ライフサイエンスコーパス: cardiac progenitor

1 smooth muscle cells, endothelial cells, and cardiac progenitors.

2 train WNT signaling and expand the number of cardiac progenitors.

3 sruption of anterior-posterior patterning of cardiac progenitors.

4 on factors Ci-ets1/2 and Ci-mesp to generate cardiac progenitors.

5 de evidence for Islet-1(+) cells to serve as cardiac progenitors.

6 sed to convert human dermal fibroblasts into cardiac progenitors.

7 , placing Tbx5 upstream or parallel to Hh in cardiac progenitors.

8 d signaling-directed (CASD) reprogramming to cardiac progenitors.

9 y which Hand2 may influence expansion of the cardiac progenitors.

10 sient or whether RA has sustained effects on cardiac progenitors.

11 elopment and is achieved by proliferation of cardiac progenitors.

12 wnstream of FGF receptor tyrosine kinases in cardiac progenitors.

13 (P<0.01) in the number of c-kit(+)/GATA4(+) cardiac progenitors.

14 ling regulates proliferation and survival of cardiac progenitors.

15 rs that are expressed in neighboring sets of cardiac progenitors.

16 the posterior even skipped (eve)-expressing cardiac progenitors.

17 elopment, controlling the early migration of cardiac progenitors.

18 y mesoderm and marks both haematopoietic and cardiac progenitors.

19 s, or differentiation capacities of specific cardiac progenitors.

20 t development requires precise allocation of cardiac progenitors.

21 anonical Wnt signaling promoted expansion of cardiac progenitors after initial commitment and was req

22 he adult epicardium is a potential source of cardiac progenitors after myocardial infarction (MI).

23 Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblast

24 rely co-localizes with the expression of the cardiac progenitor and myogenic marker Nkx2.5, or that o

25 Nog cells also results in ectopically placed cardiac progenitors and cardiomyocytes in the somites.

26 by the lack of genetic tools to purify early cardiac progenitors and define their developmental poten

27 ical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocyte

28 in situ, such as reactivation of endogenous cardiac progenitors and induction of cardiomyocyte proli

29 beta-catenin is required for development of cardiac progenitors and is a positive regulator of proli

30 reduced ability to give rise to mesodermal, cardiac progenitors and mature cardiomyocytes and an enh

31 ese findings elucidate the origin of cKit(+) cardiac progenitors and suggest that a nonpermissive car

32 dge is limited regarding the interactions of cardiac progenitors and surrounding ECM during dramatic

33 ignificantly in lineage-specific iPS-derived cardiac progenitors, and these progenitor cells can be i

34 o function during vertebrate development and cardiac progenitors are among the first cell lineages to

35 ugh Isl1 expression is downregulated in most cardiac progenitors as they differentiate, analysis of a

36 associated with an overall decrease of early cardiac progenitors as well as a reduction in the area o

37 ed induction, proliferation and viability of cardiac progenitors as well as up-regulation of genes as

38 urified proteins reprograms fibroblasts into cardiac progenitors, as shown by the de novo appearance

39 nscription factors during differentiation of cardiac progenitors at embryonic day 9.0.

40 143 are co-transcribed in multipotent murine cardiac progenitors before becoming localized to smooth

41 We show that CPPs arise from cardiac progenitors before lung development.

42 gineering technologies with patient-specific cardiac progenitor biology holds great promise for the d

43 lt myocytes to proliferate and may influence cardiac progenitor biology.

44 on cardiogenesis, promoting the induction of cardiac progenitors but later inhibiting their different

45 t Wnt3a concomitantly guides the movement of cardiac progenitors by a novel mechanism involving RhoA-

46 jumu and CHES-1-like control the division of cardiac progenitors by regulating the activity of Polo,

47 it gene expression in iPSCs and iPSC-derived cardiac progenitors, cardiomyocytes, and T lymphocytes.

48 Deletion of Ezh2 in cardiac progenitors caused postnatal myocardial patholog

49 Endogenous cardiac progenitor cell (CPC) activation may partially o

50 sults from clinical trials support expanding cardiac progenitor cell (CPC) based therapies.

51 ction and mechanisms of SWI/SNF in mediating cardiac progenitor cell (CPC) differentiation during car

52 ) mice arises as a consequence of defects in cardiac progenitor cell (CPC) function, and that neonata

53 aging myopathy dictated by depletion of the cardiac progenitor cell (CPC) pool is unknown.

