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1 r (1R,3S,4S)-3-amino-4-fluoro cyclopentane-1-carboxylic acid (1), in this work, we rationally designe
2 inhibitor, 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA/hydrogel), to promote regenera
3 oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (43d), showing promising antitumor activ
4 cluding pyocyanin (PYO), 5-methylphenazine-1-carboxylic acid (5-MCA), and 1-hydroxyphenazine (OHPHZ),
7 mino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]28) have been prepared in 10 and
8 mino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]9) and (1S,3S,4R)-1-amino-3-fluo
10 iated stabilization of 1-aminocyclopropane-1-carboxylic acid (ACC) synthases (ACSs), the rate-limitin
11 the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) was found to promote the emergence
12 s immediate precursor, 1-aminocyclopropane-1-carboxylic acid (ACC), is a non-proteinogenic amino acid
13 ng 3a-hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxylic acid (HPIC) in a single, scalable step with e
16 e metabolites including Delta1-piperideine-6-carboxylic acid (P6C), alpha-aminoadipic semialdehyde (a
17 e synthesized a water-based ink using pyrene carboxylic acid (PCA) through non-covalent pai-pai stack
18 oss; low urocanic acid (UCA) and pyrrolidone carboxylic acid (PCA), both of which are filaggrin break
19 degradation of emerging perfluoroalkyl ether carboxylic acid (PFECA) pollutants with ultraviolet-gene
21 -N formation that proceeds through a cascade carboxylic acid activation, acyl azide formation, Curtiu
24 ,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with up to a 1000-fold increas
25 d for the conductance of TPA bridged through carboxylic acid anchoring groups (3.8 x 10(-4)-3.2 x 10(
26 esign due to not only their bioisosterism to carboxylic acid and amide moieties but also to their met
27 A Ugi four-component reaction with indole-2-carboxylic acid and an aniline followed by a Pd-catalyze
29 hed beta-thio-alpha-hydroxy and alpha-chloro carboxylic acid and ester building blocks by diazotizati
30 not impair its ability to act as an ordinary carboxylic acid and to efficiently protonate physiologic
31 king isatoic anhydride-8-amide from isatin-7-carboxylic acid as a tool to easily produce a range of q
32 tified a methyl substitution adjacent to the carboxylic acid as an appropriate means to accomplish fa
35 We report that a readily accessible chiral carboxylic acid catalyst exerts control over asymmetric
38 ism of the asymmetric BINOL-derived hydroxyl carboxylic acid catalyzed allylboration of benzaldehyde
40 cage is capable of co-encapsulating multiple carboxylic acid containing guests in its cavity, and the
41 utility of the E-RANSY method by extracting carboxylic acid containing metabolites from human urine,
42 lites generated from energy expenditure, tri-carboxylic acid cycle, tocopherol, polyamine metabolism,
43 such, the invention of new reactions between carboxylic acid derivatives and amines that strategicall
44 ubstituted piperidines with aryl, alkyl, and carboxylic acid derivatives at multiple different sites.
45 sformations that allow for the conversion of carboxylic acid derivatives to functional groups bearing
48 ide esters (primary, secondary, and tertiary carboxylic acid derived), several saturated and unsatura
50 the intermolecular radical C-H amination of carboxylic acid esters with organic azides via Co(II)-ba
51 ketone synthesis that couples two different carboxylic acid esters, N-hydroxyphthalimide esters and
52 oved applicable to a variety of (hetero)aryl carboxylic acid fluorides as well as diverse diboron rea
53 N-alkyl pyridinium salts with in situ formed carboxylic acid fluorides or 2-pyridyl esters under redu
54 nickel-catalyzed decarbonylative coupling of carboxylic acid fluorides with diboron reagents to selec
55 scent bis-styryl-benzothiadiazole (BTD) with carboxylic acid functional groups (X-34/Congo red analog
57 -COOH monomer, the nanofibrous structure and carboxylic acid functionalisation of Nano-PEDOT-COOH wer
59 ur new VoltageFluor derivatives that possess carboxylic acid functionality for simple conjugation to
60 etraethylene glycol groups terminated with a carboxylic acid functionality were introduced to the CD'
61 bearing three phenol groups and three other carboxylic acid functions, each of these groups on the a
62 nge of 15.6 +/- 3.7 to 70.0 +/- 9.5 nm and a carboxylic acid group density from 0.03 to 0.18 mumol cm
64 was synthesized via an amide linkage between carboxylic acid group of HA and amine group of dopamine.
