ライフサイエンスコーパス: carotid stenosis

1 e of 8-15% of ischaemic strokes (symptomatic carotid stenosis).

2 ecent ischemic symptoms in participants with carotid stenosis.

3 n the risk stratification of atherosclerotic carotid stenosis.

4 of management of patients with asymptomatic carotid stenosis.

5 ion system in high-risk patients with severe carotid stenosis.

6 he example of endarterectomy for symptomatic carotid stenosis.

7 subjects with recently symptomatic > or =50% carotid stenosis.

8 pert population-based dietary guidelines and carotid stenosis.

9 and asymptomatic patients with extracranial carotid stenosis.

10 patients with recently symptomatic internal carotid stenosis.

11 elies on the detection of significant (>70%) carotid stenosis.

12 ascular treatment for symptomatic high-grade carotid stenosis.

13 sion, and to a lesser extent in asymptomatic carotid stenosis.

14 carotid endarterectomy for the treatment of carotid stenosis.

15 om 3007 patients with a recently symptomatic carotid stenosis.

16 can result in inaccuracies in assessment of carotid stenosis.

17 in patients with recently symptomatic 70-99% carotid stenosis.

18 intima-media thickness, carotid plaque, and carotid stenosis.

19 and cigarette smoking with the prevalence of carotid stenosis.

20 ardiovascular risk factors and the degree of carotid stenosis.

21 artery, three of them also had contralateral carotid stenosis.

22 2% of the adult population have asymptomatic carotid stenosis.

23 ion the preferred management of asymptomatic carotid stenosis.

24 red with those undergoing endarterectomy for carotid stenosis.

25 tenting (TF-CAS) for high-risk patients with carotid stenosis.

26 al stroke risk in patients with asymptomatic carotid stenosis.

27 ctomy (CEA) for the treatment of symptomatic carotid stenosis.

28 ) performed for asymptomatic and symptomatic carotid stenosis.

29 n (CSTC) involving patients with symptomatic carotid stenosis.

30 erectomy remains the treatment of choice for carotid stenosis.

31 reduces the risk of stroke in patients with carotid stenosis.

32 tenting with endarterectomy in patients with carotid stenosis.

33 time following TIA or stroke associated with carotid stenosis.

34 ombotic biomarker profile in moderate-severe carotid stenosis.

35 stenting and endarterectomy for symptomatic carotid stenosis.

36 ue vulnerability in patients with high-grade carotid stenosis.

37 l ischemic events, and stroke in symptomatic carotid stenosis.

38 intima-media thickness, carotid plaque, and carotid stenosis.

39 unstable plaques in patients with high-grade carotid stenosis.

40 vide guidelines for management of women with carotid stenosis.

41 darterectomy for symptomatic or asymptomatic carotid stenosis.

42 waveform amplitudes were lowest with common carotid stenosis.

43 arotid branch ligation and by 80% via common carotid stenosis.

44 ct stroke risk in patients with asymptomatic carotid stenosis.

45 d artery revascularization (70% asymptomatic carotid stenosis), 1025 (30%) with CAS and 2387 (70%) wi

46 t emergent and ipsilateral to the qualifying carotid stenosis; 2 additional ipsilateral TIAs occurred

47 igned in CAVATAS and completed treatment for carotid stenosis (200 patients had endovascular treatmen

48 ), ischemic stroke (11.1%), and asymptomatic carotid stenosis (8.7%).

49 atients with high-grade (>=70%) asymptomatic carotid stenosis across 155 centers in five countries.

50 ial for patients with asymptomatic > or =60% carotid stenosis (ACS), several other studies have repor

51 ur hypothesis that gradual formation of mild carotid stenosis along the life course leads to progress

52 Carotid stenosis, an indicator of subclinical atheroscle

53 mulate hypothetical cohorts of patients with carotid stenosis and calculated quality-adjusted life ex

54 evascularization in patients with high-grade carotid stenosis and delaying surgery in patients with r

55 For some patients with severe carotid stenosis and high-risk features for carotid enda

56 icenter registry of 419 patients with severe carotid stenosis and high-risk features for carotid enda

57 ted with symptomatic status in patients with carotid stenosis and occlusion, but there is relatively

58 psilateral carotid arteries of patients with carotid stenosis and recent cerebral ischemic events.

