ライフサイエンスコーパス: carbonic

1 leic acid on silica stationary phase using a carbonic acid (H(2)CO(3)*) eluent with and without a min

2 Carbonic acid (H2CO3), highly unstable at ambient condit

3 It has been known for some time that carbonic acid can be separated from strong acids by ion

4 R can result from both oxidative metabolism (carbonic acid formation) and glycolysis (lactate release

5 Carbonic acid H(2)CO(3) (CA) is a key constituent of the

6 adopts a C(2 v) symmetry structure with the carbonic acid in a planar trans-trans conformation and b

7 fixed carbon includes respiratory CO(2) and carbonic acid that propagate to the base of the critical

8 Herein, we report that carbonic acid, a thermodynamically disfavored species th

9 n potential generated by the dissociation of carbonic acid, colloidal particles move either away from

10 ticipates, on the basis of its aquation into carbonic acid, in hydrogen evolution.

11 bon dioxide system, previously identified as carbonic acid, was observed in the high-pressure diamond

12 n, despite partial equilibration of CO2 with carbonic acid-a low pKa acid.

13 acterize the structure and properties of the carbonic acid-fluoride complex, F(-)(H(2)CO(3)), and its

14 c rate because of the accelerating effect of carbonic acid.

15 and the analogous carbamic (NH(2) COOH) and carbonic acids (H(2) CO(3) ).

16 targets for the molecules are putative alpha-carbonic and gamma-carbonic anhydrases, and homology mod

17 alization by calcite slurry dissolution with carbonic and sulfuric acids.

18 ubiquitin (8.6 kDa), myoglobin (17 kDa), and carbonic anhydrase (29 kDa) upon higher energy collision

19 power of 677 000 achieved for transients of carbonic anhydrase (29 kDa) with a duration of only ~250

20 quence coverages up to 80% were achieved for carbonic anhydrase (29 kDa), 50% for aldolase (39 kDa),

21 This study examined the effects of bovine carbonic anhydrase (BCA) and CO2-rich gas streams on the

22 We compared CO(2) affinity, external carbonic anhydrase (CA(ext) ), isotopic signatures (delt

23 y our methods to model the complex between a carbonic anhydrase (CA) and its protein inhibitor, showi

24 metabolon hypothesis predicts that cytosolic carbonic anhydrase (CA) binds to NBCe1-A, promotes HCO3-

25 in interactions of these inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlightin

26 intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor p

27 Carbonic anhydrase (CA) enzymes catalyze the chemical eq

28 Carbonic anhydrase (CA) enzymes have gained considerable

29 hough many inhibitors are reported for human carbonic anhydrase (CA) enzymes, few may be considered u

30 etic sequestration based on a self-propelled carbonic anhydrase (CA) functionalized micromotor.

31 , pepsin, maltose binding protein (MBP), and carbonic anhydrase (CA) in the presence of hundreds of n

32 : see text] Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate a

33 The carbonic anhydrase (CA) inhibitors acetazolamide and its

34 Carbonic anhydrase (CA) inhibitors such as acetazolamide

35 relationship study of a series of lipophilic carbonic anhydrase (CA) inhibitors with an acetazolamide

36 g of the possibility of developing selective carbonic anhydrase (CA) inhibitors, interactions between

37 Carbonic anhydrase (CA) is a thoroughly studied enzyme.

38 Carbonic anhydrase (CA) is an abundant protein in most p

39 Carbonic anhydrase (CA) is one of nature's fastest enzym

40 e sites of the 12 catalytically active human carbonic anhydrase (CA) isoforms until no binding was ob

41 mplementary DNAs encoding four distinct beta-carbonic anhydrase (CA) isoforms were characterized from

42 ion profile against therapeutically relevant carbonic anhydrase (CA) zinc metalloenzymes.

43 eft protons: (1) generation by extracellular carbonic anhydrase (CA), (2) release from acidic synapti

44 hosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an engineered protein cage b

45 e parameterised using in vitro activities of carbonic anhydrase (CA), pyruvate, phosphate dikinase (P

46 However, carbonic anhydrase (CA), the enzyme that hydrolyses COS,

47 hydrolyzed to H2 S by the ubiquitous enzyme carbonic anhydrase (CA).

48 phosphoenolpyruvate carboxylase (PEPc), and carbonic anhydrase (CA).

