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1 a chemical microenvironment that facilitates carbamylation.
2 Two distinct pathways can promote protein carbamylation.
3 n asthmatic airways through a process called carbamylation.
4 ence of four metal-mediated stages of lysine carbamylation.
5 makes it difficult to study in vivo protein carbamylation.
6 arthritis, through the mechanism of protein carbamylation.
7 loaddition, alkene dihydroxylation, and diol carbamylation.
8 at they can adapt to the presence of urea or carbamylation.
9 nt of the 270-loop of KPC-44 facilitates AVI carbamylation.
10 ay amplify immune responses via MPO-mediated carbamylation.
15 entrations in patients with ESKD, leading to carbamylation, an irreversible modification of proteins
16 odified online with FBDSA or in solution via carbamylation and 4-sulfophenyl isothiocyanate (SPITC) p
19 eversible, noncovalent complex that precedes carbamylation and increases the rate constants of the se
22 st-translational protein modifications (e.g. carbamylation) and accumulation of small-molecular subst
23 ication (i.e., 2-mercaptoethanol adducts and carbamylation) and related to their expression (i.e., an
24 alyzing mutant proteins, proteins altered by carbamylation, and cell proteins with similar amino acid
28 the metal distribution to accomplish lysine carbamylation as well as subsequent enzymatic functions.
29 te (SCN(-)) as substrate to catalyze protein carbamylation, as monitored by PTM of protein lysine res
31 mechanism for cyanate formation and protein carbamylation at sites of inflammation and atherosclerot
32 been recognized that urea solution can cause carbamylation at the N termini of proteins/peptides and
33 le high-throughput pipeline: high-efficiency carbamylation blocks lysine side chains, and subsequent
35 of carbamylated albumin (a marker of protein carbamylation burden) were associated with a greater ris
37 glutamate, mimicking the negative charge of carbamylation, causes Cx26 GJCs to be constitutively clo
39 homocitrulline rate, the most characteristic carbamylation-derived product (CDP), over time in skin o
41 rves as a major enzymatic source for protein carbamylation during eosinophilic inflammatory models, i
44 d oxidation, reduced C4b deposition, whereas carbamylation enhanced C4b deposition on immobilized Apo
45 tion; however, the post-translational lysine carbamylation facilitates additional metal coordination
46 w that myeloperoxidase-catalyzed lipoprotein carbamylation facilitates multiple pro-atherosclerotic a
47 obenzamidine resulted in comparable rates of carbamylation for FXIa(WT) and FXIa(G193E), suggesting t
48 e metal is sufficient for stabilizing lysine carbamylation; however, the post-translational lysine ca
50 occurrence of myeloperoxidase (MPO)-mediated carbamylation in the inflamed periodontium during the ea
53 ed and suggested that the majority of apoA-I carbamylation in vivo occurs on "lipid-poor" apoA-I form
54 ch was shown to protect plasma proteins from carbamylation-induced damage in patients on hemodialysis
55 ervation that free amino acids prevented the carbamylation-induced loss of alpha (IIb) beta (3) activ
63 nd functional impairment of proteins through carbamylation is thought to promote vascular dysfunction
66 ubisco activase facilitates this spontaneous carbamylation/metal-binding process by removing phosphor
70 uggest that lamotrigine is metabolized via N-carbamylation, N-glucosidation, N-alkylation, N-formylat
72 similarly revealed significant enrichment in carbamylation of airway proteins recovered from atopic a
74 mapped carbamyllysine obtained from in vitro carbamylation of apoA-I by both the urea-driven (nonenzy
75 c results that alanosine did not inhibit the carbamylation of aspartate in the normal reaction of nat
84 of these Lys residues to Arg shows that only carbamylation of Lys125 is essential for hemichannel ope
85 Lys125, and the proposed mechanism involves carbamylation of Lys125 to allow formation of a salt bri
96 bit the catalytic activity of CEase by rapid carbamylation of the active site, a process that shows s
98 tic serine (Ser(148)) suggesting a selective carbamylation of the enzyme by AM6701 or WWL70 and confi
100 of cleavage (4 M urea, pH 7) induced partial carbamylation of the N termini of the peptides, and each
101 d products, suggesting the prominent role of carbamylation over glycoxidation reactions in age-relate
102 eferentially targeted by the enzymatic (MPO) carbamylation pathway, whereas the nonenzymatic pathway
103 e hypothesized that monitoring site-specific carbamylation patterns of apoA-I recovered from human at
104 ummary, serum PBHCit, a footprint of protein carbamylation, predicts increased cardiovascular risk in
105 homocitrulline (PBHCit), which results from carbamylation, predicts major adverse cardiac events in
107 elease (CCR) systems that mimic the Lys(201) carbamylation reaction in the active site of ribulose-1,
108 te elevations of CO(2) ( PCO2 55 mmHg) via a carbamylation reaction that depends on residues K125 and
110 e determination of K(1) and DeltaG(1) of the carbamylation reactions requires the solution of multieq
114 chemical modifications such as glycation and carbamylation serve as important biomarkers for conditio
115 rom cells exposed to urea showed significant carbamylation that increased as a function of time.
116 , we describe the mechanistic details of Lys carbamylation that leads to RuBisCO activation by atmosp
117 block alloantibody hexamerization (antibody carbamylation, the K439E Fc mutation, or treatment with
118 of sulfopeptides that have been modified via carbamylation to convert all primary amines to less basi
119 xidase (MPO) release, which mediates protein carbamylation to form anti-carbamylated proteins (anti-C
122 at ammonium ion pK(a) depression and low pH carbamylation were analyzed with (2,2,2-trifluoroethyl)b
123 plemented a derivatization strategy based on carbamylation which converts basic amine sites (Lys, N-t
125 initial conditions, (1)H NMR measurements of carbamylation yields over a wide pH range, and knowledge