ライフサイエンスコーパス: carbo

1 an apex predators (cormorants, Phalacrocorax carbo).

2 2beta-(R)-Carbo-1-fluoro-2-propoxy-3beta-(4-chlorophenyl) tro pane

3 nyl) tro pane ((R)-FIPCT, R-6) and 2beta-(S)-carbo-1-fluoro-2-propoxy-3beta-(4-chlorophenyl) tro pane

4 2Beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)pheny

5 to chemotherapy; 18 (55%) of 33 responded to CARBO; 24 (80%) of 30 responded to CARBO and CARBO-VCR-5

6 Unlike carbo[6]helicene 1, the 4,13-substituted derivative 2 fo

7 ng of two TEMPO radicals bridged by a chiral carbo[6]helicene, which after photoexcitation of the hel

8 elf-assembly of 2,15- and 4,13-disubstituted carbo[6]helicenes 1 and 2 bearing 3,4,5-tridodecyloxyben

9 Enantiopure carbo[6]helicenyl boronates were synthesized using a pho

10 the racemate of an overcrowded triply fused carbo[7]helicene of formula C(66)H(36) with three carbo[

11 ed multihelicene compound, composed of three carbo[7]helicene units fused within a central six-member

12 The racemization of the triply fused carbo[7]helicene was determined to proceed at a rate of

13 The evaluation of aromaticity in this triple carbo[7]helicene, utilizing magnetic and electronic crit

14 value significantly lower than for pristine carbo[7]helicene.

15 [7]helicene of formula C(66)H(36) with three carbo[7]helicenes fused within a central six-membered ri

16 (700 mg/m(2)), followed by three courses of CARBO (700 mg/m(2)), day 0; 5-FU (1,000 mg/m(2)/d), by c

17 were treated sequentially with one course of CARBO (700 mg/m(2)), followed by three courses of CARBO

18 ulations and were compared to those of their carbo analogues.

19 studied and compared to those of the parent carbo-analogues.

20 ponded to CARBO; 24 (80%) of 30 responded to CARBO and CARBO-VCR-5-FU; and nine (75%) of 12 responded

21 /amino-3-arylisoxazoles, bearing unsaturated carbo and heterocyclic substituents at the position 4, g

22 es access to a broad range of functionalized carbo- and hetero-cyclic structures.

23 catalytic cascade produces in one operation carbo- and heterobicyclic building blocks for the synthe

24 fide products is also demonstrated in simple carbo- and heterocycle-forming processes.

25 A variety of (arylmethyl)carbo- and heterocycles (N, O) can be synthesized with t

26 Carbo- and heterocycles of five- and six-membered rings

27 an atom-economical approach to five-membered carbo- and heterocycles that contain two new stereogenic

28 ion are shown and lead to highly substituted carbo- and heterocycles with excellent diastereocontrol.

29 uding arylation processes, formation of both carbo- and heterocycles, alpha- and beta-functionalizati

30 lation strategy for the synthesis of various carbo- and heterocycles, based on an intramolecular aryn

31 bene, chalcone, cinnamic acid, various fused carbo- and heterocycles, etc.

32 the synthesis of a wide number of different carbo- and heterocycles.

33 assembly of a new class of [5,5] spirocyclic carbo- and heterocycles.

34 e approach exclusively targets five-membered carbo- and heterocyclic aldehydes, involving unusual ald

35 gy gives access to substituted five-membered carbo- and heterocyclic compounds in good yields and exc

36 eta-amino ketones and highly enantioenriched carbo- and heterocyclic compounds.

37 ates of [1,5]-hydrogen shifts in a series of carbo- and heterocyclic dihydroaromatic compounds were e

38 ion delivers diverse trans-3,4-disubstituted carbo- and heterocyclic five-membered rings in high yiel

39 ri- and tetrasubstituted pyridines including carbo- and heterocyclic fused ones.

