ライフサイエンスコーパス: caninum

1 olated from the canine hookworm (Ancylostoma caninum).

2 ed by infective hookworm larvae (Ancylostoma caninum).

3 a tenella, Sarcocystis neurona, and Neospora caninum).

4 gh degree of resistance to infection with N. caninum.

5 protein produced by the hookworm Ancylostoma caninum.

6 s with abortion confirmed to be caused by N. caninum.

7 h the related apicomplexan parasite Neospora caninum.

8 titudinal gradient, with the exception of N. caninum.

9 T-1, a GST from the dog hookworm Ancylostoma caninum.

10 osely related apicomplexan parasite Neospora caninum.

11 ondii is also true for its relative Neospora caninum.

12 tion against congenital transfer of Neospora caninum.

13 apicomplexan protozoan closely related to N. caninum.

14 s anticoagulant activity than extracts of A. caninum.

15 e isolated from the dog hookworm Ancylostoma caninum.

16 Neospora caninum, a causative agent of bovine abortions, is an ap

17 Neospora caninum, a cyst-forming apicomplexan parasite, is a lead

18 for detection of serum antibody to Neospora caninum, a major cause of bovine abortion.

19 Neospora caninum, a protozoan parasite closely related to Toxopla

20 Comparisons with Neospora caninum, a species that diverged from Toxoplasma ~28 mya

21 The routine diagnosis of Neospora caninum abortion is based upon histopathologic changes i

22 inant Ancylostoma secreted protein 1 from A. caninum (Ac-ASP-1) results in protection against hookwor

23 ian parasites Toxoplasma gondii and Neospora caninum activated GABAergic signaling in phagocytes.

24 rease in the numbers of mice transmitting N. caninum and a lower frequency of transmission by individ

25 ion in mice that had been vaccinated with N. caninum and challenged with T. gondii was observed.

26 lin-like signals may regulate recovery of A. caninum and could be potential targets for antihelminthi

27 ed by coccidian parasites including Neospora caninum and Eimeria tenella.

28 these parasites and present evidence that N. caninum and H. heydorni are separate species.

29 ated coccidian parasites, including Neospora caninum and Hammondia hammondi, complement TgDeltaGRA12

30 Neospora caninum and Hammondia heydorni are two coccidian parasit

31 Acan1 and Nak1 peptides from the Ancylostoma caninum and Necator americanus hookworms and assessed th

32 canine parvovirus, Ehrlichia canis, Neospora caninum and perhaps rabies virus, but not with exposure

33 compared mouse innate immune responses to N. caninum and T. gondii and found marked differences in cy

34 e viruses, but higher odds of exposure to N. caninum and T. gondii; the opposite was true for wolves

35 ds of the dog-infecting hookworm Ancylostoma caninum and the human-infecting hookworm Ancylostoma cey

36 distemper virus-and two parasites: Neospora caninum and Toxoplasma gondii.

37 ing stage of the canine hookworm Ancylostoma caninum and vaccinated dogs with the purified protease.

38 f exposure of polar bears to C. burnetii, N. caninum, and F. tularensis.

39 nsferase from the adult hookworm Ancylostoma caninum, and its possible role in parasite blood feeding

40 a system specifically designed for Neospora caninum, and used this system as a heterologous platform

41 hookworm Ancylostoma caninum termed AcAP (A. caninum anticoagulant protein).

42 s to the cELISA included capturing native N. caninum antigen with a parasite-specific MAb (MAb 5B6-25

43 inhibited by mild periodate treatment of N. caninum antigen, demonstrating the carbohydrate nature o

44 -reactive antibodies recognizing multiple N. caninum antigens by immunoblot assay, did not inhibit bi

45 mechanisms involved in protection against N. caninum-associated abortions.

46 olated from the canine hookworm (Ancylostoma caninum), binds to the I domain of CD11a and CD11b and i

47 of 8 fetuses that had typical lesions of N. caninum but were immunohistochemistry negative, indicati

48 In summary, the modified N. caninum cELISA provided a simple, rapid, and versatile m

49 membrane of the canine hookworm, Ancylostoma caninum, contains aspartic proteases (APR-1), cysteine p

50 ays/networks for Toxoplasma gondii, Neospora caninum, Cryptosporidium and Theileria species, and Babe

51 bial protein in the N. caninum tachyzoite N. caninum cyclophilin (NcCyP) as a major component of the

52 ne potently inhibits in vitro recovery of A. caninum dauer arrest.