66 methyl-substituted alkenes with a hydroxy or carboxylic acid group were thus prepared in 51-97 % yiel
67 ransformation of the isoxazole moiety into a carboxylic acid group, thus opening access to dicarboxyl
68 ter was observed with a surfactant bearing a carboxylic acid group, which anchored amine monomers ver
69 cular orientation via dehydrogenation of the carboxylic acid group, which we confirmed using polariza
71 ce with a tunable 3D nanofibrous network and carboxylic acid groups (i.e. Nano-PEDOT-COOH) via contro
73 ling with multi-biorecognition molecules via carboxylic acid groups for the development of a range of
75 e functionalities, e.g., hydroxy, amino, and carboxylic acid groups, glucuronidation can occur at any
79 -4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride (1) was found to be a sele
80 balance between two opposing effects of the carboxylic acid in the reaction mixture: generation of m
81 d use of "dry ozonolysis" to reveal a masked carboxylic acid in the total synthesis of a natural prod
82 trated for the ligand 4'-hydroxyazobenzene-2-carboxylic acid interacting with avidin protein immobili
83 n was further demonstrated by converting the carboxylic acid into cyclopropyl amine without loss of o
84 hyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid is a natural product found in Dodonaea v
85 alcohols to their corresponding aldehyde or carboxylic acid is one of the most important classes of
87 ar and charged anchor point residues for the carboxylic acid moiety of the agonist in the interhelica
89 zation of substrates bearing an alcohol or a carboxylic acid moiety, is highlighted in the context of
90 to the (1S,2R)-2-(aminomethyl)cyclopentane-1-carboxylic acid monomer precursor, which has a cis-confi
91 ear receptor modulators, which often feature carboxylic acid motifs for target engagement, have emerg
92 6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid o-tolylamide (TM(inh)-23) with 30 nM hal
95 p (Z) and at the C-terminus carried either a carboxylic acid or an isophthalic acid (Ipa) anchor grou
98 the substrate, leading to the corresponding carboxylic acid product for the latter, while the former
99 we show the unexplored role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in 2 models of n
100 eimides, M(p) and M(m), each equipped with a carboxylic acid recognition site, results in the formati
101 alcohol oxidase (AO) or (ii) carboxylic acid/carboxylic acid reductase (CAR) to affect N-alkylation r
102 nonribosomal peptide synthetase (NRPS)-like carboxylic acid reductase (Fub8) in making an aliphatic
103 ated by expanding the substrate scope of the carboxylic acid reductase toward noncognate omega-hydrox
104 ion/transformation of AA to 6-ACA and HMD by carboxylic acid reductases (CARs) and transaminases (TAs
106 actions are highly charged and often rich in carboxylic acid side chains(1-5), but the structures of
108 of the same 4-substituted Delta1-pyrroline-2-carboxylic acid substrate, making LmbY and GriH unusual,
112 tween an aryl methyl ether and a neighboring carboxylic acid was developed for creating the chromenon
113 MNPs) coated with poly (pyrrole-co-pyrrole-2-carboxylic acid) (Py/Py-COOH/MNPs) cross-linked with Ab-
114 ecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) and a polyethylene glycol 4 linker, at
115 carbons) and functional groups (sulfonic and carboxylic acid) in zebrafish ( Danio rerio) embryo.
116 2) and VOCs (mainly aldehydes, ketones and a carboxylic acid) were detected as the gaseous products r
118 vel cyclodextrin (CD)-based amphiphilic poly(carboxylic acid)s that self-assemble into highly ordered
120 deprotection for a substrate that contains a carboxylic acid, a known QD-binding group, is accelerate
122 ylic acid (tACBC)(n) with N-aminoazetidine-2-carboxylic acid, an 8-helical topology is shown to domin
123 containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophi
124 and simultaneous emission involving coumarin carboxylic acid, furocoumarin and dansyl aniline played
126 alt hydride occurred in the presence of free carboxylic acid, producing the same alkane enantiomer as
128 fic chemical moieties, namely, allyl, amine, carboxylic acid, thiol, aldehyde, and catechol, were pre
129 ibe the design, synthesis, and evaluation of carboxylic acid-based ACC inhibitors with organic anion
130 our betalains, named indicaxanthin, indoline carboxylic acid-betacyanin, phenylalanine-betaxanthin, a
131 strategy can be generalized to a variety of carboxylic acid-containing drug structures that satisfy
133 re widely used to decrease volatilization of carboxylic acid-containing herbicides including dicamba.