49 COS), which is quickly converted to H(2)S by carbonic anhydrase (CA).

50 ized from three established aminosulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor pharmacoph

51 mide series 11a-11g, 14a-14h, and 16a-16e as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors are prese

52 cently entered the topic of anticancer human carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, as they

53 rimary/secondary amines and COS as potential carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, using th

54 esulfonamide derivatives acting as effective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.

55 4-sulfamoylphenyl-omega-aminoalkyl ethers as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.

56 re thus obtained, which showed an increasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action wi

57 ity/selectivity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and

58 vant human (h) isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).

59 tive and potent inhibitors of the beta-class carbonic anhydrase (CA; EC 4.2.1.1) enzyme expressed in

60 es of small-molecule hybrids consisting of a carbonic anhydrase (CA; EC 4.2.1.1) inhibitor linked to

61 Human carbonic anhydrase (CA; EC 4.2.1.1) isoforms II and VII

62 In this study, we show that carbonic anhydrase (Car) enzymes are up-regulated in typ

63 ndogenous metal affinity of Escherichia coli carbonic anhydrase (ECCA).

64 ry activity against the cancer-related human carbonic anhydrase (hCA) IX and XII isoforms in the nano

65 oldamer 2 was synthesized and bound to human carbonic anhydrase (HCA) using a nanomolar active site l

66 ss-coupling reactions and evaluated as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors against

67 lly and pharmacologically relevant human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, the cytos

68 This study uses mutants of human carbonic anhydrase (HCAII) to examine how changes in the

69 Arg160His mutation of Haemophilus influenzae carbonic anhydrase (HICA), which mimics the endogenous m

70 from small molecules to proteins as large as carbonic anhydrase (molecular weight ca. 29,000).

71 ed when buffering was augmented by exogenous carbonic anhydrase (XCAR).

72 We characterized CARBONIC ANHYDRASE 1 (CAH1) as an essential component of

73 globin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon

74 ession of tomato (Solanum lycopersicum) beta-CARBONIC ANHYDRASE 3 (betaCA3) is induced by the virulen

75 of plasma creatine kinase M-type (CK-M) and carbonic anhydrase 3 (CA-3) in the blood, more than 90%

76 e the cell to the thylakoid lumen, where the carbonic anhydrase 3 (CAH3) dehydrates accumulated HCO(3

77 ECs are transcriptionally distinct-marked by Carbonic anhydrase 4 (Car4)-and arise from bulk ECs, as

78 annexins transfer calcium into vesicles and carbonic anhydrase 4 catalyzes the formation of bicarbon

79 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory pr

80 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein

81 S-PLA2 (secreted phospholipase A2), and CA6 (carbonic anhydrase 6).

82 ion of hypoxia-regulated genes (for example, carbonic anhydrase 9 (CA9) and vascular endothelial grow

83 del also includes the activity of the enzyme Carbonic Anhydrase 9 (CA9), a known marker of tumor aggr

84 gulation, including the extracellular facing carbonic anhydrase 9 (CA9).

85 tween PD-L1 expression and that of NFKB2 and carbonic anhydrase 9 (CA9).

86 s exhibited reduced expression of myocardial carbonic anhydrase 9 and collagen, surrogate markers of

87 ontrast, the well-established zinc-catalyzed carbonic anhydrase activity (p-nitrophenyl acetate, pNPA

88 ations, photosynthetic attributes along with carbonic anhydrase activity whereas its higher concentra

89 cable for rapid and simple quantification of carbonic anhydrase activity which is very important to p

90 Our studies cover the invariance of carbonic anhydrase activity with different site position

91 half-saturation constants for CO2 fixation, carbonic anhydrase activity, CO2 /HCO3 (-) uptake, delta

92 s needs to be tested in species with diverse carbonic anhydrase activity.

93 Panicum bisulcatum, which has naturally low carbonic anhydrase activity.

94 is dependent on H(+) V-ATPase, together with carbonic anhydrase and five further transporters or chan

95 nd heme cofactor, and the Zn-binding protein carbonic anhydrase and its binding with ethoxzolamide.

96 al hundred molecules of RuBisCO, and contain carbonic anhydrase and other accessory proteins.

