ライフサイエンスコーパス: carbamoyl

1 reviously found that the 4-[4-(N-substituted carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazolines can

2 481,715 (quinoxaline-2-carboxylic acid [4(R)-carbamoyl-1(S)-(3-fluorobenzyl)-2(S),7-dihydroxy-7-methy

3 n produced the corresponding N-substituted C-carbamoyl-1,2,3-triazoles 7a-12a in good to excellent yi

4 -(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4'-carbamoyl-1-pyridinium)).

5 lted in the corresponding 3-functionalized 1-carbamoyl-1H-pyrroles.

6 tetramethyl-1-piperidynyloxyl (Tempol) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (3CP), a

7 ified via LC-LTQ-Orbitrap MS and NMR as N-(4-carbamoyl-2-imino-5-oxoimidazolidin)formamido-N-methoxya

8 ine aminopeptidase type 2 inhibitor, [(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5

9 iota, and its synthetic derivative, the N-(1-carbamoyl-2-phenyl-ethyl) butyramide, FBA, have been dem

10 /- 0.03 nM) > 4-{3-[6-amino-9-(5-cyclopropyl-carbamoyl-3,4-dihydroxytetrahydrofuran-2-yl )-9H-purin-2

11 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-

12 This reaction provides ready access to N-carbamoyl-3-monosubstituted oxindoles.

13 ibitors, URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) and URB694 (6-hydroxy-[1,1'-biphen

14 The beta1-adrenoceptor antagonist 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4

15 oprolol, bisoprolol, and CGP-20712 [1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4

16 [2-(3-Carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-4

17 nel of beta1-AR antagonists, including [2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-4

18 talyzed conjugate addition of Et(2)Zn to a N-carbamoyl-4-pyridone with an er of 91.5:8.5.

19 N-carbamoyl-4-pyridones undergo conjugate addition reactio

20 ntigen (PSMA), N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-l-cysteine ((18)F-DCFBC)

21 e cancer using N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-L-cysteine ((18)F-DCFBC)

22 onstrated that N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-L-cysteine ((18)F-DCFBC)

23 = 3 nM); its prodrug amino-acetic acid 4-[2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-trifluoromethyl-4,5,6,

24 fied compound 35 (cyclohexylcarbamic acid 3'-carbamoyl-5-hydroxybiphenyl-3-yl ester) as the most pote

25 The nitrone 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) was synthe

26 novel and analogous amido nitrone 2-amino-5-carbamoyl-5-methyl-1-pyrroline N-oxide (NH(2)-AMPO).

27 -aminophenyl)-1, 2-dihydro-1-methyl-2-propyl-carbamoyl-6,7-methylenedioxyphthalazine++ +, suppressed

28 ibitor URB937 (3, cyclohexylcarbamic acid 3'-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from

29 unds of most interest were found to have a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2 H-1-benzopyran

30 Compounds containing a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2H-1-benzopyran a

31 ietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acet ate (YH439)]-treated and suspension cells

32 stability and reversibility of the avibactam carbamoyl acyl-enzyme complex, highlighting the effect o

33 for a universal tRNA modification, threonyl carbamoyl adenosine (t6A), found in all tRNAs that pair

34 , vinyl, cyano, aryl and N-heteroaryl, acyl, carbamoyl, alkoxycarbonyl, imidoyl, boryl, silyl, phosph

35 tions from N-Boc pyrrolidine via an alpha-(N-carbamoyl)alkylcuprate vinylation reaction followed by N

36 yields obtained in the reactions of alpha-(N-carbamoyl)alkylcuprates [i.e., N-Boc-protected alpha-ami

37 alpha-(N-Carbamoyl)alkylcuprates prepared from high-quality sec-b

38 es or perfluorobenzoates react with alpha-(N-carbamoyl)alkylcuprates to afford scalemic alpha-(N-carb

39 y treatment with CuCN.2LiCl affords alpha-(N-carbamoyl)alkylcuprates which react with propargyl halid

40 te adducts obtained via coupling of alpha-(N-carbamoyl)alkylcuprates with alpha,beta-ynoates, alpha-a

41 lfonates, and phosphates give good yields of carbamoyl allenes, while the acetates afford low yields.

