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1 rus honey (caffeine, 2-oxindole and indole-3-carbinol).
2 n (FLIP) were all down-regulated by indole-3-carbinol.
3 n demonstrated in the case of methyl mesityl carbinol.
4 composed by reaction with the medium to give carbinol.
5 ield, and in the presence of the unprotected carbinol.
6 tiated rearrangement of protected thiazolium carbinols.
7 sis of seemingly trivial enantiopure dialkyl carbinols.
8 nyl-ene reaction) to functionalized tertiary carbinols.
9 mall number of methods can generate tertiary carbinols.
10  chiral diaryl carbinols and a few arylalkyl carbinols.
11 chirality transfer from the optically active carbinols.
12  use in the petrocortyne family of dialkynyl carbinols.
13 .995), ethyl isovalerate (-0.994) and benzyl carbinol (0.993) are the key variables that most contrib
14 C-H arylation is preferred for unsubstituted carbinol 1, an outcome from combined factors like carboc
15 C-H arylation is preferred for unsubstituted carbinol 1, an outcome from combined factors like carboc
16 ved through derivatization with deuterated 3-carbinol-1-methyl-d3-pyridinium iodide.
17 with 2-bromo-1-methylpyridinium iodide and 3-carbinol-1-methylpyridinium iodide, forming 3-acyloxymet
18 e-induced desilylation-cyclization to afford carbinol 12.
19 ,7-disubstituted fluoren-9-one to afford the carbinol 16.
20 re for the asymmetric epoxidation of divinyl carbinol (3) was described, and the product was used in
21 bly more advantageous for the acquisition of carbinol 37e than in the absence of the additive (exo/en
22  6 has the S,S and (-)-(methylenecyclopropyl)carbinol (4) the R configuration.
23 scorbigen (13.0 mumol/100 g FW) and indole-3-carbinol (4.52 mumol/100g FW) with their higher concentr
24 periments show that the reaction of indole-3-carbinol, a breakdown product of indol-3-ylmethylglucosi
25           Based on the structure of indole-3-carbinol, a chemopreventive phytochemical, we developed
26                       We identified indole-3-carbinol, a compound found in cruciferous vegetables, as
27 IM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferou
28 her supporting the possibility that indole-3-carbinol acts as an auxin antagonist.
29  of otherwise unknown stereogenic, secondary carbinol (alcohol) centers (R1R2CHOH (or the analogous a
30  (TBAF) yielded polyfunctionalized (2E,4E)-4-carbinol alkadienoate-a valuable building block-in highl
31 idly added to silylallenes, leading to gamma-carbinol allenoates at low temperatures.
32 rotocol used involves the reaction of cyclic carbinol amides with triflic anhydride.
33 logue was oxidized to the syn spiromethylene carbinol analogue of the major spirosulfonamide product.
34 dipyrromethane and a 9-bromodipyrromethane-1-carbinol and (ii) intramolecular cyclization of the 1-br
35 ity including the reactive cyclopropylmethyl carbinol and alpha,beta-unsaturated ketone.
36 tency with the absolute configuration of the carbinol and amine moieties, whose observed DeltadeltaL(
37 d that oviposition was increased by indole-3-carbinol and decreased by indole-3-acetonitrile (IAN).
38 group are nonessential since both pyridine-3-carbinol and pyridine-4-carboxylate support the base exc
39        A direct interaction between indole-3-carbinol and the auxin perception machinery was suggeste
40  positioning of the substituents on both the carbinol and the cyclopropane determine both chemo- and
41                                 Benzofuranyl carbinols and 1,3-dicarbonyls in the presence of a catal
42 (2), with aldehydes to produce chiral diaryl carbinols and a few arylalkyl carbinols.
43 ocess is tolerant of a variety of thiazolium carbinols and nitroalkene substrates and can be rendered
44     Compounds containing acid, ester, amide, carbinol, and aldehyde groups at the 3-position of the q
45 rolide bearing an esterified trichloromethyl carbinol, and may be produced by a cyanobacterium that a
46 ercetin, flavone, chlorogenic acid, indole-3-carbinol, and rutin) and three insecticides (diazinon, c
47 monoacyl dipyrromethane to the corresponding carbinol, and self-condensation of the carbinol to form
48 ur ylide acts as the equivalent of the alpha-carbinol anion.
49 es and of alpha-alkoxyallenyl vinyl tertiary carbinols are covered (Section 3).
