ライフサイエンスコーパス: carboxylase

1 g Acc1p, the rate-limiting enzyme acetyl-CoA carboxylase.

2 the chloroplast genome, ribulose diphosphate carboxylase.

3 ted protein kinase and its target acetyl-CoA carboxylase.

4 accumulate chloroplastic phosphoenolpyruvate carboxylase.

5 As, and we have named it long-chain acyl-CoA carboxylase.

6 cant change in phosphorylation of acetyl CoA carboxylase.

7 es the second partial reaction of acetyl-CoA carboxylase.

8 sed phosphorylated (p-)AMPK and p-acetyl CoA carboxylase.

9 AMPK and of its downstream target acetyl-CoA carboxylase.

10 carbonate, the required substrate of various carboxylases.

11 erent from those of related biotin-dependent carboxylases.

12 anslational biotinylation of acyl coenzyme A carboxylases.

13 rent from that of the other biotin-dependent carboxylases.

14 xation reactions by supplying bicarbonate to carboxylases.

15 zymes collectively known as biotin-dependent carboxylases.

16 or multiple metabolic reactions catalyzed by carboxylases.

17 Acetyl-CoA carboxylase 1 (Acc1) connects central energy metabolism

18 cell-specific deletion of acetyl coenzyme A carboxylase 1 (ACC1), an enzyme that catalyzes conversio

19 rements of key lipogenic enzymes [acetyl CoA carboxylase 1 (ACC1), fatty acid synthase (FASN), and st

20 nzyme of fatty acid biosynthesis, acetyl-CoA carboxylase 1 (ACC1), is O-GlcNAcylated and necessary fo

21 re and mice via the inhibition of acetyl-CoA carboxylase 1 (ACC1), resulting in neuroprotection and i

22 nfection, a specific inhibitor of acetyl CoA carboxylase 1, 5-(tetradecyloxy)-2-furoic acid, was admi

23 lipogenesis: fatty acid synthase, acetyl-CoA carboxylase 1, and glycerol-3-phosphate acyltransferase.

24 arly pharmaceutical inhibition of acetyl CoA carboxylase 1, the rate limiting step of FAS, inhibit ge

25 under the control of the phosphoenolpyruvate carboxylase-1 (Pck1) promoter in mice increased hepatic

26 tochondria via deletion of acetyl coenzyme A carboxylase 2 (ACC2) does not cause cardiomyopathy in no

27 nt abundance via hydroxylation of acetyl-coA carboxylase 2 (ACC2).

28 t of adipose triglyceride lipase, acetyl-CoA carboxylase 2 and AMP-activated protein kinase (AMPK)gam

29 reasing FAO via deletion of ACC2 (acetyl-CoA-carboxylase 2) in phenylephrine-stimulated cardiomyocyte

30 2-ketopropyl-coenzyme M oxidoreductase/carboxylase (2-KPCC) is a bacterial disulfide oxidoreduc

31 nservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and

32 ed by decreased protein levels of acetyl-CoA carboxylase, a key regulator of both lipid oxidation and

33 e lipid synthesis is catalyzed by acetyl-CoA carboxylase, a large complex composed of four subunits.

34 ased abundances of mRNA encoding Acetyl Co-A carboxylase (Acc) (up 25%) and Hsp70 (up 32%) in experim

35 that required phosphorylation of acetyl-CoA carboxylase (ACC) 1 and/or ACC2 at the AMPK sites.

36 ated by the SREBP-SCD pathway, an acetyl-CoA carboxylase (ACC) and certain nuclear hormone receptors

37 otein kinase activation of acetyl-coenzyme A carboxylase (ACC) and increased lipid content in human h

38 Acetyl-CoA carboxylase (ACC) catalyzes the rate-determining step in

39 c, fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) gene expression.

