n = 8) or control/caloric restriction (CON:CR; n = 8) diet.

101 In mammals, caloric restriction consistently results in extended lif

102 sir2.1 deletion, we show that heat shock and caloric restriction cooperate to promote increased survi

103 CONCLUSIONS Improved S(I) during caloric restriction correlated with a preferential abdom

104 Whether caloric restriction (CR) acts synergistically with RT to

105 ric restriction, we show that the effects of caloric restriction (CR) and the GHRH mutation are addit

106 Caloric restriction (CR) can increase longevity in roden

107 is unclear, but prior evidence suggests that caloric restriction (CR) can slow thymic aging by mainta

108 It has been shown that caloric restriction (CR) delays aging and possibly delay

109 In yeast, caloric restriction (CR) delays aging by activating the

110 Because caloric restriction (CR) delays aging, at least in part,

111 that adult female mice maintained under 40% caloric restriction (CR) did not exhibit aging-related i

112 Caloric restriction (CR) enhances the sensitivity of ske

113 Importantly, caloric restriction (CR) extends lifespan in several org

114 Caloric restriction (CR) extends the life span and healt

115 Caloric restriction (CR) extends the lifespan of flies,

116 h to ad libitum low-fat diet (DIO-switch) or caloric restriction (CR) for 4 weeks before being killed

117 Caloric restriction (CR) has been found to extend the li

118 Long-term caloric restriction (CR) has been repeatedly shown to in

119 Caloric restriction (CR) has been shown to retard aging

120 We determined whether caloric restriction (CR) has cardiac-specific effects th

121 Caloric restriction (CR) has long been known to increase

122 Caloric restriction (CR) has SSRI-like effects on neural

123 Caloric restriction (CR) improves health span and life s

124 Caloric restriction (CR) improves insulin sensitivity an

125 ectra of blood serum in a long-term study of caloric restriction (CR) in the dog (n = 24 control fed

126 Mice under caloric restriction (CR) increased Sirt3 protein levels,

127 In lean mice, caloric restriction (CR) induces bouts of compulsive bin

128 Caloric restriction (CR) is a dietary intervention known

129 Caloric restriction (CR) is a dietary regimen known to p

130 Caloric restriction (CR) is commonly recommended for imp

131 Caloric restriction (CR) is proposed to decrease tumorig

132 Caloric restriction (CR) is the most potent intervention

133 Caloric restriction (CR) markedly extends life span and

134 was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease

135 is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis

136 e examined whether these features are due to caloric restriction (CR) or altered nutrient handling.

137 tion was modulated in a group of old rats by caloric restriction (CR) or by surgical removal of visce

138 Caloric restriction (CR) protects against aging and dise

139 Caloric restriction (CR) reduces the incidence and progr

140 Caloric restriction (CR) reduces the pathological effect

141 In animal models, caloric restriction (CR) suppresses these diseases as we

142 e to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy int

143 Caloric restriction (CR) without malnutrition extends li

144 Caloric restriction (CR) without malnutrition increases

145 Caloric restriction (CR), a manipulation that protects t

146 (iePPARgammaKO) to a two-week period of 25% caloric restriction (CR), following which iePPARgammaKO

147 activities similar to those associated with caloric restriction (CR), such as increased life span an

148 Caloric restriction (CR), the consumption of fewer calor

149 Caloric restriction (CR), the consumption of fewer calor

150 ntly mediate the health-promoting effects of caloric restriction (CR), which includes the retardation

151 Caloric restriction (CR), without malnutrition, delays a

152 s throughout the body that may be delayed by caloric restriction (CR).

153 xtension of chronological life span (CLS) by caloric restriction (CR).

154 ction of resting energy expenditure (REE) to caloric restriction (CR).

155 for 6 months on a reduced-calorie diet [30% caloric restriction (CR)] or an ad libitum control diet

156 Caloric restriction decreases oxidative damage and exten

157 +-dependent protein deacetylases involved in caloric restriction-dependent life span extension.

158 tmenopausal women were randomized to 1-year: caloric restriction diet (goal of 10% weight loss, N = 1

159 nth randomized controlled trial, comparing a caloric restriction diet arm (goal: 10% weight loss, N =

160 , when Car(-/-) animals were placed on a 40% caloric restriction diet for 12 weeks, Car(-/-) animals

161 In this study we find that caloric restriction dramatically rescues the motor incoo

162 the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on s

163 sponsivity and orexigenic drives by moderate caloric restriction experience.

164 Gene expression and caloric restriction experiments in model organisms confi

165 Caloric restriction extends lifespan in numerous species

166 mates, and exposure of Ghsr-null mice to 60% caloric restriction fails to elicit antidepressant-like

167 ditis elegans BAF-1 mobility is regulated by caloric restriction, food deprivation, and heat shock.

168 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 mont

169 treatment with 2.24 mg/kg.d rapamycin or 40% caloric restriction for 9 weeks partially rescued cardio

170 Biase et al. independently demonstrate that caloric restriction from fasting and pharmacologic inhib

171 nsumption and did not include weight loss or caloric restriction goals.