42 The alpha-(N-carbamoyl) allenes can be cyclized to 2-oxazolidinones o

43 tes, acetates, and epoxides to give alpha-(N-carbamoyl) allenes via an anti-S(N)2' substitution proce

44 yl)alkylcuprates to afford scalemic alpha-(N-carbamoyl) allenes which undergo N-Boc deprotection and

45 The reluctance of gamma-carbamoyl-alpha,beta-enoates to undergo E/Z isomerizatio

46 gue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid (13b) decreased prolif

47 phenyl region of compound 3, focusing on the carbamoyl and hydroxyl groups in the distal and proximal

48 The addition of carbamoyl anions derived from N,N-disubstituted formamid

49 Carbamoyl anions were found to smoothly react with chira

50 Carbamoyl anions, generated from N,N-disubstituted forma

51 catalyzing the reversible interconversion of carbamoyl aspartate and dihydroorotate.

52 The transient time for carbamoyl aspartate formation was 26 s, compared with th

53 The side chain carboxylate of carbamoyl aspartate is polarized through a direct electr

54 At pH 7.4, the equilibrium ratio of carbamoyl aspartate to dihydroorotate is 17 and complex

55 the pH-rate profiles for the condensation of carbamoyl aspartate to dihydroorotate showed that a sing

56 catalyzing the reversible interconversion of carbamoyl aspartate to dihydroorotate.

57 .2.3) catalyze the reversible cyclization of carbamoyl aspartate to form dihydroorotate in de novo py

58 se) catalyzes the reversible condensation of carbamoyl aspartate to form dihydroorotate in de novo py

59 This implies that carbamoyl aspartate, an intermediate of this pathway, mu

60 During the cyclization of carbamoyl aspartate, Asp 250 initiates the reaction by a

61 re has citrate, a near isosteric analogue of carbamoyl aspartate, bound to the active sites of both e

62 ecursors, carbamoyl phosphate, aspartate, or carbamoyl aspartate.

63 f an electron-withdrawing group (i.e., acyl, carbamoyl) at this position increased the stability of t

64 synthesized, based on 2'(3')-O-(2-aminoethyl)carbamoyl-ATP (edaATP).

65 (7-diethylaminocoumarin-3-carboxamido)propyl]carbamoyl}ATP), which was hydrolyzed to the diphosphate.

66 The N7 carbamoyl azaindoles undergo regioselective metalation a

67 phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl) benzoic acid (11) was the most effective whil

68 nd 2-((9,10-dioxo-9,10-dihydroanthracen-2-yl)carbamoyl) benzoic acid (H2L5828102), novel nonlipid and

69 143), 4,5-dichloro-2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic acid (H2L5547924), and 2-((9,10-dioxo-

70 yielded compounds 2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic acid (NSC12404), 2-((3-(1,3-dioxo-1H-b

71 omeric ratios are obtained with the alpha-(N-carbamoyl)benzylcuprates.

72 roxyphenyl)propanoic acid and a new N(delta)-carbamoyl-beta-sulfated asparagine.

73 the FAAH inhibitor cyclohexylcarbamic acid 3-carbamoyl biphenyl-3-yl ester (URB597) on mechanically e

74 ndamide (AEA) and cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), an inhibitor of

75 URB597 (3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate) reduces thi

76 hanism involving oxidative addition into the carbamoyl chloride bond to generate a high valent Pd(IV)

77 at despite the presence of the electrophilic carbamoyl chloride function the products show remarkable

78 rivative, but rather gives (N-ethoxycarbonyl)carbamoyl chloride upon thermolysis, or (N-ethoxycarbony

79 goes an intramolecular cross-coupling with a carbamoyl chloride.

80 gen chloride being formed as coproducts, and carbamoyl chlorides or isocyanates generated as yield-di

81 loromethylene)oxindoles from alkyne-tethered carbamoyl chlorides using PdCl2(PhCN)2 as the catalyst.

82 d included 3B-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol (DC-Chol), dimethyldioctadecylammo

83 ic lipid 3beta-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Chol), two potent adjuvants, d

84 FP and 7-diethylamino-3-[N-(2-maleimidoethyl)carbamoyl]coumarin (MDCC).

85 Acyl-, alkoxycarbonyl-, and carbamoyl cyanates R-CO-OCN are predicted to be in some

86 By using (N-tosyloxy)-3-O-carbamoyl-D-glucal 10, which removes the need for a hype

87 ingle-crystal X-ray analysis or studies with carbamoyl derivatives of amines of known configuration.

