ライフサイエンスコーパス: carbonic anhydrase

1 on ATPase), and inorganic carbon regulation (carbonic anhydrase).

2 ly converted to H2S by the ubiquitous enzyme carbonic anhydrase.

3 ulfide, which is rapidly converted to H2S by carbonic anhydrase.

4 osphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.

5 determines enzyme activity of chloroplastic carbonic anhydrase.

6 ts reveal that the pH gradient is created by carbonic anhydrase.

7 iochemical function for Cd, an unusual Cd/Zn carbonic anhydrase.

8 ding proteins 1 and 3, Rubisco activase, and carbonic anhydrase.

9 OS), which is quickly hydrolyzed to H(2)S by carbonic anhydrase.

10 isco, the principal CO(2)-fixing enzyme, and carbonic anhydrase.

11 eature not previously observed in alpha-type carbonic anhydrases.

12 on of CO2-controlled stomatal development by carbonic anhydrases.

13 crimination among selected human isoforms of carbonic anhydrases.

14 based on actual hydration rates of CO(2) by carbonic anhydrases.

15 We characterized CARBONIC ANHYDRASE 1 (CAH1) as an essential component of

16 globin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon

17 on of NP markers FoxF1, Pax-1, keratin-8/18, carbonic anhydrase-12, and NC markers brachyury, galecti

18 ubiquitin (8.6 kDa), myoglobin (17 kDa), and carbonic anhydrase (29 kDa) upon higher energy collision

19 power of 677 000 achieved for transients of carbonic anhydrase (29 kDa) with a duration of only ~250

20 quence coverages up to 80% were achieved for carbonic anhydrase (29 kDa), 50% for aldolase (39 kDa),

21 ession of tomato (Solanum lycopersicum) beta-CARBONIC ANHYDRASE 3 (betaCA3) is induced by the virulen

22 of plasma creatine kinase M-type (CK-M) and carbonic anhydrase 3 (CA-3) in the blood, more than 90%

23 e the cell to the thylakoid lumen, where the carbonic anhydrase 3 (CAH3) dehydrates accumulated HCO(3

24 ECs are transcriptionally distinct-marked by Carbonic anhydrase 4 (Car4)-and arise from bulk ECs, as

25 annexins transfer calcium into vesicles and carbonic anhydrase 4 catalyzes the formation of bicarbon

26 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory pr

27 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein

28 S-PLA2 (secreted phospholipase A2), and CA6 (carbonic anhydrase 6).

29 ion of hypoxia-regulated genes (for example, carbonic anhydrase 9 (CA9) and vascular endothelial grow

30 del also includes the activity of the enzyme Carbonic Anhydrase 9 (CA9), a known marker of tumor aggr

31 tween PD-L1 expression and that of NFKB2 and carbonic anhydrase 9 (CA9).

32 gulation, including the extracellular facing carbonic anhydrase 9 (CA9).

33 s exhibited reduced expression of myocardial carbonic anhydrase 9 and collagen, surrogate markers of

34 ontrast, the well-established zinc-catalyzed carbonic anhydrase activity (p-nitrophenyl acetate, pNPA

35 Carbonic anhydrase activity emerges in the same region o

36 ations, photosynthetic attributes along with carbonic anhydrase activity whereas its higher concentra

37 cable for rapid and simple quantification of carbonic anhydrase activity which is very important to p

38 Our studies cover the invariance of carbonic anhydrase activity with different site position

39 half-saturation constants for CO2 fixation, carbonic anhydrase activity, CO2 /HCO3 (-) uptake, delta

40 s needs to be tested in species with diverse carbonic anhydrase activity.

41 Panicum bisulcatum, which has naturally low carbonic anhydrase activity.

42 The alpha-carbonic anhydrases (alpha-CAs) are a large and ancient

43 ng the rate constants of interaction between carbonic anhydrase and acetazolamide.

44 is dependent on H(+) V-ATPase, together with carbonic anhydrase and five further transporters or chan

45 nd heme cofactor, and the Zn-binding protein carbonic anhydrase and its binding with ethoxzolamide.

46 al hundred molecules of RuBisCO, and contain carbonic anhydrase and other accessory proteins.

