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1 dicating HS Fe(II) in deoxy and LS Fe(II) in carboxy.
2 of nitroxide and reference hydroxylamine (3-carboxy-1-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl-
3 ypropanoic acid (oxo-C(7) product), and 2-(1-carboxy-1-hydroxyethoxy)-2-methyl-3-oxobutanoic acid (ox
4 margin; also 5-formyl-2'-deoxycytidine and 5-carboxy-2'-deoxycytidine were lower in colorectal carcin
5 -deoxycytidine, 5-formyl-2'-deoxycytidine, 5-carboxy-2'-deoxycytidine, 5-(hydroxymethyl)-2'-deoxyurid
6 (18)F-PSMA-1007 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-(18)F-fluoronicotinamid o)
7 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-(18)F-fluoronicotinamid o)butanamido)butana
8 in variants capable of providing access to 1-carboxy-2-aryl-cyclopropanes with high trans-(1R,2R) sel
9 properties singled out compound 73 ((E)-3-(5-carboxy-2-fluorophenyl)-2-(4-cyanostyryl)quinazolin-4(3H
10 hway ofPseudomonas putidaKT2440 requires a 4-carboxy-2-hydroxymuconate (CHM) hydratase (GalB), which
11 tion by identifying 5-carboxyvanillate and 4-carboxy-2-hydroxypenta-2,4-dienoate as the products and
12 llylamine hydrochloride and in poly-1-[p-(3'-carboxy-4'-hydroxyphenylazo) benzenesulfonamido]-1,2-eth
13 7 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreas
15 osapentaenoic acid (fish) (P-raw = 0.041), 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) (
16 oxidized analogue of the natural substrate 6-carboxy-5,6,7,8-tetrahydropterin (CPH4), is shown to be
17 e was generated using the highly efficient 4-carboxy-5,7-dinitroindolinyl (CDNI) photocleavable prote
18 The PSMA-targeting Auger emitter 2-[3-[1-carboxy-5-(4-(125)I-iodo-benzoylamino)-pentyl]-ureido]-p
20 PET/CT tracers, first (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-p
21 CT measurements using (18)F-DCFPyL ([2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-p
22 brane antigen-targeted (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-p
24 h prostate cancer were studied using 2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-p
25 aphy were referred for (18)F-DCFPyL (2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-p
27 m a full pharmacokinetic analysis of 2-(3-(1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-p
29 d with (68)Ga-PSMA-11, (18)F-DCFPyL (2-(3-(1-carboxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-
31 membrane antigen PET agents such as 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine 3-carbonyl)-amino]-pe
33 -based, 4-(5-(((4-acetoxybenzyl)oxy)amino)-2-carboxy-5-oxopentyl)benzoic acid, 12, provided 5-fold hi
34 nversion of the carboxylic acid containing 7-carboxy-7-deazaguanine (CDG) into its corresponding nitr
37 reactions for molecules containing methoxy, carboxy, amino, and sulfide substituents were carried ou
41 OOH and -OH bonds leads to the wide range of carboxy and hydroxy functionalized alpha-amino esters (2
42 g (mDia1DeltaN3/Phb2 FL or mDia1DeltaN3/Phb2-Carboxy) and non-interacting pairs (mDia1H + P/Phb2 FL o
43 ructures of unligated (deoxy), CO-inhibited (carboxy), and O2-bound (oxy) hemes in myoglobin (MB) and
47 trained so as to juxtapose the amino (N) and carboxy (C) termini; several of these designed structure
48 expression, but not the expression of a CD81 carboxy (C)-terminal deletion mutant, increases cellular
57 the main urinary metabolite of THC, 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) with ch
58 nabidiol (CBD), and the metabolites 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH), 11-hyd
59 trahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol glucuronide (THC-C
60 Delta9-tetrahidrocannabinol (THC), 11-nor-9-carboxy-Delta(9)-THC (THC-COOH) and 11-hidroxy-Delta(9)-
61 on antigenic regions, we first expressed the carboxy domain of the hMPV N protein that was the most h
62 ly 20 degrees rotation between the amino and carboxy domains, which opens up a cleft in arrestin to a
63 rder to selectively capture HbA1c in sample, carboxy-EG6-undecanethiol was self-assembled on a gold t
64 ins in regulating legumain proteases via its carboxy-extended domain and papain-like proteases by its
66 study reinforce the bifunctional ability of carboxy-extended phytocystatins in regulating legumain p