40 of synthesizing the cis-selective saturated carbo- and heterocyclic germanium compounds (3D framewor

41 de range of highly functionalized 6-membered carbo- and heterocyclic molecules in a single step with

42 nization of a variety of enone acids, giving carbo- and heterocyclic products with high diastereo- an

43 cyclopropanes (ACPs) to afford five-membered carbo- and heterocyclic rings with concomitant intramole

44 raightforward methodology to access bicyclic carbo- and heterocyclic scaffolds combining different ri

45 ly highly diastereoselective installation of carbo- and heterocyclic substituents at position 1', ort

46 ls and furnishes a diverse and unique set of carbo- and heteropolycyclic ring systems in good yields

47 C bonds and one C-O bond, and two rings (one carbo- and one heterocyclic) in a single operation.

48 diastereomers (dr >20:1) via chemoselective carbo-annulation.

49 a general foundation for the definition of "carbo-aromaticity", the relevance of which is surveyed t

50 le-light irradiation to facilitate catalytic carbo-aroylation of unactivated alkenes, affording a wid

51 vian predator (great cormorant Phalacrocorax carbo) at nearby roosting sites, allowing us to directly

52 ional, aromatic, rigid, sigma,pi-macrocyclic carbo-benzene archetypes of various substitution pattern

53 Deleting a C4 edge of the rigid C18 carbo-benzene circuit results in a flexible 'carbo-butad

54 Furthermore, carbo-benzene junctions exhibit field-effect transistor

55 the first examples of direct pi-stacking of carbo-benzene rings, with inter-ring distances very clos

56 methods, molecular units of alpha-graphyne ('carbo-benzene' macrocycles) can be inserted between two

57 sport calculations are carried out on such a carbo-benzene, providing unprecedented single molecule c

58 nd characterization of p-dialkyl-tetraphenyl-carbo-benzenes (n = 2, 8, 14, 20) are thus presented and

59 several types of non-aromatic references of carbo-benzenes are then considered, i.e. freely rotating

60 splay classical UV-vis electronic spectra of carbo-benzenes in solution (lambdamax = 445.5 +/- 1 nm,

61 All alkyl-carbo-benzenes were also found to be highly crystalline.

62 Very preliminary experimental results on a carbo-benzenoid fragment are finally disclosed.

63 the chirality of beta(3) carbon in C-linked-carbo-beta(3)-amino acid (Caa) from R to S.

64 were prepared from (S)-beta-Caa(l) (C-linked carbo-beta-amino acid with D-lyxo furanoside side chain)

65 A new C-linked carbo-beta-amino acid, (R)-beta-Caa((r)), having a carbo

66 onal analysis of beta-peptides from C-linked carbo-beta-amino acids [beta-Caa(l)] with a d-lyxo furan

67 carbo-benzene circuit results in a flexible 'carbo-butadiene' molecule that has a conductance 40 time

68 Therefore, although carbo-cages have enthalpies of formation 1 order of magn

69 ular properties of polyhedranes, a series of carbo-cages is proposed in silico via density functional

70 n Europe from both subspecies (Phalacrocorax carbo carbo and P. c. sinensis) and 84 birds from two in

71 Patients treated sequentially with CARBO, CARBO-VCR-5-FU, and HDDP-ETOP had response rates

72 d then to synthetic rutile, high-temperature carbo-chlorination to produce TiCl4, and batch reduction

73 In the carbo-counterparts, the values of the magnetic response

74 ble, explaining why the similar systems like carbo-cubane have already been synthesized.

75 alides affords the corresponding hetero- and carbo-cycles in an undivided flow reactor equipped with

76 -based benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a hig

77 dienes and flexible sigma-cyclic, pi-acyclic carbo-cyclohexadienes, and to "pro-aromatic" congeners,

78 per-catalyzed radical relay approach for the carbo-difluoromethylation of alkenes.

79 Here we report the development of vicinal di-carbo-functionalization of indoles in a site- and regios

80 exchange studies and the absence of methane carbo-functionalization/oligomerization products.

81 yne, a carbon-expanded version of graphene ('carbo-graphene') that was recently evidenced as an alter

82 partners (e.g., alkenes, alkynes, nitriles, carbo/heterocycles, X-H/C-X bonds, etc.).