54 diac-specific Pim-1 kinase expression on the cardiac progenitor cell (CPC) population were examined t

55 KEY POINTS: Autologous cardiac progenitor cell (CPC) therapy is a promising app

56 of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat

57 was to demonstrate the enhancement of human cardiac progenitor cell (hCPC) reparative and regenerati

58 ) reporter gene imaging for monitoring human cardiac progenitor cell (hCPC) transplantation in a mous

59 cell [FhCPC]) and adult failing (adult human cardiac progenitor cell [AhCPC]) hearts, as well as youn

60 CPCs isolated from human fetal (fetal human cardiac progenitor cell [FhCPC]) and adult failing (adul

61 ac progenitor cell [YCPC]) and old mice (old cardiac progenitor cell [OCPC]), were studied for senesc

62 ell [AhCPC]) hearts, as well as young (young cardiac progenitor cell [YCPC]) and old mice (old cardia

63 hat the local trophic effects of MSC require cardiac progenitor cell and CM-CXCR4 expression and are

64 The role played by the Notch pathway in cardiac progenitor cell biology remains to be elucidated

65 Although transcription factors involved in cardiac progenitor cell differentiation have been descri

66 in a Notch1-independent manner, and regulate cardiac progenitor cell differentiation in an endocytosi

67 Numb regulated cardiac progenitor cell differentiation in an endocytosi

68 itional depletion of JMJD3 leads to impaired cardiac progenitor cell differentiation, phenocopying th

69 MiRNAs have also been implicated in resident cardiac progenitor cell differentiation.

70 CHES-1-like) and Jumeau (Jumu), which govern cardiac progenitor cell divisions by regulating Polo kin

71 khead domain TFs and Polo kinase to regulate cardiac progenitor cell divisions.

72 erentiation or significant contribution from cardiac progenitor cell expansion and differentiation in

73 d enhancer with genes that play key roles in cardiac progenitor cell function and cardiovascular deve

74 ic link between this surface transporter and cardiac progenitor cell function.

75 s, with selective increases in expression of cardiac progenitor cell markers and reduced differentiat

76 rine embryos that exhibit a full spectrum of cardiac progenitor cell or cardiomyocyte ablation.

77 congenital malformation, the consequences of cardiac progenitor cell or embryonic cardiomyocyte loss

78 l infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the inefficient recrui

79 the molecular identities of these different cardiac progenitor cell populations appear to be distinc

80 epair consistent with impairment of resident cardiac progenitor cell proliferative capacity associate

81 beling positive CM (-44%, P<0.01), increased cardiac progenitor cell recruitment (100.9%, P<0.01), an

82 ABSTRACT: Autologous cardiac progenitor cell therapy is a promising alternati

83 at therapies targeting this axis may enhance cardiac-progenitor cell-based regenerative therapy.

84 Percentages of cardiac progenitor cells (c-kit+ cells) and mononucleate

85 both neonatal rat cardiomyocytes (NRCM) and cardiac progenitor cells (CPC) upon exposure to doxorubi

86 Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusio

87 We report that c-kit-positive cardiac progenitor cells (CPCs) activated with insulin-l

88 and perform side-by-side comparison between cardiac progenitor cells (CPCs) and cardiomyocytes (CMs)

89 An analysis of the clonality of cardiac progenitor cells (CPCs) and myocyte turnover in

90 Cardiac progenitor cells (CPCs) and other stem cell type

91 Cardiac progenitor cells (CPCs) and skin fibroblasts fro

92 Autologous c-kit(+) cardiac progenitor cells (CPCs) are currently used in th

93 Cardiac progenitor cells (CPCs) are thought to different

94 s in the mouse heart tube are hypoxic, while cardiac progenitor cells (CPCs) expressing islet 1 (ISL1

95 rived from mouse ES (mES) cells, we isolated cardiac progenitor cells (CPCs) from differentiating mES

96 of ischemic myocardium and whether c-kit(+) cardiac progenitor cells (CPCs) function can be enhanced

97 However, the role of CaMKIIdelta in cardiac progenitor cells (CPCs) has not been previously

98 Cardiac progenitor cells (CPCs) have been shown to promo

99 We tested whether cardiac progenitor cells (CPCs) implanted in proximity o

100 Transfer of cardiac progenitor cells (CPCs) improves cardiac functio

101 Cardiac progenitor cells (CPCs) in the niches express No

102 We recently identified a population of cardiac progenitor cells (CPCs) in zebrafish expressing

103 e a versatile population of Sca-1(+)/CD45(-) cardiac progenitor cells (CPCs) into endothelial cells a