67 do derivative of the 5-carboxyl group from 5-carboxy-fluorescein diacetate or from Oregon green diace
68 lonRIalpha were measured as proliferation by carboxy-fluorescein diacetate succinimidyl ester dye dil
69 ed 2 independent assays (CD154 detection and carboxy-fluorescein succinimidyl ester dilution assays)
70 The reaction proceeded selectively at the carboxy function site to exclusively give the correspond
71 involved in functionalization of low-fouling carboxy-functional coatings have on the BRE capacity and
72 ith superior fouling resistance over various carboxy-functional low-fouling coatings including homopo
73 en compared with the widely used low-fouling carboxy-functional oligo(ethylene glycol) (OEG)-based al
74 (2-hydroxypropyl) methacrylamide (HPMAA) and carboxy-functional zwitterionic carboxybetaine methacryl
75 d-supported synthetic approach using a novel carboxy-functionalized building block which bears a func
77 annose and biotin ligands coupled to aqueous carboxy-functionalized gold nanoparticles through a spin
80 ocenter at C2 (allylic methine, alpha to the carboxy group) and the protecting groups at C17-OH and C
81 It is revealed that, in contrast to free carboxy-group-terminated OEG-SAMs, only a partial deacti
83 activation of EDC/NHS-activated zwitterionic carboxy groups by spontaneous hydrolysis is possible in
86 specific mechanisms of EDC/NHS activation of carboxy groups, BRE attachment, and deactivation of resi
87 de target compounds displaying amino groups, carboxy groups, hydroxy groups, or triazolo-pyridines, w
92 At first, naphthalene is transformed into 4-carboxy-indanone within a four-step process by means of
93 direct decarboxylative arylation of 1- and 3-carboxy isoquinaldic acid N-oxides with aryl iodides is
95 g migration of a carboxylate group to form 2-carboxy-l-lyxonolactone; the lactone is hydrolyzed by a
96 out with a conjugated push-pull system and a carboxy linker for a conceivable coupling with biomolecu
97 evented by disrupting the interaction of the carboxy-lobe of calmodulin with a calmodulin-binding dom
98 rate that despite IGPS's classification as a carboxy-lyase (i.e. decarboxylase), decarboxylation is n
99 e also proposed for future investigation: 4'-carboxy-mephedrone, 4'-carboxy-normephedrone, 1-dihydro-
103 ated moiety that is attached to the terminal carboxy-methylated cysteine, in addition to electrostati
104 ted KRAS4b terminal KSKTKC-farnesylation and carboxy-methylation is sufficient for binding and define
105 trations of the NOC-specific DNA adduct O(6)-carboxy-methylguanine when pork underwent a more intense
108 ity as a precursor to heterocycle synthesis, carboxy-MIDA-boronate is an excellent in situ CO surroga
109 The carbon monoxide-releasing capacity of carboxy-MIDA-boronate was also examined and applied in p
113 ure investigation: 4'-carboxy-mephedrone, 4'-carboxy-normephedrone, 1-dihydro-mephedrone, 1-dihydro-n
114 a nucleoside monophosphonate scaffold, alpha-carboxy nucleoside phosphonate (alpha-CNP), was designed
117 combining alpha-amylase, protease and gamma-carboxy peptidase allowing complete sample preparation w
120 functions as a soluble glycoprotein via its carboxy-proximal Fas1 domain and its normal cellular tra
121 ntly by molecular interactions involving its carboxy-proximal fasciclin 1 domain and that its amino-p
126 enzyme that recognizes the unique metabolite carboxy-S-adenosine-L-methionine (Cx-SAM) and catalyzes
127 generate a previously undescribed co-factor, carboxy-S-adenosyl-l-ethionine (cxSAE), thereby enabling
128 boxymethyltransferase enzymes that utilise a carboxy-SAM (cxSAM) cofactor generated from SAM by a cxS
129 in of MccB and the MccS enzyme that produces carboxy-SAM, which serves as a donor of the carboxymethy
131 targeted to the Z ring through the conserved carboxy tail of FtsZ leading to breakage of FtsZ filamen
132 s to protein storage vacuoles is mediated by carboxy terminal and internal sorting determinants (ISDs
134 is specifically mediated by the beta cleaved carboxy terminal fragment of APP (APP-betaCTF, C99).
137 e also present data suggesting that a second carboxy-terminal 4-helix bundle domain stabilizes LD bin
139 tment and the tagging of nascent chains with carboxy-terminal Ala and Thr extensions ("CAT tails").