53 cattle experimentally infected with Neospora caninum develop parasite-specific CD4+ cytotoxic T lymph

54 In fresh or frozen tissues, PCR detected N. caninum DNA in 10 of 13 true-positive fetuses (77%) and

55 d paraffin-embedded tissues, PCR detected N. caninum DNA in 13 of 13 true-positive fetuses (100%) and

56 PCR also detected N. caninum DNA in 6 of 8 fetuses that had typical lesions o

57 PCR detection of N. caninum DNA in formalin-fixed, paraffin-embedded tissues

58 N. caninum DNA was amplified most consistently from brain t

59 that Nod2-dependent responses account for N. caninum elimination.

60 rnetii, Francisella tularensis, and Neospora caninum, estimate concentrations of persistent organic p

61 this approach, we here demonstrated that N. caninum expressing T. gondii's GRA15 and ROP16 kinase ar

62 N. caninum expressing TgGRA15 differentially disturbed the

63 On the other hand, N. caninum expressing TgROP16 induced host STAT3 phosphoryl

64 e IkappaB kinase activity was detected in N. caninum extracts, thereby implying that this parasite is

65 d in dermatological lesions, and Ancylostoma caninum has been associated with eosinophilic enteritis

66 ogs in 1984, the protozoan parasite Neospora caninum has been found to infect a wide range of animals

67 In cattle, N. caninum has particular significance as a cause of aborti

68 oluble protein extracts of adult Ancylostoma caninum hookworms.

69 sera defined by fetal histopathology and N. caninum immunohistochemistry and by maternal N. caninum

70 rching the vertical transmission of Neospora caninum in cattle that the terms 'vertical', 'congenital

71 and characterization of CTL responses to N. caninum in the natural, outbred, bovine host will facili

72 inum immunohistochemistry and by maternal N. caninum indirect fluorescence assay (IFA) at a 1:200 ser

73 NF-kappaB subunit p65 was not detected in N. caninum-infected cells, although this host transcription

74 Four N. caninum-infected Holstein cattle developed NcSRS2 peptid

75 N. caninum-infected mice produced significantly higher leve

76 transfer of CD8+ T-cell splenocytes from N. caninum-infected mice was protective against challenge w

77 subsets indicated that CD4(+) CTL killed N. caninum-infected, autologous target cells and that killi

78 Bovine abortions due to Neospora caninum infection are a major cattle-production problem

79 Confirmation of N. caninum infection by immunohistochemistry has low sensit

80 zes several pathogens and its role during N. caninum infection has not yet been described.

81 Current diagnostic methods for N. caninum infection in cattle and the advances necessary t

82 tochemistry determined the true status of N. caninum infection in each fetus.

83 examined the utility of PCR in detecting N. caninum infection in fetal tissues from spontaneous bovi

84 d versatile method to accurately identify N. caninum infection status in cattle using a single cutoff

85 or-mediated apoptosis is repressed during N. caninum infection, and the data further showed that the

86 gamma(-/-) mice, MyD88(-/-) mice survived N. caninum infections at the dose used in this study.

87 MyD88(-/-) mice were more susceptible to N. caninum infections than wild-type (WT) mice, and control

88 of mice with either third-stage Ancylostoma caninum infective hookworm larvae (L3) or alum-precipita

89 from the hematophagous nematode Ancylostoma caninum inhibit blood coagulation with picomolar inhibit

90 Neospora caninum is a closely related coccidian parasite of rumin

91 Neospora caninum is a coccidial protozoan parasite that appears m

92 The protozoan Neospora caninum is a primary infectious cause of abortion in cat

93 cate that heterologous gene expression in N. caninum is a useful tool for the study of specific gene

94 Neospora caninum is an Apicomplexan parasite related to important

95 Neospora caninum is an apicomplexan parasite responsible for majo

96 Neospora caninum is an apicomplexan parasite that is closely rela

97 Neospora caninum is an obligate intracellular protozoan parasite

98 fection with the protozoan parasite Neospora caninum is emerging as a major cause of reproductive los

99 ng the first hours after infection, while N. caninum is not, and this is likely due to the early MyD8

100 study was conducted to establish whether N. caninum is similarly capable of subverting apoptotic pat

101 olated from the canine hookworm (Ancylostoma caninum), is a beta2 integrin antagonist that inhibits P

102 he intracellular protozoan parasite Neospora caninum, is fatal when there is a complete lack of IFN-g

103 o analyze several independent and diverse N. caninum isolates; both antigens were recognized in all i

104 e the anatomic sites of expression within A. caninum L3 to secretory granules in the glandular esopha

