ライフサイエンスコーパス: canine

1 C, tumor fluorescence was observed in 6 of 7 canines.

2 urgically disrupted epicardial myocardium in canines.

3 left gas exchange shunt in normal humans and canines.

4 ange shunt in nine anaesthetized, ventilated canines.

5 samples from seven anaesthetized, ventilated canines.

6 f conduction direction and velocities in all canines.

7 dge to better understand, train, and utilize canines.

8 uid volume (GCF) were evaluated for teeth 6 (canine), 7 (lateral incisor) and 8 (central incisor) of

9 ts, another virus with retrograde tropism, a canine adenovirus expressing Cre recombinase, was inject

10 d structural study of representative bat and canine adenoviruses to better understand the relationshi

11 ing in overexpression of MUC5AC and MUC5B in canine airway cells.

12 atitidis and Histoplasma capsulatum-infected canine and feline lungs and airway epithelial cells coul

13 loris is considered to be a commensal of the canine and feline oral cavities.

14 on of complete wet (n = 97) and dry (n = 80) canine and feline pet food sold in the UK was measured t

15 In this study, EV were isolated from canine and human cell cultures for immunolabeling and ch

16 gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine k

17 well as highlight some similarities between canine and human osteosarcomas.

18 rvations evidence a great similarity between canine and human V-SVZ indicating that the dog may be be

19 erited retinal degenerations (RDs) including canine and murine ciliopathies.

20 statistically significant similarity between canine and previously published human PMN-MDSC gene expr

21 Comparative evaluation of adult canine and rat neurogenesis revealed significant differe

22 Recent findings across species (humans, canines and bats) provide converging evidence that spect

23 ing intracranial electroencephalography from canines and humans with epilepsy.

24 D are linked to retinitis pigmentosa (RP) in canines and humans, and while recent studies have establ

25 of root coverage achievable, with maxillary canines and incisors being associated with the highest o

26 nt on noncontacting surfaces of incisors and canines and nonfunctional cusps of posterior teeth.

27 Particularly for cone disorders, rodent, canine, and feline models with no true macula have subst

28 plore the lack of PD-1 expression on murine, canine, and human NK cells and the clinical implication

29 he contacting surfaces of incisors, cusps of canines, and functional cusps of posterior teeth.

30 knowledge of the odors cuing the canine, but canines are easily exposed to unintentional explosive od

31 siology with human hippocampus, establishing canines as excellent animal models for the study of adul

32 Canine atopic dermatitis (cAD) is a common hereditary cl

33 ency-dependent process, with rapid pacing in canine atrial myocytes inducing oxidative injury through

34 stern blotting (WB) for the serodiagnosis of canine bartonelloses has not been critically investigate

35 s (IFAs), a reliable serodiagnostic test for canine bartonelloses is of clinical importance.

36 e the utility of WB for the serodiagnosis of canine bartonelloses.

37 conduction after surgical incision in all 6 canines based on activation mapping.

38 d for behaviour traits using the established Canine Behavioural Assessment and Research Questionnaire

39 ing cascade and (2) establish the utility of canine bladder cancer as a naturally-occurring model for

40 1) identify a novel combination strategy for canine bladder cancer treatment: targeting the ErbB/MAPK

41 addition, the gyrencephalic structure of the canine brain is more similar to that of human than roden

42 ur morphometric parameters measured from 286 canine brain magnetic resonance imaging scans were combi

43 r for neurological disease modeling, however canine brain morphometric diversity creates computationa

44 ical atlas provides a reference standard for canine brain research and will improve and standardize p

45 a detailed MRI-based cortical atlas for the canine brain.

46 related coccidian parasite of ruminants and canines but is not naturally transmitted by rodents.

47 for actual knowledge of the odors cuing the canine, but canines are easily exposed to unintentional

48 All of these observations suggest that canines can detect CLas directly rather than only host v

49 We show that plumbagin induces apoptosis in canine cancer cells via oxidative stress.

50 In contrast, when the canine cancer cells were pre-treated with the oxygen rad

51 Canine cancers are likely more representative of human c

52 understanding of the molecular landscape of canine cancers have occurred in the past 10 years, facil

53 Canine cancers represent a tremendous natural resource d

54 CC) of the bladder comprises 2% of diagnosed canine cancers.

55 alterations, we explored their relevance in canine cancers.

