ライフサイエンスコーパス: can tolerate

1 t are much higher than non-transformed cells can tolerate.

2 ill exceed the limits of what the human body can tolerate.

3 s that DNA and RNA biological macromolecules can tolerate.

4 tly on how much stress the affected organism can tolerate.

5 evel of Bim that effector and memory T cells can tolerate.

6 ighest level of disturbance that the species can tolerate.

7 While the wild-type strain can tolerate 10% oxygen for growth, the growth of the md

8 ental studies have shown that although axons can tolerate 100% strain under slow loading rates, even

9 resumed lactose intolerance or malabsorption can tolerate 12 to 15 g of lactose.

10 t Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn-conform

11 We present a ballistic scheme which can tolerate a 10.4% probability of suffering photon los

12 Normally, rats can tolerate a 60% fat diet because 96% of the surplus f

13 The described method can tolerate a broad spectrum of functional groups, incl

14 The structure helps explain how B4e8 can tolerate a certain degree of sequence variation with

15 Although Env can tolerate a high degree of mutation in five variable

16 loss leads to cell lysis and necrosis, cells can tolerate a limited level of plasma membrane damage,

17 sis and in vivo validation revealed that LNs can tolerate a loss of approximately 50% of their FRCs w

18 It is observed that the proposed design can tolerate a relatively wide variation in physiologica

19 The resulting MOFs can tolerate a remarkable extent of linker vacancy (with

20 results demonstrate that the enzyme complex can tolerate a size difference between the two b subunit

21 cyclohexadiene and xanthene derivatives and can tolerate a variety of aryl azides having methyl grou

22 This method can tolerate a variety of functional groups and does not

23 hange reactions proceed regioselectively and can tolerate a variety of functional groups, thus provid

24 nsitive to the emergence of such figures and can tolerate a variety of spectral and temporal perturba

25 eding aims to improve current germplasm that can tolerate a wide range of biotic and abiotic stresses

26 The reaction conditions can tolerate a wide variety of functional groups.

27 y and that the 4-position of the phenyl ring can tolerate a wide variety of substituents.

28 The zebrafish embryo is transparent and can tolerate absence of blood flow because its oxygen is

29 cellular immune response so that the patient can tolerate allergen contact.

30 ral entry activity, identifying regions that can tolerate altered structure without loss of function.

31 indicate that many adults with Down syndrome can tolerate amyloid-beta deposition without deleterious

32 solate pectate lyase-producing bacteria that can tolerate an alkaline environment at moderate tempera

33 xylic acid and alkyne coupling partners, and can tolerate an array of functional groups, including ca

34 han FGF22-FGFR1c2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine r

35 Our results showed that NDV can tolerate an IGS length of at least 365 nt.

36 e subunits, we find that the packaging motor can tolerate an inactive subunit.

37 se results indicate that the HAV polyprotein can tolerate an insertion at the 2A/2B junction and that

38 of treatment burden and benefit the patient can tolerate and about emotional, cognitive, spiritual,

39 asive, fast-growing grass with high biomass, can tolerate and accumulate large quantities of Pb in it

40 g regimens should be chosen that the patient can tolerate and adhere to, and the consequences of resi

41 The fern Pteris vittata can tolerate and hyperaccumulate levels of arsenic that

42 ollution of a learned floral-odor bumblebees can tolerate and identify which scent-pollutants are pro

43 Adapted herbivores can tolerate and sometimes sequester these metabolites,

44 me animals, such as Drosophila melanogaster, can tolerate anoxia for prolonged periods without appare

45 It can tolerate any nucleotide at the first three positions

46 Each can tolerate any unpaired nucleotide (A, G, C, or U) at

47 Thus, wild-type E. coli can tolerate applied exogenous spermidine stress, but De

48 hysiological function, indicating that GDF11 can tolerate at least some modifications of its C-termin

49 es, while healthy tissue with functional ATM can tolerate ATR inhibition.

50 rly good prognosis, perhaps because the host can tolerate autoimmune reactions that destroy tumour ce

51 While many egg-allergic children can tolerate baked or hard-boiled eggs, there is limited

52 indicate that nucleocytoplasmic trafficking can tolerate both partial depletion of RanGAP and deloca

53 nd that other positions on the inositol ring can tolerate bulky substituents.

54 harbour a subpopulation of cancer cells that can tolerate castration de novo, enabling the tumour to

55 Our results indicate that MCM can tolerate catalytically inactive subunits and still f

56 enomic loci by a 20 nt guide sequence, which can tolerate certain mismatches to the DNA target and th

57 in the presence of mismatches, whereas Dmc1 can tolerate certain mismatches.

