ライフサイエンスコーパス: carboxyl-terminal tail

1 one of the conserved acylation sites in the carboxyl terminal tail.

2 hirds of the molecule and a more hydrophilic carboxyl terminal tail.

3 long cytoplasmic loop and a relatively short carboxyl terminal tail.

4 or by the re-expression of the polycystin-1 carboxyl terminal tail.

5 is a seven-transmembrane protein with a long carboxyl terminal tail.

6 through palmitoylation of the GLP-1R at its carboxyl-terminal tail.

7 al ubiquitin-like domain and a 34-amino acid carboxyl-terminal tail.

8 osphorylated serine residues in the receptor carboxyl-terminal tail.

9 i-acidic code (DXE) located in the cytosolic carboxyl-terminal tail.

10 ds on the integrity of the Akt PH domain and carboxyl-terminal tail.

11 radius of gyration, and the expulsion of the carboxyl-terminal tail.

12 ct PDZ-binding motif at the end of the CRFR1 carboxyl-terminal tail.

13 ula Occludens-1) domains followed by a short carboxyl-terminal tail.

14 promised by genetic perturbations within the carboxyl-terminal tail.

15 ein that targets to mitochondria through its carboxyl-terminal tail.

16 ween multiple phosphorylated residues in the carboxyl-terminal tail.

17 d threonine residues located in the receptor carboxyl-terminal tail.

18 eptor and, unlike the type I receptor, has a carboxyl-terminal tail.

19 most unique of the four by possessing a long carboxyl-terminal tail.

20 n followed by two hydrophobic segments and a carboxyl-terminal tail.

21 n be attributed solely to differences in the carboxyl-terminal tail.

22 which comprises four putative loops and the carboxyl-terminal tail.

23 2A and CCR2B, exist and differ only in their carboxyl-terminal tails.

24 of the conserved core, and Tyr-330 from the carboxyl-terminal "tail."

25 ine-based internalization signal in the CFTR carboxyl-terminal tail 1424YDSI1427.

26 ucted with full-length HasAp showed that the carboxyl-terminal tail (21 residues) is disordered and c

27 onine residues in the receptor's cytoplasmic carboxyl-terminal tail ablated phosphorylation and yield

28 tial screen, we propose a model in which the carboxyl-terminal tail acts together with the intracellu

29 esult of truncations or point mutants in the carboxyl-terminal tail allowed gB-mediated fusion with e

30 of the alpha5 helix, which lies between the carboxyl-terminal tail and a loop contacting the nucleot

31 with IBAT and a chimeric molecule having the carboxyl-terminal tail and membrane spanning domain of C

32 after PTH stimulation on two regions of the carboxyl-terminal tail and that agonist-dependent phosph

33 ization involves phosphorylation of both the carboxyl-terminal tail and the second intracellular loop

34 activity depends on a disinhibition from the carboxyl-terminal tail and the simultaneous phosphorylat

35 ir enzyme 6-4 PHOTOLYASE, CRYs have extended carboxyl-terminal tails and cannot repair DNA damage (re

36 No other regions in the carboxyl-terminal tail appeared to contain motifs requir

37 erve that both the ubiquitin-like domain and carboxyl-terminal tail are conserved in Drosophila melan

38 ficant intermolecular contacts involving the carboxyl-terminal tail are discussed with respect to rec

39 indicating that the helicase domain and the carboxyl-terminal tail are not required for the stimulat

40 nected by a cytoplasmic loop; the amino- and carboxyl-terminal tails are oriented toward the endoplas

41 ndependent of the third cytoplasmic loop and carboxyl-terminal tail, both the sixth and seventh trans

42 structure of the ternary structure of ATG9A carboxyl-terminal tail bound to the ATG13:ATG101 Hop1/Re

43 differing in the length of their cytoplasmic carboxyl-terminal tails, but no definitive evidence of t

44 ptimal Ang II-induced phosphorylation of its carboxyl-terminal tail by GRKs.

45 Here, we provide evidence that distal carboxyl-terminal tail (C-tail), but not proximal, phosp

46 ulk of the nestin protein consists of a long carboxyl-terminal tail composed of various highly charge

47 tative phosphotyrosine binding domain, and a carboxyl-terminal tail containing multiple tyrosine phos

48 the dynamic and coordinated movement of the carboxyl terminal tail, contributes directly to substrat

49 a-arrestin with a specific motif in the GPCR carboxyl-terminal tail dictates the rate of receptor dep

50 Surprisingly, complete removal of the carboxyl-terminal tail did not impair C5a receptor signa

51 Class V myosins have a globular carboxyl terminal tail domain that is proposed to mediat

52 Contrary to speculation, the divergent carboxyl-terminal tail domain (CTD) is dispensable, but

53 report, we investigated the role of the PTEN carboxyl-terminal tail domain in regulating its membrane

54 ine/threonine residues located in the distal carboxyl-terminal tail domain of the full-length recepto

55 rize all intermediate filament proteins, the carboxyl-terminal tail domain.