172 eeding analysis revealed that mutant mice on caloric restriction had a growth rate and body compositi

173 ension of life span in response to long-term caloric restriction, had lower GSH/GSSG ratios and highe

174 Caloric restriction has been associated with increased l

175 rift is a determinant of lifespan in mammals.Caloric restriction has been shown to increase lifespan

176 Caloric restriction has been shown to increase longevity

177 Caloric restriction has cardiac-specific effects that am

178 BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low

179 eral drugs to the gene expression profile of caloric restriction identified metformin as a drug whose

180 sely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effect

181 and includes peri-operative antibiotics and caloric restriction in addition to the altered anatomy.

182 , it is significantly prevented by long-term caloric restriction in aged mice.

183 ges in offspring fitness or plasticity under caloric restriction in B. manjavacas.

184 eplacement of ghrelin blocked the effects of caloric restriction in beta1AR-deficient mice.

185 F-1 immobilization as a specific response to caloric restriction in C. elegans intestinal cells.

186 hypothesis, we have determined the effect of caloric restriction in Caenorhabditis elegans on activat

187 Severe caloric restriction in humans may confer protection from

188 tion drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results i

189 sized by the hypoglycemia that is induced by caloric restriction in mouse models of deficient ghrelin

190 Caloric restriction in obese diabetic patients quickly i

191 n inhibitor of fat absorption, combined with caloric restriction in overweight subjects with nonalcoh

192 iated with more weight loss during sustained caloric restriction in overweight subjects.

193 a drug whose action could potentially mimic caloric restriction in vivo.

194 In a mouse model of moderate caloric restriction in which a 10-15% weight loss simila

195 ovement in glucose metabolism, after 1 wk of caloric restriction, in severely obese diabetic patients

196 ficial effects that met or exceeded those of caloric restriction including reduced serum glucose and

197 energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and was

198 Both obesity and caloric restriction increase fracture risk and are regul

199 Also, caloric restriction increased apoptosis of DG subgranula

200 ers of enhanced neuroendocrine adaptation to caloric restriction, increased hunger, and a shift in re

201 We propose that caloric restriction increases bioavailability of NO, dec

202 Caloric restriction increases lifespan in all offspring,

203 Finally, we show that caloric restriction increases the ability of heat shock

204 We have previously reported that caloric restriction increases the expression of one of t

205 many forms of reward-seeking behavior, with caloric restriction increasing the drive for drugs of ab

206 role of the plasma membrane redox system in caloric restriction-induced pathways responsible for sen

207 ht thereby adjunctively aid consolidation of caloric restriction-induced weight loss and might also b

208 Caloric restriction inhibits hepatosteatosis, reduces Wn

209 Leanness secondary to caloric restriction is known to be associated with impro

210 Caloric restriction is known to improve inflammatory and

211 Caloric restriction is known to up-regulate expression o

212 ller reductions in energy expenditure during caloric restriction is not known.

213 ed with an increased risk for cancers, while caloric restriction is protective, perhaps through clear

214 Longevity-promoting caloric restriction is thought to trigger downregulation

215 Starvation, or caloric restriction, is known to activate the transcript

216 Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia i

217 short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white ad

218 Our data indicate that caloric restriction leads to a marked improvement in glu

219 Our studies show that caloric restriction leads to an altered anticipatory fee

220 th the FXR-TGR5 dual agonist INT-767 induced caloric restriction-like effects and reversed age-relate

221 LG isoflavone supplementation resulted in a caloric restriction-like gene expression profile for bot

222 of chronic viral infection, suggesting that caloric restriction may modulate viremia to some extent

223 mechanisms that prevent inflammation during caloric restriction may yield promising therapeutic targ

224 nd nutritional factors, such as exercise and caloric restriction, may exert their known health benefi

225 While exercise, caloric restriction, metformin and many natural products

226 Caloric restriction mimetic drugs have geroprotective ef

227 y systems, or longevity pathways targeted by caloric restriction mimetic drugs.

228 ccurring polyamine, has been recognized as a caloric restriction mimetic that confers health benefits

229 Caloric restriction mimetics (CRMs) mimic the biochemica

230 anism, effects, and organ specificity of the caloric restriction mimetics RSV and SRT.

231 regulated by caloric restriction and act as caloric restriction mimetics.

232 "habit," supporting the view that persistent caloric restriction mimics some aspects of addiction to

233 low intestinal penetrance (n = 12), and (3) caloric restriction (n = 8).