135 have been developed through the addition of carboxylic acid-functionalized polycarbonate block copol
137 s, consisting of poly(ethylene oxide) (PEO), carboxylic acid-functionalized polyphosphoester (PPE), a
139 n of reactive intermediates, including mixed carboxylic acid-phosphoric acid anhydrides, for the synt
146 degrees alcohol/alcohol oxidase (AO) or (ii) carboxylic acid/carboxylic acid reductase (CAR) to affec
147 dihydro-5-(2-methoxyethoxy)-4-oxocinnoline-3-carboxylic acid; Croisor 100) to 27 genotypes in replica
149 -based complex, treatment of a hydroxy- or a carboxylic-acid-containing olefin with commercially avai
150 simultaneously transformed to perfluoroalkyl carboxylic acids (C2-C7 PFCAs) of different chain length
151 s (furfural and 5-hydroxymethylfurfural) and carboxylic acids (lactic acid, succinic acid, fumaric ac
155 ride and sulfate, short-chain perfluorinated carboxylic acids (PFCAs) were identified and quantified
156 yl sulfonic acids (PFSAs) and perfluoroalkyl carboxylic acids (PFCAs) were readily degraded, other st
157 redictor of the enrichment of perfluoroalkyl carboxylic acids (PFCAs) with >=7 perfluorinated carbons
158 oefficients, K(mem/w), of six perfluoroalkyl carboxylic acids (PFCAs), three perfluoroalkanesulfonic
159 lfonates (PFSAs, C(4-12)), 10 perfluoroalkyl carboxylic acids (PFCAs, C(4-13)), and perfluorooctane s
160 ge: 1-110 ng/g) and two perfluorinated ether carboxylic acids (PFO(4)DA and PFO(5)DoDA; PFO(5)DoDA ra
161 PFAA congeners, summation of perfluoroalkyl carboxylic acids (SigmaPFCAs), and SigmaPFAAs correlated
162 ess, probably owing to differences in target carboxylic acids (which can bind to the aniline (AN) m-a
163 his deterrence is based on the feces-emitted carboxylic acids 3-methylpentanoic acid and hexanoic aci
164 oxidants for the construction of esters from carboxylic acids and alcohols in the presence of stoichi
168 tereoisomers of tetrasubstituted azetidine-2-carboxylic acids and derivatives that possess three chir
169 d NSSM, respectively, which mainly belong to carboxylic acids and derivatives, polyketides and fatty
170 sing the measured (-)ESI efficiencies of the carboxylic acids and dimer esters as more representative
171 ity of the reaction in the presence of other carboxylic acids and its utility in the functionalizatio
174 xidation of residual carbon atoms first into carboxylic acids and then volatile carbon species, while
175 d variants often require a pre-activation of carboxylic acids and/or employment of costly transition-
179 he developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines
180 The reaction uses naturally abundant organic carboxylic acids as carbon sources, readily prepared azi
181 An alternative approach is to use ubiquitous carboxylic acids as starting materials and perform a dec
182 commodates a large variety of heteroaromatic carboxylic acids as well as olefins, and facilitates a d
183 DFT studies, aided by crystal structures of carboxylic acids bound by the catalyst, point to a plaus
184 chromones, 3-formylchromones, and chromone-3-carboxylic acids by means of visible-light photoredox ca
185 nyl complexes, a chelator was selected whose carboxylic acids can easily be converted into various de
186 hat a Mn-catalyzed C-H oxidation directed by carboxylic acids can overcome these challenges to yield
187 ce of two alpha-methyl groups; (2) aliphatic carboxylic acids containing alpha-hydrogens are compatib
188 s for enantiodiscrimination of alpha-racemic carboxylic acids containing tertiary or quaternary stere
189 method allows unprecedented direct access to carboxylic acids derived from beta,beta-trisubstituted a
191 and epsilon-lactonization reactions of free carboxylic acids enabled by a novel cyclopentane-based m
193 se-catalyzed chemoselective hydroboration of carboxylic acids has been developed with a high turnover
196 and NRPS-like enzymes activate and transform carboxylic acids in both primary and secondary metabolis
197 h cis- and trans-1,3-disubstituted housane-1-carboxylic acids in diastereoselective manner on up to 8
198 s and enantioselectivities, affording chiral carboxylic acids including Naproxen, (S)-Flurbiprofen, a
201 and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environ
202 catalysis (BAC), electrophilic activation of carboxylic acids leads to the formation of amides from a
203 nd used for classification of wines based on carboxylic acids levels, which were indirectly related t
206 reased over time, and >=C(11) perfluorinated carboxylic acids only seem to level off during the last
207 have shown that introducing large amounts of carboxylic acids or ammonium hydroxide to LC eluents pos
208 ed into an aldehyde or ketone (for instance, carboxylic acids or organic carbonate or nitriles) or in
211 alkylation of amines with either alcohols or carboxylic acids represents a mild and safe alternative
212 nessed to activate nucleoside phosphates and carboxylic acids through catalysis by acid and 4,5-dicya
214 ed the gamma-C(sp(3) )-H olefination of free carboxylic acids to form diverse six-membered lactones.