104 ABSTRACT: Therapeutic use of c-kit(+) cardiac progenitor cells (CPCs) is being evaluated for r

105 T) and PG(TR) were expressed in c-Kit+:Sca1+ cardiac progenitor cells (CPCs) isolated from the hearts

106 Cardiac progenitor cells (CPCs) must control their numbe

107 Cardiac progenitor cells (CPCs) possess the insulin-like

108 We now show that Nkx2-5(+) cardiac progenitor cells (CPCs) that express the Sry-typ

109 In vertebrate embryos, cardiac progenitor cells (CPCs) undergo long-range migra

110 nerative potential of adoptively transferred cardiac progenitor cells (CPCs) via genetic engineering

111 Cardiac progenitor cells (CPCs) were isolated from trans

112 Here, we hypothesize that codelivery of cardiac progenitor cells (CPCs) with a nonviral minicirc

113 teome of human embryonic stem cells (hESCs), cardiac progenitor cells (CPCs), and cardiomyocytes duri

114 tent stem cells (hPSCs), adult heart-derived cardiac progenitor cells (CPCs), and reprogrammed fibrob

115 c characteristics and the secretome of human cardiac progenitor cells (CPCs), and their potential to

116 the transition from mesodermal precursors to cardiac progenitor cells (CPCs).

117 d recent therapeutic application of resident cardiac progenitor cells (CPCs).

118 f aged stem cells and in particular c-kit(+) cardiac progenitor cells (CPCs).

119 tential mechanisms by which diabetes affects cardiac progenitor cells (CPCs).

120 ssociated with cellular senescence in c-kit+ cardiac progenitor cells (CPCs).

121 Human cardiac progenitor cells (hCPC) improve heart function a

122 2+ initiate division of c-kit-positive human cardiac progenitor cells (hCPCs) and determine their fat

123 Human cardiac progenitor cells (hCPCs) are a promising cell so

124 harmacological/genetic modification of human cardiac progenitor cells (hCPCs) are necessary intervent

125 on is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically c

126 ogous stem cell therapy using human c-Kit(+) cardiac progenitor cells (hCPCs) is a promising therapeu

127 Human cardiac progenitor cells (hCPCs) may promote myocardial

128 generate expandable and multipotent induced cardiac progenitor cells (iCPCs) from mouse adult fibrob

129 er, reprogramming into proliferative induced cardiac progenitor cells (iCPCs) remains to be accomplis

130 it(+) cell populations yielding a mixture of cardiac progenitor cells and endothelial progenitor cell

131 ISL1 is expressed in cardiac progenitor cells and plays critical roles in car

132 eacetylation of Gata4, which is expressed by cardiac progenitor cells and plays critical roles in the

133 can improve the engraftment of transplanted cardiac progenitor cells and therapeutic efficacy for tr

134 After cardiac injury, cardiac progenitor cells are acutely reduced and are rep

135 RATIONALE: Cardiac progenitor cells are an attractive cell type for

136 Cardiac progenitor cells are an attractive cell type for

137 Multipotent cardiac progenitor cells are found in the fetal and adul

138 Cardiac progenitor cells are multipotent and give rise t

139 From a clinical perspective, the ideal cardiac progenitor cells are those that can proliferate,

140 cessary and sufficient to specify a field of cardiac progenitor cells as the heart-valve-inducing reg

141 gle-cell RNA sequencing to interrogate early cardiac progenitor cells as they become specified during

142 Remarkably, ablation of up to 60% of cardiac progenitor cells at embryonic day 7.5 was well t

143 rentiation of a subset of second heart field cardiac progenitor cells at the epicardium to adipocytes

144 ription factor gene Six1, which functions in cardiac progenitor cells but is stably silenced upon car

145 on of freshly isolated, c-kit-enriched human cardiac progenitor cells confirmed frequent coexpression

146 During mammalian embryogenesis, cardiac progenitor cells constituting the second heart f

147 yoblasts, HL-1 atrial myocytes, and c-kit(+) cardiac progenitor cells demonstrated higher expression

148 mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiote

149 olved image data show that a subset of these cardiac progenitor cells do not overlap with the express