56 The domestic canine (canis familiaris) is a growing novel model for h

57 es (hiPSC-CMs), but potentiated I(to) in the canine cardiomyocytes.

58 NS5806 has been shown to potentate I(to) in canine cardiomyocytes; however, its effects on I(to) in

59 The H3N8 LACIV replicates efficiently in canine cells at 33 degrees C but is impaired at temperat

60 allowed efficient entry into both feline and canine cells without successful infection.

61 to block general gene expression in human or canine cells.

62 at the amino acid residue at position 163 of canine cellular prion protein (PrP(C) ) is a major deter

63 e, we resolved a quantitative trait locus on canine chromosome 1 to a 188-kb critical interval that e

64 mapping defined a 26-Mb candidate region in canine chromosome 20.

65 research colony determined a 4.6 Mb locus on canine chromosome 32.

66 tified a 1.3 Mb disease-associated region on canine chromosome 33, followed by whole-genome sequencin

67 the internal nasal fossa, retained deciduous canine, clefts of the first cervical vertebra, unilatera

68 The atlas was validated using an additional canine cohort with variable cranial conformations.

69 l to absent in an extended RPGRIP1 (ins/ins) canine colony, irrespective of the MAP9 genotype.

70 A form of canine cone-rod dystrophy (cord1) was originally associa

71 bjects, with an increase in sharpness of the canine coronary arteries of 85% +/- 72%.

72 studies has generating a need for a standard canine cortical atlas that provides common spatial refer

73 vestigate the impact of domestication on the canine cortical surface, we compared the gyrification in

74 heir alerts were not a response to stress as canine cortisol levels were not significantly changed.

75 We determine that in the canine CSNB retina, the mutant LRIT3 is correctly locali

76 o construct a clinical data repository using canine data obtained during routine clinical care at a v

77 nd domain-specific approaches to construct a canine data repository of clinical data collected during

78 Canine deaths have resulted from the consumption of indo

79 ves understanding of the etiopathogenesis of canine degenerative myelopathy.

80 roxide dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occur

81 s possible and economically sustainable when canine detection was followed by intervention (i.e., cul

82 ociated dorsal (dDG) and ventral (vDG) adult canine DG were comparatively examined over a period of 3

83 Canine diabetes mellitus (DM) affects 0.6% of the canine

84 ies are warranted to evaluate the utility of canine diabetes to provide novel mechanistic insights to

85 Herein, we consider the potential for canine diabetes to provide valuable insights for human t

86 Additionally, canine distemper epizootics may have altered lion spatia

87 o major pathogens that infect African lions: canine distemper virus (CDV) and feline parvovirus.

88 Both canine distemper virus (CDV) and rabies virus (RABV) cau

89 gous CDV strains.IMPORTANCE Rabies virus and canine distemper virus (CDV) cause high mortality rates

90 Canine distemper virus (CDV) has recently emerged as an

91 oss of sympathetic innervation is ongoing in canine DM and does not necessarily precede it.

92 s contribution, we performed HRV analysis on canine electrocardiograms containing basal and ANS-block

93 tivity against the compounds was highest for canine erythrocytes, intermediate for rat and human cell

94 es in humans and pet store puppies even when canine exposure information was unknown, aiding the epid

95 titative trait loci that are responsible for canine facial shapes and sizes.

96 istration of AAV8 or AAV9 vectors expressing canine factor VIII (AAV-cFVIII) corrected the FVIII defi

97 bility of a stabilization device to preserve canine fecal samples under various storage conditions si

98 field have naturally occurring large animal (canine, feline, ovine, caprine, and bovine) models been

99 om 70 species, including non-human primates, canines, felines, equids, ovids, suids, bovins, salmonid

100 illary anterior teeth and was most common at canines, followed by lateral incisors and central inciso

101 ated fractional precapillary gas exchange in canines for O(2) and two inert gases, sulphur hexafluori

102 ulinomas (INS) are the most common human and canine functioning pancreatic neuroendocrine tumours.

