ライフサイエンスコーパス: cardiac regeneration

1 on of critical controversies in experimental cardiac regeneration.

2 ure has stimulated interest in understanding cardiac regeneration.

3 in the scar of treated pigs, consistent with cardiac regeneration.

4 rial-to-ventricular transdifferentiation and cardiac regeneration.

5 ture development of cell-based therapies for cardiac regeneration.

6 t injury, providing a platform for enhancing cardiac regeneration.

7 and advance translational implementation of cardiac regeneration.

8 on required to realize the goal of effective cardiac regeneration.

9 sist at least 1 year and are consistent with cardiac regeneration.

10 have not been fully utilized in the field of cardiac regeneration.

11 thood and their implications for therapeutic cardiac regeneration.

12 pletion, which might be useful for eliciting cardiac regeneration.

13 rogenitor cell differentiation to facilitate cardiac regeneration.

14 e the number and function of these cells for cardiac regeneration.

15 a unique yet poorly understood capacity for cardiac regeneration.

16 borate in an Fgf-dependent manner to achieve cardiac regeneration.

17 may be delivered therapeutically to enhance cardiac regeneration.

18 cally dissecting the molecular mechanisms of cardiac regeneration.

19 is to identify drugs highly likely to induce cardiac regeneration.

20 gnition receptor Mertk in newborns prevented cardiac regeneration.

21 he collagen-containing injured tissue during cardiac regeneration.

22 of YAP acetylation in cardiomyocytes during cardiac regeneration.

23 ew treatments that reverse heart failure via cardiac regeneration.

24 therapeutic interventions aimed at effecting cardiac regeneration.

25 on, suggesting the potential for therapeutic cardiac regeneration.

26 cidate new strategies for the stimulation of cardiac regeneration.

27 al emilin2a and cxcl8a expression to promote cardiac regeneration.

28 ate respective nonCM cell types critical for cardiac regeneration.

29 ht relate to cardiomyocyte proliferation and cardiac regeneration.

30 -enters the cell cycle postinjury to promote cardiac regeneration.

31 tochore binding protein is also required for cardiac regeneration.

32 ithin the cytoplasm, which is detrimental to cardiac regeneration.

33 ent of cardiosphere-derived cells (CDCs) for cardiac regeneration.

34 g-related research that could be used to aid cardiac regeneration.

35 proliferative state is essential to enhance cardiac regeneration.

36 cell cycle exit and loss of the capacity for cardiac regeneration.

37 promote coronary network reestablishment and cardiac regeneration.

38 yocytes to complete mitosis during zebrafish cardiac regeneration.

39 hes underlying stage-dependent constraint on cardiac regeneration.

40 ort a robust immune response permissible for cardiac regeneration.

41 ronary endothelial cell proliferation during cardiac regeneration.

42 okine (C-X-C) motif receptor 1) signaling in cardiac regeneration.

43 ology to assess various aspects of zebrafish cardiac regeneration.

44 placenta may represent a novel cell type for cardiac regeneration.

45 on medicine, and therapeutic applications in cardiac regeneration.

46 yocytes have been specifically implicated in cardiac regeneration.

47 ivities of natural stem cells in therapeutic cardiac regeneration.

48 rve as a promising therapeutic for pediatric cardiac regeneration.

49 V vectors may serve as a powerful system for cardiac regeneration.

50 s and Hippo signaling-a central regulator of cardiac regeneration.

51 in situ represents a promising strategy for cardiac regeneration.

52 ent and future studies directed at enhancing cardiac regeneration.

53 vivo and provide a more robust platform for cardiac regeneration.

54 ight be exploited therapeutically to enhance cardiac regeneration.

55 ming has enabled exciting new strategies for cardiac regeneration.

56 okinesis, also facilitates cell division and cardiac regeneration.

57 nd experimental research in animal models of cardiac regeneration.

58 e the key mechanism responsible for neonatal cardiac regeneration.

59 fs in regions that gain accessibility during cardiac regeneration.