56 To investigate the function of the carboxyl-terminal-tail domain of Myo2p, we have overexpr

57 The carboxyl terminal "tail" domains of the heavy and middle

58 The phosphorylated carboxyl-terminal "tail" domains of the neurofilament (N

59 nd serine/threonine phosphorylation in their carboxyl-terminal tails exhibited robust insulin potenti

60 77, and 88-108 and a hydrophilic cytoplasmic carboxyl-terminal tail from residues 109-161.

61 orresponding chimeric beta2AR with the AT1AR carboxyl-terminal tail gains the ability to translocate

62 (EGFRK) including forty amino acids from the carboxyl-terminal tail has been determined to 2.6-A reso

63 r construct (T903-Rhoc) in which the ECD and carboxyl-terminal tail have been deleted to produce a rh

64 (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in

65 he amino-terminal region of the protein, and carboxyl-terminal tail identity both contribute to MLO a

66 e segment, preventing proper position of the carboxyl-terminal tail in a proportion of mutant molecul

67 ons and that alterations affecting the ATP7A carboxyl-terminal tail induce release of the copper tran

68 receptor (GPCR) family because it lacks the carboxyl-terminal tail involved in GPCR desensitization.

69 subunit is in an open conformation, and its carboxyl-terminal tail is disordered.

70 ld type and mutant kinases indicate that the carboxyl-terminal tail is largely dispensable for autoph

71 ons in the region of human LMNA encoding the carboxyl-terminal tail Lamin A/C are associated with for

72 PTH/PTHrP receptor map to two regions of the carboxyl-terminal tail located between residues A480 and

73 determine the function(s) of a 32-amino acid carboxyl-terminal tail (Mgm101(238-269)) conserved in th

74 nd genetic data support a model in which the carboxyl-terminal tail modulates DNA binding and mediate

75 cysteine residues 621 and 622 located in the carboxyl terminal tail of the receptor.

76 The carboxyl-terminal tail of 5-HT2AR encodes a motif that m

77 f each invasion protein to the intracellular carboxyl-terminal tail of a membrane-bound eukaryotic re

78 -specific protease Usp4 as a partner for the carboxyl-terminal tail of adenosine A2A receptors and sh

79 beta-Arrestin binding to the carboxyl-terminal tail of beta(1)-ARs promotes a conform

80 sponding to the cytoplasmic loops and/or the carboxyl-terminal tail of bovine opsin either singly, or

81 Mutation of the two lysine residues in the carboxyl-terminal tail of CD36 markedly attenuated ubiqu

82 re we show that a second substitution in the carboxyl-terminal tail of CFTR, I1427A, on Y1424A backgr

83 er-368, Ser-405, Thr-407, and Ser-408 in the carboxyl-terminal tail of CKIepsilon were identified as

84 nase serine phosphorylation sequences in the carboxyl-terminal tail of connexin-43 and purified MAP k

85 Cx26/43T-Aeq) in which the short cytoplasmic carboxyl-terminal tail of Cx26 was replaced with the ext

86 zed domains of PSD-95 but is mediated by the carboxyl-terminal tail of D1 and the NH(2) terminus of P

87 h the phosphotyrosine binding domain and the carboxyl-terminal tail of Dok (in particular residues 33

88 gered by one or two tyrosines located in the carboxyl-terminal tail of EAT-2 but not found in SAP.

89 nteracts with the last three residues in the carboxyl-terminal tail of eye-PKC, Thr-Ile-Ile.

90 We conclude that the carboxyl-terminal tail of FPRs is necessary for ligand-m

91 tion of either 41 or 56 amino acids from the carboxyl-terminal tail of gp110 resulted in loss of rete

92 ein interaction interface in the cytoplasmic carboxyl-terminal tail of Gpr161.

93 orylation sites Thr(308) and Ser(310) in the carboxyl-terminal tail of its receptor LTB4R in a manner

94 hibit calmodulin (CaM) interactions with the carboxyl-terminal tail of mGluR7.

95 a novel human protein, Narf, that binds the carboxyl-terminal tail of prelamin A.

96 (Ser256, Ser261, Ser264, and Ser269) in the carboxyl-terminal tail of rat AQP2.

97 e of the putative regulatory tyrosine in the carboxyl-terminal tail of STK.

98 DZ 10) associates with Ser458-Ser-Val at the carboxyl-terminal tail of the 5-HT2C R.

99 The isozyme-specific carboxyl-terminal tail of the 9-2 protein was shown, by

100 in the RIIbeta subunit, which docks onto the carboxyl-terminal tail of the adjacent C subunit, thereb

101 The roles of the carboxyl-terminal tail of the alpha(1B)-adrenergic recep

102 Surprisingly the carboxyl-terminal tail of the C5a receptor is the most i

103 The carboxyl-terminal tail of the CRFR1 terminates in a PDZ-

104 ults suggest that an interaction between the carboxyl-terminal tail of the DHPR alpha(1)-subunit with

105 of this peptide with both calmodulin and the carboxyl-terminal tail of the DHPR alpha(1)-subunit.