58 ly, we find that the S1 and S3 binding sites can tolerate changes that are expected to increase or de

59 r of stretches of the polypeptide chain that can tolerate changes without compromising protein functi

60 exhibit significant organ proteotoxicity and can tolerate chemotherapy.

61 osomes are remarkably robust structures that can tolerate considerable changes in protein composition

62 This confirms that these fish can tolerate considerable metal accumulation, highlighti

63 equirements, the cage domain of the molecule can tolerate considerable structural modifications witho

64 e readily under experimental conditions that can tolerate considerable variation and form micrometer-

65 Even PEG-allergic patients can tolerate COVID-19 vaccines.

66 mplement-containing milk from wild-type dams can tolerate CR challenge.

67 data with noisy incomplete samples, i.e. it can tolerate data missing from individual time points.

68 eling activity while DNA remodeling activity can tolerate defective ATP hydrolysis of alternating sub

69 ease, but only for the very few species that can tolerate deforestation.

70 main unclassified, implying that yeast cells can tolerate deletion of a substantial number of individ

71 Yeast cells can tolerate deletion of either the YPT31 or the YPT32 g

72 he maximal rate of SLR that these ecosystems can tolerate depends partly on mineral sediment depositi

73 inding proteins (found mostly in eukaryotes) can tolerate disorder.

74 ntly, cells cultured on stiff ECM substrates can tolerate disruption of multiple stress fibers with n

75 However, it is poorly understood how bats can tolerate diverse viral infections.

76 the regions of the antigen-binding site that can tolerate diversity without compromising stability.

77 equire a moderate amount of PD treatment and can tolerate dopamine agonist therapy.

78 zag backbone curvature is highly dopable and can tolerate dopant-induced disorder.

79 f MNAs of the species, the proposed approach can tolerate edge loss in PPI networks and even discover

80 ur study provides evidence that some sponges can tolerate environments that appear unsuitable to many

81 n, preferring lower local flows speeds, they can tolerate exposure to high-flow speeds of up to 114 c

82 evolutionary flexibility in SCR, whereby SCR can tolerate extensive amino acid changes within the lim

83 X inactivation in the extraembryonic lineage can tolerate extensive demethylation while normal levels

84 Most egg-allergic children can tolerate extensively cooked eggs.

85 protein domains under certain circumstances can tolerate extreme mutations giving rise to partial, b

86 A number of crop wild relatives can tolerate extreme stress to a degree outside the rang

87 as if their social and economic environments can tolerate false alarms, such predictions would be imp

88 eye movements (79 to 393 mN), the NFVB alone can tolerate forces of 98 mN at 0% to 10% strain and 393

89 trated that the first position of this motif can tolerate functional substitution.

90 Parasites with an intact glycolysis can tolerate genetic deletions of TgPEPCKmt as well as o

91 It can tolerate geometric variations and even permits conju

92 Both CbAgo and LrAgo can tolerate guide/target mismatches in the seed region,

93 ernative to polymers to address this as they can tolerate harsh oil reservoir conditions.

94 Most critically ill patients can tolerate hemoglobin levels as low as 7 mg/dL, so a m

95 Moreover, the catalyst can tolerate high contaminates, even the landfilled plas

96 Immunocompetent humans and animals, however, can tolerate high doses of L. monocytogenes without deve

97 Thus, cell lines and animals can tolerate high doses of these modified cytidines with

98 pt enrollment and reasonable reliability but can tolerate high measurement burden.

99 birds, indicating that resistant lymphocytes can tolerate high Myc expression.

100 quire an extended ordered lattice array, and can tolerate high noise and some missing intensity data

101 These results indicate that Delta Smelt can tolerate high temperatures and salinities for a shor

102 s more pronounced in species with xylem that can tolerate highly negative water potentials, typically

103 synthesis requires processing machinery that can tolerate highly variable substrates.

104 and pharmacology and a healthy pipeline that can tolerate inevitable attrition.

105 ed by 66 to 78 nucleotides and show that HAV can tolerate insertions at the N terminus of the polypro

106 njugation, highlighting regions of TraI that can tolerate insertions of a moderate size.

107 her must contain an intrinsic fluorophore or can tolerate its introduction by mutagenesis.

108 The finding that highly connected proteins can tolerate just as many amino acid substitutions as ot

109 res the presence of PS1, Pen2, and Aph1a but can tolerate knockdown of PS2 or Aph1b.