97 Carbonic anhydrase and phosphoenolpyruvate carboxylase i

98 c carbon into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous micr

99 h the realization that several isoenzymes of carbonic anhydrase are associated with the development o

100 fically in a kappa(2)-fashion to the protein carbonic anhydrase as a ligand.

101 r data argue against a physiological role of carbonic anhydrase as a nitrous anhydrase or nitrite red

102 Carbonic anhydrase buffers tissue pH by catalyzing the r

103 We find that the carbonic anhydrase CAH6 is in the flagella, not in the s

104 Carbonic anhydrase converts COS into H2S, allowing NTAs

105 For comparison we assayed recessive ca1ca4 carbonic anhydrase double mutant plants, based on their

106 bat VRE, we have repurposed the FDA-approved carbonic anhydrase drug acetazolamide to design potent a

107 eties were investigated as inhibitors of the carbonic anhydrase enzyme (CA; EC 4.2.1.1).

108 possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquapor

109 onic anhydrase gene (ca19) beyond the single carbonic anhydrase gene (ca18) that was known previously

110 We have identified a novel carbonic anhydrase gene (ca19) beyond the single carboni

111 LCI1, CCP1, CCP2 and LCIA) and mitochondrial carbonic anhydrase genes (CAH4 and CAH5) are up regulate

112 alysis and synteny studies suggest that both carbonic anhydrase genes form one or two independent gen

113 herapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glauc

114 Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and pr

115 Carbonic anhydrase I (Car1) is a gene expressed uniquely

116 ral stability and unfolding process of human carbonic anhydrase I (HCA-I).

117 Tryptic digestion of differentially labeled carbonic anhydrase I and hemoglobin allowed the identifi

118 ng these proteins, the strict association of carbonic anhydrase I and S100A8 with ECM was verified by

119 , human serum albumin, hemoglobin, and human carbonic anhydrase I were successfully labeled.

120 s, which was demonstrated by modification of carbonic anhydrase I with electrochemically generated re

121 We present a new approach to carbonic anhydrase II (CA II) inhibitor design that enab

122 r binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II).

123 a fragment screening campaign against human carbonic anhydrase II (CA II).

124 ions in a model metalloenzyme system, human carbonic anhydrase II (CA II).

125 ts to analyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, r

126 P1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences.

127 This work employs carbonic anhydrase II (CAII) binding to immobilized 4-(2

128 f MCT1 and MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalyti

129 TFGs containing CB[6]- and carbonic anhydrase II (CAII)-binding domains were synthe

130 MPR1A)/activin-like kinase 3 (ALK3), but not carbonic anhydrase II (CAII).

131 Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O

132 onic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated.

133 ione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated.

134 e corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA p

135 The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a complex and long-deba

136 ose active-site residues in the enzyme human carbonic anhydrase II (hCAII) that constitute the evolut

137 This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to e

138 ound to have anti-retinal antibodies against carbonic anhydrase II and enolase proteins with a negati

139 We have reported previously that carbonic anhydrase II augments transport activity of MCT

140 res rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reacti

141 lls arise mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (a

142 tested using a panel of binders specific to carbonic anhydrase II, with dissociation constants rangi

143 rker tartrate-resistant acid phosphatase, or carbonic anhydrase II.

144 lated known genes, whereas Srpx2, Cd200, and carbonic anhydrase III (CAIII) were identified as novel

145 Carbonic anhydrase III protects osteocytes from oxidativ

146 Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secr

147 In this study, we exploited the action of carbonic anhydrase in equilibrating CO(2) with leaf wate

148 control over the activity of zinc-dependent carbonic anhydrase in solution as an isolated protein, i

149 roportion of Rubisco and the thylakoid lumen carbonic anhydrase in the pyrenoid rose substantially, c

150 can differentially regulate the activity of carbonic anhydrase in the trans and cis configurations.