40 ice by liver-specific knockout of acetyl-CoA carboxylase (ACC) genes and treat the mice with the hepa

41 Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabo

42 The development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabo

43 al and clinical data suggest that acetyl-CoA carboxylase (ACC) inhibitors have the potential to rebal

44 Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential

45 le systemic insecticide targeting acetyl-CoA carboxylase (ACC) of pest insects and mites upon foliar

46 ent excess, induced both AMPK and acetyl-CoA carboxylase (ACC) phosphorylation.

47 utical inhibition of acetyl-coenzyme A (CoA) carboxylase (ACC), a key fatty acid biosynthetic enzyme,

48 olled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intra

49 ymes [fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)].

50 RNAi silencing of Acetyl Co-A carboxylase (ACC), highly expressed in JGM-treated BPH,

51 olecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first ra

52 ophagy and the phosphorylation of acetyl-CoA carboxylase (ACC), whereas alone it could block the auto

53 AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), which catalyzes carboxylation of acet

54 get is the multifunctional enzyme acetyl-CoA carboxylase (ACC), which catalyzes the first committed s

55 levels of phosphorylated AMPK and acetyl-CoA carboxylase (ACC).

56 lation and inactivation of acetyl coenzyme A carboxylase (ACC).

57 downstream target phospho-acetyl-coenzyme A carboxylase (ACC).

58 an allosteric inhibitor of acetyl-coenzyme A carboxylases (ACC) ACC1 and ACC2, reduces hepatic de nov

59 element-binding protein [SREBP], acetyl-CoA carboxylase [ACC], peroxisome proliferator-activator rec

60 reased phosphorylation, decreased acetyl-CoA carboxylase Acc1 phosphorylation, and sterol response el

61 s is regulated by the activity of acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme o

62 of fatty acid synthase (Fas) and acetyl-CoA carboxylase (Acc1).

63 evels in chicken liver, activated acetyl-CoA carboxylase (ACCalpha), and increased FASN, ATP citrate

64 Acetyl-CoA carboxylase (ACCase) catalyzes the committed step of de

65 Acetyl-CoA carboxylase (ACCase) catalyzes the first committed step

66 C2) that targets homomeric acetyl-coenzyme A carboxylase (ACCase) to plastids.

67 is (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this

68 Acetone carboxylases (ACs) catalyze the conversion of substrates

69 s of pyruvate kinase and phosphoenolpyruvate carboxylase activities indicate that pyruvate is supplie

70 olysis, hepatic acetyl CoA content, pyruvate carboxylase activity and hepatic glucose production.

71 evolution, despite its competition with the carboxylase activity necessary for carbon fixation, yet

72 They enhance the carboxylase activity of RuBisCO by increasing the local

73 High ratios of RuBisCO:phosphoenolpyruvate carboxylase activity support a C(3) mode of photosynthes

74 ssing seeds indicated the in vivo acetyl-CoA carboxylase activity was reduced to approximately half t

75 ydroxylase alleviated the reduced acetyl-CoA carboxylase activity, restored the rate of fatty acid sy

76 ropose may be related to phosphoenolpyruvate carboxylase activity.

77 nctional enzyme phosphoribosylaminoimidazole carboxylase (AIRC, EC 4.1.1.21)/phosphoribosylaminoimida

78 hosphate synthetase 1 (urea cycle), pyruvate carboxylase (anaplerosis, gluconeogenesis), propionyl-Co

79 ynthesis and consists of two enzymes: biotin carboxylase and carboxyltransferase.

80 is associated with activation of acetyl-CoA carboxylase and changes in the expression profiles of re

81 sis, as well as the expression of acetyl-CoA carboxylase and fatty acid synthase.

82 ssion of the mSREBP1 target genes acetyl-CoA carboxylase and fatty-acid synthase was suppressed, alon

83 RNAs for simultaneous repression of pyruvate carboxylase and glutaminase by selecting all seed matche

84 g AMPK-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K/AKT pathway throu

85 sts, and this flux depended on both pyruvate carboxylase and malic enzyme 1 activity.