88 Overall, the controlled migration of the carbamoyl directing group allows multiple functionalizat

89 The title (chlorocarbonyl)(carbamoyl)disulfane cannot be converted to the elusive D

90 n the reaction of the title (chlorocarbonyl)(carbamoyl)disulfane with excess N-methylaniline.

91 are reported for the title (chlorocarbonyl)(carbamoyl)disulfane; for (methoxycarbonyl)(N-ethoxycarbo

92 an umpolung fashion to the beta-carbon of N-carbamoyl enamines (N-vinyl ureas).

93 The BlaR1-avibactam structure of the carbamoyl-enzyme intermediate revealed that avibactam is

94 chloro-2-methox y-acridin-9-ylamino)-propyl]-carbamoyl]-ethyl)-carbamic acid tert-butyl ester, showed

95 iogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are thus emerging as a

96 the angiogenesis inhibitor O-(N-chloroacetyl-carbamoyl)-fumagillol (TNP-470) and the alkylating agent

97 iogenesis inhibitor, AGM-1470,O-chloroacetyl-carbamoyl-fumagillol (TNP-470), after two-thirds hepatec

98 P and Q contain urea/carbamoyl functionalities designed to increase potential

99 des, ether glucuronides, N-glucuronides, and carbamoyl glucuronides, have been shown to be substrates

100 s 14 and 24 commenced with removal of the 10-carbamoyl group from MC, followed by reductive conversio

101 es indicate that FeIIiso-PEPLM, in which the carbamoyl group is shifted on the mannose sugar, forms t

102 In these cases, the carbamoyl group plays a dual role as a directing group,

103 f a catalytic amount of ClCONR(2) promotes a carbamoyl group shift or dance from N7 to N1.

104 cluded hydroxylation, ring cleavage, loss of carbamoyl group, and decarboxylation, as well as O-methy

105 roxylation, ring contraction, or loss of the carbamoyl group, followed by conjugation to glucose or c

106 nosubstituted in the 3-position by alkyl and carbamoyl groups undergo nucleophilic ring opening by ar

107 lorination, and the introduction of acyl and carbamoyl groups.

108 fonamido group yielded greater activity than carbamoyl groups.

109 Especially N-carbamoyl imines were found to be useful in the enantios

110 to cover enantioselective methods based on N-carbamoyl imines, focusing on synthetically useful proto

111 ch previously have not been reported using N-carbamoyl-imines with simple ketone enolates, became our

112 likely proceeding through the formation of N-carbamoyl iminium.

113 yl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-in doline), or vehicle were microinjected bil

114 Strikingly, in subunit II, carbamoyl L-aspartate is observed binding near the binuc

115 7-O-Carbamoyl-l,d-heptose and d-glycero-alpha-d-manno-heptos

116 oyl phosphate (CP) and l-aspartate to form N-carbamoyl-l-aspartate and inorganic phosphate.

117 that conversion of l-aspartate (l-Asp) to N-carbamoyl-l-aspartate by PyrB may reduce the amount of l

118 5-Difluoro-4-[bis(2-chloroethyl)amino]phenyl]carbamoyl-l-glutamic acid gave a differential of >227 in

119 Sixteen lipophilic N-(X)sulfonyl carbamoyl lariat ethers with polyether ring sizes of 12-

120 al-D4Cpa-D3Pal-Ser-4Aph(L-hydroorotyl)-D4Aph(carbamoyl)-Leu-ILys-Pro -DAla-NH2 (acetate salt is FE200

121 The carbamoyl linkage of these nucleotide analogs undergoes

122 -hydroxyllup-20(29)-en-28-oyl]-7-aminoheptyl]carbamoyl]methane (A43D, 4) was a potent HIV-1 entry inh

123 Here, we report a class of propynoic acid carbamoyl methyl amides (PACMAs) that are active against

124 in, we discovered a series of propynoic acid carbamoyl methyl-amides (PACMAs) with potent cytotoxicit

125 of functional groups through the 1,5-O -> N carbamoyl migration.