47 Carbonic anhydrase and phosphoenolpyruvate carboxylase i

48 c carbon into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous micr

49 CO2 better than any small molecule model of carbonic anhydrase and with an efficiency within 1400-fo

50 tified in key C4 metabolism genes, including carbonic anhydrases and a malate transporter.

51 consist of inorganic carbon transporters and carbonic anhydrases (and other supporting components) th

52 BisCO reaction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation re

53 (pH 6.9), several proteins (i.e., myoglobin, carbonic anhydrase, and cytochrome c) could be analyzed

54 ctive inorganic carbon transport components, carbonic anhydrases, and aggregation of Rubisco in the c

55 ecules are putative alpha-carbonic and gamma-carbonic anhydrases, and homology modeling and molecular

56 s, coagulation factors, complement proteins, carbonic anhydrases, and redox enzymes that ostensibly c

57 acteria and expansion of gene families (e.g. carbonic anhydrase, anti-oxidative related genes), many

58 h the realization that several isoenzymes of carbonic anhydrase are associated with the development o

59 fically in a kappa(2)-fashion to the protein carbonic anhydrase as a ligand.

60 revisiae as the folding modulators and human carbonic anhydrase as a model protein, we demonstrate th

61 r data argue against a physiological role of carbonic anhydrase as a nitrous anhydrase or nitrite red

62 We demonstrate this system using carbonic anhydrase as the target and a library of 144,00

63 ivity which is very important to prevent the carbonic-anhydrase-associated disorders in human.

64 This study examined the effects of bovine carbonic anhydrase (BCA) and CO2-rich gas streams on the

65 Carbonic anhydrase buffers tissue pH by catalyzing the r

66 We compared CO(2) affinity, external carbonic anhydrase (CA(ext) ), isotopic signatures (delt

67 y our methods to model the complex between a carbonic anhydrase (CA) and its protein inhibitor, showi

68 The process employs the enzyme carbonic anhydrase (CA) as a catalyst to accelerate the

69 metabolon hypothesis predicts that cytosolic carbonic anhydrase (CA) binds to NBCe1-A, promotes HCO3-

70 in interactions of these inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlightin

71 Carbonic anhydrase (CA) catalyzes the first biochemical

72 intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor p

73 Carbonic anhydrase (CA) enzymes catalyze the chemical eq

74 Carbonic anhydrase (CA) enzymes have gained considerable

75 hough many inhibitors are reported for human carbonic anhydrase (CA) enzymes, few may be considered u

76 ective inhibition of cancer-associated human carbonic anhydrase (CA) enzymes, specifically CA IX and

77 es, which act as effective inhibitors of the carbonic anhydrase (CA) from Trypanosoma cruzi (TcCA).

78 etic sequestration based on a self-propelled carbonic anhydrase (CA) functionalized micromotor.

79 , pepsin, maltose binding protein (MBP), and carbonic anhydrase (CA) in the presence of hundreds of n

80 : see text] Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate a

81 The carbonic anhydrase (CA) inhibitors acetazolamide and its

82 Carbonic anhydrase (CA) inhibitors such as acetazolamide

83 relationship study of a series of lipophilic carbonic anhydrase (CA) inhibitors with an acetazolamide

84 g of the possibility of developing selective carbonic anhydrase (CA) inhibitors, interactions between

85 Carbonic anhydrase (CA) is a thoroughly studied enzyme.

86 Carbonic anhydrase (CA) is an abundant protein in most p

87 Carbonic anhydrase (CA) is one of nature's fastest enzym

88 e sites of the 12 catalytically active human carbonic anhydrase (CA) isoforms until no binding was ob

89 mplementary DNAs encoding four distinct beta-carbonic anhydrase (CA) isoforms were characterized from

90 ion profile against therapeutically relevant carbonic anhydrase (CA) zinc metalloenzymes.

91 eft protons: (1) generation by extracellular carbonic anhydrase (CA), (2) release from acidic synapti

92 hosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an engineered protein cage b

93 e parameterised using in vitro activities of carbonic anhydrase (CA), pyruvate, phosphate dikinase (P

94 However, carbonic anhydrase (CA), the enzyme that hydrolyses COS,

95 hydrolyzed to H2 S by the ubiquitous enzyme carbonic anhydrase (CA).

96 phosphoenolpyruvate carboxylase (PEPc), and carbonic anhydrase (CA).

