ライフサイエンスコーパス: carbon-11

1 specific for MAO A (clorgyline labeled with carbon 11).

2 lective radiotracer carfentanil labeled with carbon 11.

3 derivative, such as amides and esters, with carbon-11.

4 ted log D, and amenability for labeling with carbon-11.

5 th a positron-emitting radionuclide, such as carbon-11.

6 elopment using the short-lived radionuclides carbon-11.

7 ad compound MT107 (7f) was radiolabeled with carbon-11.

8 e very rapid owing to the short half-life of carbon-11.

9 n N-methyl group as a site for labeling with carbon-11.

10 rbamates and radiolabeled eight of them with carbon-11.

11 Myelin content was detected with carbon 11 ((11)C) Pittsburgh compound B (PIB).

12 Carbon-11 ((11)C) is one of the most ideal positron emit

13 iciently labeled with fluorine-18 ((18)F) or carbon-11 ((11)C).

14 The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique

15 roxybenzothiazole (2b) was radiolabeled with carbon-11 ((11)C-(2b)) and used in vivo for microPET sca

16 itron emission tomography (PET) radionuclide carbon-11 ([(11)C]biotin) to enable the quantitative stu

17 ioid receptor (MOR) system when labeled with carbon-11 ([(11)C]CFN).

18 After radiolabeling with positron-emitting carbon-11, [(11)C]CIC-PET was conducted in longitudinal

19 ission tomographic (PET) imaging study using carbon 11 ([11C])-labeled PBR28 in patients with tempora

20 Microbial communities utilized ancient carbon (11,300 to >50,000 (14)C years) in permafrost tha

21 [1-Carbon-11]acetate has been used as a tracer for oxidativ

22 eled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studi

23 and potent antagonist activity suggests that carbon-11 and iodine-123 analogues may be useful as PET

24 is not constrained by the short half-life of carbon-11 and is an attractive alternative to convention

25 nd pyrazinamide (PZA) have been labeled with carbon-11 and the biodistribution of each labeled drug h

26 14a, 14b, 16, and 20 were radiolabeled with carbon-11 and their log P(7.4) was calculated as a measu

27 atus between carbons 7 and 8 (7' and 8') and carbons 11 and 12 (11' and 12') as well as the methyl gr

28 emistry for three key isotopes: fluorine-18, carbon-11, and zirconium-89, and their applications in p

29 radiochemistry differs from fluorine-18 and carbon-11 approaches.

30 s that can be conveniently radiolabeled with carbon-11 as PET tracers for the in vivo imaging of an a

31 s, which were conveniently radiolabeled with carbon-11, as potential positron emission tomography (PE

32 eS-IMPY ( 3, K i = 7.93 nM) was labeled with carbon-11 at its S- or N-methyl position to give [ (11)C

33 rapid access to (11)C-labeled compounds with carbon-11 attached at various hybridized carbons as well

34 for in vivo molecular imaging applications (carbon-11, beta(+), t(1/2) = 20.4 min).

35 Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons wi

36 Carbon-11-carfentanil brain kinetics were monitored for

37 Carbon-11-CFT (WIN 35,428, 2 beta-carbomethoxy-3 beta-(4

38 agents such as fluorine 18 fluciclovine and carbon 11 choline, and to highlight some of the individu

39 1-[Carbon-11]-D-glucose ([11C]-glucose) is an important ima

40 ssion tomography and raclopride labeled with carbon 11 (D2/D3 receptor radioligand sensitive to compe

41 We show that carbon 11 derives not from dimethyl sulfoxide as propose

42 Carbon-11-EPI traces sympathetic nerve terminals in the

43 Carbon-11-EPI was added to the perfusate during wash-in

44 nthesized and successfully radiolabeled with carbon-11, fluorine-18, and gallium-68.

45 Positron emission tomography using carbon-11 hydroxyephedrine was used to characterize left

46 Carbon-11-hydroxyephedrine cardiac retention was quantif

47 Carbon-11-hydroxyephedrine is a positron-emitting tracer

48 derivatives that have been synthesized using carbon-11 inserted different functional groups obtained

49 lity of this method for the incorporation of carbon-11 into acyl amidines and 1,2,4-oxadiazoles, stru

50 is an attractive strategy for incorporating carbon-11 into radiotracer targets, particularly given t

51 late-stage installation of both tritium and carbon-11 into the desired compounds via methylation of

52 Carbon-11 is most often incorporated into small molecule

53 Carbon-11 is one of the promising radiotracers that can

54 Carbon-11-L-159,884 was prepared by alkylation of the no

55 the pharmacokinetics and distribution of the carbon-11 labeled 5HT2C agonists.

