ライフサイエンスコーパス: carboxyl termini

1 catalytic domains followed by less conserved carboxyl termini.

2 B), are otherwise identical except for their carboxyl termini.

3 B) domain of p300/CBP via both its amino and carboxyl termini.

4 worms and yeast contain this domain at their carboxyl termini.

5 ants that differ from GRK6A at their extreme carboxyl termini.

6 ing to generate three variants with distinct carboxyl termini.

7 subunit of the Arp2/3 complex through their carboxyl termini.

8 dic transactivating domains at the amino and carboxyl termini.

9 o one of four distinct 3' exons encoding the carboxyl termini.

10 y two nonconserved segments at the amino and carboxyl termini.

11 activation regions located at the amino and carboxyl termini.

12 nding on alternative splicing, four possible carboxyl termini.

13 n cells overexpressing c-Cbl mutants lacking carboxyl termini.

14 hGRalpha and hGRbeta, which differ at their carboxyl termini.

15 ate transactivation domains at the amino and carboxyl termini.

16 d form and three novel isoforms with altered carboxyl termini.

17 smembrane domains with cytoplasmic amino and carboxyl termini.

18 prenylated on a cysteine residue near their carboxyl termini.

19 and PKD2 contain PDZ-binding motifs at their carboxyl termini.

20 teins Rep52 and Rep40, which differ in their carboxyl termini.

21 xtracellular loop, and cytoplasmic amino and carboxyl termini.

22 nduced interactions between the AR amino and carboxyl termini.

23 (Tid1-L and -S), which differ only at their carboxyl termini.

24 repressor domains, located at the amino and carboxyl termini.

25 ents and intracellularly localized amino and carboxyl termini.

26 ed the intracellular nature of the amino and carboxyl termini.

27 (HVR) flanked by highly conserved amino and carboxyl termini.

28 e last 120 amino acids in the conserved CLIC carboxyl termini.

29 h contain a high degree of homology in their carboxyl termini.

30 een AQP0 and AQP1) but not for the amino and carboxyl termini.

31 panning domains with intracellular amino and carboxyl termini.

32 y linked cholesterol intermediate near their carboxyl-termini.

33 membrane spans with intracellular amino- and carboxyl-termini.

34 s progressive reduction in their cytoplasmic carboxyl termini (822, 788, and 769 residues, respective

35 the chondrosarcoma cell line SW1353 via its carboxyl termini activation domain in a cell type-specif

36 We found that the TERT amino and carboxyl termini, although evolutionarily poorly conserv

37 The carboxyl termini among group I germinal center kinases a

38 transmembrane domains, cytoplasmic amino and carboxyl termini, an amino-terminal helix, and conserved

39 inhibitor-resistant peptides contain diverse carboxyl termini and are derived from protein substrates

40 eins contain a so-called CaaX motif at their carboxyl termini and are subject to a maturation process

41 s extending beyond the pentapeptide at their carboxyl termini and assayed methylation, demethylation,

42 Three QKI isoforms have different carboxyl termini and different subcellular localization.

43 in and the ectodomain, whereas the amino and carboxyl termini and first transmembrane domain are poor

44 glutamines and lysines on only the amino and carboxyl termini and in functionally non-polar ways.

45 eptide is linked by isopeptide bonds between carboxyl termini and Lys-48 residues of successive monom

46 s of two invariable domains at the amino and carboxyl termini and one central variable domain.

47 ylation sites substituted into the amino and carboxyl termini and the M1 segment gave results consist

48 nd gamma, which have intracellular amino and carboxyl termini and two membrane-spanning domains conne

49 re predicted to have intracellular amino and carboxyl termini and two transmembrane domains connected

50 subtype consists of intracellular amino and carboxyl termini and two transmembrane domains connected

51 of IRKs consists of intracellular amino and carboxyl termini and two transmembrane segments (M1 and

52 r binding Domains I and III at the amino and carboxyl termini, and a central Domain II homologous to

53 egments (M1 and M2), intracellular amino and carboxyl termini, and a large extracellular loop.

54 are anchored to the virus envelope at their carboxyl termini, and E(rns) loosely associates with the

55 membrane domains, rather than the amino- and carboxyl-termini, and the large intracellular loop betwe

56 We conclude that the amino and carboxyl termini are critical to the function of perilip

57 C or N terminus revealed that both amino and carboxyl termini are important for increasing the stabil

58 hibits a trimeric configuration in which the carboxyl termini are no longer exposed; however, the pro

59 respective WT receptors, indicating that the carboxyl termini are not necessary for these processes.