83 yridines, tetralins, pyrrolidines, and other carbo/heterocyclic cores via [n+2] (n=3-5) (hetero)annul

84 fro sigma -> sigma* type interaction, namely carbo-hydrogen bonding, is also present in protein-ligan

85 s are halogen, chalcogen, pnictogen, tetrel, carbo-hydrogen, and spodium bonding, and n -> pai* inter

86 l, optical and mechanical properties of such carbo-materials are surveyed.

87 etic, physical, and theoretical chemistry of carbo-mers and in particular macrocyclic-polycyclic repr

88 With respect to their parent molecules, carbo-mers are constitutionally defined as "carbon-enric

89 It is shown that functional carbo-mers are entering the field of "molecular material

90 Since total or partial carbo-mers of aromatic carbon-allotropes of infinite siz

91 dered, i.e. freely rotating sigma,pi-acyclic carbo-n-butadienes and flexible sigma-cyclic, pi-acyclic

92 llenoate, 2-sulfonamidoindole acts only as a carbo-nucleophile in (p-tolyl)(3)P-directed [4 + 1] spir

93 -3-([3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbo nyl]-1H-pyrrol-2-yl]methylene)-N-methyl-2-oxo-2,3-

94 eir ability to participate in anti-selective carbo- or heteroannulation with non-conjugated alkenyl a

95 dingly categorized by the number of built-in carbo- or heterocycles.

96 direct enrichment of short-chain carboxylic (CARBO)-OxPLs, whereas detection of aldehydic (ALDO)-OxPL

97 C, while not cost effective compared with IV-CARBO/PAC at 7 years, becomes cost effective if a longer

98 may also be cost effective compared with IV-CARBO/PAC if proven as effective as inpatient IP-CIS/PAC

99 sis, the ICER of IP-CIS/PAC compared with IV-CARBO/PAC was $26,311.

100 f intravenous carboplatin and paclitaxel (IV-CARBO/PAC), intravenous cisplatin and paclitaxel (IV-CIS

101 Compared with IV-CARBO/PAC, IP-CIS/PAC had an incremental cost-effectiven

102 66, 57, 51, and 48 months for IP-CIS/PAC, IV-CARBO/PAC, IV-CIS/PAC (GOG 172), or IV-CIS/PAC (GOG 158)

103 costly and had lower life expectancy than IV-CARBO/PAC.

104 est that this process occurs via a concerted carbo-palladation across the thiophene double bond, foll

105 In the particular case of a carbo-prismane, no structural change is perceived until

106 " congeners, i.e. rigid sigma,pi-macrocyclic carbo-quinoids.

107 EOB)) by preparation of the precursors 2beta-carbo-R-1-mesyloxy-2-propoxy-3beta-(4-chlorop hen yl)tro

108 be development was illustrated by the direct carbo(radio)fluorination of electron-rich alkenes.

109 panied by the amide counterpart due to rapid carbo(S-to-O) exchange during the preparation of amino(c

110 a-(4-chlorop hen yl)tropane (R-12) and 2beta-carbo-S-1-mesyloxy-2-propoxy-3beta-(4-chlorop hen yl)tro

111 ren whose tumors remained unresectable after CARBO-VCR-5-FU or who demonstrated no response or progre

112 Patients treated sequentially with CARBO, CARBO-VCR-5-FU, and HDDP-ETOP had response rates and EFS

113 and then received two additional courses of CARBO-VCR-5-FU.

114 CARBO; 24 (80%) of 30 responded to CARBO and CARBO-VCR-5-FU; and nine (75%) of 12 responded to HDDP-E

115 CARBO was given on day 1 at an area under the curve of 6

116 th a fixed systemic exposure of carboplatin (CARBO) with or without granulocyte colony-stimulating fa

117 dophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carbo xamide].

118 12-hexahydro-10-(R)hydroxy-9-methyl-1-oxo-10-carbo xylate (K-252a) and 2-[N-(2-hydroxyethyl)-N-(4-met

119 H-diazirin-3-yl)phenyl)ethyl)-1H-imidazole-5-carbo xylate (trifluoromethyldiazirinyl-etomidate), or T

120 henyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carbo xylate) (CXL017), reveals selective cytotoxicity t