56 rfentanil ([(11)C]CFN) is the only selective carbon-11 labeled radiotracer currently available for po

57 atives as functional analogues to the native carbon-11 labeled versions with similar pharmacological

58 We developed a carbon-(11)-labeled radiotracer, [(11)C]YL9, which exhib

59 t of 50 patients also underwent imaging with carbon 11-labeled 3-amino-4-(2-dimethylaminomethyl-pheny

60 Binary classification of carbon 11-labeled [11C]PMP acetylcholinesterase and caud

61 ion tomography (PET) tumor imaging; however, carbon 11-labeled acetate appears to show improved sensi

62 the mu-opioid receptor selective radiotracer carbon 11-labeled carfentanil during a neutral state.

63 hy with the dopamine D2 receptor radiotracer carbon 11-labeled FLB457 before and after amphetamine ad

64 Positron emission tomographic imaging with carbon 11-labeled FLB457 before and following 0.5 mg/kg

65 sitron emission tomographic D2/3 radiotracer carbon 11-labeled FLB457 in combination with the ampheta

66 are psychiatric hospital, 58 women underwent carbon 11-labeled harmine positron emission tomography.

67 ARTICIPANTS: This cross-sectional study used carbon 11-labeled N,N-diethyl-2-(4-methoxyphenyl)-5,7-di

68 underwent positron emission tomography using carbon 11-labeled N-(2-(1-(4-(2-methoxyphenyl)-1-piperaz

69 T) imaging for tau and Pittsburgh compound B carbon 11-labeled PET (PiB-PET) imaging for Abeta.

70 nderwent flortaucipir 18 T807 (18F-T807) and carbon 11-labeled Pittsburgh Compound B (11C-PiB) positr

71 F]AV-1451 PET imaging to measure tau burden, carbon 11-labeled Pittsburgh Compound B ([11C]PiB) PET i

72 inimal brain amyloid burden as measured with carbon 11-labeled Pittsburgh Compound B ([11C]PiB) posit

73 ion-based controls, underwent amyloid ligand carbon 11-labeled Pittsburgh Compound B (PiB) positron e

74 ositron emission tomography (PET) scans with carbon 11-labeled Pittsburgh Compound B (PiB), and cereb

75 Carbon 11-labeled Pittsburgh Compound B (PiB)-, florbeta

76 groups based on their amyloid load shown on carbon 11-labeled Pittsburgh Compound B positron emissio

77 ND MEASURES beta-Amyloid burden, measured by carbon 11-labeled Pittsburgh compound B positron emissio

78 lume, and Abeta deposition (quantified using carbon 11-labeled Pittsburgh compound B positron emissio

79 Disease Neuroimaging Initiative (ADNI) using carbon 11-labeled Pittsburgh Compound B scanning.

80 PET acquired with carbon 11-labeled Pittsburgh compound B tracer was avail

81 Positron emission tomography (PET) and carbon-11-labeled 2B-carbomethoxy-3B-(4-fluorophenyl)tro

82 ron emission tomography demonstrated reduced carbon-11-labeled 2beta-carbomethoxy-3beta-(4-fluorophen

83 Three different carbon-11-labeled catecholamines were used for positron

84 Carbon-11-labeled D2/3R agonists have been developed, bu

85 y aimed to determine the pharmacokinetics of carbon-11-labeled DACA ([11C]DACA) and evaluate the effe

86 measured at hours 1, 3, 5, and 7 by using a carbon-11-labeled imaging agent (Altropane) and positron

87 Using two analytes, carbon-11-labeled m-hydroxyephedrine and alpha-methylepi

88 Amyloid deposition was assessed using carbon-11-labeled Pittsburgh compound B positron emissio

89 ed through the preliminary evaluation of two carbon-11-labeled racemic structures [(11)C]11 and [(11)

90 Carbon-11-labeled triamcinolone acetonide was formulated

91 positron-emission tomography (PET) with the carbon-11-labeled, R-enantiomer form of PK11195 ([(11)C]

92 Carbon-11 labeling of (+)-31 yielded [(11)C]-(S)-30, whi

93 Carbon-11 labelled tryptophan derivatives are feasible a

94 with positron emission tomography (PET) and carbon-11-labelled (R)-PK11195, a specific ligand for th

95 rform rapid synthesis of 20 tritiated and 10 carbon-11-labelled complex pharmaceuticals and PET radio

96 Carbon-11-labelled lorlatinib is routinely prepared with

97 ission tomography (PET) with the radioligand carbon-11-labelled McN-5652, which selectively labels th

98 positron emission tomography tracers such as carbon-11-labelled Pittsburgh compound-B.