126 (R5 = Me, Ph, CH2Ph), and different acyl and carbamoyl moieties (R7) were appended on the 7-amino gro

127 receptor (Y1R) antagonist BIBP3226, bearing carbamoyl moieties at the guanidine group, revealed subn

128 equence depends on the steric demands of the carbamoyl moiety and the substituents in the meta positi

129 fficulties connected with the removal of the carbamoyl moiety in target molecules.

130 photoconjugation reactions and by using the carbamoyl moiety to tether a plethora of productive func

131 Sn ligands, 9-N-(4H-thieno[3,2-c]chromene-2-carbamoyl)-Neu5Acalpha2-3Galbeta1-4GlcNAc ((TCC)Neu5Ac),

132 ation intermediate, whether generated from N-carbamoyl- or N-sulfonyl-substituted allenamides.

133 cation activation for transforming 1-acyl-1-carbamoyl oximes to cyanoformamides.

134 y-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl) carbamoyl)oxy)indolin-1-ium hydrochloride) with IC50s of

135 gen mustard analog of [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride (McN

136 produces a broad range of previously unknown carbamoyl-, oxycarbo- and thiocarboboronates.

137 transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (

138 o-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)carbamoyl]p yrazolo[1,5-a]pyrimidine-7-carbonyl}amino)in

139 Intradermal injection of carbamoyl PAF (CPAF; 1-hexadecyl-2-N-methylcarbamoyl gly

140 he metabolically stable PAF receptor agonist carbamoyl-PAF resulted in increased interleukin-8 mRNA a

141 ithelial cell adhesion molecule (EPCAM), and carbamoyl palmitate synthase-1] also had the most cells

142 An additional two series of (-)- and (+)-O-carbamoyl phenols of pyrroloindole and furoindole were o

143 M for BChE), with the exception of the (+)-O-carbamoyl phenols of pyrroloindole, which lacked activit

144 inhibitors of cholinesterase: (-)- and (+)-O-carbamoyl phenols of tetrahydrofurobenzofuran and methan

145 ic acid-Schiff staining, urea production via carbamoyl phosphatase synthetase I staining, and cell vi

146 ucleotide biosynthesis, the reaction between carbamoyl phosphate (CP) and l-aspartate to form N-carba

147 responds to the position of the phosphate of carbamoyl phosphate (CP) and the position of the phospho

148 Carbamoyl phosphate (CP) has a half-life for thermal dec

149 A saturating concentration of carbamoyl phosphate alone has little influence on the sm

150 ropic cooperativity, and the binding of both carbamoyl phosphate and aspartate were extremely comprom

151 little change in the Km for the substrates, carbamoyl phosphate and aspartate.

152 ing established that the natural substrates, carbamoyl phosphate and L-aspartate, do not induce in th

153 lts in impaired synthesis of citrulline from carbamoyl phosphate and ornithine.

154 of the mutants were unable to synthesize any carbamoyl phosphate and the rest were severely crippled.

155 absence and presence of the first substrate carbamoyl phosphate are reported.

156 lex with citric acid bound in the postulated carbamoyl phosphate binding site, was determined in two

157 l change that interferes with the binding of carbamoyl phosphate but has little effect once carbamoyl

158 The carboxy phosphate (residues 1-400) and carbamoyl phosphate domains (residues 553-933) also cont

159 e the absolute requirement of the binding of carbamoyl phosphate for the creation of the high-affinit

160 oyl-phosphate synthetase 1 activity produces carbamoyl phosphate for urea synthesis, and deficiency r

161 of the partial reactions, the diminution of carbamoyl phosphate formation, and the percentage of the

162 Escherichia coli catalyzes the formation of carbamoyl phosphate from 2 mol of ATP, bicarbonate, and

163 of CPS.A and CPS.B proteins that synthesized carbamoyl phosphate from ATP, bicarbonate, and ammonia.