60 ted in the presence of c-Cbl mutants lacking carboxyl termini, as detected by changes in the cytosoli

61 Both the amino and carboxyl termini, as well as amino acids 422 to 443 of p

62 nine dimer spokes radiate, placing the Sas-6 carboxyl termini at the outer edge of the approximately

63 ive transmembrane domains with the amino and carboxyl termini being least identical to GalR1.

64 possess heterogeneity at both the amino and carboxyl termini, beta- and gamma-secretases may actuall

65 e in the -3 and -4 positions, 2) exchange of carboxyl termini between alpha q and alpha z allows acti

66 and synaptobrevin SNARE motifs, while their carboxyl termini bind to distal sites of Munc18-1.

67 y in how the portal and head-to-tail adaptor carboxyl termini bond with the capsid at the fivefold ve

68 Peptides at the amino and carboxyl termini bound heparin, and one peptide showed r

69 otions are evident not only at the amino and carboxyl termini but also in the turn between strands be

70 tion of the beta and gamma subunits in their carboxyl termini, but none of these agents induced de no

71 osin heavy chains differ at their respective carboxyl termini by 43 versus 9 unique amino acids.

72 structure of soluble TNF so that the cryptic carboxyl termini, centrally located at the base of the t

73 igase III-alpha and XRCC1 interact via their carboxyl termini, close to or within regions that contai

74 tein, a disulfide bond forms between the two carboxyl termini, covalently and intradimerically cross-

75 encoded by a single gene but have different carboxyl termini created by alternative splicing.

76 In this report, we determined the role of carboxyl termini (CTs) of alpha2B-adrenergic receptor (A

77 ng hydrophilic and hydrophobic residues, and carboxyl termini, each of which can be varied to probe t

78 onsensus CheR-binding motif (NWETF) at their carboxyl termini, exhibit the highest basal levels of me

79 edicted hairpin-like structure and amino and carboxyl termini facing the cytoplasm, this membrane top

80 wo membrane-spanning sequences and amino and carboxyl termini facing the cytoplasm.

81 d two extracellular loops with the amino and carboxyl termini facing the cytoplasm.

82 bly are currently restricted to the amino or carboxyl termini, greatly limiting the diversity of Nb m

83 ution of beta2AR sequence into ICL3 amino or carboxyl termini had no appreciable effect on Gi couplin

84 al, gp100 is cleaved at the amino and at the carboxyl termini in a series of specific steps that resu

85 oforms) were found to be methylated at their carboxyl termini in normal rat islets, human islets and

86 differences in the location of the amino and carboxyl termini in the crystal and in the phospholipid

87 a decreased interaction between the amino to carboxyl termini in the functional tagged murine TRPC6 t

88 on enzyme-catalyzed oxygen exchange at their carboxyl termini in the presence of H(2)(18)O has been w

89 ion between the juxtatransmembrane amino and carboxyl termini in the regulation of P2X7 receptor gati

90 emarkable similarity to SCR throughout their carboxyl-termini, indicating that SCR is the prototype o

91 sequence responsible for association of the carboxyl termini into dimers.

92 10 transmembrane domains with both amino and carboxyl termini intracellular.

93 A basic region in the carboxyl termini is encoded in a separate exon in ART1 a

94 which, excluding the unstructured amino and carboxyl termini, is 90% identical to human Kir2.2.

95 zyme; it suggests instead that the amino and carboxyl termini may also be involved in determining sub

96 mulated interaction between the AR amino and carboxyl termini (N-C interaction), which is required fo

97 The amino and carboxyl termini, not resolved in the density map, appea

98 amino termini of 285 residues and identical carboxyl termini of 245 residues.

99 ubunits, and 3) association of the amino and carboxyl termini of adjacent Shaker subunits.

100 In contrast, the amino and carboxyl termini of adjacent subunits associate late dur

101 ot establish proximity between the amino and carboxyl termini of adjacent subunits.

102 The carboxyl termini of all four isoforms are post-translati

103 cl-x(L) bind with comparable affinity to the carboxyl termini of all three mammalian InsP(3)R isoform

104 action employing full-length IKKbeta and the carboxyl termini of all three subunits confirmed a stron

105 atoms are incorporated universally into the carboxyl termini of all tryptic peptides during the prot

106 The carboxyl termini of alpha(1B) bind to the first PDZ doma

107 The proline-rich region present in the carboxyl termini of alpha(1B) binds to the SH3 domain of

108 er, these results suggest that the amino and carboxyl termini of alpha- and gamma-tubulin and perhaps

109 Third, we found that the amino and carboxyl termini of alpha-tubulin were necessary for inc

110 imately 4-5 nm, revealing that the amino and carboxyl termini of Ana2 are located in the outer cartwh

111 A sequence motif was identified in carboxyl termini of axonemal beta-tubulins in diverse ta

112 n serine/threonine (Ser/Thr) residues in the carboxyl termini of beta and gamma subunits of epithelia

113 tions that delete or alter PY domains in the carboxyl termini of beta or gamma ENaC subunits, leading

114 proteolytic cleavages produce the amino and carboxyl termini of beta-amyloid, with the latter cleava

115 eolytic cleavages that produce the amino and carboxyl termini of betaA4.