60 ownstream from Pim-1 signaling that enhances cardiac regeneration.

61 Promising progress has been made in studying cardiac regeneration.

62 ESC exosomes possess cardiac regeneration ability and modulate both cardiomyo

63 edge about the core mechanisms that regulate cardiac regeneration across vertebrate species.

64 nhibited sympathetic regrowth and subsequent cardiac regeneration after apical resection significantl

65 Cardiac regeneration after injury is limited by the low

66 n of this pathway is also essential to drive cardiac regeneration after injury.

67 extracellular matrix protein agrin promotes cardiac regeneration after MI in adult mice.

68 ing now pave the way to applications such as cardiac regeneration after myocardial infarction and gen

69 onatal and adult hearts as a means to induce cardiac regeneration after myocardial infarction in mice

70 the mouse heart using viral vectors, induce cardiac regeneration after myocardial infarction.

71 l cardiomyogenic differentiation and role in cardiac regeneration after myocardial injury.

72 ramming as a therapeutic approach to promote cardiac regeneration after myocardial injury.

73 This allows for the analysis of cardiac regeneration after surgical amputation of the le

74 ipheral nervous system, we hypothesized that cardiac regeneration also requires reinnervation.

75 turbed caudal fin regeneration and abrogated cardiac regeneration altogether.

76 s advances in our understanding of zebrafish cardiac regeneration, an aspect that remains less studie

77 ight be potential therapeutic candidates for cardiac regeneration and congenital heart diseases.

78 to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contract

79 growth factor receptor inhibition to arrest cardiac regeneration and enable scar formation, experime

80 eview of techniques currently used to assess cardiac regeneration and functional integration of de no

81 EIS1) transcriptional factor was reported in cardiac regeneration and hematopoietic stem-cell (HSC) r

82 g limits CSP cell renewal, blocks endogenous cardiac regeneration and impairs cardiac performance, hi

83 CDCs are cardiogenic in vitro; they promote cardiac regeneration and improve heart function in a mou

84 itor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function.

85 pression of Nat10 in cardiomyocytes promotes cardiac regeneration and improves cardiac function after

86 ve form of Yap in the adult heart stimulates cardiac regeneration and improves contractility after my

87 ession of Notch signaling profoundly impairs cardiac regeneration and induces scar formation at the a

88 during heart development, improves neonatal cardiac regeneration and is cardioprotective after myoca

89 tion, autophagy plays a critical role during cardiac regeneration and its regulation can directly aff

90 ry size, does not induce known mechanisms of cardiac regeneration and leads to a sustained reduction

91 demonstrates synergistic effects to enhance cardiac regeneration and left ventricular functional rec

92 Cardiac regeneration and neovascularization were not obs

93 ing and improves LV performance by promoting cardiac regeneration and probably also by exerting other

94 gs identify Yap as an important regulator of cardiac regeneration and provide an experimental entry p

95 the transcriptional regulation of mammalian cardiac regeneration and provides the founding circuitry

96 This may allow percutaneous cardiac regeneration and repair approaches, or injectabl

97 rdiogenic potential of these progenitors for cardiac regeneration and repair.

98 he microenvironment that may be required for cardiac regeneration and repair.

99 ippo signaling pathway and are essential for cardiac regeneration and repair.

100 hat these ligands mediate inverse effects on cardiac regeneration and specifically on cardiomyocyte (

101 The results establish CSCs as candidates for cardiac regeneration and support an approach in which th

102 without immunosuppression is safe, promotes cardiac regeneration, and improves heart function in a r

103 resents a promising therapeutic strategy for cardiac regeneration, and the first clinical studies in

104 inal cardiac MRI assessed three hallmarks of cardiac regeneration: angiogenesis, resolution of fibros

105 c function, and the implications of this for cardiac regeneration are causing great excitement.