234 immune response to weight loss was dynamic; caloric restriction of high-fat diet-fed mice led to an

235 These results suggest that although caloric restriction on a HFD provides metabolic benefits

236 (AE) versus resistance exercise (RE) without caloric restriction on abdominal adiposity, ectopic fat,

237 uin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promo

238 The effects of caloric restriction on DNA methylation were detectable a

239 east Sir2 gene, which mediates the effect of caloric restriction on life span extension in yeast and

240 exercise, and aerobic capacity compared with caloric restriction on regulating intrahepatic lipids an

241 herefore determined the effects of aging and caloric restriction on the expression of FXR and TGR5 in

242 and induced in a VHR1 dependent manner upon caloric restriction, on non-fermentable carbon sources,

243 older patients with clinically stable HFPEF, caloric restriction or aerobic exercise training increas

244 te of oxygen consumption was not affected by caloric restriction or by the exclusion of proteins and

245 normalization of weight was mediated not by caloric restriction or increased activity, but by increa

246 magnitude of this change is primarily due to caloric restriction or is unique to the surgical procedu

247 uggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to

248 -dependent lifespan extension resulting from caloric restriction or loss of germline stem cells.

249 Dietary habits such as caloric restriction or nutrients that mimic these effect

250 e on control diet or one of 2 diet regimens (caloric restriction or rapamycin) that altered protein t

251 signed to address features of aging, such as caloric restriction or visceral fat depletion, have succ

252 6 y] men were recruited to either WL through caloric restriction or weight maintenance (WM) for 6 mo.

253 xtend life span in response to sensory cues, caloric restriction, or stress.

254 idative stress, exercise-induced adaptation, caloric restriction, osmotic stress, mechanical stress,

255 ce to weight loss during extended periods of caloric restriction, our findings have important implica

256 Caloric restriction partially or completely restored the

257 eater decreases in energy expenditure during caloric restriction predict less weight loss, indicating

258 s are decreased in the aging kidney and that caloric restriction prevents these age-related decreases

259 Animal studies reveal that fasting and caloric restriction produce increased activity of specif

260 Kume et al. demonstrated that caloric restriction protected the aging kidney by preser

261 Evidence suggests that caloric restriction protects against age-associated loss

262 he current study demonstrate that short-term caloric restriction readily normalizes hypothalamic resp

263 Leptin-induced lipopenia prevented and caloric restriction reduced steatosis, hyperglycemia, an

264 Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapie

265 We further show that caloric restriction rescues SIRT1 levels in transgenic M

266 Moreover, short-term caloric restriction restores hepatic expression of this

267 hotgun lipidomics to demonstrate that modest caloric restriction results in phospholipid depletion, m

268 red with depletions by exercise alone, acute caloric restriction results in rapid changes in appetite

269 Caloric restriction retards the aging process in small m

270 ell-like features, whereas CtBP depletion or caloric restriction reverses gene repression and increas

271 Reducing lipogenesis by leptin or caloric restriction should prevent or reduce the destruc

272 how that both short-term fasting and chronic caloric restriction significantly reduce the percentage

273 to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7-14 years of age showed atten

274 mpromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of

275 seen in 2.7-3.2-year-old mice exposed to 40% caloric restriction starting at 0.3 years of age.

276 cations such as reduced carbohydrate intake, caloric restriction, structured exercise, and/or pharmac

277 ect to 140 (1)H NMR rat urine spectra from a caloric restriction study and is compared with several o

278 by specific interventions: metabolic risk by caloric restriction, systemic inflammation by statins, p

279 es with overfeeding, lose less weight during caloric restriction than those with a "spendthrift" phen

280 d accumulation of triglycerides during brief caloric restriction that represented 50% of total myocar

281 In the context of caloric restriction, there seems to be no additional ben

282 nstituents, particularly under conditions of caloric restriction, thereby normalizing cellular metabo

283 F levels increase with physical activity and caloric restriction, thus BDNF may mediate some of the o

284 persons who may need additional exercise or caloric restriction to minimize the likelihood of furthe

285 tuin linked to lifespan-enhancing effects of caloric restriction, was measured by immunoblot.

286 While these effects overlap with those of caloric restriction, we show that the effects of caloric

287 to increased energy expenditure rather than caloric restriction, we were interested in determining w

288 We examined the effects of a caloric restriction weight loss diet and exercise on inf

289 Our findings indicate that a caloric restriction weight loss diet with or without exe

290 The effects of age and caloric restriction were qualitatively similar in C57BL/

291 e after bariatric surgery independently from caloric restriction, whereas the level of WAT TGR5 prote

292 ergic nature of AgRP neurons is increased by caloric restriction, whether the GABAergic phenotype of

293 be more effective for reducing body fat than caloric restriction, which is currently the treatment of

294 lipolysis and preserve thermogenesis during caloric restriction, which thereby markedly accelerates

295 in Ghsr-null mice exposed to either CSDS or caloric restriction, while the more highly active analog

296 14 days of moderate caloric restriction with 8.5 or 5.5 hours of nighttime s

297 oluntary wheel running (HFD+Ex) and then 25% caloric restriction with exercise (Ex/CR), each for an a

298 nimal model of binge eating where history of caloric restriction with footshock stress (R + S) causes

299 ls of cAMP, thereby mimicking the effects of caloric restriction with respect to metabolic reprogramm

300 We hypothesized that caloric restriction would have beneficial effects on the