97 COS), which is quickly converted to H(2)S by carbonic anhydrase (CA).

98 ized from three established aminosulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor pharmacoph

99 mide series 11a-11g, 14a-14h, and 16a-16e as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors are prese

100 cently entered the topic of anticancer human carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, as they

101 rimary/secondary amines and COS as potential carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, using th

102 esulfonamide derivatives acting as effective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.

103 4-sulfamoylphenyl-omega-aminoalkyl ethers as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.

104 re thus obtained, which showed an increasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action wi

105 ity/selectivity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and

106 gent of Chagas disease, encodes for an alpha-carbonic anhydrase (CA, EC 4.2.1.1) possessing high cata

107 A beta-carbonic anhydrase (CA, EC 4.2.1.1) was cloned and chara

108 vant human (h) isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).

109 d assayed as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).

110 tive and potent inhibitors of the beta-class carbonic anhydrase (CA; EC 4.2.1.1) enzyme expressed in

111 es of small-molecule hybrids consisting of a carbonic anhydrase (CA; EC 4.2.1.1) inhibitor linked to

112 Human carbonic anhydrase (CA; EC 4.2.1.1) isoforms II and VII

113 ged from the immunohistochemical analysis of carbonic anhydrases (CA) IX and XII expression in thyroi

114 Carbonic anhydrases (CA), which catalyze the reversible

115 ncorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clin

116 We find that the carbonic anhydrase CAH6 is in the flagella, not in the s

117 esults suggest that intra- and extracellular carbonic anhydrases can work in concert to ensure rapid

118 In this study, we show that carbonic anhydrase (Car) enzymes are up-regulated in typ

119 Two putative carbonic anhydrases (CAs) are encoded in the genome of C

120 on between different Ci species catalyzed by carbonic anhydrases (CAs) are key components in the CCM,

121 mechanisms (CCMs) involving transporters and carbonic anhydrases (CAs) are well known, but the contri

122 Carbonic anhydrases (CAs) are zinc metalloenzymes that c

123 Carbonic anhydrases (CAs) are zinc metalloenzymes that i

124 cotransporter, suggesting that inhibition of carbonic anhydrases (CAs) confers the beneficial thiazid

125 hypothesis, direct association of cytosolic carbonic anhydrases (CAs) with the electrogenic Na/HCO(3

126 version between CO2 and HCO3(-) catalyzed by carbonic anhydrases (CAs), and active inorganic carbon (

127 HCO3 (-) availability that is determined by carbonic anhydrases (CAs).

128 Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes

129 we exploited the validated antitumor targets carbonic anhydrases (CAs; EC 4.2.1.1) IX and XII to atta

130 Carbonic anhydrase converts COS into H2S, allowing NTAs

131 en alga Chlamydomonas reinhardtii, a luminal carbonic anhydrase, CrCAH3, was suggested to improve pro

132 -pumping module and the plant-specific gamma-carbonic-anhydrase domain (gammaCA).

133 For comparison we assayed recessive ca1ca4 carbonic anhydrase double mutant plants, based on their

134 recently isolated Arabidopsis thaliana beta-carbonic anhydrase double mutants (ca1 ca4) exhibit an i

135 bat VRE, we have repurposed the FDA-approved carbonic anhydrase drug acetazolamide to design potent a

136 ndogenous metal affinity of Escherichia coli carbonic anhydrase (ECCA).

137 ing atmospheric CO2 elevation, including the carbonic-anhydrase-encoding genes CA1 and CA4 and the se

138 eties were investigated as inhibitors of the carbonic anhydrase enzyme (CA; EC 4.2.1.1).

139 Carbonic anhydrase enzymes (CAs) catalyse the reversible

140 possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquapor

141 Taken together, the study shows that carbonic anhydrases form transport metabolons with acid/

142 a subcomplex, containing the ancestral gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-

143 onic anhydrase gene (ca19) beyond the single carbonic anhydrase gene (ca18) that was known previously

144 We have identified a novel carbonic anhydrase gene (ca19) beyond the single carboni

145 LCI1, CCP1, CCP2 and LCIA) and mitochondrial carbonic anhydrase genes (CAH4 and CAH5) are up regulate

146 alysis and synteny studies suggest that both carbonic anhydrase genes form one or two independent gen

147 herapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glauc

148 Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and pr

149 ry activity against the cancer-related human carbonic anhydrase (hCA) IX and XII isoforms in the nano

150 oldamer 2 was synthesized and bound to human carbonic anhydrase (HCA) using a nanomolar active site l

151 ss-coupling reactions and evaluated as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors against

152 lly and pharmacologically relevant human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, the cytos

153 This study uses mutants of human carbonic anhydrase (HCAII) to examine how changes in the

154 ent inhibitors of the tumor-associated human carbonic anhydrases (hCAs) IX and XII.

