ライフサイエンスコーパス: carbonic anhydrase II

1 is associated with mutations in cytoplasmic carbonic anhydrase II.

2 ithm was used to design inhibitors for human carbonic anhydrase II.

3 ibrary of fluoroaromatic inhibitors of F131V carbonic anhydrase II.

4 nhibitor (K(d) approximately 30 pM) of human carbonic anhydrase II.

5 nding of Zn(II), Cu(II), and Co(II) to human carbonic anhydrase II.

6 ding of the crystal lattice of Phe-131-->Val carbonic anhydrase II.

7 t kinase and a panel of compounds binding to carbonic anhydrase II.

8 from the large subunit of Rubisco and human carbonic anhydrase II.

9 rker tartrate-resistant acid phosphatase, or carbonic anhydrase II.

10 ton transfers in two solution systems and in Carbonic Anhydrase II.

11 ted expression of the differentiation marker carbonic anhydrase II.

12 fer, who used this method to renature bovine carbonic anhydrase II.

13 of the selected scFvs was shown to recognize carbonic anhydrase II, an up-regulated enzyme involved i

14 trated diminished or no immunoreactivity for carbonic anhydrase II and calretinin in the retinal laye

15 Four doubly spin-labeled variants of human carbonic anhydrase II and corresponding singly labeled v

16 ound to have anti-retinal antibodies against carbonic anhydrase II and enolase proteins with a negati

17 Human carbonic anhydrase II and rat liver arginase serve as we

18 his approach using the 29 kDa protein, human carbonic anhydrase II and the 30 kDa protein, calbindin

19 Here, the degree of loading with carbonic anhydrase II and the resulting binding signal o

20 chemistry using antibodies against vimentin, carbonic anhydrase II, and glutamine synthetase.

21 Human carbonic anhydrase II, and possibly carbonic anhydrase I

22 Y64H/F65A murine CAV, wild-type human alpha-carbonic anhydrase II, and the gamma-carbonic anhydrase

23 far, autoantibodies against lactoferrin and carbonic anhydrase II are most frequently detected in se

24 Using carbonic anhydrase II as a model system, we characterize

25 We have reported previously that carbonic anhydrase II augments transport activity of MCT

26 uted benzenesulfonamide inhibitors to bovine carbonic anhydrase II (BCA II), the observed thermodynam

27 of residual mobility in complexes of bovine carbonic anhydrase II (BCA) and para-substituted benzene

28 the thermodynamics of association of bovine carbonic anhydrase II (BCA) and para-substituted benzene

29 of the lysine epsilon-NH3+ groups of bovine carbonic anhydrase II (BCA).

30 to follow a globular metalloprotein--bovine carbonic anhydrase II (BCA, EC 4.2.1.1)--on unfolding up

31 A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (BCAII).

32 A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (BCAII).

33 ntly identified as a weak inhibitor of human carbonic anhydrase II by Iyer et al.

34 ne-rich proteins, lactoferrin, lysozyme, and carbonic anhydrase II by probing in vivo pellicle with s

35 ent homology, using the crystal structure of carbonic anhydrase II (CA II) and the sequence of CA IX,

36 Others report that carbonic anhydrase II (CA II) binds to the C termini of

37 We present a new approach to carbonic anhydrase II (CA II) inhibitor design that enab

38 s investigators suggested that intracellular carbonic anhydrase II (CA II) interacts at high affinity

39 a covalently attached sulfonamide ligand to carbonic anhydrase II (CA II) resulted in the inhibition

40 these assays, we determined the affinity of carbonic anhydrase II (CA II), a prototypical zinc enzym

41 a fragment screening campaign against human carbonic anhydrase II (CA II).

42 ions in a model metalloenzyme system, human carbonic anhydrase II (CA II).

43 r binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II).

44 ed cells was confirmed by immunodetection of carbonic anhydrase II (CA-II), cellular retinaldehyde-bi

45 ed cells was confirmed by immunodetection of carbonic anhydrase II (CA-II), cellular retinaldehyde-bi

46 g topiramate ( 1) is a moderate inhibitor of carbonic anhydrase-II (CA-II) ( K i or K d = 0.3-0.6 mic

47 Binding experiments for a model system of carbonic anhydrase-II (CA-II) analyte and immobilized 4-

48 ulfamide derivatives for inhibition of human carbonic anhydrase-II (CA-II) by using a direct binding

49 e and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).

50 ), sodium-bicarbonate transporter (NBC), and carbonic anhydrase II (CA2) increased 5- to 10-fold.