151 uolar-type H(+)-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying t

152 nonsteroidal anti-inflammatory drug (NSAID)-carbonic anhydrase inhibitor (CAI) agents for the manage

153 il approach" has become a milestone in human carbonic anhydrase inhibitor (hCAI) design for various t

154 ich was sensitive to Na(+)withdrawal, to the carbonic anhydrase inhibitor acetazolamide and to H2DIDS

155 Treatment of MG with an oral carbonic anhydrase inhibitor hastened anatomic recovery

156 chronically treated with bicarbonate or the carbonic anhydrase inhibitor hydrochlorothiazide had par

157 difluprednate with the addition of a topical carbonic anhydrase inhibitor in 6 eyes and nonsteroidal

158 Cystoid macular edema refractory to carbonic anhydrase inhibitor therapy and ultimately amen

159 Given methazolamide, a potent carbonic anhydrase inhibitor, can penetrate the blood-br

160 ves were successfully translated into potent carbonic anhydrase inhibitors (IC(50) = 20.1-68.7 nM), w

161 on was greater in subjects treated with oral carbonic anhydrase inhibitors (P = .016) or Nd:YAG laser

162 icarbonate co-transporter (P </= 0.0001) and carbonic anhydrase inhibitors (P = 0.0021).

163 Nd:YAG laser hyaloidotomy and oral carbonic anhydrase inhibitors may lead to greater IOP re

164 my may impede time to recovery from MG, oral carbonic anhydrase inhibitors may shorten the time to an

165 Azide derivatives of 2 carbonic anhydrase inhibitors, 4-(2-aminoethyl)benzenesu

166 the dye were more potent agents with higher carbonic anhydrase inhibitory action than the parent dye

167 ficiency, bacteria often enclose RubisCO and carbonic anhydrase into microcompartments called carboxy

168 ished nitrite bioactivation, but the role of carbonic anhydrase is abrogated when physiological conce

169 was also observed, in line with patterns of carbonic anhydrase isoform expression in those tissues.

170 vatives have been developed as inhibitors of carbonic anhydrase isoform IX.

171 ding protein binding to maltose, and for two carbonic anhydrase isoforms binding to each of four inhi

172 While several carbonic anhydrase isoforms have been identified in nume

173 luated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV usin

174 t that the human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of h

175 rs (encoded by Slc26a4, Slc4a8, and Slc4a9), carbonic anhydrase isoforms, and V-type H(+)-ATPase subu

176 -the-haystack" screen for inhibitors against carbonic anhydrase isozyme II is performed, in which kno

177 MCT4 can be facilitated by the extracellular carbonic anhydrase IV (CAIV) via a noncatalytic mechanis

178 Carbonic anhydrase IV (Car4) was a top dysregulated gene

179 Carbonic anhydrase IX (CA IX) is a target for hypoxic ca

180 Carbonic anhydrase IX (CA IX) is a well-established biom

181 Carbonic anhydrase IX (CA IX) is an extracellular transm

182 Human carbonic anhydrase IX (CA IX) is highly expressed in tum

183 Human carbonic anhydrase IX (CA IX) is overexpressed in a numb

184 n of hypoxic tumors is possible by targeting carbonic anhydrase IX (CA IX), an enzyme overexpressed i

185 Carbonic anhydrase IX (CA-IX), a transmembrane enzyme, m

186 Carbonic anhydrase IX (CA9) is a transmembrane glycoprot

187 of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor

188 d epithelial cell adhesion molecule (EpCAM), carbonic anhydrase IX (CA9), epidermal growth factor rec

189 Carbonic anhydrase IX (CAIX) is a transmembrane enzyme t

190 It was induced by carbonic anhydrase IX (CAIX) overexpression and inhibite

191 MCT4 remained unchanged, while expression of carbonic anhydrase IX (CAIX) was greatly enhanced.

192 CC tumors, which also express high levels of carbonic anhydrase IX (CAIX), a HIF1-dependent protein.

193 The present study demonstrates that carbonic anhydrase IX (CAIX), one of the major acid/base

194 ide, a high-affinity small organic ligand of carbonic anhydrase IX (CAIX).

195 Carbonic anhydrase IX (CAIX, CA9) expression is highly u

196 Inhibition of human carbonic anhydrase IX (hCA IX) has shown to be therapeut

197 armacodynamics from tumor biomarkers such as carbonic anhydrase IX and topoisomerase I by immunohisto

198 lices also were sensitive to hypoxia because carbonic anhydrase IX and zinc finger E-box binding home

199 beta-catenin) and function (aquaporin 1 and carbonic anhydrase IX).