86 stimulated flux through phosphoenolpyruvate carboxylase and malic enzyme, altered the balance betwee

87 ng enzyme AMPK, and inhibition of acetyl-CoA carboxylase and mammalian target of rapamycin signaling

88 ltiple biotin-related genes, disrupting both carboxylase and mitochondrial function.

89 nslational regulation of phosphoenolpyruvate carboxylase and nitrate reductase.

90 al human enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarbo

91 AMPK-mediated phosphorylation of acetyl-CoA carboxylase and polyunsaturated fatty acid biosynthesis.

92 flux rates through PDH, as well as pyruvate carboxylase and pyruvate cycling activities, are signifi

93 orylate its endogenous substrates acetyl CoA carboxylase and Raptor, and provokes mitochondrial bioge

94 activity of the anabolic factors acetyl-CoA carboxylase and ribosomal protein S6 and inhibiting aero

95 pheric CO(2) is fixed by phosphoenolpyruvate carboxylase and stored as malic acid in the vacuole.

96 abolic pathway from NaAD using unprecedented carboxylase and sulfur transferase reactions to form the

97 keto acid dehydrogenase E1 component, biotin carboxylase and superoxide dismutase were related to ene

98 a conserved component among biotin-dependent carboxylases and catalyzes the MgATP-dependent carboxyla

99 these proteins likely function as guanidine carboxylases and guanidine transporters, respectively.

100 the expression of proteins annotated as urea carboxylases and multidrug efflux pumps.

101 anaplerosis, gluconeogenesis), propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase (branc

102 g-term irreversible inhibition of ACETYL-COA CARBOXYLASE, and consequently FA synthesis.

103 sed phosphorylation of raptor and acetyl-CoA carboxylase, and decreased phosphorylation of ULK1 (Ser-

104 malic acid inhibition of phosphoenolpyruvate carboxylase, and enzyme kinetics) was simulated.

105 y element-binding protein, acetyl coenzyme A carboxylase, and fatty acid synthase.

106 nt-binding protein 1c (SREBP-1c), acetyl-CoA carboxylase, and fatty-acid synthase, three key function

107 enolpyruvate carboxykinase (PEPCK), pyruvate carboxylase, and glucose-6-phosphatase, and the neonate'

108 red the phosphorylations of AMPK, acetyl CoA carboxylase, and glycogen synthase kinase-3, decreased g

109 lement-binding proteins 1c and 2, acetyl-CoA carboxylase, and HMG-CoA reductase mRNAs/proteins and in

110 -CoA content, a potent activator of pyruvate carboxylase, and increased glycerol conversion to glucos

111 n fatty acid synthesis, including acetyl-CoA carboxylase, and three out of five putative type II digl

112 Carboxylases are biocatalysts that capture and convert c

113 Biotin-dependent carboxylases are widely distributed in nature and have i

114 Interestingly, pyruvate carboxylase ASO also reduced adiposity, plasma lipid con

115 Pyruvate carboxylase ASO did not alter de novo fatty acid synthes

116 1-c, SREBP2, fatty-acid synthase, acetyl-CoA carboxylase, ATP citrate lyase, and Glut-1 were signific

117 ACC contains biotin carboxylase (BC) and carboxyltransferase (CT) activities

118 LmPC), a biotin-dependent enzyme with biotin carboxylase (BC) and carboxyltransferase (CT) activities

119 catalyzed by the holo-ACC components, biotin carboxylase (BC) and carboxyltransferase (CT), were simu

120 an competently and independently bind biotin carboxylase (BC) but differ in responses to pH changes r

121 ncy of pyridopyrimidine inhibitors of biotin carboxylase (BC) by up to 64-fold and 16-fold against Es

122 Biotin carboxylase (BC) is a conserved component among biotin-d

123 PC contains biotin carboxylase (BC), carboxyltransferase (CT) and biotin ca

124 consists of four catalytic subunits: biotin carboxylase (BC), carboxyltransferase (CT)-alpha, CT-bet

125 Finally, carboxylase biotin levels are reduced in mammalian tauop

126 yl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase (branched chain amino acids catabolism).