50                               These tertiary carbinols are formed in high diastereoselectivities, wit
51                                The 8'-methyl carbinols are the only metabolites formed by CYP1A2, and
52 ides trisubstituted alpha-hydroxycyclopropyl carbinols as single diastereomers in good to excellent y
53                       Because chiral dialkyl carbinols, as well as their derived esters, are signific
54 wn products (indole-3-acetonitrile, indole-3-carbinol, ascorbigen and 3,3'-diindolylmethane released
55 the absolute configuration of the lipid tail carbinols at pH 4.0 and 8.0.
56  group at the 5-position, a dipyrromethane-1-carbinol bearing an acetal group at the 5-position or ca
57 ecreasing the rotation rate of the quinoline-carbinol bond, the relatively bulky CF(3) group enables
58 r: upon enantiospecific bio-oxidation of the carbinol by the HSD17B11 short-chain dehydrogenase/reduc
59 ts for the kinetic resolutions of aryl alkyl carbinols by benzoylation (16, 21, 22) or iso-butyroylat
60 ation) is superseded by a pathway leading to carbinol C-alkylation under the conditions of rhodium-ca
61 ary alcohol reactant releases the product of carbinol C-alkylation with regeneration of the ketone.
62 ng studies, we determined that (i) it is the carbinol C-H and adjacent O-H hydrogen atoms that are tr
63 t the diene C4-position, resulting in direct carbinol C-H prenylation and geranylation, respectively.
64 ary alcohol reactant releases the product of carbinol C-H vinylation and regenerates ketone and zero-
65                    Versatile trichloromethyl carbinols can be prepared in one pot from primary alcoho
66 uents at the carbons adjacent to the allylic carbinol carbon (i.e., C-2 or C-6 in cyclohexenone-deriv
67 ations involves hydride abstraction from the carbinol carbon of the alcohol substrate.
68 he unpaired electron is localized on C1 (the carbinol carbon) of the substrate.
69 methylmalate, involving the migration of the carbinol carbon.
70  experimental effects of substituents on the carbinol carbon.
71  stereochemistry is controlled from a single carbinol center installed through catalytic enantioselec
72 se/reductase (SDR) known to oxidize the C-17 carbinol center of androstan-3-alpha,17-beta-diol to the
73                 The configuration at the new carbinol center was deduced by proton NMR analysis of (R
74 ylidene protection involving a C8-quaternary carbinol center.
75 onic environment at the stereogenic tertiary carbinol centre.
76                   The dramatic effect of the carbinol configuration on cytotoxicity was confirmed wit
77 id, diastereoselective synthesis of tertiary carbinol containing fragments with relevance to polyketi
78 ing enantioselective diboration of a divinyl carbinol derivative and high-yielding late-stage cross-m
79                                  Cyclopropyl carbinol derivatives undergo a regio- and stereoselectiv
80 r bromonium ion-induced rearrangement of the carbinol derived by addition of 2-lithio-4,5-dihydrofura
81                                        Vinyl carbinols derived from 2-methyl-2-phenylpropanal react w
82 romethane and a 9-protected dipyrromethane-1-carbinol (derived from a 9-protected 1-acyldipyrromethan
83         An alternative approach to the alpha-carbinol diastereomer proceeds by initial alpha-oxygenat
84                        A bromodipyrromethane carbinol (Eastern half) was prepared by sequential acyla
85                                      Allenyl carbinol ester 3 isomerizes to an E,Z mixture of the cor
86                                 Although the carbinol esters yield stereo- and regiochemically hetero
87 tives (carboxylate esters, carboxamides, and carbinol esters) were investigated as substrates for rin
88                                              Carbinol formation is further characterized by high intr
89 heterocyclic-fused indoles with aryl, bromo, carbinol, formyl, and vinyl groups.
90                                     Indole-3-carbinol, found in Brassica species vegetables (such as
91 on is induced by herbivory, such as indole-3-carbinol, function not only to repel herbivores, but als
92 rivatives decorated with trifluoromethylated carbinol functionality.
93 roviding efficient access to trifluoromethyl carbinol-functionalized dihydrobenzo[k]phenanthridinones
94 The glucosinolate breakdown product indole-3-carbinol functions in cruciferous vegetables as a protec
95 oxidation of the resultant diastereoisomeric carbinols, gave the acetylenic ketone 24.
96 ns that focused on modifications to the aryl carbinol group of this series.