110 This highly chemoselective method can tolerate labile and reactive chemical functionalitie

111 the SARS-CoV-2 receptor binding domain (RBD) can tolerate large numbers of simultaneous antibody esca

112 talytically-dead Streptococcus pyogenes Cas9 can tolerate large single deletions in the REC2, REC3, H

113 itch, and suggests that stable RNA scaffolds can tolerate larger variation than has hitherto been app

114 These observations reveal that the replisome can tolerate leading-strand template lesions without dis

115 For patients who respond and can tolerate lifelong therapy, HIV infection may become

116 nd their precise three-dimensional locations can tolerate little to no overlap.

117 Although cells can tolerate loss of either protein, identifying their c

118 east, Caenorhabditis elegans and human cells can tolerate loss of frataxin when grown in 'permissive'

119 These results argue that cells can tolerate low levels of p180 as long as Mcm10 is pres

120 e show that surveying macrophage populations can tolerate lowered actomyosin contractility, but canno

121 erogeneous hypervariable region (HVR), which can tolerate major genomic rearrangements.

122 nt of fidelity and suggests that polymerases can tolerate many substitutions that alter fidelity with

123 ith the idea that the L-selectin protease(s) can tolerate minor structural alterations at the cleavag

124 The RNAi machinery can tolerate mismatches but is exquisitely sensitive to

125 er-adjacent motif (PAM) in some Cas9 enzymes can tolerate mismatches with the target DNA(3,4).

126 out which regions in NDD-associated proteins can 'tolerate' missense variants and which ones are 'ess

127 ces cerevisiae, is a facultative aerobe that can tolerate mitochondrial mutations that would be letha

128 t the linker regions between the two modules can tolerate moderate structural changes and that the bu

129 the hypothesis that the adult primate brain can tolerate moderately reduced levels of wild-type Hunt

130 resectable PDA is challenging; (2) Patients can tolerate modern systemic therapy and undergo success

131 nd those of others suggest that although DNA can tolerate modifications with RNA-like (North) nucleot

132 HIV-infected individuals can tolerate more intensive chemotherapy, as they have b

133 at a lower efficiency, indicating that CPAF can tolerate more mutations inside Chlamydia-infected ce

134 to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maint

135 Pa has no specific P1 residue preference and can tolerate most amino acids at the P1 position, except

136 evolutionary routes to generalism: organisms can tolerate multiple environments or they can modify th

137 n urgent need to develop crop varieties that can tolerate multiple stresses.

138 to minimize solid deposition, the technique can tolerate Na matrix up to 10000 ppm (1%) with only ap

139 Strain F2 can tolerate NaCl concentrations up to 70 g/L, and its m

140 We show that the 5' pseudoknot can tolerate near complete modification when design is g

141 technologies involve polymeric materials and can tolerate neither the high-temperature nor the high-p

142 al identification is highly reproducible and can tolerate numerous variables, including differences i

143 We also found that the ICA homo-trimer can tolerate one copy of Myrf-V679A or Myrf-R695H for it

144 Not all patients with rheumatoid arthritis can tolerate or respond to methotrexate, a standard trea

145 with low oxygen tolerance, while those that can tolerate oxygen or form spores may be able to transm

146 In summary, our finding that mOLF can tolerate particular substitutions that render the pr

147 assays of mutants show that the apical loop can tolerate perturbation in length and surface residues

148 aken together, our model suggests that cells can tolerate perturbations to localization phenotypes, w

149 neages inspire questions about how organisms can tolerate physiochemical stressors and whether the re

150 These results reveal that cells can tolerate protein waste, but not the amino acid scarc

151 demonstrating that the RealTime HIV-1 assay can tolerate raltegravir-selected mutations.

152 diated protection and the extent to which it can tolerate sequence mismatches in the challenge virus.

153 We demonstrate that M-Probes can tolerate sequence variations of up to 7 nt at prescr

154 lencing and activating functions of the m-AH can tolerate significant changes in length and sequence.

155 t the calculations predict that the membrane can tolerate significant differences in the resting area

156 We find that VH-B1a can tolerate significant diversity within all three comp

157 the morphological event and also that cells can tolerate significant levels of unphosphorylated SpoI

158 to the 3' end of transcripts for detection, can tolerate significant RNA degradation, while still yi

159 leotides found at the 5' mRNA start sequence can tolerate significant sequence variability without af

160 A degradation channel that can tolerate some steric bulk may reconcile the two oppo

161 We designed a set of probes that can tolerate specific cross-species mutations.

162 strate that tetramolecular i-motif structure can tolerate specific flanking G-repeats.