127 esign to engineer these enzymes further into carboxylases by increasing interactions of the proteins

128 gulation of the model C4 phosphoenolpyruvate carboxylase (C4-Pepc) promoter in maize (Zea mays).

129 x ), the maximum rate of phosphoenolpyruvate carboxylase carboxylation (Vpmax ), and foliar dark resp

130 In human cells, biotin-dependent carboxylases catalyze key reactions in gluconeogenesis,

131 ncoding a plastid-targeted acetyl-coenzyme A carboxylase, cause hypersensitivity to spectinomycin.

132 ioesters catalysed by crotonyl-CoA reductase/carboxylase (CCRC) homologues.

133 e AMPK substrates, p53 and acetyl-coenzyme A carboxylase, changes that correlated with increased miR-

134 on hypotheses by feeding leaves with the PEP carboxylase competitive inhibitors malate and diethyl ox

135 34H encodes a 3-octaprenyl-4-hydroxybenzoate carboxylase (CpsUbiX, UniProtKB code: Q489U8) that is in

136 cle defects, organic acidurias, and pyruvate carboxylase deficiency as a treatable condition in the d

137 host was supported by experiments with a PEP carboxylase-deficient mutant strain in blood and cerebro

138 c group must first gain access to the biotin carboxylase domain and become carboxylated and then tran

139 version, consisting of little more than the carboxylase domain of the plastidic accD gene fused to a

140 s and shed light on the emergence of natural carboxylases during evolution.

141 onments, where heteromeric acetyl-coenzyme A carboxylase encoded in part by the chloroplast genome ca

142 Microorganisms use carboxylase enzymes to form new carbon-carbon bonds by i

143 We confirmed that BPL-1 biotinylates four carboxylase enzymes, and we demonstrate that BPL-1 is re

144 tty acid synthesis genes, namely, acetyl-CoA carboxylase, fatty acid synthase, SREBP1c, chREBP, gluco

145 al citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC) in vivo.

146 hepatic mitochondrial oxidation and pyruvate carboxylase flux in healthy volunteers following both an

147 decreased, whereas rates of hepatic pyruvate carboxylase flux remained unchanged.

148 sis, hepatic acetyl-CoA content and pyruvate carboxylase flux, while also increasing mitochondrial fa

149 ssue (WAT) leading to reductions in pyruvate carboxylase flux.

150 acetyl-CoA allosteric activation of pyruvate carboxylase flux.

151 uvate dehydrogenase and anaplerotic pyruvate carboxylase fluxes.

152 one, the latter required by the enzyme gamma-carboxylase for gamma-carboxylation of all vitamin K-dep

153 used bioinformatics to identify a "sleeping carboxylase function" in the superfamily of medium-chain

154 ession of genes encoding PEX7 and acetyl-CoA carboxylase further improved fatty alcohol production by

155 Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudom

156 First, the phosphoenolpyruvate carboxylase gene (ppc) from Klebsiella pneumoniae was ov

157 e dexamethasone system to silence acetyl-CoA carboxylase gene and observed prolific root growth when

158 trix, OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a ce

159 associated with mutations in gamma-glutamyl carboxylase (GGCX) that often has fatal outcomes.

160 tem for studying mutations in gamma-glutamyl carboxylase (GGCX), the enzyme responsible for convertin

161 Eleven spontaneous mutations of acetyl-CoA carboxylase have been identified in many herbicide-resis

162 crystal structure of the long-chain acyl-CoA carboxylase holoenzyme from Mycobacterium avium subspeci

163 and BCCP domains and other biotin-dependent carboxylase holoenzymes are known, there is currently no

164 ses a multicomponent, heteromeric acetyl-CoA carboxylase (htACCase), which catalyzes the generation o

165 ain (120 kDa), multi-domain biotin-dependent carboxylase in bacteria.

166 on catalyzed by phosphoribosylaminoimidazole carboxylase in purine metabolism.