97 ons of steroids in the presence of secondary carbinol groups and carbon-carbon double bonds, as in en
98        Among them, sulforaphane and indole-3-carbinol have attracted a lot of attention, since their
99 posed reaction pathway, silylated thiazolium carbinols have been identified to provide good yields of
100 eaction is found to be general even on furyl carbinols; however, it generates the rearranged polysubs
101                                     Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) are two b
102 chemical and biological interest in indole-3-carbinol (I3C) and its metabolites has resulted in the d
103 ion for 3,3-diindolylmethane (DIM), indole-3-carbinol (I3C) and sulforaphane (SFN).
104 -231 human breast cancer cells with indole-3-carbinol (I3C) directly inhibited the extracellular elas
105                                 The indole-3-carbinol (I3C) metabolite 3,3'-diindolylmethane (DIM) is
106                                     Indole-3-carbinol (I3C), a component of Brassica vegetables, is u
107                                     Indole-3-carbinol (I3C), a compound naturally occurring in Brassi
108 ted the chemopreventive efficacy of indole-3-carbinol (I3C), a constituent of Brassica vegetables, an
109                                     Indole-3-carbinol (I3C), a dietary compound found in cruciferous
110     We investigated the efficacy of indole-3-carbinol (I3C), a dietary supplement, and AHR precursor
111                       The effect of indole-3-carbinol (I3C), a major indolic metabolite in cruciferou
112                             Dietary indole-3-carbinol (I3C), a natural compound present in vegetables
113                                     Indole-3-carbinol (I3C), a naturally occurring component of Brass
114                                     Indole-3-carbinol (I3C), a naturally occurring component of Brass
115 hed the cellular mechanism by which indole-3-carbinol (I3C), a promising anticancer phytochemical fro
116 ypothesized that the phytochemical, indole-3-carbinol (I3C), and some of its acid-condensation deriva
117 er the antiestrogenic phytochemical indole-3-carbinol (I3C), found in cruciferous vegetables, adminis
118                   The phytochemical indole-3-carbinol (I3C), found in cruciferous vegetables, and its
119    The naturally occurring chemical indole-3-carbinol (I3C), found in vegetables of the Brassica genu
120 ral classes of compounds, including Indole-3-carbinol (I3C), may have chemopreventive activity agains
121 ovides phytochemicals, particularly indole-3-carbinol (I3C), which may be responsible for the prevent
122             The Tg is driven by the indole-3-carbinol (I3C)-inducible rat cytochrome P450 1A1 promote
123  treatment with the AHR pro-agonist indole-3-carbinol (I3C).
124 emented with the dietary AhR ligand indole-3-carbinol (I3C).
125  efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast can
126 the ability of dietary AhR ligands (indole-3-carbinol [I3C] and 3,3'-diindolylmethane [DIM]) and an e
127 rastatin is accomplished by the use of furyl carbinol in 13 linear steps from furfural with ~11% over
128 s determination of sulforaphane and indole-3-carbinol in broccoli using UPLC-HRMS/MS is described.
129 pplementation of the AHR pro-ligand indole-3-carbinol in newborn mice promotes resistance to infectio
130 U-A9 was 100 times more potent than indole-3-carbinol in suppressing the viability of Hep3B, Huh7, an
131 onyl substrates to provide the corresponding carbinols in yields up to 99%.
132 t inhibit carcinogenesis, including indole-3-carbinol, indole-3-carboxaldehyde, ferulic acid, vanilli
133 ndole-containing chemicals, such as indole-3-carbinol, indolo[3, 2-b]carbazole, and UV photoproducts
134  administration of low-dose dietary indole-3-carbinol induces moderate hypertension.
135 Overall, our results indicated that indole-3-carbinol inhibits NF-kappaB and NF-kappaB-regulated gene
136 is responsible for the observed formation of carbinols instead of the desired haloketones.
137                    Alternative protocols for carbinol inversion at C(11), one early and one late in t
138 rporation of oxygen from the medium into the carbinols is observed.
139 1) for the formation of a syn spiromethylene carbinol, K(m) 7 microM).
140 urants included ethyl acetate, acetyl methyl carbinol, methylhexanoate, sabinene, p-cymene, methylben
141 he parent ketone afforded the diastereomeric carbinol mixture which showed reduced inhibitory potency
142 paB (NF-kappaB), we postulated that indole-3-carbinol must mediate its activity through NF-kappaB mod
143 n to other metabolic products, the 8'-methyl carbinols of these N7-methyl-8-methylxanthines are forme
144  (NA) moiety in NAADP to either an uncharged carbinol or from the 3-position to the 4-position of the
145 old(I) indazol-3-ylidene complexes bearing a carbinol or silanol group at the 4-position.