164 Escherichia coli catalyzes the formation of carbamoyl phosphate from bicarbonate, glutamine, and two

165 y 118 kDa) and catalyzes the biosynthesis of carbamoyl phosphate from MgATP, bicarbonate, and glutami

166 channeling ensures the efficient transfer of carbamoyl phosphate from the active site of CPSase to th

167 gh rapidly degraded at high temperature, the carbamoyl phosphate generated in situ by A. aeolicus car

168 hosphate synthetase-1 (CPS1), which produces carbamoyl phosphate in the mitochondria from ammonia and

169 d-type enzyme is required for the binding of carbamoyl phosphate in the proper orientation so as to i

170 vatization method revealed that the level of carbamoyl phosphate in these NSCLC extracts is below the

171 ontrast to the wild-type enzyme, addition of carbamoyl phosphate induced a significant alteration in

172 rbamoyl phosphate but has little effect once carbamoyl phosphate is bound.

173 the catalytic cysteine residue, can generate carbamoyl phosphate only in the presence of free ammonia

174 ng the altered CAD with the ATCase substrate carbamoyl phosphate or the bisubstrate analogue N-phosph

175 the catalytic activity for the synthesis of carbamoyl phosphate relative to the wild type CPS, respe

176 Vaccination with the carbamoyl phosphate synthase (CPS) mutant strain of Toxo

177 ioxin resulted in concomitant recruitment of carbamoyl phosphate synthase 1 (CPS1) to the NC-XRE.

178 ed to increase the level of succinylation on carbamoyl phosphate synthase 1, which is a known target

179 erence-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nit

180 acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).

181 ammonemia from reduced expression of hepatic carbamoyl phosphate synthase-I.

182 arbamoylases, and an internal duplication in carbamoyl phosphate synthase.

183 The partial recovery of carbamoyl phosphate synthesis activity in the double mut

184 alues of K(m) for glutamine, but the overall carbamoyl phosphate synthesis reaction is unperturbed.

185 5L exhibited a substantially reduced rate of carbamoyl phosphate synthesis, but the rate of ATP turno

186 ne or free ammonia as the nitrogen donor for carbamoyl phosphate synthesis.

187 imiting step in this pathway is catalysed by carbamoyl phosphate synthetase (CPS II), part of the mul

188 rt of carbamate through the large subunit of carbamoyl phosphate synthetase (CPS) from Escherichia co

189 Carbamoyl phosphate synthetase (CPS) from Escherichia co

190 Carbamoyl phosphate synthetase (CPS) from Escherichia co

191 The X-ray crystal structure of carbamoyl phosphate synthetase (CPS) from Escherichia co

192 Carbamoyl phosphate synthetase (CPS) from Escherichia co

193 Carbamoyl phosphate synthetase (CPS) from Escherichia co

194 Carbamoyl phosphate synthetase (CPS) is a member of the

195 The transfer of ammonia in carbamoyl phosphate synthetase (CPS) was investigated by

196 st three enzymes in pyrimidine biosynthesis, carbamoyl phosphate synthetase (CPS), aspartate transcar

197 individual mutant lines deficient in either carbamoyl phosphate synthetase (CPS), the first enzyme i

198 l phosphate generated in situ by A. aeolicus carbamoyl phosphate synthetase (CPSase) was channeled to

199 a large multifunctional protein that carries carbamoyl phosphate synthetase (CPSase), aspartate trans

200 Human carbamoyl phosphate synthetase (hCPS) has evolved critic

201 Carbamoyl phosphate synthetase 1 (CPS1) is a liver-speci

202 the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, cata

203 Systematic optimization of a carbamoyl phosphate synthetase 1 derived, glutarylated p

204 ylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the fir

205 proteins 70 and 90 (HSP-70; HSP-90), and the carbamoyl phosphate synthetase 2/aspartate transcarbamyl

206 he inhibitor UTP and the activator PRPP, the carbamoyl phosphate synthetase activity is controlled by

207 the sequential action of MAPK and PKA on the carbamoyl phosphate synthetase activity of CAD.

208 The carbamoyl phosphate synthetase domain of the multifuncti

209 Carbamoyl phosphate synthetase from E. coli catalyzes th

210 Carbamoyl phosphate synthetase from Escherichia coli cat

211 x-ray crystal structure of the heterodimeric carbamoyl phosphate synthetase from Escherichia coli has

212 arginine serum levels on chromosome 2 at the carbamoyl phosphate synthetase I locus, on chromosome 5

213 ine nucleotide synthesis is catalyzed by the carbamoyl phosphate synthetase II (CPSase) domain of CAD

214 Carbamoyl phosphate synthetase II (CPSII) is part of car

215 the virulence of T. gondii mutants that lack carbamoyl phosphate synthetase II (uracil auxotrophs) to

216 mately 25 A in length, whereas the tunnel in carbamoyl phosphate synthetase is nearly 100 A long.