167 increased UCP-3 and inhibition of acetyl-CoA carboxylase in skeletal muscle, findings consistent with

168 Carbonic anhydrase and phosphoenolpyruvate carboxylase in vitro activity varied significantly despi

169 ibited increased sensitivity to the pyruvate carboxylase inhibitor phenylacetate.

170 ession of fatty acid synthase and acetyl-CoA carboxylase involved in de novo biosynthesis of palmitat

171 Tissue-specific inhibition of pyruvate carboxylase is a potential therapeutic approach for nona

172 metabolic diseases in humans, and acetyl-CoA carboxylase is a target for drug discovery in the treatm

173 In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool

174 ed protein kinase called phosphoenolpyruvate carboxylase kinase (PPCK).

175 s (67%-82%) coding the ribulose-bisphosphate carboxylase large chain in the Calvin cycle.

176 ria monocytogenes by inhibiting its pyruvate carboxylase (LmPC), a biotin-dependent enzyme with bioti

177 luding the central metabolic enzyme pyruvate carboxylase (LmPC).

178 -dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC).

179 rucial in bicarbonate provision for pyruvate carboxylase-mediated oxaloacetate synthesis.

180 levels of Fatty Acid Synthase and Acetyl CoA Carboxylase mRNAs, enzymes responsible for lipid synthes

181 inus resembles aminoimidazole ribonucleotide carboxylase/mutase, LarC binds Ni and could act in Ni de

182 stinct lineages of biotin-dependent acyl-CoA carboxylases, one carboxylating the alpha carbon of a sa

183 result of enhanced activity of cytosolic PEP carboxylase or by limited supply of energetic and reduct

184 Ribulose 1,5 bisphosphate carboxylase oxygenase (Rubisco) concentrations were quan

185 educed affinity of ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCO) to CO2 under conditions

186 lvin Cycle enzyme, Ribulose 1,5 bisphosphate carboxylase oxygenase (Rubisco).

187 re BMCs containing ribulose-1,5-bisphosphate carboxylase oxygenase and carbonic anhydrase that enhanc

188 tosynthesis (e.g., ribulose-1,5-bisphosphate carboxylase oxygenase genes rbcS and rbcL), imply large-

189 colate formed when ribulose-1,5-bisphosphate carboxylase-oxygenase oxygenates rather than carboxylate

190 100 genes encoding ribulose-1,5 bisphosphate carboxylase-oxygenase subunit proteins of the Calvin cyc

191 ies of the enzymes ribulose 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilit

192 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) activase (Rca) is a AAA(

193 Ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase uses the energy

194 boxysomal enzymes, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (

195 n by concentrating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 wi

196 of carbon, ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (Rubisco) catalyzes primary carbon

197 The enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyzes two competing

198 O(2) fixing enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) forms dead-end inhibited

199 rbon-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) in a paracrystalline lat

200 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) is a critical yet severe

201 CO2-fixing enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (rubisco) is inhibited by nonprodu

202 Ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the cornerstone of at

203 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the key enzyme involv

204 hetic organisms, D-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the major enzyme assi

205 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the most abundant enz

206 Ribulose-1,5-biphosphate carboxylase/oxygenase (Rubisco) is the most abundant enz

207 CO2-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) often limit plant produc

208 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) plays a critical role in

209 (2)-fixing enzymes ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) to enhance carbon assimi

210 unolocalization of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) to show that the sterile

211 ntalize the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.

212 om the reaction of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) with O2 instead of CO2 ,

213 e dikinase (PPDK), ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), and phosphoenolpyruvate

214 zyme of the CBB cycle, ribulose-bisphosphate carboxylase/oxygenase (RubisCO), is a main determinant o

215 ion at the site of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), simultaneously enhancin

216 Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), the carboxylating enzym

217 CO2 fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

218 e carboxylating enzyme ribulose bisphosphate carboxylase/oxygenase (RuBisCO).

219 ion at the site of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

220 alog-bound form II ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

221 on the function of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco).