155 s can strongly inhibit the activity of human carbonic anhydrases (hCAs), which are ubiquitous enzymes

156 against four physiologically relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I,

157 Arg160His mutation of Haemophilus influenzae carbonic anhydrase (HICA), which mimics the endogenous m

158 Carbonic anhydrase I (Car1) is a gene expressed uniquely

159 ral stability and unfolding process of human carbonic anhydrase I (HCA-I).

160 Tryptic digestion of differentially labeled carbonic anhydrase I and hemoglobin allowed the identifi

161 ng these proteins, the strict association of carbonic anhydrase I and S100A8 with ECM was verified by

162 , human serum albumin, hemoglobin, and human carbonic anhydrase I were successfully labeled.

163 s, which was demonstrated by modification of carbonic anhydrase I with electrochemically generated re

164 We present a new approach to carbonic anhydrase II (CA II) inhibitor design that enab

165 r binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II).

166 a fragment screening campaign against human carbonic anhydrase II (CA II).

167 ions in a model metalloenzyme system, human carbonic anhydrase II (CA II).

168 ts to analyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, r

169 P1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences.

170 This work employs carbonic anhydrase II (CAII) binding to immobilized 4-(2

171 f MCT1 and MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalyti

172 TFGs containing CB[6]- and carbonic anhydrase II (CAII)-binding domains were synthe

173 MPR1A)/activin-like kinase 3 (ALK3), but not carbonic anhydrase II (CAII).

174 Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O

175 onic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated.

176 ione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated.

177 e corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA p

178 The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a complex and long-deba

179 ose active-site residues in the enzyme human carbonic anhydrase II (hCAII) that constitute the evolut

180 This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to e

181 ound to have anti-retinal antibodies against carbonic anhydrase II and enolase proteins with a negati

182 We have reported previously that carbonic anhydrase II augments transport activity of MCT

183 res rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reacti

184 lls arise mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (a

185 three proteins (ubiquitin, cytochrome c, and carbonic anhydrase II) were investigated.

186 tested using a panel of binders specific to carbonic anhydrase II, with dissociation constants rangi

187 rker tartrate-resistant acid phosphatase, or carbonic anhydrase II.

188 lated known genes, whereas Srpx2, Cd200, and carbonic anhydrase III (CAIII) were identified as novel

189 Carbonic anhydrase III protects osteocytes from oxidativ

190 Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secr

191 In this study, we exploited the action of carbonic anhydrase in equilibrating CO(2) with leaf wate

192 control over the activity of zinc-dependent carbonic anhydrase in solution as an isolated protein, i

193 roportion of Rubisco and the thylakoid lumen carbonic anhydrase in the pyrenoid rose substantially, c

194 can differentially regulate the activity of carbonic anhydrase in the trans and cis configurations.

195 uolar-type H(+)-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying t

196 we investigate the repertoire of cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marin

197 nonsteroidal anti-inflammatory drug (NSAID)-carbonic anhydrase inhibitor (CAI) agents for the manage

198 il approach" has become a milestone in human carbonic anhydrase inhibitor (hCAI) design for various t

199 ich was sensitive to Na(+)withdrawal, to the carbonic anhydrase inhibitor acetazolamide and to H2DIDS

200 tment of B. pertussis-infected mice with the carbonic anhydrase inhibitor acetazolamide reduced lung

201 Treatment of MG with an oral carbonic anhydrase inhibitor hastened anatomic recovery

202 chronically treated with bicarbonate or the carbonic anhydrase inhibitor hydrochlorothiazide had par

203 difluprednate with the addition of a topical carbonic anhydrase inhibitor in 6 eyes and nonsteroidal

204 Cystoid macular edema refractory to carbonic anhydrase inhibitor therapy and ultimately amen

205 Given methazolamide, a potent carbonic anhydrase inhibitor, can penetrate the blood-br

206 ves were successfully translated into potent carbonic anhydrase inhibitors (IC(50) = 20.1-68.7 nM), w

207 on was greater in subjects treated with oral carbonic anhydrase inhibitors (P = .016) or Nd:YAG laser

208 icarbonate co-transporter (P </= 0.0001) and carbonic anhydrase inhibitors (P = 0.0021).