103 c monotherapy with intrathecal AAV9 encoding canine GALC administered into the cisterna magna increas

104 In the isolated canine gastrocnemius model, we evaluated the effects of

105 Isolated canine gastrocnemius muscles in situ (n = 8) were studie

106 al and electroencephalographic features of a canine generalized myoclonic epilepsy with photosensitiv

107 n/harmonization, improving annotation of the canine genome and immune system, and generation of canin

108 LUPA consortium to substantially expand the canine genome annotation to include 10 374 novel lncRNAs

109 Canine gliomas showed high similarity with human pediatr

110 We compared the molecular profiles of canine gliomas with those of human pediatric and adult g

111 nscriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between cani

112 Canine HACD1 deficiency is histopathologically classifie

113 low level of DPP6-S expression was found in canine heart, whereas levels of KChIP2 expression were c

114 fection by Dirofilaria immitis, the agent of canine heartworm disease, mounts a stronger immune respo

115 Lymphoma is the most common type of canine hematological malignancy where the multicentric (

116 s to indospicine is consistent with observed canine hepatotoxicity, and considering the higher in vit

117 YB5R3 deficiency is the predominate cause of canine hereditary methemoglobinemia.

118 e performed whole exome sequencing (WES) and canine high-density (cHD) SNP genotyping of 28 dogs from

119 Canine hippocampus presents many similarities in fetal d

120 moderate risk to public health and that the canine host should be monitored for emerging IAVs.IMPORT

121 nfection experiments were carried out in the canine host with pools of mutant organisms.

122 Canine hypodense MHC class II(-)CD5(-)CD21(-)CD11b(+) ce

123 ty alongside associations with MHC and other canine immune response genes parallel that of different

124 n of avian-origin IAVs in mammals.IMPORTANCE Canine influenza is a respiratory disease of dogs caused

125 Canine influenza is a respiratory disease of dogs caused

126 A single subtype of canine influenza virus (CIV), A(H3N8), was circulating i

127 a is a respiratory disease of dogs caused by canine influenza virus (CIV).

128 ic virus, a seasonal H3N2 virus, and an H3N2 canine influenza virus during experimental passage.

129 The H3N2 canine influenza virus showed increases in frequency of

130 n reported in dogs in the last 16 years: the canine influenza viruses (CIV) H3N8 and H3N2 of equine a

131 Equine-origin H3N8 and avian-origin H3N2 canine influenza viruses (CIVs) prevalent in dogs are th

132 stand the underlying molecular mechanisms of canine INS.

133 Canine insulin deficiency diabetes is, in some cases, co

134 the novel peptide-peptoid hybrid B1 against canine isolates of S. pseudintermedius and P. aeruginosa

135 l versus clinical isolates, and human versus canine isolates.

136 Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high level

137 recycling pathway of megalin in Madin-Darby canine kidney (MDCK) cells and found that it is a long-l

138 e mutant formed large plaques in Madin-Darby canine kidney (MDCK) cells and grew robustly in vitro an

139 an expanding island of confluent Madin-Darby canine kidney (MDCK) cells as a model system to quantify

140 the establishment of polarity in Madin-Darby canine kidney (MDCK) cells in part through phosphorylati

141 isolates that failed to grow in Madin-Darby canine kidney (MDCK) cells, and resulted in fewer domina

142 show that compared with control Madin-Darby canine kidney (MDCK) cells, EXOC5 overexpression increas

143 ar apical junctions of polarized Madin-Darby canine kidney (MDCK) cells.

144 basolateral surface proteins in Madin-Darby canine kidney (MDCK) cells.

145 were tracked during infection of Madin-Darby canine kidney (MDCK) cells.

146 ng sequence-mutated (EXOC5CTS-m) Madin-Darby canine kidney (MDCK) cells.

147 Those produced in hen egg, Madin-Darby canine kidney (MDCK), and insect (Sf9) expression system

148 Tension across Madin-Darby canine kidney cell monolayers was increased by a low lev

149 ain, we studied the dynamics of Madine-Darby canine kidney cells after permeabilization by saponin mo

150 we applied atorvastatin (ATV) to Madin-Darby Canine Kidney cells before infecting them.

