ライフサイエンスコーパス: cardiac ryanodine receptor

1 current amplitude or open probability of the cardiac ryanodine receptor.

2 body MA3-916, also raised against the canine cardiac ryanodine receptor.

3 es and regulation by CaM of the skeletal and cardiac ryanodine receptors.

4 alcium release activity of both skeletal and cardiac ryanodine receptors.

5 rm of verticilide (ent-verticilide) inhibits cardiac ryanodine receptor 2 (RyR2) and exhibits antiarr

6 Mutations in the cardiac ryanodine receptor 2 (RyR2) have been associated

7 coplasmic reticulum can be normalized by the cardiac ryanodine receptor 2 (RyR2) inhibitor, dantrolen

8 rm a protein complex that is associated with cardiac ryanodine receptor 2 (RyR2) SR Ca(2+) release ch

9 ch is caused by loss-of-function variants in cardiac ryanodine receptor 2 (RyR2), is an emerging caus

10 ired beta-agonist-induced denitrosylation of cardiac ryanodine receptor 2 (RyR2), resulting in calciu

11 hibitor of cardiac calcium release channels [cardiac ryanodine receptor 2 (RyR2)] at doses threefold

12 in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphos

13 Moreover, SERCA2a, cardiac ryanodine receptor 2, and sodium-calcium exchang

14 2+-binding protein that associates with both cardiac ryanodine receptors and L-type Ca2+ channels and

15 Ca(2+)-ATPase [SERCA2a], phospholamban, and cardiac ryanodine receptor), and contractile function (m

16 nteract with and disrupt the function of the cardiac ryanodine receptor Ca(2+) release channel (RyR2)

17 ith PKA-mediated hyperphosphorylation of the cardiac ryanodine receptor/Ca(2+)-release channel, which

18 arcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor/calcium release channel (RyR2

19 ple targets in cardiac muscle, including the cardiac ryanodine receptor/calcium release channel (RyR2

20 The cardiac ryanodine receptor/calcium release channel (RyR2

21 constructed models of the pore region of the cardiac ryanodine receptor channel (RyR2) monomer and te

22 study, we addressed whether Zn(2+) modulates cardiac ryanodine receptor gating and Ca(2+) dynamics in

23 RATIONALE: Mutations in the cardiac Ryanodine Receptor gene (RYR2) cause dominant ca

24 ia syndrome associated with mutations in the cardiac ryanodine receptor gene (Ryr2) in the majority o

25 prevalence of mutations in the RYR2-encoded cardiac ryanodine receptor in cases with exertional sync

26 These results appear to indicate that the cardiac ryanodine receptor is capable of being activated

27 Skeletal and cardiac ryanodine receptor isoforms show different calmo

28 hmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor-mediated Ca(2+) release and t

29 including voltage-gated Na and Ca channels, cardiac ryanodine receptors, Na/Ca-exchanger, and SR Ca-

30 hypothesis for elevated Ca(2+) leak through cardiac ryanodine receptors (ryanodine receptor 2 [RyR2]

31 The peripheral distributions of the cardiac ryanodine receptor (RyR) and a junctional protei

32 ion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from wit

33 Cardiac ryanodine receptor (RyR) gating in rats and shee

34 studied the effect of a peptide (Ac-10C) on cardiac ryanodine receptor (RyR) opening.

35 Increased phosphorylation of the cardiac ryanodine receptor (RyR)2 by protein kinase A (P

36 1.2 Ca(2+)/CaM-dependent inactivation, while cardiac ryanodine receptor (RyR2) activity remained unaf

37 connection between molecular defects in the cardiac ryanodine receptor (RyR2) and arrhythmias remain

38 with mutations in the genes encoding for the cardiac ryanodine receptor (RyR2) and cardiac calsequest

39 Mutations in cardiac ryanodine receptor (RYR2) and cardiac calsequest

40 ic disorder associated with mutations in the cardiac ryanodine receptor (RyR2) and cardiac calsequest

41 determine the CaM binding properties of the cardiac ryanodine receptor (RyR2) and to identify potent

42 d its metabolite, doxorubicinol, bind to the cardiac ryanodine receptor (RyR2) and to the sarco/endop

43 Activation of the cardiac ryanodine receptor (RyR2) by elevating cytosolic

44 Phosphorylation of the cardiac ryanodine receptor (RyR2) by protein kinase A (P

45 Oxidation of the cardiac ryanodine receptor (RyR2) Ca(2+) channel causes

46 a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel

47 Cardiac ryanodine receptor (Ryr2) Ca(2+) release channel

48 To study the function and regulation of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel

49 CPVT) require spontaneous Ca(2+) release via cardiac ryanodine receptor (RyR2) channels affected by g

50 e crossing region (the proposed gate) of the cardiac ryanodine receptor (RyR2) completely abolishes l

51 pryn co-purifies with myospryn and the major cardiac ryanodine receptor (RyR2) from heart.