163 rystal electronic devices were obtained that can tolerate strains (e) of more than 13 % while maintai

164 The present strategy can tolerate structurally discrete substrates with steri

165 ing studies have shown that some individuals can tolerate substantial amounts of Alzheimer's patholog

166 e effectors operate as a robust network that can tolerate substantial contractions.

167 These findings demonstrate that telomeres can tolerate substantial degeneracy while remaining func

168 indicating that the DNA of replicating cells can tolerate substantial substitution with ClU.

169 ndicate that the ring N3 of 6-anilinouracils can tolerate substituents of considerable size and struc

170 emic injury, thereby extending the time they can tolerate such an insult.

171 Robust beta-hairpins that can tolerate such changes are attractive tools for study

172 lux, giving rise to a model that silent loci can tolerate such fluctuations without functional conseq

173 single nucleotide polymorphism analyses that can tolerate such imperfections in archived tissues.

174 ion (HSCT), at least in younger patients who can tolerate such intensive treatments.

175 deficiency is cell lethal, but the intestine can tolerate such lethality at the organ level.

176 For example, ground squirrels and camels can tolerate temperatures more than 40 degrees C better

177 owever, very few methods for epitope mapping can tolerate the complexity of a pAb sample.

178 s, we identify mutants of P. aeruginosa that can tolerate the depletion of MvaT in an DeltamvaU mutan

179 rapy for patients with chronic-phase CML who can tolerate the drug.

180 ng why most individuals carrying this allele can tolerate the drug.

181 jacketed capillary columns were used as they can tolerate the elevated pressures required.

182 roductivity; at low productivity few species can tolerate the environmental stresses, and at high pro

183 vely, these data suggest that polymerase eta can tolerate the geometric distortions in DNA conferred

184 addition, we have demonstrated that the PRR can tolerate the insertion of a peptide-binding domain,

185 (i) SIN nsP3 can tolerate the insertion of GFP into different fragmen

186 As an immune-privileged organ, the placenta can tolerate the introduction of antigens without induci

187 es pointed to the sites on the scaffold that can tolerate the introduction of aryl azide, biotin, and

188 oduce the replicative form of the Pf4 genome can tolerate the loss of both MvaT and MvaU.

189 rganisms, the yeast Saccharomyces cerevisiae can tolerate the loss of mitochondrial DNA (mtDNA).

190 Here, we explore whether mice can tolerate the loss of Prdm9 By generating Prdm9 funct

191 The assay is stable over a 24-h period and can tolerate the presence of dimethyl sulfoxide up to 8%

192 The selectivity of this surface reaction can tolerate the presence of internal cysteines in close

193 LIG1 can tolerate the RNA strand upstream of the nick, yet an

194 Cyanobacterium Nostoc commune can tolerate the simultaneous stresses of desiccation, U

195 s may disproportionately represent those who can tolerate the therapy or are less frail, leading to b

196 and could be considered for older adults who can tolerate them.

197 sites selects for antibody sublineages that can tolerate these changes, thereby providing a mechanis

198 Ideally, a robust plan can tolerate these projected changes in climatic behavio

199 When mounted on skin, the array can tolerate to repeated cycles at 30% strain.

200 hanisms, we isolated suppressor mutants that can tolerate toxic serine concentrations by three target

201 unction, whereas the amino terminus of VP19C can tolerate transposon insertions.

202 nd shows that if liver transplant recipients can tolerate treatment for 1 year there is a reasonable

203 o be able to predict critical positions that can tolerate two different amino acids and retain functi

204 Thus human physiology can tolerate ubiquitously elevated mutation burdens.

205 In addition, we found that CSOD can tolerate up to 3.9% dimethyl sulfoxide (DMSO) and up

206 uch as Streptococcus pyogenes Cas9 (SpCas9), can tolerate up to seven mismatches between guide RNA (g

207 rther show that our RNA*DNA-DNA triple helix can tolerate up to two consecutive non-canonical A*G-C b

208 FOXP3 can tolerate variable inter-rung spacings, explaining it

209 These observations indicate that ATF3 can tolerate variations in the center of the binding sit

210 The Co(II)-catalyzed process can tolerate various substitution patterns and produces

211 promiscuous donor substrate specificity and can tolerate various substitutions at C-5 or C-9 of the

212 mine the mutational burden that active sites can tolerate, we randomly mutated a stretch of 13 amino

213 domain to the cytoplasmic membrane and thus can tolerate wide divergence and multiple insertions and

214 r, how highly aggressive cancer cells, which can tolerate widespread DNA damage, respond to DSBs alon

215 ell as the degree of modifications the sgRNA can tolerate without compromising its association with S

216 the degree of plaque load that an individual can tolerate would depend on the efficiency of their mic