150 In the absence of SHP-2 signaling, cardiac progenitor cells downregulate genes associated w

151 ying enzyme histone deacetylase 3 (Hdac3) in cardiac progenitor cells exhibit precocious cardiomyocyt

152 erived CDCs demonstrated increased number of cardiac progenitor cells expressing c-kit(+), flk-1, and

153 rt-derived cell subpopulations that included cardiac progenitor cells expressing c-kit(+), Islet-1, a

154 ppearing to be more suitable than c-kit(POS) cardiac progenitor cells for widespread clinical therape

155 Primary cardiac progenitor cells formed new human cardiac myocyt

156 tly by a strategy that implements the use of cardiac progenitor cells from the recipient to repopulat

157 elivery, engraftment, and differentiation of cardiac progenitor cells from the recipient.

158 The isolation and culturing of cardiac progenitor cells has demonstrated that growth fa

159 c-kit-expressing cardiac progenitor cells have been reported as the prima

160 Human cardiac progenitor cells have demonstrated great potenti

161 , the mechanisms underlying ISL1 function in cardiac progenitor cells have not been fully elucidated.

162 Cardiac progenitor cells hold great potential for clinic

163 c positional fate maps resolve the origin of cardiac progenitor cells in amniotes.

164 kx2.5, an evolutionarily conserved marker of cardiac progenitor cells in both fields.

165 d abundance and cardiac myogenic capacity of cardiac progenitor cells in failing human hearts, the ne

166 The identification of cardiac progenitor cells in mammals raises the possibili

167 naling leads to premature differentiation of cardiac progenitor cells in mice.

168 muscles share a gene regulatory network with cardiac progenitor cells in pharyngeal mesoderm of the s

169 Resident cardiac progenitor cells in ScaKI mice do not respond to

170 on factor essential for the specification of cardiac progenitor cells in the second heart field, as a

171 ons of impaired growth and survival of ScaKI cardiac progenitor cells in vitro.

172 The molecular basis of the defect in ScaKI cardiac progenitor cells is associated with increased ca

173 Understanding the origins and roles of cardiac progenitor cells is important for elucidating th

174 enitor cells, but the expression of CXCR4 in cardiac progenitor cells is very low.

175 ), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field.

176 rnative strategies using autologous resident cardiac progenitor cells or embryonic stem cell-derived

177 ebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation

178 Infarct size, cardiac function, cardiac progenitor cells recruitment, fibrosis, and card

179 Deletion of Hdac3 in cardiac progenitor cells releases genomic regions from t

180 regeneration by differentiation of recipient cardiac progenitor cells restored a significant portion

181 scored the importance of Gata4 in regulating cardiac progenitor cells specification and differentiati

182 se studies suggest that ISO injury activates cardiac progenitor cells that can differentiate into new

183 ow that Hoxb1 plays a key role in patterning cardiac progenitor cells that contribute to both cardiac

184 ), Fgf10 promotes the proliferation of these cardiac progenitor cells that form the arterial pole of

185 s reveal that Hdac3 plays a critical role in cardiac progenitor cells to regulate early cardiogenesis

186 tion of addition of second heart field (SHF) cardiac progenitor cells to the poles of the heart tube

187 The abundance of these cardiac progenitor cells was increased nearly 4-fold in

188 cKit+ cardiac progenitor cells were BrdU labeled during injury

189 rotein 3 (ltbp3) transcripts mark a field of cardiac progenitor cells with defining characteristics o

190 esult from disruption of discrete subsets of cardiac progenitor cells(1), but the transcriptional cha

191 and the self-renewal and differentiation of cardiac progenitor cells).

192 ecify fate and differentiation in individual cardiac progenitor cells, and exposes mechanisms of disr

193 smooth muscle alpha-actin gene expression in cardiac progenitor cells, as an agonist of myofibroblast

194 humans has identified the presence of adult cardiac progenitor cells, capable of cardiomyogenic diff

195 rentiating into cardiomyocytes like proposed cardiac progenitor cells, cardiac SP cells fuse with pre

196 Human cardiac progenitor cells, cultured as cardiospheres (CSp

197 alized phenotypic properties consistent with cardiac progenitor cells, endothelial progenitor cells,

198 differentiation of mouse and human PSCs into cardiac progenitor cells, followed by intramyocardial de

199 ons for proliferation and differentiation of cardiac progenitor cells, implicate Su(H) in regulating

200 influence of hypoxia on CXCR4 expression in cardiac progenitor cells, on the recruitment of intraven

201 ion via proliferation and differentiation of cardiac progenitor cells, proliferation of pre-existing

202 re we uncover a hierarchical role of ISL1 in cardiac progenitor cells, showing that ISL1 directly reg

203 Among cardiac progenitor cells, there is a distinct subpopulat

204 central regulator of genome organization in cardiac progenitor cells, which is crucial for cardiac l

205 ften result from improper differentiation of cardiac progenitor cells.