146 , the absolute configuration of the original carbinol (or amino) stereocenter can be reliably deduced
147           The tryptophan derivative indole-3-carbinol, or tryptophan-metabolizing Lactobacillus murin
148 intramolecular isotope effects; however, the carbinol oxygen is derived exclusively from molecular ox
149 ein interaction studies showed that indole-3-carbinol perturbs the auxin-dependent interaction of Tra
150 ere we examined the hypothesis that indole-3-carbinol plays a role in influencing plant growth and de
151 bearing an acetal group at the 5-position or carbinol position, or a dipyrromethane-1,9-dicarbinol be
152                Differing substitution at the carbinol position, phenyl ring, and carbon-carbon double
153 -1,9-dicarbinol bearing an acetal group at a carbinol position.
154 ed a large coupling constant between vicinal carbinol protons.
155 earrangement of the alpha-hydroxycyclopropyl carbinols provides access to both cis- and trans-2,3-dis
156                    Some of the synthesized 4-carbinol quinolines have shown interesting antiprolifera
157                        We show that indole-3-carbinol rapidly and reversibly inhibits root elongation
158 l, we have found that azabicyclo[1.1.0]butyl carbinols, readily obtained from the highly strained aza
159 a diverse set of functionalities in the aryl carbinol region.
160 es that are induced in the plant by indole-3-carbinol remain relatively uninvestigated.
161 ddition of the plant-derived ligand indole-3-carbinol rescued the barrier deficiency even in aged mic
162 ry was suggested, as application of indole-3-carbinol rescues auxin-induced root phenotypes.
163 e and 0.997, 0.42mg/L, 1.29mg/L for indole-3-carbinol, respectively.
164 xa-1,3-dienes upon acid-promoted cyclopropyl carbinol ring opening.
165 uced 99% pure S-(-)-1-isoquinolyl tert-butyl carbinol [(S)-16].
166 tage that the alpha- and beta-stereoisomeric carbinol series can be obtained on demand.
167             However, during storage indole-3-carbinol slowly degraded to 0.68 mumol/100 g FW, while a
168 angement resulted in the creation of the C18 carbinol stereogenic center and chain elongation.
169                                              Carbinol substituents determine the extent of cyclopropy
170 This protocol showed good generality for the carbinol substrates as well as alkynes and allowed the g
171  in the case of the less hindered aryl alkyl carbinol substrates.
172     Because of the ubiquity of the secondary carbinol subunit, the development of new methods for its
173                We demonstrated that indole-3-carbinol suppressed constitutive NF-kappaB activation an
174                                     Indole-3-carbinol suppressed constitutive NF-kappaB activation in
175 y enriched and functionally complex tertiary carbinols that may be easily accessed.
176 rise to degradation products (e.g., indole-3-carbinol) that can enhance tumorigenesis.
177 enerated ketone group into the corresponding carbinol, the effect of a number of different acidic con
178                With o-substituted aryl alkyl carbinols, the enantioselectivities exceed 100, and s =
179 secondary alcohols (specifically, aryl alkyl carbinols) through enantioselective acylation, and we su
180 n (1b) was selectively alkylated at the C-32 carbinol, thus providing esters and amides of 32-ascomyc
181 nding carbinol, and self-condensation of the carbinol to form the porphyrin.
182 dition of the natural phytochemical indole-3-carbinol to the purified diet.
183 ning cyclization of (hetero)aryl cyclopropyl carbinols to form alpha-alkylidene-gamma-butyrolactones
184 (i.e., those derived from conjugation of the carbinol under interrogation with MTPA) display differen
185                 However, the introduction of carbinol units required the development of new building
186     The content of sulforaphane and indole-3-carbinol varied between 72+/-9-304+/-2mg and 77+/-1-117+
187                                     Indole-3-carbinol was an exceptionally potent AHR agonist (EC50 a
188                         Several aryl pyridyl carbinols were obtained in high yields.
189 ethanol to the corresponding trichloromethyl carbinol with complete stereochemical fidelity, despite
190  cyclopropanation to afford aminocyclopropyl carbinols with three continuous stereocenters in a one-p

 
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