106 Stem cell-based approaches to cardiac regeneration are increasingly viable strategies

107 cells (iPSC-CMs) offer a potential route to cardiac regeneration as a treatment for chronic ischemic

108 suggest a mechanism underlying the improved cardiac regeneration associated with combination therapy

109 m dysrhythmia are likely to be distinct from cardiac regeneration associated with ventricular injury.

110 tions of this finding may be significant for cardiac regeneration biology and therapeutics.

111 nic stem cells (ESCs) hold great promise for cardiac regeneration but are susceptible to various conc

112 tion is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited

113 h oncogene expression is sufficient to drive cardiac regeneration, but elucidation of endogenous deve

114 cardiomyocyte proliferation during zebrafish cardiac regeneration, but the mechanisms whereby macroph

115 ) have tremendous promise for application in cardiac regeneration, but their translational potential

116 We found that tadpoles display efficient cardiac regeneration, but this capacity is abrogated dur

117 ioxygenase-derived kynurenine level promotes cardiac regeneration by functioning as an endogenous reg

118 hypothesis that HASF can also contribute to cardiac regeneration by stimulating cardiomyocyte divisi

119 There was no evidence of cardiac regeneration by the infused MSC or endogenous ca

120 on effect of the micromatrix and the in situ cardiac regeneration by the injected cells.

121 y the SP phenotype, contribute to endogenous cardiac regeneration by triggering cardiomyocyte cell cy

122 ade inflammation superimposed on the limited cardiac regeneration capacity.

123 We dissected a cardiac regeneration enhancer in zebrafish to elucidate

124 This analysis also revealed that cardiac regeneration enhancers are not only activated by

125 s the main technologies being pursued in the cardiac regeneration field and how they are impacted by

126 ropriate number of cardiomyocytes; likewise, cardiac regeneration following injury relies upon the re

127 fate of transplanted cells participating in cardiac regeneration, given its ability to observe livin

128 Recently, cardiac regeneration has been demonstrated in fish and n

129 Cell-based cardiac regeneration has been the focus of intensive eff

130 er, the potential utility of platelet gel in cardiac regeneration has yet to be tested.

131 ivated cell states and their contribution to cardiac regeneration have been studied, the extracellula

132 nscriptional changes that underpin mammalian cardiac regeneration have not been fully characterized a

133 on of this macrophage-dependent mechanism of cardiac regeneration highlights immunomodulation as a po

134 ed ERBB2 in cardiomyocytes (OE CMs) promotes cardiac regeneration in a heart failure model.

135 o, a single administration of agrin promotes cardiac regeneration in adult mice after myocardial infa

136 al crest gene sox10 are essential for proper cardiac regeneration in adult zebrafish.

137 nesis suggested that hand2 could also impact cardiac regeneration in adult zebrafish; indeed, we find

138 fe, but it is largely ineffective in driving cardiac regeneration in adults, because of permanent epi

139 (CM)-like cells is a promising strategy for cardiac regeneration in conditions such as ischemic hear

140 cell-based manufactured products to promote cardiac regeneration in congenital heart disease has dem

141 an, the heart, and can longitudinally follow cardiac regeneration in individual animals after major i

142 The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative

143 as accelerated research on the mechanisms of cardiac regeneration in mammals.

144 vely active YAP factor boosted indicators of cardiac regeneration in mice and improved the function o

145 resent an alternative model for the study of cardiac regeneration in neonatal mice in which cryoinjur

146 prototypic model of apical resection-induced cardiac regeneration in neonatal mice.

147 the increase in glucose metabolism promotes cardiac regeneration in neonatal mouse heart.

148 gy to both prevent remodeling and to promote cardiac regeneration in pathological states.

149 l trials, and we suggest that achieving true cardiac regeneration in patients may ultimately require

150 s cardiomyocyte proliferation and stimulates cardiac regeneration in response to myocardial infarctio

151 injury; however, the factors that facilitate cardiac regeneration in the neonatal heart are not known

152 Innate cardiac regeneration in the pediatric setting is measura

153 A focus on preemptive cardiac regeneration in the pediatric setting may offer

154 cells (MSCs) produce and/or stimulate active cardiac regeneration in vivo after myocardial infarction

155 Cs), have been shown to be capable of direct cardiac regeneration in vivo.

156 show that lymphatic vessels are required for cardiac regeneration in zebrafish as mutants lacking lym

157 Here, we report that cardiac regeneration in zebrafish relies on Notch signal

158 is a dynamic structure that is essential for cardiac regeneration in zebrafish.