200 is a chimeric monoclonal antibody that binds carbonic anhydrase IX, a cell surface glycoprotein ubiqu

201 he network correlates with the expression of carbonic anhydrase IX, and this biomarker was harnessed

202 n screens against horseradish peroxidase and carbonic anhydrase IX, and we developed a novel, Poisson

203 line phosphatase, ALP) and a ligand-protein (carbonic anhydrase IX, CA IX) binding event.

204 wth factor but was associated with increased carbonic anhydrase IX, hepatocyte growth factor, placent

205 ed on cells that express a cancer biomarker, carbonic anhydrase IX, in response to hypoxia.

206 escribed a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tum

207 It has been postulated that carbonic anhydrase may act as a nitrous anhydrase in viv

208 alpha-Carbonic anhydrase of Helicobacter pylori (HpalphaCA) pl

209 les of successful designs include those with carbonic anhydrase or nitrite reductase activity by inco

210 Carbonic anhydrase plays a key role in CO2 transport, ac

211 release of HCO(3)(-) from shell promoted by carbonic anhydrase provides a source of C(i).

212 e-1,5-bisphosphate carboxylase oxygenase and carbonic anhydrase that enhance carbon dioxide fixation.

213 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fixation in cyan

214 Intracellular carbonic anhydrase transcript abundance increased with t

215 68 and mannose receptor-positive, expressing carbonic anhydrase type II, but relatively low levels of

216 Carbonic anhydrase VI (CA6) catalyses the reversible hyd

217 lective inhibitors of five isoforms of human carbonic anhydrase was also explored.

218 inate dehydrogenase enzyme levels as well as carbonic anhydrase were enhanced with URC, contributing

219 The reactions of apo human carbonic anhydrase with [Rh(nbd)2]BF4 or [M(CO)2(acac)]

220 carbon fixation by sequestering RubisCO and carbonic anhydrase within a protein shell that impedes C

221 icarbonate into the cell and localization of carbonic anhydrase within the carboxysome shell with Rub

222 ein drug efflux activity as a consequence of carbonic anhydrase XII (CA XII) inhibition.

223 The expression of carbonic anhydrase XII (CA12) is associated with the exp

224 Carbonic anhydrase XII (CA12) is the key carbonic anhydr

225 n of one specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by w

226 Here we describe variants in CA12 encoding carbonic anhydrase XII in two pedigrees exhibiting CF-li

227 Panning on carbonic anhydrase yielded a potent ligand, sulfonamide-

228 ditions we find dorzolamide (an inhibitor of carbonic anhydrase) results in diminished nitrite bioact

229 on ATPase), and inorganic carbon regulation (carbonic anhydrase).

230 BisCO reaction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation re

231 (pH 6.9), several proteins (i.e., myoglobin, carbonic anhydrase, and cytochrome c) could be analyzed

232 acteria and expansion of gene families (e.g. carbonic anhydrase, anti-oxidative related genes), many

233 ncorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clin

234 en alga Chlamydomonas reinhardtii, a luminal carbonic anhydrase, CrCAH3, was suggested to improve pro

235 H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-

236 ient CO2 We identified CAH1 as an alpha-type carbonic anhydrase, providing a biochemical role in CCM

237 e, biotin, mannose) against matched targets (carbonic anhydrase, streptavidin, concanavalin A) to ide

238 Carbon acquisition enzymes, primarily carbonic anhydrase, stress, degradation and signaling pr

239 ely conserved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A,

240 died: ribonuclease A, trypsin inhibitor, and carbonic anhydrase, where the latter had impurities of s

241 on of NP markers FoxF1, Pax-1, keratin-8/18, carbonic anhydrase-12, and NC markers brachyury, galecti

242 eric complex, which contains a putative beta-carbonic anhydrase-like active site and functions as an

243 chitecture (F-Zn(ii)) and exhibit remarkable carbonic anhydrase-like catalytic activity.

244 munoisolated from mouse brain, we identified carbonic anhydrase-related proteins CA10 and CA11, two h

245 isco, the principal CO(2)-fixing enzyme, and carbonic anhydrase.

246 ly converted to H2S by the ubiquitous enzyme carbonic anhydrase.

247 ulfide, which is rapidly converted to H2S by carbonic anhydrase.

248 osphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.

249 determines enzyme activity of chloroplastic carbonic anhydrase.

250 ts reveal that the pH gradient is created by carbonic anhydrase.

