ライフサイエンスコーパス: capsomere

1 ific RNA-induced stabilisation of a trimeric capsomere.

2 id protein, each of which forms an arch-like capsomere.

3 ting the cytoplasmic assembly of papovavirus capsomeres.

4 l hollow spikes that clustered into distinct capsomeres.

5 an interconnected network within and across capsomeres.

6 s, respectively, which compose the hexameric capsomeres.

7 tained one monomer from each of two adjacent capsomeres.

8 g the local symmetry axes of the surrounding capsomeres.

9 molecules of both pentavalent and hexavalent capsomeres.

10 es for the 5B6 epitope in the 12 pentavalent capsomeres.

11 igenic domains are contained entirely within capsomeres.

12 americ capsomeres and capsids composed of 72 capsomeres.

13 apsomeres and flexible links that form among capsomeres.

14 tiple domains capable of interacting with L1 capsomeres.

15 he corresponding N termini of the pentameric capsomere A subunits were not visible at all in electron

16 omogeneity as pentamers (equivalent to viral capsomeres), after thrombin cleavage from the GST moiety

17 Remarkably, HPV16 L1 capsomeres also interacted with Kap beta2 and binding of

18 rved, flexible and asymmetric, revealing the capsomere and not the previously touted dimer or trimer

19 mbly autocatalytic cleavage product from the capsomere and the target membrane.

20 gthened association between the two types of capsomeres and an, apparently, more stable capsid.

21 n the cytoplasm, L1 and VP1 pentamerize into capsomeres and are then imported into the nucleus using

22 tein denoted L1, which forms both pentameric capsomeres and capsids composed of 72 capsomeres.

23 equence of stable contacts that occur within capsomeres and flexible links that form among capsomeres

24 The absence of mAb 5B6 from the pentavalent capsomeres and its inability to prevent viral binding to

25 nsition could occur by shedding of hexameric capsomeres and restructuring of remaining pentamers acco

26 The protein subunits forming hexameric capsomeres, and particularly dimers, appear to interact

27 and partially degraded capsids with missing capsomeres; and 5) the DNA extruded from damaged virions

28 The capsomere antisera were then tested in an in vitro infec

29 ly and bivalently to the sides of hexavalent capsomeres approximately two-thirds of the way down from

30 avirus family) are composed of 72 pentameric capsomeres arranged on a skewed icosahedral lattice (tri

31 Both forms have star-shaped capsomeres, as do BPV-1 and HPV-1, but the open CRPV cap

32 The newly formed extensive inter-capsomere bonding appears to compensate for release of S

33 found that recombinant MCPyV VP1 pentameric capsomeres both hemagglutinated sheep red blood cells an

34 Both VP1 and L1 capsomeres bound by karyopherin alpha2beta1 were unable

35 and human papillomavirus type 11 (HPV11) L1 capsomeres bound the karyopherin heterodimer alpha2beta1

36 helix (helix 2(58-72)) is likely involved in capsomere-capsomere interactions during shell accretion.

37 along with fragments of the membrane; 3) the capsomeres composing the capsid and their surface arrang

38 sts that the cross-linked species is a cross-capsomere contact between a pentamer and hexamer at the

39 er at the quasi-threefold axis or is a cross-capsomere contact between hexamers at the threefold axis

40 VP1 and L1 capsomeres could bind both karyopherin alpha2 and DNA si

41 y of purified HPV-11 L1 VLPs to the level of capsomeres, demonstrating that disulfide bonds alone are

42 ighboring subunit to stabilize homo-trimeric capsomeres during assembly.

43 ical arrangements of the VP5 subunits in the capsomeres exposes different residues, resulting in the

44 he B and C subunits comprising the hexameric capsomeres formed an annulus about the interior of the c

45 HPV16 L1 capsomeres formed complexes with Kap alpha2beta1 heterod

46 Furthermore, CyPs released L1 capsomeres from partially disassembled HPV16 pseudovirio

47 The particles are composed of pentameric capsomeres from the wild-type virions which have reorien

48 /or neutralizing monoclonal antibodies, both capsomeres generated by disulfide reduction of purified

49 highly immunoreactive with trypsin-generated capsomeres in an enzyme-linked immunosorbent assay (ELIS

50 JAM-A), which binds to the outer face of the capsomere, inducing a conformational change in the capsi

51 Significantly, HPV16 L1 capsomeres inhibited the nuclear import of Kap beta2 and

52 he region of maximum contact, papillomavirus capsomeres interact in a manner similar to that found in

53 ction and by their ability to assemble viral capsomeres into capsids in vitro.