209 Nd:YAG laser hyaloidotomy and oral carbonic anhydrase inhibitors may lead to greater IOP re

210 my may impede time to recovery from MG, oral carbonic anhydrase inhibitors may shorten the time to an

211 Azide derivatives of 2 carbonic anhydrase inhibitors, 4-(2-aminoethyl)benzenesu

212 Other glaucoma medications (beta blockers, carbonic anhydrase inhibitors, parasympathomimetics, and

213 the dye were more potent agents with higher carbonic anhydrase inhibitory action than the parent dye

214 ficiency, bacteria often enclose RubisCO and carbonic anhydrase into microcompartments called carboxy

215 ished nitrite bioactivation, but the role of carbonic anhydrase is abrogated when physiological conce

216 H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-

217 was also observed, in line with patterns of carbonic anhydrase isoform expression in those tissues.

218 vatives have been developed as inhibitors of carbonic anhydrase isoform IX.

219 n efficiency within 1400-fold of the fastest carbonic anhydrase isoform, CAII, and 11-fold of CAIII.

220 ding protein binding to maltose, and for two carbonic anhydrase isoforms binding to each of four inhi

221 While several carbonic anhydrase isoforms have been identified in nume

222 luated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV usin

223 t that the human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of h

224 rs (encoded by Slc26a4, Slc4a8, and Slc4a9), carbonic anhydrase isoforms, and V-type H(+)-ATPase subu

225 -the-haystack" screen for inhibitors against carbonic anhydrase isozyme II is performed, in which kno

226 MCT4 can be facilitated by the extracellular carbonic anhydrase IV (CAIV) via a noncatalytic mechanis

227 Carbonic anhydrase IV (Car4) was a top dysregulated gene

228 Carbonic anhydrase IX (CA IX) is a target for hypoxic ca

229 Carbonic anhydrase IX (CA IX) is a well-established biom

230 Carbonic anhydrase IX (CA IX) is an extracellular transm

231 Human carbonic anhydrase IX (CA IX) is highly expressed in tum

232 Human carbonic anhydrase IX (CA IX) is overexpressed in a numb

233 n of hypoxic tumors is possible by targeting carbonic anhydrase IX (CA IX), an enzyme overexpressed i

234 Carbonic anhydrase IX (CA-IX) is upregulated in cancer i

235 Carbonic anhydrase IX (CA-IX), a transmembrane enzyme, m

236 Carbonic anhydrase IX (CA9) is a transmembrane glycoprot

237 of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor

238 d epithelial cell adhesion molecule (EpCAM), carbonic anhydrase IX (CA9), epidermal growth factor rec

239 body-mediated therapy with the chimeric anti-carbonic anhydrase IX (CAIX) antibody girentuximab (cG25

240 t vascularization and acid-extruding protein carbonic anhydrase IX (CAIX) expression.

241 Carbonic anhydrase IX (CAIX) is a transmembrane enzyme t

242 It was induced by carbonic anhydrase IX (CAIX) overexpression and inhibite

243 MCT4 remained unchanged, while expression of carbonic anhydrase IX (CAIX) was greatly enhanced.

244 CC tumors, which also express high levels of carbonic anhydrase IX (CAIX), a HIF1-dependent protein.

245 The present study demonstrates that carbonic anhydrase IX (CAIX), one of the major acid/base

246 o facilitate the intraoperative detection of carbonic anhydrase IX (CAIX)-expressing tumor lesions wi

247 ide, a high-affinity small organic ligand of carbonic anhydrase IX (CAIX).

248 Carbonic anhydrase IX (CAIX, CA9) expression is highly u

249 Inhibition of human carbonic anhydrase IX (hCA IX) has shown to be therapeut

250 armacodynamics from tumor biomarkers such as carbonic anhydrase IX and topoisomerase I by immunohisto

251 lices also were sensitive to hypoxia because carbonic anhydrase IX and zinc finger E-box binding home

252 beta-catenin) and function (aquaporin 1 and carbonic anhydrase IX).