215 A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azahe
216 ght in the presence of acetic acid and other carboxylic acids to generate methyl and alkyl radicals,
219 e N-acylation of glycosamine with a range of carboxylic acids under physiological reaction conditions
220 cert to decarboxylate alpha-beta unsaturated carboxylic acids using a highly modified flavin cofactor
222 tric hydrogenation of alpha,beta-unsaturated carboxylic acids using readily prepared bis(phosphine) c
224 of N-hydroxyimides with ketones, esters, and carboxylic acids was achieved employing the di-tert-buty
225 s and (alpha,beta-unsaturated) nitriles from carboxylic acids was realized through oxidative decarbox
226 initial formation of the Castagnoli-Cushman carboxylic acids was shown to be the case, and their dec
229 one single step, the desired carbon tag into carboxylic acids with no need of structural modification
231 , catalyzing the transvinylation reaction of carboxylic acids without losing their original metatheti
232 s relies upon one high-availability reagent (carboxylic acids) and one low-availability reagent (orga
233 e present in HULIS, oxygen-containing (i.e., carboxylic acids) and reduced-nitrogen-containing organi
236 s revealed methyl ketones, alcohols, esters, carboxylic acids, and nitrogen- and sulfur-containing co
237 carbonyl derivatives, such amides, ester and carboxylic acids, are presented in a systematic manner.
238 alyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides, and aryl/alkenyl boronic
239 turated aliphatic hydrocarbons, esters, free carboxylic acids, as well as minor amounts of amides and
241 cyclic and heterocyclic amines directly with carboxylic acids, by-passing their preactivation as redo
243 droxyphenyl)propanoic and 5-oxopyrrolidine-2-carboxylic acids, diacetyl, acetoin, and an unidentified
244 provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions
245 ylate a wide range of aromatic and aliphatic carboxylic acids, have multiple reusability, and are a r
246 is accepting of a broad scope of alkene and carboxylic acids, including challenging ones that produc
247 is displayed, and application of a range of carboxylic acids, including secondary alpha-amino acids,
250 of amino acids, as well as into alcohols and carboxylic acids, rapidly and in excellent yields, using
251 remote C-H activation reactions of alcohols, carboxylic acids, sulfonates, phosphonates, and amines.
253 ion in the number of glomeruli responding to carboxylic acids-chemicals associated with microbial act
274 g the palladium-catalyzed alpha-arylation of carboxylic aids and secondary amides with aryl halides.
279 mides as fuels to generate transient aqueous carboxylic anhydrides has recently been used in examples
281 ly nucleophilic coupling partners with other carboxylic derivatives (to produce ketones), imines (to
284 er-catalyzed gamma-alkylation of phthalide 3-carboxylic esters has been developed, giving access to 3
287 ly due to the complexation of VO(2+) ions by carboxylic functions at the interface between bitumen an
288 between the skeleton of the molecule and the carboxylic group and the liberation of carbon dioxide.
289 e hydrogen bonds between the ligand proximal carboxylic group and the main chain of two conserved loo
290 ation of the hydroxylated carbon 1 to give a carboxylic group by TcADH2 and TcALDH1, the same enzymes
291 successive oxidation of carbon 10 (C10) to a carboxylic group by TcCHH, a cytochrome P450 oxidoreduct
292 ed that such sugar derived acids with active carboxylic groups could cause instability in products ri
293 tensities higher than those corresponding to carboxylic groups in samples from the supernatant from b
294 (ii) by formation of the amide bonds between carboxylic groups of rGO-Fc(COOH)(2) and amine groups fr
295 of membranes with a greater concentration of carboxylic groups so that it was negative across the ent
296 howed that alcoholic groups are converted to carboxylic groups while reducing Cr (VI) to Cr (III).
299 hod uses carbodiimide chemistry to footprint carboxylic residues, whereby 1-ethyl-3-(3-(dimethylamino
300 eagents exhibiting acidic functional groups (carboxylic, sulfonic), which become deprotonated and neg