116 tity with C and appears to interact with the carboxyl termini of both alpha and sigma 70.

117 Our results also documented that the carboxyl termini of both Cxs were required in this cell

118 ide sequences (peptides 4 to 6) found in the carboxyl termini of both the classical (Cl) and El Tor (

119 tence of such extensive homology between the carboxyl termini of both the prtT and hemR genes on the

120 lls; (b) we observed that both the amino and carboxyl termini of BRCA1 are required for regulation of

121 Both the amino and carboxyl termini of BRCA1 are required for this activity

122 ell transformation, and the unique amino and carboxyl termini of Chp represent atypical mechanisms of

123 nals in the amino terminus of TTP and in the carboxyl termini of CMG1 and TIS11D.

124 Current evidence suggests that the carboxyl termini of cognate peptides bind to the amino t

125 of the disulfide loops, which are toward the carboxyl termini of each of the chains, had different ef

126 ucts with hexahistidine tag at the amino and carboxyl termini of each subunit were coexpressed.

127 not mediated via phosphorylation within the carboxyl termini of ENaC.

128 Second, we found that both the amino and carboxyl termini of gamma-tubulin were essential for its

129 ino terminus of gp52; and both the amino and carboxyl termini of gp36.

130 Little is known about the carboxyl termini of group II family members.

131 To determine the role of the cytoplasmic carboxyl termini of human B1 and B2 kinin receptors (B1K

132 Peptides derived from the carboxyl termini of human Rheb and Rheb2 are in vitro su

133 localization signals (NLS) in the amino and carboxyl termini of IRF-5 and showed that both of these

134 eceptor binding both reside in the amino and carboxyl termini of KGF, which are spatially juxtaposed

135 ns-1 (PDZ) domains of PATJ could bind to the carboxyl termini of known tight junction constituents.

136 The intracellular domains of the amino and carboxyl termini of Kv4.2 were expressed as glutathione

137 is, we demonstrate that the homeodomains and carboxyl termini of mammalian PROP1 proteins are highly

138 We identify a short motif in the carboxyl termini of Mixer and Milk, which is demonstrate

139 ATM phosphorylated the carboxyl termini of mMCM3 and human MCM3 in vivo and the

140 unit (Tac) and each of the three cytoplasmic carboxyl termini of mouse ENaC (Tac-Ct) or with gamma-gl

141 number of proteins that interacted with the carboxyl termini of murine epithelial sodium channel (EN

142 ylation studies indicate that both amino and carboxyl termini of NS2 are located in the endoplasmic r

143 ersity was seen in NS5A and in the amino and carboxyl termini of patients with an ER, compared with t

144 nt study examines the roles of the amino and carboxyl termini of perilipin A in facilitating triacylg

145 The results indicate that the amino and carboxyl termini of PHO1 are both oriented toward the cy

146 The carboxyl termini of proteins often contain regions assoc

147 nvolves interactions with both the amino and carboxyl termini of receptors.

148 the DNA-binding domain in both the amino and carboxyl termini of REST.

149 sary for interaction with both the amino and carboxyl termini of RHA.

150 Amphipathic helices at the amino- and carboxyl termini of saposins A and C were shown to inser

151 ere we reexamined the roles of the amino and carboxyl termini of SecA in promoting its dimerization a

152 he specificity of NHERF interaction with the carboxyl termini of several membrane receptors and ion c

153 e activity of ENaC by phosphorylation of the carboxyl termini of the beta and gamma subunits.

154 e motifs DSLL, DSFL, and DTRL present at the carboxyl termini of the beta(2) adrenergic receptor (bet

155 iesterase, suggesting that the isoprenylated carboxyl termini of the catalytic subunits may be involv

156 Whereas the carboxyl termini of the human and bovine PROP1 proteins

157 volve specific MAPK docking sites within the carboxyl termini of the MAPKAPKs that determine the casc

158 enone groups, respectively, at the amino and carboxyl termini of the monothiazole zwitter-ion.