59 ious studies suggest that some patients with carotid stenosis and serious comorbid conditions are at

60 ormulated regarding the relationship between carotid stenosis and vascular cognitive impairment.

61 ts 79 years of age or younger who had severe carotid stenosis and were asymptomatic (i.e., had not ha

62 nd peripheral arterial disease, asymptomatic carotid stenosis, and 10-year risk of acute coronary eve

63 d duration of filter deployment, symptomatic carotid stenosis, and baseline renal insufficiency.

64 of the brain parenchyma and of the degree of carotid stenosis, and charted test results (such as elec

65 Age, significant contralateral carotid stenosis, and complex aortic arch type were pred

66 carotid branches, creating an outflow common carotid stenosis, and constructing a midgraft stenosis.

67 with recently symptomatic than asymptomatic carotid stenosis, and decreases over time following TIA

68 Older age, symptomatic carotid stenosis, and nonelective hospital admission wer

69 d, are frequent in patients with symptomatic carotid stenosis, and predict recurrent stroke risk.

70 l arterial disease, coronary artery disease, carotid stenosis, and recurrent surgery and a higher log

71 utility of abnormal diffusion-weighted MRI, carotid stenosis, and transient ischaemic attack within

72 Patients with asymptomatic carotid stenosis are at increased vascular risk but opti

73 Many patients with asymptomatic carotid stenosis are offered carotid stenting for the pr

74 g carotid intima-media thickness values, and carotid stenosis as 50% or more stenosis.

75 medical therapy for adults with asymptomatic carotid stenosis, as well as single-group prospective co

76 ring system on 990 ECST patients with 70-99% carotid stenosis assigned surgery (594) or medical treat

77 In the men, the odds ratio for moderate carotid stenosis associated with an increase of 20 mm Hg

78 b event at 33.3 nmol/L [8.7-158.2], incident carotid stenosis at 29.5 nmol/L [8.5-116.3], and carotid

79 alues that warranted the diagnosis of severe carotid stenosis at centers in the 5th percentile, but n

80 d deviation] +/- 10.5; 75% men) with 16%-79% carotid stenosis at duplex ultrasonography were imaged w

81 Among participants with prevalent PAD and carotid stenosis at enrollment, 196 (2.7%) and 67 (1.9%)

82 In multivariable analysis, carotid stenosis at or over 70% (odds ratio, 5.72 [95% C

83 clinical interest in patients with unstable carotid stenosis at risk of stroke.

84 or ischemic stroke: 18 patients with culprit carotid stenosis awaiting carotid endarterectomy and 8 c

85 ifferent control groups: 16 patients without carotid stenosis before and after diagnostic cerebral an

86 rterectomy depends not only on the degree of carotid stenosis, but also on several other clinical cha

87 tive to endarterectomy for the management of carotid stenosis, but its long-term safety and efficacy

88 nt to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not establish

89 is replacing intra-arterial angiography for carotid stenosis, but the accuracy remains uncertain des

90 cross subgroups defined by sex and degree of carotid stenosis, but there was a nonsignificant trend s

91 pirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) is a randomized, double-blind

92 for any reason and received the diagnosis of carotid stenosis, carotid dissection, and extra or intra

93 appropriately selected patients with severe carotid stenosis, carotid revascularization reduces isch

94 relative risk of stroke was increased in all carotid stenosis categories but was most elevated in the

95 In patients with recently symptomatic carotid stenosis, combination therapy with clopidogrel a

96 likely to undergo procedural management for carotid stenosis compared with those in the salary-based

97 my by screening asymptomatic populations for carotid stenosis costs more per quality-adjusted life-ye

98 erectomy (CEA) for patients with symptomatic carotid stenosis (CS).

99 with carotid endarterectomy for symptomatic carotid stenosis decreased over an 8-year period, indepe

100 nued embolization is common in patients with carotid stenosis despite aspirin therapy.