206 reMer and the MLC-2v promoters are active in cardiac progenitor cells.

207 tion of dmiR-1 in regulating the polarity of cardiac progenitor cells.

208 s, suggesting that GSK-3beta-MSCs upregulate cardiac progenitor cells.

209 tly higher activation of endogenous c-kit(+) cardiac progenitor cells.

210 fied disease of disrupted differentiation of cardiac progenitor cells.

211 protein (Bmp) signaling regulates miRNAs in cardiac progenitor cells.

212 fied a family of closely related multipotent cardiac progenitor cells.

213 ain survival of proliferating populations of cardiac progenitor cells.

214 nd heart field (SHF), an important source of cardiac progenitor cells.

215 from the second heart field, a population of cardiac progenitors cells (CPCs).

216 in contrast to a proposed role in inhibiting cardiac progenitor (CP) specification.

217 embryonic stem cells (ESCs), mesoderm (MES), cardiac progenitors (CP) and cardiomyocytes (CM)].

218 r regulator MESP1 can by themselves generate cardiac progenitors de novo from fibroblasts, forced coe

219 hes toward this goal, and the engraftment of cardiac progenitors derived from human embryonic stem ce

220 Furthermore, the variability between cardiac progenitors derived from independent iPS lines w

221 inhibits beta-catenin signaling and promotes cardiac progenitor development in differentiating embryo

222 The function of NFPs in cardiac progenitor differentiation and cardiac morphogen

223 Their functions in cardiac progenitor differentiation and cardiac morphogen

224 derstanding of the regulatory hierarchies of cardiac progenitor differentiation and outflow tract dev

225 ment of JMJD3 to specific target loci during cardiac progenitor differentiation, but also modulates i

226 lethal and displayed a variety of defects in cardiac progenitor differentiation, cardiomyocyte prolif

227 a-catenin is required for Isl1 expression in cardiac progenitors, directly regulating the Isl1 promot

228 murine ETS2 has a critical role in directing cardiac progenitors during cardiopoiesis in embryonic st

229 g in the establishment of haematopoietic and cardiac progenitors during embryogenesis.

230 Individual cardiac progenitors emerge at defined positions within e

231 ied tmem88a, which is expressed in the early cardiac progenitor field and was previously implicated i

232 thesis that appropriate Fgf signaling in the cardiac progenitor field downstream of RA signaling is r

233 econd lineage myocardium revealing that this cardiac progenitor field is patterned asymmetrically.

234 but its identity and contribution to the two cardiac progenitor 'fields' has remained undefined.

235 ctivation enables expansion and migration of cardiac progenitors, followed by Wnt inhibition permitti

236 adigm defining molecular requirements in SHF cardiac progenitors for cardiac septum morphogenesis has

237 ings provide insight into the arrangement of cardiac progenitors for systemic circulation.

238 ude that pnr is not only essential for early cardiac progenitor formation, along with tinman and T-bo

239 imposed by retinoic acid signaling to select cardiac progenitors from a multipotent population.

240 an approach for generating large numbers of cardiac progenitors from ES cells.

241 diated effector mechanism that downregulates cardiac progenitor genes and enhances myocardial differe

242 NA-17-92 seed sequences within the 3' UTR of cardiac progenitor genes such as Isl1 and Tbx1.

243 bone marrow cells or putative adult resident cardiac progenitors has been largely disproven.

244 Identification of multipotent cardiac progenitors has provided important insights into

245 Several categories of cardiac progenitors have been described but, thus far, t

246 In the chick, cardiac progenitors have been mapped in the epiblast of

247 ell documented; however, migration routes of cardiac progenitors have not been directly observed with

248 tal hearts suggested that Islet-1 also marks cardiac progenitors in adult life.

249 Using FACS enrichment of cardiac progenitors in RBPJ and RBPJ/Axin2 mutants, embr

250 utflow tract myocardial differentiation from cardiac progenitors in vivo.