140 -dependent ubiquitination and Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elonga
141 l subunit elongate stalled polypeptides with carboxy-terminal alanine and threonine residues (CAT tai
142 from classical IgE by the replacement of two carboxy-terminal amino acids with eight novel residues t
143 s a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determinin
145 ad and body domains connected to an extended carboxy-terminal arm, which wraps atop the head domain o
146 cognized by GGTase3 despite having a typical carboxy-terminal CaaX prenylation motif that is predicte
147 B1 inhibits neutrophil serine proteases, its carboxy-terminal CARD-binding motif restrained the activ
149 pha), and bone metabolism (osteocalcin [OC], carboxy-terminal collagen crosslinks [CTX], and N-termin
152 sons revealed that multiple genes related to carboxy-terminal domain (CTD) family proteins, including
153 man immunodeficiency virus type 1 (HIV-1) CA carboxy-terminal domain (CTD) is essential for CA-CA int
154 i-subunit complex stably associated with the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP
155 hnRNPG directly binds to the phosphorylated carboxy-terminal domain (CTD) of RNA polymerase II (RNAP
157 NAPII) foci, predominantly phosphorylated at carboxy-terminal domain (CTD) residue Tyr1, at DSBs.
158 inase 9 (CDK9) recruitment and phospho-Ser 2 carboxy-terminal domain (CTD) RNA polymerase (Pol) II fo
159 its, a core that binds UPF1 and a protruding carboxy-terminal domain (CTD) that binds the SMG1 kinase
160 n of the amino-terminal domain (NTD) and the carboxy-terminal domain (CTD) was found to be essential
164 the intrinsically disordered linker histone carboxy-terminal domain (H1 CTD) influences chromatin st
165 using a recombinant OcXII harboring only the carboxy-terminal domain and this part did not exhibit an
166 leosomal DNA and tethers H2A-H2B through its carboxy-terminal domain by acting as a placeholder for D
168 and involving a region of the middle domain/carboxy-terminal domain interface previously suggested t
172 s located in the surface-exposed loop of the carboxy-terminal domain of nsP2 and exhibits high variab
173 is model suggested that POA binds within the carboxy-terminal domain of ribosomal protein S1 (RpsA) a
174 CDK11 phosphorylates serine 2 (Ser2) of the carboxy-terminal domain of RNA polymerase II (RNAPII), w
175 nscription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selecti
177 ce the conformational states of the proximal carboxy-terminal domain of TcdB and could contribute to
178 ates Serine 5 of heptapeptide repeats on the carboxy-terminal domain of the largest Pol II subunit Rp
181 HV terminal-repeat (TR) sequence through its carboxy-terminal domain to mediate DNA replication.
182 fy unique contributions for the spectrin and carboxy-terminal domains during different phases of spin
183 catalytic core domain flanked by amino- and carboxy-terminal domains essential for the concerted int
185 rface on FACT appears to be protected by the carboxy-terminal domains of both of its subunits, and th
186 rface on FACT appears to be protected by the carboxy-terminal domains of both of its subunits, and th
187 arged regions conserved in the J-domains and carboxy-terminal domains of each J-protein class, and ar
188 of phosphorylation in the amino-terminal and carboxy-terminal domains that are positioned to alloster
189 l as alpharetroviruses by providing critical carboxy-terminal domains to the intasome core that canno
190 and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization,
201 Three layers of hydrophobic residues on the carboxy-terminal half of the TM1 helices form a bottlene
207 mposed of a four-helix bundle connected to a carboxy-terminal immunoglobulin (Ig)-like domain through
208 s N-SH2 domain and a previously unrecognized carboxy-terminal immunoreceptor tyrosine-based activatio
210 chromosomes by binding histones H2A/H2B, and carboxy-terminal LANA contributes to mitotic-chromosome
213 o acids between the leucine-rich repeats and carboxy-terminal low-complexity acidic region domains.
215 ents to Rosetta modeling, we reveal that the carboxy-terminal part of the S4 helix exhibits an unexpe
217 al sequence, the protein was identified as a carboxy-terminal peptide of the acute phase protein seru
218 t cleaves the GLUT8 protein and releases the carboxy-terminal peptide to a separate vesicle populatio
219 tsZ, referred to here as the CCTP (conserved carboxy-terminal peptide), is required for the interacti
224 en type-I deposition or CD+ (i.e., increased carboxy-terminal propeptide of procollagen type-I) has b
225 cleolar (NoLS) localization signals near the carboxy-terminal region of AAP2 (amino acid positions 14
226 inus, or deletion of regions in the internal carboxy-terminal region of E protein, led to virus atten
227 an extended alpha-helix from the disordered carboxy-terminal region of nucleoprotein-core links nucl
228 ns or deletions in the amino-terminal or the carboxy-terminal regions of the E protein were generated
230 d with Bacillus subtilis spores expressing a carboxy-terminal segment (TcdA26-39) of C. difficile tox
232 claudin trafficking and half-life depend on carboxy-terminal sequences and that different claudins c
235 m substrates have been proposed to contain a carboxy-terminal signal sequence that is necessary and s
236 factors favour one or the other, such as the carboxy-terminal site of the peptide and specific co-dep
237 Several PPR proteins in plants harbor a carboxy-terminal small-MutS-related (SMR) domain, but th
238 s with the increased ubiquitination of EphB4 carboxy-terminal tail and with its rapid degradation.