222 O(2) concentration for Ribulose bisphosphate carboxylase/oxygenase (Rubisco).

223 sulate the enzymes ribulose 1,5-bisphosphate carboxylase/oxygenase and carbonic anhydrase.

224 e small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase and its reverse peptide with a ser

225 e dual activity of ribulose-1,5-bisphosphate carboxylase/oxygenase and the resulting loss of CO(2) by

226 Mg(2+) within the ribulose-1,5-bisphosphate carboxylase/oxygenase family of enzymes.

227 imple kinetic model of ribulose bisphosphate carboxylase/oxygenase function.

228 enitrification and ribulose 1,5-bisphosphate carboxylase/oxygenase gene clusters, underscoring its ab

229 Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) catalyses the key reaction in the

230 Rubisco (d-ribulose 1,5-bisphosphate carboxylase/oxygenase) is responsible for the vast major

231 ng enzyme Rubisco (ribulose 1,5-bisphosphate carboxylase/oxygenase) to release tightly bound sugar ph

232 ng enzyme Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase), a major component of the liquid-

233 ss II aldolase, or ribulose 1,5-bisphosphate carboxylase/oxygenase, large subunit (RuBisCO) superfami

234 ontribution of the ribulose-1,5-bisphosphate carboxylase/oxygenase-bypass to seed storage metabolism

235 the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase.

236 cid oxidation, activated the AMPK-acetyl-CoA carboxylase pathway, and promoted inefficient metabolism

237 rent correlation with gluconeogenic pyruvate carboxylase (PC) activity in hepatocytes.

238 mine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively.

239 Pyruvate carboxylase (PC) has important roles in metabolism and i

240 in the structure of the tetrameric pyruvate carboxylase (PC) holoenzyme.

241 Pyruvate carboxylase (PC), a multifunctional biotin-dependent enz

242 ression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished production of

243 y of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC) composed of six alpha (PCCA) and six b

244 onyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC).

245 The activities of phosphoenolpyruvate (PEP) carboxylase (PEPC) and the PEP-regenerating enzyme, pyru

246 Phosphoenolpyruvate carboxylase (PEPC) is a crucial enzyme that catalyzes an

247 Phosphoenolpyruvate carboxylase (PEPC) is a tightly controlled cytosolic enz

248 ymatic rates of Rubisco, phosphoenolpyruvate carboxylase (PEPc), and carbonic anhydrase (CA).

249 e for C4 photosynthesis, Phosphoenolpyruvate Carboxylase (PEPC), evolved from nonphotosynthetic PEPC

250 oxygenase (RuBisCO), and phosphoenolpyruvate carboxylase (PEPc).

251 tion after inhibition of phosphoenolpyruvate carboxylases (PEPCs), and increases in PEPC transcript a

252 le via a stage-dependent phosphoenolpyruvate carboxylase/phosphoenolpyruvate carboxykinase process th

253 ed AMPK activation and downstream acetyl-CoA carboxylase phosphorylation and glucose uptake in isolat

254 vels, and diminished acetyl coenzyme A (CoA) carboxylase phosphorylation than in the wild-type livers

255 Acetyl-CoA carboxylase phosphorylation was increased in gastrocnemi

256 K activity, particularly phosphoenolpyruvate carboxylase (PPC) and PPDK in rNAD-ME1.

257 production of the enzyme phosphoenolpyruvate carboxylase (PPC) and that adventitious overexpression o

258 quences of the C(4) type phosphoenolpyruvate carboxylase (Ppc) gene from three C(4) grass species cou

259 Phosphoenolpyruvate carboxylase (PPC; EC 4.1.1.31) catalyzes primary nocturn

260 CO(2) in the dark using phosphoenolpyruvate carboxylase (PPC; EC 4.1.1.31).

261 osphate synthase (PpsAB) and phenylphosphate carboxylase (PpcABCD) and syntrophic terephthalate-degra

262 EPC is phosphorylated by Phosphoenolpyruvate Carboxylase Protein Kinase (PPCK).

263 ecimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemi

264 umulated a chloroplastic phosphoenolpyruvate carboxylase protein, albeit at reduced amounts relative

265 or biotin auxotrophs and identified pyruvate carboxylase (Pyc) as required for biotin biosynthesis.