251 can instruct the differentiation of chamber cardiac progenitors into specialized conduction-like cel

252 diated repression of Six1 in differentiating cardiac progenitors is essential for stable gene express

253 e find that Fgf8a, which is expressed in the cardiac progenitors, is expanded into the posterior in R

254 rate that Ldb1 binds to the key regulator of cardiac progenitors, Isl1, and protects it from degradat

255 progenitor pools, including mesoderm-derived cardiac progenitors known as the first and second heart

256 iomyocytes were able to dedifferentiate into cardiac progenitor-like cells (CPCs).

257 ic pathways regulating individual subsets of cardiac progenitors likely underlies many forms of human

258 heterochromatin at the nuclear lamina during cardiac progenitor lineage restriction.

259 sing Isl1 as an exclusive second heart field cardiac progenitor marker and suggests that some Isl1-ex

260 ipotent stem cell (iPSC)-derived multipotent cardiac progenitor (MCPs) cells and, in parallel, in the

261 Here we use live imaging to show that cardiac progenitors migrate in highly directed trajector

262 and senescence with cell cycle arrest, fewer cardiac progenitors, myocytes and endothelial lineages,

263 nonoverlapping cardiac-specific genes in the cardiac progenitors: Nkx2-5, Isl1 and Baf60c are control

264 Cardiac progenitors of the first heart field (FHF) do no

265 edomain protein that plays a pivotal role in cardiac progenitors of the second heart field.

266 erpretations for studies on more specialized cardiac progenitors, offering a novel perspective for re

267 human mesenchymal stem cells (hMSCs) into a cardiac progenitor phenotype and assess therapeutic bene

268 at the graded loss of Hand2 function in this cardiac progenitor pool can cause a spectrum of congenit

269 olation of iPS- and ES-derived NKX2-5-GFP(+) cardiac progenitor pools, marked by identical reporters,

270 on factor family, is expressed early in this cardiac progenitor population and functions near the top

271 This inhibition of etv2 expression in the cardiac progenitor population is partly mediated by Scl

272 of Second Heart Field (SHF) cells, a pool of cardiac progenitors present in anterior pharyngeal arch

273 al Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells

274 ently induced prior to the appearance of the cardiac progenitor program.

275 A late differentiating population of cardiac progenitors, referred to as the anterior second

276 wnstream pathways mediating FGF signaling in cardiac progenitors remain poorly understood.

277 During gastrulation, the cardiac progenitors reside in the lateral plate mesoderm

278 We show that conditional ablation of Bmp2 in cardiac progenitors results in cell fate changes in whic

279 mediator, IGFBP3, as key regulators of adult cardiac progenitor self-renewal in physiological and pat

280 The cardiac progenitors self-organize into an anterior domai

281 receptor is expressed in different pools of cardiac progenitors (some capable of robust cardiomyogen

282 t Hedgehog (Hh) signaling marked a subset of cardiac progenitors specific to the atrial septum and th

283 r studies define the timing and hierarchy of cardiac progenitor specification and demonstrate that th

284 n mouse embryos leads to failure of anterior cardiac progenitor specification and the development of

285 l redundancy that leads to robustness in the cardiac progenitor specification process, and illustrate

286 from the inhibition of BMP signaling during cardiac progenitor specification stages.

287 -5 homologs in numerous processes, including cardiac progenitor specification, progenitor proliferati

288 Cardiac progenitor/stem cells in adult hearts represent

289 lyses, here we define four subpopulations of cardiac progenitor/stem cells in adult mouse myocardium

290 f embryonic stem cells in monolayers produce cardiac progenitors termed cardiopoietic cells.

291 e mouse embryo have identified a multipotent cardiac progenitor that contributes to all of the major

292 s unclear whether the cell fate programme of cardiac progenitors to generate complex muscular or vasc

293 se proximity of posterior second heart field cardiac progenitors to pulmonary endoderm suggested a pu

294 lls also promotes the induction of committed cardiac progenitors, we utilized several mouse ES and in

295 opathy originate from the second heart field cardiac progenitors, which switch to an adipogenic fate

296 ventral midline arrest and are maintained as cardiac progenitors, while cells in more dorsal regions

297 pecifies and positions neighboring groups of cardiac progenitors within each segment: the anterior la

298 Via fate mapping in zebrafish, we locate cardiac progenitors within hand2-expressing mesoderm and

299 istinguish and precisely position individual cardiac progenitors within the presumptive heart-forming

300 y promoting division of late-differentiating cardiac progenitors within the second heart field.