159 of a 6-TM model for BCRP with the amino and carboxyl termini of the MSD located intracellularly.

160 f 6-7 amino acid residues near the amino and carboxyl termini of the proteins encoded.

161 second pool are cleaved analogously with the carboxyl termini of the resulting peptides containing tw

162 ur results demonstrate that deletions of the carboxyl termini of the three subunits do not inhibit sg

163 Polyhistidine tags were added to the carboxyl termini of the two homologous subunits of yeast

164 hibition was specific, that it mapped to the carboxyl termini of the two proteins and that it was dos

165 We also examined the role of the carboxyl termini of these Cxs in initiating the formatio

166 The conservation between carboxyl termini of these proteins suggests symmetrical

167 t peptide sequence, encoded by tmRNA, to the carboxyl termini of these proteins.

168 The similarity of the carboxyl termini of this connexin and the lens fiber con

169 xyl terminus of GADD34 has homology with the carboxyl termini of two viral proteins, one of which is

170 These studies indicated that the amino and carboxyl termini of UL20p contained domains that functio

171 iruses with mutations in either the amino or carboxyl termini of UL20p produced partially syncytial p

172 PDZ domains can dimerize or bind to the carboxyl termini of unrelated proteins.

173 ess is facilitated by interactions among the carboxyl termini of viral glycoproteins and tegument pro

174 th PDZ domains of PATJ can interact with the carboxyl termini of zona occludens-3 (ZO-3) and claudin

175 terdomain interaction between the amino- and carboxyl-termini of AR, termed the N/C interaction, has

176 molecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity

177 location of PrBP/delta and, thus, where the carboxyl-termini of PDE6alpha and PDE6beta must be locat

178 PDZ domains bind to the carboxyl-termini of target proteins, and some PDZ domain

179 with carboxyl-terminal ligands, such as the carboxyl-termini of the beta(2)-adrenergic receptor or t

180 ivity and that domains within the amino- and carboxyl-termini of the BRCA1 protein are required for t

181 nine additional residues from the amino- and carboxyl-termini of this polypeptide, respectively, resu

182 s independently raised against the amino- or carboxyl-termini of UBE1L.

183 ptors to cause the phosphorylation, at their carboxyl termini, of Smad2 and Smad3.

184 y conserved among different Cxs, whereas the carboxyl termini, often called the cytoplasmic tails, ar

185 cond alpha chain thus presents its amino and carboxyl termini on a solvent exposed surface, providing

186 ransmembrane domains with both the amino and carboxyl termini on the cytoplasmic side.

187 transmembrane domains per subunit (amino and carboxyl termini on the same side of the membrane), and

188 lternatively spliced isoforms with different carboxyl termini (p73alpha-eta).

189 nits with epitope tags at both the amino and carboxyl termini, proteolytic processing of the alpha- a

190 nslationally modified Rho GTPases near their carboxyl termini, releasing them from the membrane.

191 cted cells, we determined that the amino and carboxyl termini reside in the extracellular space and a

192 nd 18 amino acid residues from the amino and carboxyl termini, respectively, was found to be the mini

193 ins two invariable domains, at the amino and carboxyl termini, respectively, which collectively accou

194 8- and 13-kDa domains include the amino and carboxyl termini, respectively.

195 changing the betaarrestin1 and betaarrestin2 carboxyl termini reversed their extent of binding to cla

196 or of 25 with domains at both the amino- and carboxyl-termini showing lower intrinsic affinities for

197 3A and MUC3B have highly conserved amino and carboxyl termini, suggesting a recent duplication of the

198 amino acids, 24-25 residues longer at their carboxyl termini than the previously reported bovine Udp

199 ved Dia-autoregulatory domain (DAD) in their carboxyl termini that binds the GBD.

200 ucturally variable regions at the amino- and carboxyl termini, that 10 amino acids are conserved in a

201 We truncated porcine PAI-1 at the amino and carboxyl termini to eliminate the reactive center loop,

202 s (TM1 and TM2), and intracellular amino and carboxyl termini to the action of partial agonists (high

203 n the expression of BK transcripts with long carboxyl termini toward the apex.

204 Moreover, non-functional amino and carboxyl termini-truncated mutants of DAT inhibited wild

205 ntrast, human Ca(v)3.3 isoforms with shorter carboxyl termini were less affected by a prepulse.

206 esignated polo boxes (PBs), located in their carboxyl-termini, which with their flanking regions cons

207 y, dual substitutions of the GLUT1 amino and carboxyl termini with GLUT4 domains or the combination o

208 tantial sequence homology, especially at the carboxyl termini, with another scorpion toxin, charybdot