151 Knockdown of NCX1 in Madin-Darby canine kidney cells induced fibroblastic morphology, inc

152 hOCT2/hMATE1 double-transfected Madin-Darby canine kidney cells showed that mIBG transport in the ba

153 In contrast to monolayered Madin-Darby canine kidney cells, hepatocytic epithelial cells, which

154 and multicellular monolayers of Madin-Darby canine kidney cells, highlighting its acuity in reconstr

155 rologous expression in polarized Madin-Darby canine kidney cells, we show that beta2 is N-glycosylate

156 ntly decreases ciliary length in Madin-Darby canine kidney cells.

157 4 and 0.11 muM, respectively, in Madin-Darby canine kidney cells.

158 In a matrix-grown Madin-Darby canine kidney cyst model, AQP3 expression promoted cyst

159 n human mammary epithelial MCF-10A cells and canine kidney epithelial MDCK II cells mechanically dest

160 estingly, transwell assays using Madin-Darby canine kidney II cell line cells stably expressing speci

161 ficking pathways and kinetics in Madin-Darby canine kidney monolayers.

162 netics-generated H18N11 virus in Madin-Darby canine kidney subclone II cells and detected two mammal-

163 i.e., Madin-Darby canine kidney, Madin-Darby canine kidney subclone II, and human lung adenocarcinoma

164 microvessel endothelial, bEnd.3, Madin-Darby canine kidney transfected with multi-drug resistant prot

165 hree mammalian cell lines (i.e., Madin-Darby canine kidney, Madin-Darby canine kidney subclone II, an

166 ous, and mucosal leishmaniasis in humans and canine leishmaniasis in dogs.

167 ding tools for the control and prevention of canine leishmaniosis (CanL), including new preventative

168 We collected measurements of body size, canine length, and fat, from 125 male and 21 female free

169 -closing cycles with a 20-N mandibular right canine load.

170 As human and canine malignant INS share clinical and histopathologica

171 om human BC studies (n = 294) or from within canine mammary tumor associated regions (n = 471).

172 Here, we used RNA-profiling of canine mammary tumors (CMTs) coupled with a robust analy

173 and their close phylogenetic relationship to Canine mastadenovirus A (CAdV A) has raised important qu

174 ibits a close phylogenetic relationship with Canine mastadenovirus A (CAdV A), as previously observed

175 ylogenetically informative morphology of the canine, maxilla and temporal bone.

176 n human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped

177 malignant melanoma (OMM) is the most common canine melanocytic neoplasm.

178 ic delivery of a rAAV2/8 vector expressing a canine microdystrophin (cMD1) is effective in restoring

179 METHODS AND In a canine model (n=10), ventricular radiofrequency lesions

180 thylation during TN-DCIS progression in this canine model correspond with gene expression patterns in

181 i infection challenge in a newly established canine model for RMSF.

182 The LRIT3-CSNB canine model has direct translational potential enabling

183 n, we demonstrate in the naturally occurring canine model of GLD that presymptomatic monotherapy with

184 he pharmacokinetics in a clinically-relevant canine model of HCA-induced brain injury.

185 of cerebrospinal fluid (CSF) samples from a canine model of MPS I revealed a marked elevation of the

186 study, we evaluated the naturally occurring canine model of MPS IIIB for the onset and progression o

187 in simultaneous (18)F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated

188 sympathovagal balance and proarrhythmia in a canine model of PVC-CM.

189 Demonstration in a large animal model (canine model) exhibited its potential for human applicat

190 Our study leveraged a key advantage of the canine model, the frequent presence of multiple naturall

191 s without lowering blood pressure in the AKI canine model.

192 w report pacemaker function of iPSC-CMs in a canine model.

193 levels in relation to the crestal bone in a canine model.

194 tenosis compared with IRF postprocedure in a canine model.

195 The G6pc-/- mouse and canine models for GSD Ia were treated with the pan-perox

196 The system is validated in canine models showing capability to screen 1-2% of the e

197 or defining genetic variants associated with canine morphology include quantitative within-breed anal

198 (onset approximately 24-30 months of age) of canine MPS IIIB disease.