101 CDI was assessed for internal carotid stenosis, diabetic retinopathy, glaucoma, and br

102 ticipants with asymptomatic severe (70%-99%) carotid stenosis diagnosed between 2008 and 2012 and no

103 of CAS and CEA for treatment of symptomatic carotid stenosis (Endarterectomy versus Angioplasty in P

104 Individuals with carotid stenosis enter surveillance or are considered fo

105 We found that mild carotid stenosis, even in a unilateral occlusion, create

106 ith only 2.9% of plaques (43 of 1460) having carotid stenosis exceeding 50%.

107 emains the standard of care for extracranial carotid stenosis except in specific clinical scenarios.

108 ons include staged operations addressing the carotid stenosis first, reverse staged operations addres

109 ts who underwent CEA for severe asymptomatic carotid stenosis from 1989 to 2005 were identified.

110 26 patients with symptomatic or asymptomatic carotid stenosis from 95 centres in 24 countries.

111 nosis.Materials and MethodsParticipants with carotid stenosis from two ongoing prospective studies wh

112 The creation of an outflow common carotid stenosis generates clinically relevant (poor run

113 oronary and carotid disease with significant carotid stenosis greater than 70% in approximately 8% of

114 hed treatments for patients with symptomatic carotid stenosis >/=70%.

115 nsuitability, CCA size 4.8 to 9.8 mm, and no carotid stenosis >30%.

116 Forty-seven patients with carotid stenosis >40% on duplex ultrasonography and who

117 terectomy (CEA) in patients with symptomatic carotid stenosis >70% by a randomized, controlled trial

118 cations for CAS or CEA included asymptomatic carotid stenosis >70% or symptomatic stenosis >50%.

119 ; 76.7% were asymptomatic with flow-limiting carotid stenosis >80%.

120 lected candidates who are symptomatic with a carotid stenosis >=50% and <=99% and for asymptomatic pa

121 and <=99% and for asymptomatic patients with carotid stenosis >=70% and <=99% for stroke prevention.

122 If ultrasonography found significant carotid stenosis (> or = 60%), disease was confirmed by

123 Moderate carotid stenosis (> or =25 percent) was present in 189 m

124 s were significantly higher in patients with carotid stenosis (>/= 70%) compared to controls, with no

125 k (TIA), or retinal embolism and ipsilateral carotid stenosis (>/=50%) were included.

126 ignals (MES) in asymptomatic and symptomatic carotid stenosis has not been comprehensively assessed.

127 ; P<0.0001) was similar to that for incident carotid stenosis (HR, 1.17 [95% CI, 1.13-1.20]; P<0.0001

128 EA as the preferred treatment of symptomatic carotid stenosis if a reduction in costs can be achieved

129 s, indications for surgery were asymptomatic carotid stenosis in 167 (24.6%), transient ischemic atta

130 (11.5%) patients with > or = 50% ipsilateral carotid stenosis in 357/387 (92%) patients with carotid

131 evidence as the standard treatment of severe carotid stenosis in both symptomatic and asymptomatic pa

132 dical management in the management of severe carotid stenosis in both symptomatic and asymptomatic pa

133 is greater than the prevalence of > or = 50% carotid stenosis in carotid territory events, and is ass

134 ressure showed significant associations with carotid stenosis in men and insignificant associations i

135 th intra-arterial angiography for diagnosing carotid stenosis in patients with carotid territory isch

136 Synchronous carotid stenosis in patients with coronary artery diseas

137 ed with those from patients with symptomatic carotid stenosis in the early (</= 4 weeks) and late pha

138 stic models from data on patients with 0-69% carotid stenosis in the European Carotid Surgery Trial (

139 ve in preventing stroke and recurrent severe carotid stenosis in the medium-to-long term.

140 ients who underwent surgery for asymptomatic carotid stenosis in the Vascular Quality Initiative regi

141 ng were associated with an increased risk of carotid stenosis in this elderly population.

142 The management of carotid stenosis in women remains a topic of controversy

143 intima-media thickness, carotid plaque, and carotid stenosis increased consistently with age and was

144 In recently symptomatic carotid stenosis, inflammation-related FDG uptake was as

145 ive intensification, antihypertensive class, carotid stenosis intervention, and substance abuse refer

146 Carotid stenosis is a key source of embolic strokes.

147 Symptomatic carotid stenosis is associated with a 3-fold risk of ear

148 is beneficial for patients with asymptomatic carotid stenosis is controversial.