105 A. caninum larvae migrate through mouse lungs, with maximal

106 did not amplify Toxoplasma gondii, Neospora caninum, Leishmania infantum, Cryptosporidium parvum, or

107 Neospora caninum (NC) is a protozoan infection causing neosporosi

108 that coyotes (Canis latrans) can excrete N. caninum oocysts in their feces and that white-tailed dee

109 nterest, including Eimeria tenella, Neospora caninum, Plasmodium falciparum, Sarcocystis neurona and

110 The hematophagous hookworm Ancylostoma caninum produces a family of small, disulfide-linked pro

111 11 (TLR11), but the ectopic expression of N. caninum profilin in T. gondii had no impact on early IFN

112 ted genes of Toxoplasma gondii, driven by N. caninum promoters, have yielded robust expression and co

113 These observations demonstrate that N. caninum protects against lethal T. gondii infection by t

114 PVM) of T. gondii was not apparent on the N. caninum PVM.

115 Cattle infected with Neospora caninum readily experience transplacental parasite trans

116 activated larvae of the hookworm Ancylostoma caninum released a 42-kDa protein, termed Ancylostoma-se

117 The dog hookworm Ancylostoma caninum secretes an astacin-like metalloprotease, Ac-MTP

118 rrangements had occurred in T. gondii and N. caninum since their most recent common ancestry.

119 In this study, N. caninum-specific CTL expanded from peripheral blood mono

120 sting of the 4,323 bovine sera of unknown N. caninum status revealed a distinct bimodal distribution

121 e, and a set of 4,323 cow sera of unknown N. caninum status.

122 The binding of MAb 4A4-2 to N. caninum tachyzoite antigen was consistently inhibited by

123 Immunoblot analysis of N. caninum tachyzoite antigens with sera from cows with con

124 In N. caninum tachyzoite culture supernatant, three NcCyP band

125 inum tachyzoite lysate antigen (NcAg) and N. caninum tachyzoite culture supernatant.

126 Abundant NcCyP was detected in whole-cell N. caninum tachyzoite lysate antigen (NcAg) and N. caninum

127 has identified a microbial protein in the N. caninum tachyzoite N. caninum cyclophilin (NcCyP) as a m

128 These results indicate that the N. caninum tachyzoite naturally produces a potent IFN-gamma

129 binds a carbohydrate epitope on a single N. caninum tachyzoite surface antigen that is recognized co

130 ound diffusely to the exterior surface of N. caninum tachyzoites and recognized a single 65-kDa band

131 inoculation consisting of live, avirulent N. caninum tachyzoites followed by virulent challenge durin

132 nated Ncp29 and Ncp35, respectively) from N. caninum tachyzoites that are the predominant antigens re

133 clonal antibody (MAb), MAb 4A4-2, against N. caninum tachyzoites.

134 e reactive oxygen species (ROS) levels in N. caninum tachyzoites.

135 anticoagulants from the hookworm Ancylostoma caninum termed AcAP (A. caninum anticoagulant protein).

136 In the parasitic nematode Ancylostoma caninum, the dauer larval stage is the infective stage,

137 pathway is not central to the ability of N. caninum to prevent apoptosis of their host cells.

138 livestock; and the first report of Neospora caninum, Toxoplasma gondii, and pestiviruses associated

139 asite-specific CTL against transplacental N. caninum transmission in cattle.

140 ecrease the frequency of congenital Neospora caninum transmission.

141 Blue (DMMB) and Toluidine Blue O (TBO) on N. caninum, using in vitro and in vivo models.

142 findings support investigation of subunit N. caninum vaccines incorporating NcSRS2 gene sequences or

143 tween the morphologically similar Dipylidium caninum was challenging, we discuss the biology, epidemi

144 ost widely distributed pathogens, whereas N. caninum was relatively uncommon.

145 st, a closely related apicomplexan, Neospora caninum, was unable to inhibit IFN-gamma-induced gene ex

146 rains of T. gondii and its near relative, N. caninum We significantly improved T. gondii genome conti

147 Finally, when we compared T. gondii with N. caninum, we found that although the 13-chromosome karyot

148 that were infected intraperitoneally with N. caninum were protected against a lethal challenge from T

149 se Toxoplasma strains but also with Neospora caninum, which is closely related to Toxoplasma but has

150 nce indices resolved a single genotype of N. caninum Whole-genome sequencing of 7 isolates from 2 dif

151 re thought to be protective against Neospora caninum would be detrimental to the pregnancy.