54 e conventional penta-symmetron formed by the capsomeres is replaced by a large vertex complex in the

55 1 fusion protein formed pentamers, but these capsomere-like structures did not assemble into VLPs.

56 Thus, capsomeres may be viable vaccine candidates for the prev

57 pproximately 60 versus approximately 50 nm), capsomere morphology (11 to 12 nm star-shaped versus 8 n

58 to enhance the interactions of the hexameric capsomeres of gp27, for other phages encoding decoration

59 Capsomeres of L1, but not VP1, bound by karyopherin alph

60 rus (papovavirus) capsids are composed of 72 capsomeres of their major capsid proteins, VP1 and L1, r

61 of the particles, exhibited arrangements of capsomeres on their surfaces which were consistent with

62 actions (slightly different contacts between capsomeres), papovavirus capsids have a conserved, 72-pe

63 otein, VP5 (149 kDa), makes up both types of capsomere, pentons and hexons.

64 In this assay, HPV-11 capsomere polyclonal antisera exhibited neutralization t

65 various lengths, made up of trapezoid-shape capsomeres, provide a basis for icosahedral T = 4 and T

66 In contrast, 5B6 binds only to hexavalent capsomeres, reflecting the significant structural or env

67 intact L1 protein, likely still arranged as capsomeres, remains associated with the incoming viral g

68 ired to form both pentavalent and hexavalent capsomeres result in structures that exhibit very differ

69 onent of the triplexes that connect adjacent capsomeres), results in the formation of spherical parti

70 pose that the L1 protein, likely arranged as capsomeres, stabilizes the viral genome within the subvi

71 inding site located at the interface between capsomere subunits, suggesting the shell may play a dire

72 t-subunit interactions within and across the capsomeres that are required to stabilize the virus.

73 t it forms pentameric units resembling viral capsomeres that assemble into larger capsid-like structu

74 n can be trypsinized to generate recombinant capsomeres that retain HPV genotype-restricted capsid an

75 ized HeLa cells were incubated with HPV16 L1 capsomeres, the L1 protein was imported into the nucleus

76 s as a molecular staple between neighbouring capsomeres to ensure the particle's stability.

77 plays a distinctive skewing of the hexameric capsomeres, to the mature virion, which is larger and mo

78 compensate for release of SPs that clasp MCP capsomeres together.

79 rified VLPs and reassembled VLPs formed from capsomeres upon removal of reducing agents exhibited epi

80 Accordingly, nuclear import of HPV16 L1 capsomeres was mediated by Kap alpha2beta1 heterodimers,

81 to these epitopes and requires assembly into capsomeres, we propose that L1 protein is present in the

82 was resolved to a resolution of 6.1 nm, and capsomeres were observed to be arranged on the virus sur

83 Capsomeres were used to generate high-titer polyclonal i

84 e 3-fold axis at the center of the hexameric capsomere, where there is a pore of about 6 A diameter.

85 hat mAb #9 binds monovalently to the tips of capsomeres whereas 5B6 binds both monovalently and bival

86 ull-length L1 protein appeared as pentameric capsomeres which self-assembled into capsid-like particl

87 r particle at the center of the 20 hexameric capsomeres, which are a direct result of the K42R mutati

88 We show that the outer face of the dimeric capsomeres, which contains the receptor binding site and

89 an assembly of loosely associated hexameric capsomeres, which may be the basis for the swelling and

90 formed an annulus about the interior of the capsomere, while the corresponding N termini of the pent

91 f 195 A, is made from distinctive pentameric capsomeres with large holes along the 3-fold axis, while