251 ding proteins 1 and 3, Rubisco activase, and carbonic anhydrase.

252 OS), which is quickly hydrolyzed to H(2)S by carbonic anhydrase.

253 -pumping module and the plant-specific gamma-carbonic-anhydrase domain (gammaCA).

254 ivity which is very important to prevent the carbonic-anhydrase-associated disorders in human.

255 ing atmospheric CO2 elevation, including the carbonic-anhydrase-encoding genes CA1 and CA4 and the se

256 We examined mechanisms regulating CARBONIC ANHYDRASE4 (CA4) in C4 Gynandropsis gynandra.

257 The alpha-carbonic anhydrases (alpha-CAs) are a large and ancient

258 consist of inorganic carbon transporters and carbonic anhydrases (and other supporting components) th

259 Carbonic anhydrases (CA), which catalyze the reversible

260 Two putative carbonic anhydrases (CAs) are encoded in the genome of C

261 on between different Ci species catalyzed by carbonic anhydrases (CAs) are key components in the CCM,

262 mechanisms (CCMs) involving transporters and carbonic anhydrases (CAs) are well known, but the contri

263 Carbonic anhydrases (CAs) are zinc metalloenzymes that c

264 Carbonic anhydrases (CAs) are zinc metalloenzymes that i

265 cotransporter, suggesting that inhibition of carbonic anhydrases (CAs) confers the beneficial thiazid

266 hypothesis, direct association of cytosolic carbonic anhydrases (CAs) with the electrogenic Na/HCO(3

267 version between CO2 and HCO3(-) catalyzed by carbonic anhydrases (CAs), and active inorganic carbon (

268 HCO3 (-) availability that is determined by carbonic anhydrases (CAs).

269 Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes

270 we exploited the validated antitumor targets carbonic anhydrases (CAs; EC 4.2.1.1) IX and XII to atta

271 ent inhibitors of the tumor-associated human carbonic anhydrases (hCAs) IX and XII.

272 s can strongly inhibit the activity of human carbonic anhydrases (hCAs), which are ubiquitous enzymes

273 against four physiologically relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I,

274 tified in key C4 metabolism genes, including carbonic anhydrases and a malate transporter.

275 esults suggest that intra- and extracellular carbonic anhydrases can work in concert to ensure rapid

276 Taken together, the study shows that carbonic anhydrases form transport metabolons with acid/

277 we investigate the repertoire of cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marin

278 Overexpression of carbonic anhydrases on cell surfaces further contributes

279 rey metamorphosis resulting in distinct gill carbonic anhydrases reflecting the contrasting life mode

280 ecules are putative alpha-carbonic and gamma-carbonic anhydrases, and homology modeling and molecular

281 s, coagulation factors, complement proteins, carbonic anhydrases, and redox enzymes that ostensibly c

282 The presence of cytosolic carbonic anhydrases, the basolateral Na(+) bicarbonate c

283 larly sodium bicarbonate co-transporters and carbonic anhydrases, which were also expressed in LAM lu

284 eature not previously observed in alpha-type carbonic anhydrases.

285 on of CO2-controlled stomatal development by carbonic anhydrases.

286 crimination among selected human isoforms of carbonic anhydrases.

287 based on actual hydration rates of CO(2) by carbonic anhydrases.

288 isotopic fractionation reaction regulated by carbonic anydrase (CA) metalloenzyme.

289 ogic markers of tumor hypoxia (pimonidazole, carbonic anydrase 9 [CA9]) and vascular perfusion (Hoech

290 ophobic interactions between the analyte and carbonic chain of surfactant, the retention of cationic

291 Carbonic macerated wines had higher contents of alcohols

292 during the 2017 vintage, 40 had been made by carbonic maceration and 44 by destemming and crushing.

293 The effects of the carbonic maceration and conventional winemaking on the v

294 s (sensorial, chemical, and microbial) after carbonic maceration and fermentation.

295 composition between two winemaking methods: carbonic maceration and the standard method of destemmin

296 Wines made by carbonic maceration presented higher aromatic quality du

297 es (OAV) exhibited an increase in wines when carbonic maceration was applied.

298 lp of Gamay winegrapes during twelve days of carbonic maceration.

299 echnique already consolidated in winemaking, carbonic maceration.

300 B were considerably greater in wines made by carbonic maceration.