217 mensional structures of tryptophan synthase, carbamoyl phosphate synthetase, glutamine phosphoribosyl

218 n some cases, such as biotin carboxylase and carbamoyl phosphate synthetase, the B-domains move signi

219 KL cells express the urea cycle enzyme carbamoyl phosphate synthetase-1 (CPS1), which produces

220 the G359F (small subunit) mutant protein of carbamoyl phosphate synthetase.

221 is similar to the folding of this domain in carbamoyl phosphate synthetase.

222 ned a 240 kDa protein that was identified as carbamoyl phosphate synthetase/aspartate transcarbamoyla

223 l phosphate synthetase II (CPSII) is part of carbamoyl phosphate synthetase/aspartate transcarbamoyla

224 Carbamoyl phosphate synthetase/aspartate transcarbamylas

225 Depending on their physiological role, carbamoyl phosphate synthetases (CPSs) use either glutam

226 Carbamoyl phosphate synthetases (CPSs) utilize either gl

227 phate synthetase catalyzes the production of carbamoyl phosphate through a reaction mechanism requiri

228 tase from E. coli catalyzes the synthesis of carbamoyl phosphate through a series of four reactions o

229 ast step in this pathway, converting ADP and carbamoyl phosphate to ATP and ammonium carbamate.

230 inine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate.

231 The inability of carbamoyl phosphate to create the high-affinity binding

232 l-molecule phosphodonors acetyl phosphate or carbamoyl phosphate under conditions in which a control

233 This mutant is unable to synthesize carbamoyl phosphate using glutamine as a nitrogen source

234 However, carbamoyl phosphate was able to shift the structure of t

235 teady-state time course for the formation of carbamoyl phosphate was linear with an overall rate cons

236 bsaturating amounts of PALA or succinate and carbamoyl phosphate) caused a hyperbolic increase and de

237 of ligands, in the presence of the substrate carbamoyl phosphate, and in the presence of the bisubstr

238 xaloacetate, the phosphorylation of MgADP by carbamoyl phosphate, and the bicarbonate-dependent ATPas

239 less negatively charged than its precursors, carbamoyl phosphate, aspartate, or carbamoyl aspartate.

240 topped-flow experiments, using aspartate and carbamoyl phosphate, confirm that the change in excimer

241 gue succinate, in the presence of saturating carbamoyl phosphate, to the pyrenelabeled enzyme caused

242 our other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Delta(2)-isopenten

243 y two long interdomain helices: the putative carbamoyl phosphate-binding domain and a binding domain

244 The putative carbamoyl phosphate-binding site is similar to those in

245 t phosphodonors such as acetyl phosphate and carbamoyl phosphate.

246 mino group of Asp and the carbonyl carbon of carbamoyl phosphate.

247 rmational change induced upon the binding of carbamoyl phosphate.

248 le to utilize glutamine for the synthesis of carbamoyl phosphate.

249 is attributed to phosphorylethanolamine, not carbamoyl phosphate.

250 ammonia for the ATP-dependent generation of carbamoyl phosphate.

251 l reactions but not the overall synthesis of carbamoyl phosphate.

252 ghly conserved residue that is essential for carbamoyl-phosphate binding.

253 he lead variant on 2q24 (rs715) localizes to carbamoyl-phosphate synthase 1 (CPS1), which encodes a m

254 y facilitating pyrimidine synthesis via CAD (carbamoyl-phosphate synthase 2, aspartate transcarbamyla

255 xpression profile of the c-Myc target genes, carbamoyl-phosphate synthase-aspartate carbamoyltransfer

256 bited complex I of the respiratory chain and carbamoyl-phosphate synthase-I (CPS-I), with an EC(50) a

257 Carbamoyl-phosphate synthetase (CPS) from Escherichia co

258 hyperthermophile, has neither a full-length carbamoyl-phosphate synthetase (CPSase) resembling the e