99 nurenine pathway, but the short half-life of carbon-11 limits its application.

100 id imaging agent, but the short half-life of carbon-11 limits its clinical viability.

101 Carbon-11-MTICU was administered to a female baboon and

102 te pyridopyrazinone derivatives labeled with carbon-11 or fluorine-18 as PDE5-specific PET tracers.

103 amenability of thioethers to be labeled with carbon-11 or fluorine-18 through S-alkylation reactions.

104 specificity for SULT1E1 can be labeled with carbon-11 or fluorine-18, in vivo assays of SULT1E1 func

105 for labeling with a positron-emitter, either carbon-11 or fluorine-18.

106 A spectrum of carbon-11 PET radiotracers has been developed against ma

107 Advancements in carbon-11 photo-mediated radiochemistry have been levera

108 facilitate radiolabeling with fluorine-18 or carbon-11 positron-emitting nuclides and visualization o

109 l groups obtained from primary and secondary carbon-11 precursors.

110 This review focuses on the carbon-11 radiochemistry and various target-specific PET

111 Both tritium and carbon-11 radioisotopologues are generally necessary for

112 This review collates all the carbon-11 radiolabeled endogenous and natural exogenous

113 se (MTD) to evaluate normal tissue and tumor carbon-11 radiolabeled XR5000 ([11C]XR5000) pharmacokine

114 (IC(50) = 10.2 nM) and underwent successful carbon-11 radiolabeling.

115 erived androgens all share an oxygen atom on carbon 11, so we have collectively termed them 11-oxyand

116 synthesized as candidates for labeling with carbon-11 ( t 1/2 = 20.4 min) and imaging of A beta plaq

117 Radiotracers labeled with carbon-11 (t(1/2) = 20.4 min) are widely used with posit

118 fluoroform that has been labeled with either carbon-11 (t(1/2) = 20.4 min) or fluorine-18 (t(1/2) = 1

119 id component with a positron emitter, either carbon-11 (t(1/2) = 20.4 min) or fluorine-18 (t(1/2) = 1

120 Currently, many of the available carbon-11 (t(1/2) = 20.4 min) PET radiotracers are heter

121 For radiotracers labeled with carbon-11 (t(1/2) = 20.4 min), AIF is routinely determin

122 labeled uPSEM792 with the positron-emitter, carbon-11 (t(1/2) = 20.4 min), in high radiochemical yie

123 and the limited availability of short-lived carbon-11 (t(1/2) = 20.4 min).

124 beled with the short-lived positron emitter, carbon-11 (t(1/2) = 20.4 min).

125 inity enantiomer ((+)-12a) were labeled with carbon-11 (t1/2 ) 20.4 min) using [11C]cyanide ion as la

126 atives with the short-lived positron emitter carbon-11 (t1/2 = 20.4 min) in generally good to high yi

127 Carbon-11-thymidine is a PET tracer of DNA synthesis and

128 Carbon-11-thymidine labeled in the ring-2 position was u

129 pine receptor ligand flumazenil labeled with carbon 11 to assess the regional brain pattern of recept

130 sibility of labeling N-acylsulfonamides with carbon-11 to facilitate biological evaluation and in viv

131 cyclization can be used to label drugs with carbon-11 to study their pharmacokinetics and for evalua

132 st promising ligand 6a was radiolabeled with carbon-11 to yield 16 ([(11)C]RSR-056).

133 ated modules have allowed the development of carbon-11 tracers for clinical use.

134 Compared with the 20 min half-life of carbon-11 used in the most widely used tracer, Pittsburg

135 and vabicaserin (3), were radiolabeled with carbon-11 via Pictet-Spengler cyclization with [(11)C]fo

136 ed with the short-half-life positron emitter carbon-11, which is rather impractical for many PET cent