199 formed breeding practices, the prevalence of canine MPS IIIB has been drastically reduced in the Schi

200 i.v. administration of activated allogeneic canine MSC.

201 Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recent

202 t to predict the outcome of chemotherapy for canine multicentric lymphomas.

203 The canine mutant LRIT3 gives rise to a truncated protein wi

204 Minute virus of canine (MVC) is an autonomous parvovirus in the genus Bo

205 The NP1 protein of minute virus of canines (MVC) governs production of the viral capsid pro

206 vements in full width at half maximum of the canine myocardium of 13% +/- 5%, similar to cardiac gati

207 blative lesions in both normal and infarcted canine myocardium.

208 ding, spatial and temporal features of adult canine neurogenesis are similar to that of other gyrence

209 arose from unvaccinated or under-vaccinated canines, not from a novel CPV strain incapable of being

210 When evaluating this approach in spontaneous canine NSCLC, tumor fluorescence was observed in 6 of 7

211 murine NSCLC models and with (2) spontaneous canine NSCLCs, which closely mimic human disease.

212 owing that EPM impairment is associated with canine OA pain.

213 , but epidemiological studies characterizing canine obesity in Latin America are scarce.

214 s study aimed to determine the prevalence of canine obesity in the city of Sao Paulo, Brazil, and the

215 Canine obesity is associated with comorbidities, a short

216 ainst a collection of clinical isolates from canine, of which only B1 showed potent activity.

217 lap between the somatic mutation profiles of canine OMM and human mucosal melanomas suggest a shared

218 There is no reliable means of predicting canine OMM metastasis, and systemic therapies for metast

219 In common with human mucosal melanomas, most canine OMM metastasise.

220 ion profiling of FFPE biopsies of 18 primary canine OMM that metastasised and 10 primary OMM that did

221 o identify PMN-MDSCs and M-MDSCs in clinical canine oncology patients.

222 an international citrus pathogen collection, canines only reacted to Liberibacter pathogens of citrus

223 Failed eruption of canines or second molars in affected persons was observe

224 s from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases from mu

225 ompared the protein profiles of two isogenic canine OS cell lines, POS (low metastatic) and HMPOS (hi

226 Canine OS tumors expressed IGF2R.

227 IGF2R expression in randomly selected canine OS tumors was measured by immunohistochemistry.

228 IGF2R and to investigate IGF2R expression on canine OS tumors.

229 vironment on disease development also favors canine over rodent models.

230 Normal canine pancreas and lymph node control tissues were comp

231 rodents is distinctly different from humans, canine pancreatic endocrine cell distribution is more si

232 examine capsid substitutions that eliminate canine parvovirus (CPV) infectivity and identify how tho

233 Canine parvovirus (CPV) is a highly successful pathogen

234 Canine parvovirus (CPV) is an important pathogen causing

235 Serengeti National Park (SNP) and, second, a canine parvovirus (CPV) route of transmission among dome

236 Chimeras formed from combinations of canine parvovirus and portions of the parvovirus sequenc

237 capsid surface loops from R. norvegicus with canine parvovirus assembled, allowing some of that capsi

238 , with new host species identified, and that canine parvoviruses are present in the dog population li

239 Little evidence of transmission of canine parvoviruses into wild carnivore species was foun

240 Here, in a study of 18 canine patients with soft tissue sarcoma (STS), CIVO cap

241 s in humans, peripheral blood frequencies of canine PMN-MDSCs and M-MDSCs are significantly higher in

242 e diabetes mellitus (DM) affects 0.6% of the canine population and yet, its etiology is poorly unders

243 8 and avian-origin H3N2 influenza viruses in canine populations are examples of successful cross-spec

244 Canine, porcine, and rhesus macaque ISG15, such as human

245 human retinal disease; however, until now no canine PRAs have been associated with this gene.