159 ate with cardiomyocytes will be critical for cardiac regeneration, in which the ultimate goal is not

160 ies in humans: what is the mechanism and can cardiac regeneration indeed occur in newborn humans?

161 Cardiac regeneration involves the generation of new card

162 Cardiac regeneration involves the interplay of complex i

163 Cardiac regeneration is a rapidly evolving and controver

164 Whether the capacity for cardiac regeneration is absent in mammals or whether it

165 The vast majority of our understanding of cardiac regeneration is based on research in young anima

166 Efficient cardiac regeneration is closely associated with the abil

167 nous cells and mechanisms that contribute to cardiac regeneration is essential for the development of

168 Success of stem cell transplantation for cardiac regeneration is partially limited by low retenti

169 adult mammalian heart, a robust capacity for cardiac regeneration is seen during the neonatal period

170 g the optimal stem cell type best suited for cardiac regeneration is the key toward improving clinica

171 yocyte proliferation, heart development, and cardiac regeneration is unknown.

172 Successful strategies for cardiac regeneration may therefore depend on establishin

173 mmendations for priority areas in studies of cardiac regeneration or repair are summarized in Tables

174 t with rapamycin caused an impairment in the cardiac regeneration outcome.

175 may be feasible for large animal preclinical cardiac regeneration paradigms.

176 ced cardiomyocyte proliferation and promoted cardiac regeneration post myocardial infarction, resulti

177 tion, new studies indicate that mammals have cardiac regeneration potential during development and ve

178 all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can reg

179 nduced pathological hypertrophy and impaired cardiac regeneration, promoting scarring after injury.

180 genetic and cellular determinants of natural cardiac regeneration remain incompletely characterized.

181 one marrow (BM)-derived cells participate in cardiac regeneration remains highly controversial and th

182 scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger r

183 on parameters for the optimization of future cardiac regeneration, repair and re-muscularization appl

184 Cardiac regeneration requires coordinated participation

185 ese new findings could be applied to advance cardiac regeneration research, and how they relate to st

186 Cardiac regeneration strategies and de novo generation o

187 is of congenital heart defects and to derive cardiac regeneration strategies.

188 Animal model cardiac regeneration studies reveal that modulation of e

189 , we lack a complete understanding as to why cardiac regeneration takes place more efficiently in som

190 rged as a powerful model to study endogenous cardiac regeneration, the molecular mechanisms by which

191 a signaling has been implicated in zebrafish cardiac regeneration, the role of its individual ligands

192 eviews and meta-analyses of human cell-based cardiac regeneration therapies are still valid to inform

193 ation-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myo

194 For example, miR-590 promotes cardiac regeneration through activating cardiomyocyte pr

195 and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is no

196 on of TEAD-YAP activity in applications from cardiac regeneration to cancer.

197 is crucial to explore stimuli of endogenous cardiac regeneration to favorably shift the balance betw

198 pigenetic barriers that must be overcome for cardiac regeneration to occur.

199 For heart failure, recent work suggests that cardiac regeneration using stem/progenitor cells, gene t

200 Cardiac regeneration was via endogenous cKit(+) cardiac

201 investigate the role of immune responses in cardiac regeneration, we delayed macrophage recruitment

202 factors and embryonic genes associated with cardiac regeneration, we identified Ccl24, which encodes

203 factors, and some tantalizing insights into cardiac regeneration were some of the highlights of what

204 1 dose tuned the temporal window of neonatal cardiac regeneration, where increased MBNL1 expression a

205 ypothesis that ACCT synergistically promotes cardiac regeneration without provoking immunologic react