266 low CO2 , including both PEPCs and pyruvate carboxylase (PYC), whereas ME abundance did not change a

267 s in the acetyl-CoA binding site of pyruvate carboxylase (PycA) rescued cefuroxime resistance and res

268 taacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase from R. sphaeroides was attributed

269 asses of carboxylating enzymes are enoyl-CoA carboxylases/reductases (Ecrs), which outcompete the pla

270 Many bicarbonate-incorporating carboxylases rely on the organic cofactor biotin for the

271 ilitating high CO(2) concentrations near the carboxylase Rubisco.

272 d an archaeal-type ribulose-1,5-bisphosphate carboxylase (RubisCO) involved in AMP recycling.

273 lvin cycle enzyme, ribulose 1,5-bisphosphate carboxylase (RubisCO), prevents photoheterotrophic growt

274 ptation is that of ribulose-1,5-bisphosphate carboxylase (RubisCO), the enzyme responsible for fixati

275 The engineered carboxylases show improved CO(2)-binding and kinetic par

276 AMP-activated protein kinase and acetyl-CoA carboxylase signaling.

277 e, we show that the chloroplastic acetyl-CoA carboxylase subunit (accD) gene that is present in the p

278 in steady-state behavioural assays, acetone carboxylase subunit (acxC) mutant behaviour was altered.

279 protease subunit (clpP)-like and acetyl-CoA carboxylase subunit D (accD)-like open reading frames.

280 translation of the plastid-encoded ACC beta-carboxylase subunit.

281 1, and LHCB4), the ribulose 1.5-bisphosphate carboxylase subunits (rbcL and RbcS), and enzymes of chl

282 mide activated AMPK and inhibited acetyl-CoA carboxylase, suggesting activation of fat metabolism in

283 at the otherwise integrative enzyme pyruvate carboxylase (TgPyC) is dispensable not only in glycolysi

284 A and T7A substitutions result in functional carboxylases that are poorly activated by Rca, indicatin

285 ng system provided by a cytosolic acetyl-CoA carboxylase, the mitochondrial AAE13 protein is essentia

286 The activity of pyruvate carboxylase, the predominant enzyme for anaplerotic repl

287 x mutations on the sensitivity of acetyl-CoA carboxylase to nine herbicides representing the three ch

288 version of lactate to pyruvate, via pyruvate carboxylase to oxaloacetate, and via PCK2 to phosphoenol

289 pathways with varying flux ratio of RubisCO carboxylase to oxygenase may contribute to the adaptive

290 ene that targets homomeric acetyl-coenzyme A carboxylase to plastids, where the multidomain protein c

291 structure-function relationships of acyl-CoA carboxylases, trans-carboxytransferases, malonyltransfer

292 mary downstream targeting enzyme, acetyl-CoA carboxylase, up-regulated gene expression of carnitine p

293 The activity of pyruvate carboxylase was low in muscle, and no PEP carboxykinase

294 canola endogenous reference gene (acety-CoA-carboxylase) was constructed and used for duplex real-ti

295 os of PEPC and PPDK to ribulose bisphosphate carboxylase were substantially lower than 1, even at low

296 lism caused by a deficiency of propionyl CoA carboxylase which often manifests with frequent metaboli

297 he plastid-encoded subunit of the acetyl-CoA carboxylase, which catalyzes the first and rate-limiting

298 Pyruvate carboxylase, which catalyzes the first step of gluconeog

299 e may be fixed via the ribulose bisphosphate carboxylase, Wood-Ljungdahl pathway or reductive TCA cyc

300 of the unusual beta-subunit of the acyl-CoA carboxylase (YCC) responsible for this reaction, alone a