253 is a chimeric monoclonal antibody that binds carbonic anhydrase IX, a cell surface glycoprotein ubiqu

254 he network correlates with the expression of carbonic anhydrase IX, and this biomarker was harnessed

255 n screens against horseradish peroxidase and carbonic anhydrase IX, and we developed a novel, Poisson

256 line phosphatase, ALP) and a ligand-protein (carbonic anhydrase IX, CA IX) binding event.

257 wth factor but was associated with increased carbonic anhydrase IX, hepatocyte growth factor, placent

258 ed on cells that express a cancer biomarker, carbonic anhydrase IX, in response to hypoxia.

259 escribed a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tum

260 eric complex, which contains a putative beta-carbonic anhydrase-like active site and functions as an

261 chitecture (F-Zn(ii)) and exhibit remarkable carbonic anhydrase-like catalytic activity.

262 l gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-like, and 20.9-kDa subunits, had a si

263 It has been postulated that carbonic anhydrase may act as a nitrous anhydrase in viv

264 from small molecules to proteins as large as carbonic anhydrase (molecular weight ca. 29,000).

265 Contrastingly, transcripts of chloroplast carbonic anhydrases namely CAH6, CAH3 and LCIB are up re

266 alpha-Carbonic anhydrase of Helicobacter pylori (HpalphaCA) pl

267 Overexpression of carbonic anhydrases on cell surfaces further contributes

268 les of successful designs include those with carbonic anhydrase or nitrite reductase activity by inco

269 Carbonic anhydrase plays a key role in CO2 transport, ac

270 of incubation at 750 microatm pCO2, reduced carbonic anhydrase protein activity and shell growth occ

271 release of HCO(3)(-) from shell promoted by carbonic anhydrase provides a source of C(i).

272 ient CO2 We identified CAH1 as an alpha-type carbonic anhydrase, providing a biochemical role in CCM

273 rey metamorphosis resulting in distinct gill carbonic anhydrases reflecting the contrasting life mode

274 munoisolated from mouse brain, we identified carbonic anhydrase-related proteins CA10 and CA11, two h

275 ditions we find dorzolamide (an inhibitor of carbonic anhydrase) results in diminished nitrite bioact

276 e, biotin, mannose) against matched targets (carbonic anhydrase, streptavidin, concanavalin A) to ide

277 Carbon acquisition enzymes, primarily carbonic anhydrase, stress, degradation and signaling pr

278 ely conserved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A,

279 e-1,5-bisphosphate carboxylase oxygenase and carbonic anhydrase that enhance carbon dioxide fixation.

280 The presence of cytosolic carbonic anhydrases, the basolateral Na(+) bicarbonate c

281 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fixation in cyan

282 Intracellular carbonic anhydrase transcript abundance increased with t

283 68 and mannose receptor-positive, expressing carbonic anhydrase type II, but relatively low levels of

284 Carbonic anhydrase VA (CA-VA) was absent in liver in the

285 Carbonic anhydrase VI (CA6) catalyses the reversible hyd

286 lective inhibitors of five isoforms of human carbonic anhydrase was also explored.

287 inate dehydrogenase enzyme levels as well as carbonic anhydrase were enhanced with URC, contributing

288 died: ribonuclease A, trypsin inhibitor, and carbonic anhydrase, where the latter had impurities of s

289 larly sodium bicarbonate co-transporters and carbonic anhydrases, which were also expressed in LAM lu

290 The reactions of apo human carbonic anhydrase with [Rh(nbd)2]BF4 or [M(CO)2(acac)]

291 robenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an

292 carbon fixation by sequestering RubisCO and carbonic anhydrase within a protein shell that impedes C

293 icarbonate into the cell and localization of carbonic anhydrase within the carboxysome shell with Rub

294 ed when buffering was augmented by exogenous carbonic anhydrase (XCAR).

295 ein drug efflux activity as a consequence of carbonic anhydrase XII (CA XII) inhibition.

296 The expression of carbonic anhydrase XII (CA12) is associated with the exp

297 Carbonic anhydrase XII (CA12) is the key carbonic anhydr

298 n of one specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by w

299 Here we describe variants in CA12 encoding carbonic anhydrase XII in two pedigrees exhibiting CF-li

300 Panning on carbonic anhydrase yielded a potent ligand, sulfonamide-