51 ted by the AE1 anion exchanger is reduced by carbonic anhydrase II (CA2) inhibition or by prevention

52 We spiked bovine carbonic anhydrase II (CaII) and its inhibitor acetazola

53 ts to analyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, r

54 llography, we track the catalytic pathway of carbonic anhydrase II (CAII) at 1.2 angstrom resolution.

55 P1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences.

56 This work employs carbonic anhydrase II (CAII) binding to immobilized 4-(2

57 We have recently shown that carbonic anhydrase II (CAII) binds in vitro to the C-ter

58 The three-dimensional structure of human carbonic anhydrase II (CAII) complexed with the sulfonam

59 Carbonic anhydrase II (CAII) deficiency in humans is ass

60 In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently catalyzes the c

61 s surrounding the zinc binding site of human carbonic anhydrase II (CAII) in determining the metal io

62 f MCT1 and MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalyti

63 ic residues in the hydrophobic core of human carbonic anhydrase II (CAII) influence metal ion binding

64 The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three his

65 e generated transgenic mice expressing human carbonic anhydrase II (CAII) promoter: Cre recombinase (

66 In carbonic anhydrase II (CAII) residues Phe93, Phe95, and

67 A65F, A65L, A65H, A65T, A65S, and A65G human carbonic anhydrase II (CAII) variants have been solved b

68 Carbonic anhydrase II (CAII)(Cre);Pdx1(Fl) mice were eug

69 factors that dictate the proton transfer in carbonic anhydrase II (CAII), an enzyme that has been us

70 ctivity of a prototypical zinc enzyme, human carbonic anhydrase II (CAII), and a number of active sit

71 Immunohistochemical staining for NHE3, carbonic anhydrase II (CAII), and aquaporin-I (AQP1) was

72 ed with doxorubicin induce the expression of carbonic anhydrase II (CAII), inhibitor of differentiati

73 However, E117 of human carbonic anhydrase II (CAII), which is part of the E117-

74 TFGs containing CB[6]- and carbonic anhydrase II (CAII)-binding domains were synthe

75 MPR1A)/activin-like kinase 3 (ALK3), but not carbonic anhydrase II (CAII).

76 terminus of the anion exchanger AE1 binds to carbonic anhydrase II (CAII).

77 4, a biomarker in esophageal tumorigenesis), carbonic anhydrase II (CAII, a regulator of acid-base ho

78 rase I (CAI, approximately 7 amol/cell), and carbonic anhydrase II (CAII, approximately 0.8 amol/cell

79 tive stabilities of noncovalent complexes of carbonic anhydrase II (CAII, EC 4.2.1.1) and benzenesulf

80 ct complexes detected in lysed RBCs included carbonic anhydrase II (CAII-Zn at approximately 0.8 amol

81 Acetazolamide (222 g/mol) binding to carbonic anhydrase II (CAII; 30000 Da) was chosen as a m

82 fied by positive staining for H+ -ATPase and carbonic anhydrase II constituted 35% to 40% of all cell

83 s to search for tight binding inhibitors for carbonic anhydrase II (EC 4.2.1.1).

84 When the technique was applied to bovine carbonic anhydrase II, even combining data from several

85 etric stretching vibration of azide bound to carbonic anhydrase II exhibits a pronounced evolution of

86 ) other than laminin-1 that can sustain both carbonic anhydrase II expression and, possibly, the capa

87 estingly, there appeared to be a decrease in carbonic anhydrase II expression over time when the epit

88 specific cytodifferentiation, in the form of carbonic anhydrase II expression, is not necessarily cou

89 res rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reacti

90 The kinetics of refolding of carbonic anhydrase II following transfer from a buffer c

91 owns (melittin, ubiquitin, GroES, myoglobin, carbonic anhydrase II), from more than 1000 possible dat

92 The rat carbonic anhydrase II gene was characterized and found t

93 med on was sections using antibodies against carbonic anhydrase II, H+ -ATPase and Band 3 protein.

94 ites of human carbonic anydrase I and bovine carbonic anhydrase II have been targeted for cleavage by

95 te kinase (PK), lactate dehydrogenase (LDH), carbonic anhydrase II, Hb, and band 3 (AE1).