52 show that PC2 coimmunoprecipitates with the cardiac ryanodine receptor (RyR2) from mouse heart.

53 Abnormal cardiac ryanodine receptor (RyR2) function is recognized

54 Cardiac ryanodine receptor (RyR2) gain-of-function mutat

55 NH2-terminal region (residues 1-543) of the cardiac ryanodine receptor (RyR2) harbors a large number

56 Deficient S-nitrosylation of the cardiac ryanodine receptor (RyR2) has a variable effect

57 m the sarcoplasmic reticulum mediated by the cardiac ryanodine receptor (RyR2) is a fundamental event

58 Cardiac ryanodine receptor (RyR2) is a homotetramer of 5

59 Intracellular Ca(2+) leak from cardiac ryanodine receptor (RyR2) is an established mech

60 The cardiac ryanodine receptor (RyR2) is an untapped target

61 t the single-channel level, oxidation of the cardiac ryanodine receptor (RyR2) is known to activate a

62 Calstabin2 is a component of the cardiac ryanodine receptor (RyR2) macromolecular complex

63 Ca from sarcoplasmic reticulum (SR) via the cardiac ryanodine receptor (RyR2) may contribute to cont

64 s a hetero-oligomer with FKBP12, whereas the cardiac ryanodine receptor (RyR2) more selectively assoc

65 Arrhythmogenic cardiac ryanodine receptor (RyR2) mutations are associat

66 Most cardiac ryanodine receptor (RyR2) mutations associated w

67 tachycardia (CPVT) is caused by mutations in cardiac ryanodine receptor (RyR2) or calsequestrin (Casq

68 n kinase A (PKA) hyperphosphorylation of the cardiac ryanodine receptor (RyR2) resulting in dissociat

69 isease often caused by point variants in the cardiac ryanodine receptor (RyR2) that enhance diastolic

70 bility to reduce the open probability of the cardiac ryanodine receptor (RyR2) while having no effect

71 riments we characterized another site on the cardiac ryanodine receptor (RyR2) with which ryanoids in

72 rdiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+

73 in calcium handling in myocytes, such as the cardiac ryanodine receptor (RyR2), critically regulate c

74 lation of the calcium (Ca2+) release channel/cardiac ryanodine receptor (RyR2), required for cardiac

75 cytes with a functional knockout (KO) of the cardiac ryanodine receptor (RyR2).

76 of FKBP, is selectively associated with the cardiac ryanodine receptor (RyR2).

77 ung adults and is linked to mutations in the cardiac ryanodine receptor (RyR2).

78 ivation, resulting in phosphorylation of the cardiac ryanodine receptor (RyR2).

79 Defective regulation of the cardiac ryanodine receptor (RyR2)/calcium release channe

80 The cardiac ryanodine receptor (RyR2)/calcium release channe

81 sphodiesterase 4D3 (PDE4D3) was found in the cardiac ryanodine receptor (RyR2)/calcium-release-channe

82 ssible for flecainide to directly affect the cardiac ryanodine receptor (RyR2); however, an extracell

83 lasmic reticulum (SR) Ca(2+) release through cardiac ryanodine receptors (RyR2) aggravate cardiac rem

84 Diffusion of cardiac ryanodine receptors (RyR2) in lipid bilayers was

85 kinase A (PKA)-dependent phosphorylation of cardiac ryanodine receptors (RyR2) is linked to the deve

86 eins FKBP12.6 and FKBP12 are associated with cardiac ryanodine receptors (RyR2), and cAMP-dependent p

87 ses sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or ca

88 r tachyarrhythmias (VTs) in a mouse model of cardiac ryanodine-receptor (RyR2)-linked catecholaminerg

89 In contrast, the cardiac ryanodine receptor, RyR2, appears to bind select

90 rhythmogenesis through redox modification of cardiac ryanodine receptors (RyR2s).

91 nels is a critical step in the activation of cardiac ryanodine receptors (RyRs) and release of Ca2+ v

92 We have previously shown that cardiac ryanodine receptors (RyRs) are protein kinase A-

93 cytes and single channel recordings from rat cardiac ryanodine receptors (RyRs) incorporated into pla

94 ein kinase A-mediated phosphorylation of the cardiac ryanodine receptor (the Ca(2+) release channel o

95 rdia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestri

96 Cardiac ryanodine receptor type 2 plays a key role in ex

97 ised against a peptide sequence from the dog cardiac ryanodine receptor was employed.

98 The cardiac ryanodine receptor was not altered in transcript

99 tabolic labeling experiments showed that the cardiac ryanodine receptor was phosphorylated at additio