149 a percentage change of 58.97% from 2000; and carotid stenosis is estimated to be 1.5% (1.1-2.1), equi

150 e stroke with unilateral asymptomatic 70-99% carotid stenosis is likely small based on several observ

151 benefit from endarterectomy for asymptomatic carotid stenosis is small, but can sometimes be justifie

152 agement of patients with asymptomatic severe carotid stenosis is uncertain, due to advances in medica

153 th >=70% and symptomatic patients with >=50% carotid stenosis, <=80 years of age, and at standard or

154 ymptomatic and symptomatic participants with carotid stenosis.Materials and MethodsParticipants with

155 Inaccuracy in the measurement of carotid stenosis may contribute to conflicting estimates

156 ny patients with recently symptomatic 70-99% carotid stenosis may not benefit from carotid endarterec

157 patients had correction of a severe internal carotid stenosis (mean 95.6 +/- 3.7%) with a concurrent

158 r carotid occlusion (n = 48) or asymptomatic carotid stenosis (n = 59).

159 Successful CS for severe carotid stenosis/occlusion improves NCF, but only in pat

160 r a history of clinical disease, an internal carotid stenosis of > or = 40% by duplex scan, or an ank

161 se vitamins were 2.5 times as likely to have carotid stenosis of >30%.

162 with acute ischemic stroke with ipsilateral carotid stenosis of >=50% underwent FDG-positron-emissio

163 or patients with asymptomatic or symptomatic carotid stenosis of 50% or greater with a low or interme

164 rs or older with asymptomatic or symptomatic carotid stenosis of 50% or greater, and a 5-year predict

165 as beneficial for symptom-free patients with carotid stenosis of 60% or more.

166 In humans, carotid stenosis of 70% and above might be the cause of

167 Imaging diagnosis of asymptomatic carotid stenosis of 70% to 99%.

168 vational study in patients with asymptomatic carotid stenosis of at least 70% from 26 centres worldwi

169 risk, 47.4% were symptomatic, and 97.4% had carotid stenosis of at least 70%.

170 valence of > or = 50% apparently symptomatic carotid stenosis on ultrasound imaging in consecutive pa

171 worst stroke risk]), who do not have severe carotid stenosis or atrial fibrillation, should receive

172 In patients with carotid stenosis or chronic occlusion ipsilateral to the

173 orts (n=12 781), all with either symptomatic carotid stenosis or major acute stroke.

174 Patients with carotid stenosis or occlusion may be at increased risk f

175 ck (OR 3.3, 95% CI 1.8-5.8), and ipsilateral carotid stenosis (OR 4.7, 95% CI 2.6-8.6) were associate

176 nd in the carotid occlusion (P: = 0.019) and carotid stenosis (P: = 0.015) groups alone.

177 e was enriched to patients with asymptomatic carotid stenosis (P=0.038).

178 Among participants with carotid stenosis, participants had 1.40 times the risk o

179 Symptomatic carotid stenosis patients are at high risk of early recu

180 tid stenosis at 29.5 nmol/L [8.5-116.3], and carotid stenosis progression to stroke at 37.8 nmol/L [1

181 s carotid revascularization for asymptomatic carotid stenosis, require reassessment given advances in

182 One patient developed carotid stenosis requiring surgery.

183 3%) developed the first incidence of PAD and carotid stenosis, respectively.

184 Simultaneous assessment of CH and degree of carotid stenosis revealed combined effects on cardiovasc

185 which emerging catheter-based therapies for carotid stenosis should be compared.

186 screening to identify cases of asymptomatic carotid stenosis should be implemented.

187 inty around which patients with asymptomatic carotid stenosis should be offered surgical intervention

188 Patients with symptomatic carotid stenosis should receive carotid revascularizatio

189 Clinical trials in patients with symptomatic carotid stenosis showed a higher procedural risk of non-

190 ardiac surgery include giant cell arteritis, carotid stenosis, stroke, hypercoagulable state, and DM

191 ghly dependent on the degree of asymptomatic carotid stenosis, suggesting that the benefit of endarte

192 Carotid stenosis, symptomatic and asymptomatic, is preva

193 atients with concomitant aortic atheroma and carotid stenosis that may predispose to stroke in the pe

194 Among patients with symptomatic carotid stenosis, the 3-year stroke risk was also lower

195 ng patients with symptomatic or asymptomatic carotid stenosis, the risk of the composite primary outc

196 versus CEA for the treatment of symptomatic carotid stenosis to assess long-term outcomes.