239 Here we investigate the negatively charged carboxy-terminal tail domains (CTTs) of alpha- and beta-
242 eting post-translational modification of its carboxy-terminal tail via phosphorylation of its tyrosin
243 tameric ring around a region of the receptor carboxy-terminal tail, while a second KCTD domain, H1, e
244 glutamates to internal glutamates in tubulin carboxy-terminal tails (branch initiation, through an is
245 investigate the inhibition effect of tubulin carboxy-terminal tails using peptide sequences of alpha-
247 ype-I cross-linking or CCL+ (i.e., decreased carboxy-terminal telopeptide of collagen type-I to matri
251 ith STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated Smad3 interacts with S
254 ditionally, Rqc2 modifies stalled NCs with a carboxy-terminal, Ala- and Thr-containing extension-the
255 protection was successful, and the resulting carboxy-terminated dendrimers were analyzed by NMR and D
256 olymer brushes (pCB) as well as conventional carboxy-terminated oligo(ethylene glycol)-based alkaneth
257 ly related ryanodine receptor, the cytosolic carboxy termini are uniquely arranged in a left-handed a
264 II (hCA II) nor fusing hCA II to the NBCe1-A carboxy terminus affects background-subtracted NBCe1 slo
265 ugh an isopeptide bond between the ubiquitin carboxy terminus and a substrate lysyl amino group.
266 Together, the data show that P, M, and the F carboxy terminus are sufficient for robust viral protein
269 on between its HECT (homologous to the E6-AP carboxy terminus domain) and two central WW domains.
270 s PKC-dependent phosphorylation of the Kv7.5 carboxy terminus is associated with a reduction in PIP(2
271 apsids via their amino terminus, whereas the carboxy terminus is unstructured and therefore may bette
273 dentify clusters of basic amino acids in the carboxy terminus of AAP from AAV serotype 2 (AAV2) that
276 Vpx binding domain of SAMHD1 is fused to the carboxy terminus of green fluorescent protein (GFP) and
278 dence that mapped interactions with N to the carboxy terminus of M, it was not possible to define a s
280 iciently cleaves Stp1 even when fused to the carboxy terminus of the endoplasmic reticulum (ER) membr
281 tion is enhanced by a positive charge at the carboxy terminus of the peptide, which triggers an inwar
282 and E3 three-enzyme cascade, which links the carboxy terminus of ubiquitin to the epsilon-amino group
283 ins a tethered cluster-binding domain at its carboxy terminus that moves in and out of the active sit
286 tional crosstalk between the pore region and carboxy terminus, involved in Ca(2+)-calmodulin-mediated
287 TtsA depends on a discrete domain within its carboxy terminus, which targets the enzyme to the bacter
289 el CLH-3b is reduced by phosphorylation of a carboxy-terminus "activation domain," which disrupts its
290 terozygous frameshift mutation affecting the carboxy-terminus (439fs) of perilipin 1 in two unrelated
291 elices designated "A-R" and an intracellular carboxy-terminus containing two cystathionine-beta-synth
292 n binding (Fab) (scFab) format, in which the carboxy-terminus of the light chain is linked to the ami
293 ropose that alteration and elongation of the carboxy-terminus of the protein has a dominant-negative
294 eas deletion of the S. Typhimurium flagellin carboxy-terminus prevented caspase-1 maturation only.
296 These frameshifts often create cationic carboxy-terminus residues that replace hydrophobic amino
297 , and two major metabolites of THC, 11-nor-9-carboxy-THC and 11-hydroxy-THC, in active users and part
298 ass metabolites (11-hydroxy-THC and 11-nor-9-carboxy-THC) in blood and brain following acute injectio
300 ng cerebrovascular perfusion with ROX, SE (5-Carboxy-X-Rhodamine, Succinimidyl Ester), a fluorescent