106 s for binding to the tyrosine-phosphorylated carboxyl-terminal tail of the epidermal growth factor (E

107 ld interact with the intracellular loops and carboxyl-terminal tail of the GPCR.

108 lymerase and an electrostatic binding of the carboxyl-terminal tail of the helicase to a basic patch

109 roline-rich, SH3 binding sites (PXXP) in the carboxyl-terminal tail of the human P2Y(2) nucleotide re

110 TRIP6 directly binds to the carboxyl-terminal tail of the LPA(2) receptor through it

111 The carboxyl-terminal tail of the LPA(2) receptor, but not L

112 The intracellular carboxyl-terminal tail of the m2 receptor is neither suf

113 o-site cluster located at the extreme distal carboxyl-terminal tail of the receptor is responsible fo

114 ach of the three intracellular loops and the carboxyl-terminal tail of the receptor.

115 autoinhibitory alpha helix is present in the carboxyl-terminal tail of the RSK isozymes ((697)HLVKGAM

116 ng amino acids 1393-1527 (D1393-1527) of the carboxyl-terminal tail of the skeletal muscle L-type vol

117 ction with a beta2-adrenoceptor fused to the carboxyl-terminal tail of the vasopressin type 2 recepto

118 f either a YX(2)phi or YX(3)phi motif in the carboxyl-terminal tail of TPalpha induced tonic internal

119 esidue) found in the proximal portion of the carboxyl-terminal tail of TPbeta was critical for tonic

120 Xis residues 57-69 strongly suggest that the carboxyl-terminal tail of Xis and the alpha-helix of the

121 e previously demonstrated that Ser129 in the carboxyl-terminal tail of yeast histone H2A is important

122 Switching the carboxyl-terminal tails of class A and class B receptors

123 These data indicate that the amino- and carboxyl-terminal tails of H2A are essential for wild-ty

124 mparison of the docking site of RSK with the carboxyl-terminal tails of other MAPK-activated kinases

125 resensitize is completely reversed when the carboxyl-terminal tails of these two receptors are switc

126 sferase (GST)-fusion proteins containing the carboxyl-terminal tails of three p90 ribosomal S6 kinase

127 of several aspects of mitosis, and divergent carboxyl-terminal tails of varying length.

128 todomain, a transmembrane helix, and a short carboxyl-terminal tail, or as a soluble ectodomain that

129 ation within the Homer binding region in the carboxyl-terminal tail (P1148L) does not alter the intra

130 bound to the chimera with a wild-type LET-23 carboxyl-terminal tail (P75t-Let23WT), but not a mutant

131 ive Elongin ABC complex, suggesting that the carboxyl-terminal tail performs an additional function n

132 ied an interaction between the 71-amino acid carboxyl-terminal tail region and the CBRIII motif of th

133 of the Mps1 kinase domain revealed that the carboxyl-terminal tail region of Mps1 is unstructured, r

134 tical function for the structurally flexible carboxyl-terminal tail region of Skp2 in Cks1 recognitio

135 dues are located in the largely unstructured carboxyl-terminal tail region of Skp2.

136 egion of approximately310 amino acids, and a carboxyl-terminal tail region of variable length.

137 ng of the amino-terminal (residues 2-78) and carboxyl-terminal tail regions (residues 1391-1476) of C

138 Deletion of 16 amino acids from the carboxyl-terminal tail resulted in gp110 intracellular l

139 ivation of a chimeric AT1AR with the beta2AR carboxyl-terminal tail results in a beta-arrestin membra

140 Deletion of the carboxyl-terminal tail results in constitutive activatio

141 togen-activated protein kinase family, has a carboxyl-terminal tail that is required for ERK7 activat

142 ared with AVR1, A-L is shorter and lacks the carboxyl-terminal tail, the T-region that is crucial for

143 n autoinhibitory segment in the noncatalytic carboxyl-terminal tail; Thr-252 in the activation loop o

144 We synthesized peptide mimics of the H2AX carboxyl-terminal tail to test whether antagonizing H2AX

145 The binding of the L-type channel carboxyl-terminal tail to the calmodulin binding site on

146 including the last three amino acids in its carboxyl-terminal tail to the membrane fusion regulatory

147 (362), Ser(363) and Thr(366) residues at the carboxyl-terminal tail were primarily responsible for ss

148 h the phosphotyrosine binding domain and the carboxyl-terminal tail were required for optimal enhance

149 or DOR and KOR desensitization reside in the carboxyl-terminal tail, whereas MOR depends on Thr-180 i

150 oncatalytic amino-terminal region and in the carboxyl-terminal tail, which contains a proline-rich re

151 al DNA and disrupting interactions of the H1 carboxyl-terminal tail with DNA.