259 On the contrary, carbamoyl-phosphate synthetase 1 (CPS1), ALB, the prolif

260 In mitochondria, carbamoyl-phosphate synthetase 1 activity produces carba

261 The tri-functional enzyme contains carbamoyl-phosphate synthetase 2 (CPS2), aspartate trans

262 which directly phosphorylates S1859 on CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamo

263 hatidylinositol 4-kinases (PI4KA and PI4KB), carbamoyl-phosphate synthetase 2, aspartate transcarbamy

264 Moreover, EGFR signaling activated carbamoyl-phosphate synthetase 2, aspartate transcarbamy

265 Cytoplasmic carbamoyl-phosphate synthetase 2, however, is part of a

266 uted to altered allosteric regulation of the carbamoyl-phosphate synthetase activity of CAD (carbamoy

267 Carbamoyl-phosphate synthetase catalyzes the production

268 The frequencies of the carbamoyl-phosphate synthetase genotypes in the study po

269 ferential plasma proteins detected by iTRAQ, carbamoyl-phosphate synthetase I (CPSI, related to urea

270 this closed form of biotin carboxylase with carbamoyl-phosphate synthetase is presented.

271 skewed distribution of the genotypes for the carbamoyl-phosphate synthetase variants at position 1405

272 trations of amino acids and genotypes of the carbamoyl-phosphate synthetase variants were determined

273 e thioester intermediate of Escherichia coli carbamoyl-phosphate synthetase, indicates that the subst

274 for threonine at position 1405 [T1405N]) in carbamoyl-phosphate synthetase, which controls the rate-

275 urea cycle--in particular, the efficiency of carbamoyl-phosphate synthetase--may contribute to the av

276 bamoyl-phosphate synthetase activity of CAD (carbamoyl-phosphate synthetase-aspartate carbamoyltransf

277 ession of mature hepatocytic markers such as carbamoyl-phosphate synthetase1 and several cytochrome P

278 oning was used to identify a mutation in the carbamoyl-phosphate synthetase2-aspartate transcarbamyla

279 Although carbamoyl-phosphate synthetases (CPSs) share sequence id

280 with antagonist ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZ

281 The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allyla

282 ne-porphyrin bears an S-acetyl or S-(N-ethyl)carbamoyl-protected thiol moiety, thereby avoiding handl

283 inoalanine is an FeII ligand and the mannose carbamoyl provides either a ligand to the FeII or signif

284 ido-2,2,5,5-tetramethylpyrrolidine-N-oxyl (3-carbamoyl-proxyl) [3-CP] was performed.

285 n of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and ammonia.

286 tivity studies evolved a tricyclic series of carbamoyl pyridines that demonstrated properties indicat

287 These drugs stem from a series of carbamoyl pyridone analogues designed using a two-metal

288 ing fusion stereocenter within the tricyclic carbamoyl pyridone scaffold led to a critical substrate

289 Stereogenic 2-(N-carbamoyl)pyrrolidinylcuprates prepared from scalemic (i

290 ough group-transfer cyclization reactions of carbamoyl radicals, undergo a Chugaev-like thermal elimi

291 A 1,5-O -> N carbamoyl shift, a new variation of the anionic Fries-ty

292 ethyl 2-(N-((4-iodo-6-methoxypyrimidin-2-yl)carbamoyl)sulfamoyl)benzoate (10c), which has a K(i) val

293 lyzed coupling reaction of azoles with alpha-carbamoyl sulfides.

294 Alkoxycarbonyl-, (alkylthio)carbonyl- and carbamoyl thiocyanates are isolable and have higher calc

295 amino acid residues, including an uncommon 3-carbamoyl threonine, and a phosphoserine residue in cele

296 -beta-D-ribofuranosyl-2-methylthiopurin-6-yl)carbamoyl]threonine, (ms2t6A) is reported.

297 a combined metalation-addition of a carbonyl-carbamoyl transfer to reveal in situ stereodefined alpha

298 of carbamoylphosphate synthase and aspartate carbamoyl transferase, respectively.

299 From this enhanced set, we identified the carbamoyl triazole TCMDC-134379 (1), a known serine prot

300 we demonstrate that modification of the C13-carbamoyl unit can be accommodated in the binding site o