197 t uses plaque composition data and degree of carotid stenosis to detect symptomatic carotid plaques i

198 omy or stenting, is offered to patients with carotid stenosis to prevent stroke based on the results

199 reshold would assign a diagnosis of moderate carotid stenosis to twice as many individuals as the 95t

200 ed patients with symptomatic or asymptomatic carotid stenosis to undergo carotid-artery stenting or c

201 Among patients undergoing treatment for carotid stenosis, transcarotid artery revascularization,

202 l risks among 4597 patients with symptomatic carotid stenosis treated with carotid artery stenting (n

203 need to evaluate real-world effectiveness of carotid stenosis treatments.

204 ioplasty in Patients with Symptomatic Severe Carotid Stenosis trial, Stent-Protected Percutaneous Ang

205 four randomised controlled trials within the Carotid Stenosis Trialists' Collaboration (CSTC) involvi

206 ls from a cohort of people with asymptomatic carotid stenosis undergoing carotid endarterectomy.

207 METHODS AND Thirty patients with severe carotid stenosis underwent (18)F-fluorodeoxyglucose-posi

208 Forty-five patients with 30%-99% carotid stenosis underwent dynamic contrast-enhanced MR

209 The diagnostic threshold for carotid stenosis varies considerably.

210 ptomatic population with a 40% prevalence of carotid stenosis was found).

211 The risk of carotid stenosis was greater for people who had weighed

212 Angioplasty Study (CAVATAS), early recurrent carotid stenosis was more common in patients assigned to

213 risk factors and, in contrast to > or = 50% carotid stenosis was not associated with evidence of cor

214 ral and contralateral angiographic degree of carotid stenosis was recorded at the time of the operati

215 In men, only carotid stenosis was statistically significantly associa

216 f CVD at baseline who were not recruited for carotid stenosis was too small to draw any meaningful co

217 th moderate or severe (>/= 50%) asymptomatic carotid stenosis were compared with those from patients

218 Forty-two patients with >70% carotid stenosis were enrolled.

219 002, and April 1, 2017, who had asymptomatic carotid stenosis were included in these analyses.

220 enting Study), 231 patients with symptomatic carotid stenosis were randomized to undergo CAS (n=124)

221 Patients with symptomatic carotid stenosis were randomly assigned 1:1 to open trea

222 ndred and six patients with mild to moderate carotid stenosis were recruited in this study (53 sympto

223 with cerebrovascular ischemia ipsilateral to carotid stenosis were selected randomly for CEA or carot

224 ting stroke among patients with asymptomatic carotid stenosis, whereas the role of stenting remains t

225 ng embolization in patients with symptomatic carotid stenosis who already were taking aspirin.

226 used to identify patients with asymptomatic carotid stenosis who are at a higher risk of stroke and

227 fining particular subgroups of patients with carotid stenosis who are at higher risk of stroke who mi

228 the selection of patients with asymptomatic carotid stenosis who are likely to benefit from endarter

229 tool to identify asymptomatic patients with carotid stenosis who are most likely to benefit from rev

230 cohort of patients with asymptomatic severe carotid stenosis who did not undergo surgical interventi

231 involving asymptomatic patients with severe carotid stenosis who were not at high risk for surgical

232 nd development of percutaneous treatment for carotid stenosis will provide neurovascular anesthesiolo

233 Ys) and costs for asymptomatic patients with carotid stenosis with 70%-89% carotid luminal narrowing

234 r patients with asymptomatic and symptomatic carotid stenosis with a low or intermediate predicted ri

235 ion between IgA seropositivity and >50% mean carotid stenosis with an odds ratio of 5.24 (95% CI 1.24

236 tic and low or intermediate risk symptomatic carotid stenosis with OMT alone until further data from

237 id stenting is equivalent to CEA in reducing carotid stenosis without increased risk for major compli

238 leading approaches to revascularization for carotid stenosis, yet contemporary data on trends in rat