96 Human carbonic anhydrase II (HCA II) catalyzes the reversible

97 Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalyti

98 nt in the site-specific mutant N67L of human carbonic anhydrase II (HCA II) has been examined by kine

99 Human carbonic anhydrase II (HCA II) is a monomeric zinc-conta

100 Human carbonic anhydrase II (HCA II) is a zinc-metalloenzyme t

101 Histidine at position 64 (His64) in human carbonic anhydrase II (HCA II) is believed to be the pro

102 The catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) is limited in maximal vel

103 Catalysis by the zinc metalloenzyme human carbonic anhydrase II (HCA II) is limited in maximal vel

104 Human carbonic anhydrase II (HCA II) is one of the fastest kno

105 The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolut

106 all molecule rescue of mutant forms of human carbonic anhydrase II (HCA II) occurs by participation o

107 ity of catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) requires proton transfer

108 Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O

109 Variants of human carbonic anhydrase II (HCA II) with amino acid replaceme

110 13C and 1H(N)/15N chemical shifts for human carbonic anhydrase II (HCA II), a 259 residue 29 kDa met

111 xide and dehydration of bicarbonate by human carbonic anhydrase II (HCA II), a histidine residue (His

112 Human carbonic anhydrase II (HCA II), among the fastest enzyme

113 In human carbonic anhydrase II (HCA II), the mutation of position

114 have utilized the recombinant form of human carbonic anhydrase-II (hCA-II) as the enzyme source and

115 interaction energy between the protein human carbonic anhydrase II (HCAII) and the fluorine-substitut

116 onic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated.

117 ione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated.

118 e corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA p

119 The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a complex and long-deba

120 Human carbonic anhydrase II (hCAII) is a metalloenzyme essenti

121 Human carbonic anhydrase II (hCAII) naturally catalyzes the re

122 ose active-site residues in the enzyme human carbonic anhydrase II (hCAII) that constitute the evolut

123 te derivatives against steroid sulfatase and carbonic anhydrase II (hCAII) was also observed, and the

124 nvestigation of the CD spectrum of the Human Carbonic Anhydrase II (HCAII), with main focus on the ne

125 This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to e

126 H2Ph)NH3+) bound at the active site of human carbonic anhydrase II (HCAII; E.C. 4.2.1.1).

127 23 is nonestrogenic and potently inhibits carbonic anhydrase II (IC(50) 86 nM).

128 seizures, with very weak inhibition of human carbonic anhydrase-II (IC(50) = 110 microM).

129 K, tartrate-resistant acid phosphatase, and carbonic anhydrase II in bone marrow macrophages (BMMs),

130 alpha methylacyl racemase in papillary RCC, carbonic anhydrase II in chromophobe RCC and K19 in TCC.

131 te crystal growth and inducing expression of carbonic anhydrase II in monocytic cells and promoting a

132 ohistochemistry demonstrated the presence of carbonic anhydrase II in these cells.

133 nd was observed in a site-specific mutant of carbonic anhydrase II in which a prominent proton shuttl

134 mino acids of varying size at position 65 in carbonic anhydrase II (including four amino acids found

135 yzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of re

136 Deprotonation of zinc-bound water in carbonic anhydrase II is the rate-limiting step in the c

137 These include mutations of genes encoding carbonic anhydrase II, kidney anion exchanger 1, and dif

138 lls arise mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (a

139 a negatively charged transition state in the carbonic anhydrase II mechanism, whereas a neutral trans

140 rast, no high charge states of either bovine carbonic anhydrase II or IgG1 were formed in AmmAc or Na

141 he model proteins in this study (calmodulin, carbonic anhydrase II, RmlB, Bcl-xL) were chosen to test

142 zed benezenesulfonamide complexed with human carbonic anhydrase II shows how an encapsulated xenon at

143 above background) against albumin, amylase, carbonic anhydrase II, sIgA, IgG, IgM, lactoferrin, lyso

144 on catalyzed by the zinc-metalloenzyme human carbonic anhydrase II, the binding of substrate CO(2), f

145 Proteolipid protein and carbonic anhydrase-II transcripts, measured by real-time

146 sulfonamide inhibitors binding to the enzyme carbonic anhydrase II using Biacore optical biosensors.

147 selective labeling of purified HCA II (human carbonic anhydrase II) was achieved.

148 t of small-molecule inhibitors of the enzyme carbonic anhydrase II, we tested the reproducibility, se

149 cidic protein or oligodendrocytes expressing carbonic anhydrase II were found to co-express Kir6.2 mR

150 A series of charge ladders of bovine carbonic anhydrase II were synthesized and the relative

151 three proteins (ubiquitin, cytochrome c, and carbonic anhydrase II) were investigated.

152 or a screening of 110 ligands against bovine carbonic anhydrase II, which resulted in five mutual hit

153 ants were provided with reagents (the enzyme carbonic anhydrase II, which was immobilized onto the se

154 mponent that specifically binds and inhibits carbonic anhydrase II with nanomolar affinity.

155 tested using a panel of binders specific to carbonic anhydrase II, with dissociation constants rangi

156 ncreatic duct cell-specific differentiation (carbonic anhydrase II) without ductal morphogenesis was