246 sistance prompted a thorough analysis of the canine PRNP gene and the presence of a negatively charge

247 Canine progressive retinal atrophies are a group of here

248 A splice site mutation in the canine pyruvate dehydrogenase kinase 4 (PDK4) gene has b

249 ld's population lives in a country where the canine rabies virus variant is endemic and dog bites are

250 ng a highly novel gene therapy approach in a canine, rapid atrial pacing model of AF, we demonstrate

251 Canines remain the gold standard for explosives detectio

252 disease, and its similarities to nonischemic canine results support the translational utility of the

253 fter the exclusion of 25 previously reported canine retinal mutations in LA PRA-affected dogs, we sou

254 aimed to report the incidence, fatality and canine risk factors of heat-related illness in UK dogs u

255 used FEELnc on a real data set comprising 20 canine RNA-seq samples produced by the European LUPA con

256 asts and cardiomyocytes isolated from normal canine RV and LV to cyclic overstretch and aldosterone.

257 mum inhibitory concentrations (MICs) against canine S. pseudintermedius and P. aeruginosa isolates as

258 o SPS has recently been identified in dogs ("canine Sensory Processing Sensitivity", cSPS).

259 240 and for anti-L. infantum up to 1:5120 in canine serum samples.

260 and Golden retriever (GR) owners to evaluate canine skin health with respect to clinical signs of cAD

261 humans alone would suggest that broader non-canine-specific mechanisms may be needed to explain cros

262 genome and immune system, and generation of canine-specific validated reagents to support integratio

263 hese ST1193 isolates with archival human and canine ST1193 isolates from Australia (2008).

264 In a preclinical canine study of spontaneous mast cell tumors, the treatm

265 hese results are broadly consistent with the canine surrogacy model as well as help illuminate human

266 g diets for insight into human subsistence ('canine surrogacy' model) and identified considerable use

267 Using the canine tachypacing-induced biventricular heart failure (

268 nd ErbB receptor inhibition as a therapy for canine TCC.

269 n with other gene targets as a treatment for canine TCC.

270 kinase (MAPK) pathway, is mutated in 70% of canine TCCs.

271 morphological analyses reveal that enlarged canine teeth (fangs) originated at the base of the Nemop

272 Periapical lesions were induced in 24 canine teeth of 6 ferrets.

273 After 3 mo, block sections of the canine teeth were imaged radiographically and processed

274 They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an

275 In 12 canines, the investigators implanted epicardial pacemake

276 We found that (a) in canines, the SAN and ANS contribute mainly to long- and

277 This site-specific thermogenic remodeling of canine tissue by thermogenic murine adipocytes suggests

278 Here, we study a canine TN-DCIS progression and investigate the DNA methy

279 The patches were applied on 6 canines to epicardium before and after surgical disrupti

280 d with a dental abnormality called maxillary canine-tooth mesioversion (MCM) (P = 1.53 x 10(-7)) as w

281 NM myosin during contractile stimulation of canine tracheal SM tissues.

282 Evaluation of 10 canines trained for detection of a severe exotic phytoba

283 Canines trained to detect CLas-infected citrus also aler

284 The instrument was deployed to support canine training in the field, detecting cross-contaminat

285 The canine transmissible venereal tumor (CTVT) is a cancer l

286 ency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagiou

287 fficacious and affordable vaccine to control canine-transmitted rabies in developing countries.

288 However, insightful study of canine Tregs has been restrained by the limited availabi

289 targeting IGF2R on OS in PDX and spontaneous canine tumors and sets the stage for further development

290 Six canines underwent thoracotomy, and, during epicardial ve

291 protected mice significantly better than the canine vaccine Bronchicine and provided protection again

292 PSC-CMs, while it was almost undetectable in canine ventricular myocardium.

293 In Brazil, human and canine visceral leishmaniasis is caused by infection wit

294 Ucp1 expression in canine WAT was increased at sites implanted with thermog

295 Forty canines were divided into dimethylsulfoxide (DMSO) group

296 underpinnings of such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91

297 posterior length 2; 28.31 mm for lower inter-canine width; 41.63 mm for lower inter-first molar width

298 n all subjects were 36.39 mm for upper inter-canine width; 46.88 mm for upper inter-first molar width

299 re and after pericardial resection in normal canines with open (n=3) and closed chest (n=5) and in a

300 that observed with adenosine in 3 groups of canines: without coronary stenosis, subjected to non-flo