ライフサイエンスコーパス: carriage

1 .48E -7-2.41E -5, compared with pre-existing carriage).

2 eliably distinguish between Mp infection and carriage.

3 ic resistance and antibiotic resistance gene carriage.

4 troke, smoking, and apolipoprotein Eepsilon4 carriage.

5 ho had surveillance tests performed for MRSA carriage.

6 meningococcal carriage and risk factors for carriage.

7 es were seen at 9 months of age, or for NTHi carriage.

8 sponses during transmission and asymptomatic carriage.

9 dy period, there is high persistent residual carriage.

10 h heart disease and apolipoprotein Eepsilon4 carriage.

11 d not have diarrhea; positive NAAT confirmed carriage.

12 re disease or the establishment of bacterial carriage.

13 dividual with CDI from one with asymptomatic carriage.

14 1.7; P = .03) were associated with any MDRO carriage.

15 ed for differentiation between infection and carriage.

16 ns, sterile site infections and asymptomatic carriage.

17 iage, 15% remained carriers, and 7% acquired carriage.

18 d the dominant serotype in multiple serotype carriage.

19 r densities than ST618 during nasopharyngeal carriage.

20 ed for differentiation between infection and carriage.

21 ological therapies for controlling S. aureus carriage.

22 CCs, and CC398 was associated with AMR gene carriage.

23 gen, is driven principally by nasopharyngeal carriage.

24 microbiome antibiotic resistance gene (ARG) carriage.

25 in the nasal microbiome likely modulate its carriage.

26 e more or less favorable for N. meningitidis carriage.

27 Little is known about the dynamics of ESBL-E carriage.

28 . difficile infection (CDI) and asymptomatic carriage.

29 urveys: 71% remained noncarriers, 8% cleared carriage, 15% remained carriers, and 7% acquired carriag

30 Of the 510 infants admitted without ESBL-E carriage, 238 (55%) acquired carriage during their hospi

31 h-income settings, there is high residual VT carriage 3.6-7.1 years after PCV introduction.

32 Ten students acquired serogroup B carriage: 3 after 1 MenB-FHbp dose, 4 after 2 doses, and

33 e infection and 2 children with asymptomatic carriage); 77/80 (96%) isolate sequences were successful

34 3 known risk factors for MS: HLA-DRB1*15:01 carriage, absence of HLA-A*02:01, and high anti-EBNA1 an

35 ost traits considered here (age and previous carriage) accounted for less than 5%.

36 We show that both the carriage acquisition rate and the invasion rate vary sea

37 eningococcal carriage or prevent serogroup B carriage acquisition.

38 lly from birth until twelve months in a high-carriage African setting.

39 are produced in buffalo during the prolonged carriage after acute infection, which may spread to caus

40 stool samples, 40 (40%) developed E. faecium carriage after admission based on culture, compared with

41 al factors that promote asymptomatic vaginal carriage also facilitate dissemination and virulence.

42 We identified asymptomatic C. difficile carriage among 1897 ICU patients, using rectal swabs fro

43 cine-derived protection against pneumococcal carriage among different age groupings of children.

44 Data on prevalence and acquisition of ESBL-E carriage among hospitalized neonates in the region are f

45 Compared with PCV7-immunized children, carriage among PCV13-immunized children was significantl

46 PCV13 has reduced serotype 19A carriage among vaccinated children.

47 ed the relationships between CDKN2A mutation carriage and 2-mm, 5-mm, and atypical nevus counts among

48 We assessed changes in pneumococcal carriage and antibiotic susceptibility patterns in child

49 have a large, rapid impact on meningococcal carriage and are unlikely to provide herd protection in

50 to differentiate between the effect of gene carriage and CC on clinical outcome of IMI.

51 n attractive target in preventing Salmonella carriage and colonization in chickens to reduce contamin

52 There was no relationship between GBS carriage and demographic characteristics, alpha-diversit

53 ization model to explore E. faecalis vaginal carriage and demonstrate that both vancomycin-resistant

54 dinal study was conducted to investigate the carriage and density of these bacteria in the nasal pass

55 conjugate vaccine (PCV13), there is residual carriage and disease due to PCV13-covered serotypes.

56 umococci via the joint reduction in risks of carriage and disease progression.

57 In conclusion, we showed that carriage and environmental contamination by the hospital

58 ly described GAS candidate antigens for gene carriage and gene sequence heterogeneity.

59 the effect on antibiotic-resistant organism carriage and health care-associated infections in patien

60 llele homozygosity and rs174448 major allele carriage and improved performance in 8- to 11-y-old boys

61 inked to disease severity such as gametocyte carriage and infection chronicity is less well understoo

62 o assess PCV10 effect against nasopharyngeal carriage and invasive pneumococcal disease (IPD) in chil

63 serotypes, and typically eliminates it from carriage and IPD through herd immunity.

64 ationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of

65 ers insights into the dynamics of pathobiont carriage and provides a potential platform for further d

66 , whereas type P(O) is found in asymptomatic carriage and respiratory strains.

67 showed weak associations with meningococcal carriage and risk factors for carriage.

68 However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity

69 ously shown an association between S. aureus carriage and severe allergic disease and allergic multim

70 he continuum of care, including asymptomatic carriage and transmission of CRE.

71 reptococcus pneumoniae vaccine-serotype (VT) carriage and transmission.

72 tanding of the epidemiology of O. formigenes carriage, and are consistent with the hypothesis that th

73 CV serotypes, potential overall reduction in carriage, and within-serotype nonsusceptibility resultin

74 coverage and potency to reduce pneumococcal carriage are needed.

75 Human asymptomatic carriage as a reservoir for community transmission of in

76 Human asymptomatic carriage as a reservoir for community transmission of in

77 median duration of H. somni and P. multocida carriage at 14.8 (CI(95%): 10.6-20.9) and 55.5 (CI(95%):

78 The prevalence of ESBL-E carriage at admission was 10% (59/569).

79 its ratio at T = 0 was predictive for ESBL-E carriage at T = 1 (odds ratio [OR], 1.3; 95% confidence

80 d CFU ratio at T=0 was predictive for ESBL-E carriage at T=1 (OR: 1.3, 95%CI: 1.2-1.6) and T=2 (OR: 1

81 e outcome, age (B = -0.1, SE = 0.01), APOE*4 carriage (B = -0.31, SE = 0.11), depression (B = -0.11,

82 Age (B = -0.07, SE = 0.01), APOE*4 carriage (B = -0.41, SE = 0.18), and diabetes (B = -0.18

83 Screening for ESBL-PE carriage before colorectal surgery and personalizing pro

84 Patients were screened for ESBL-PE carriage before elective colorectal surgery.

85 e aged >=18 years, were screened for ESBL-PE carriage before surgery, received routine prophylaxis wi

86 Changes in pneumococcal carriage by age (<1 year, 1-4 years, adults), site, and

87 ound to be significantly associated with GBS carriage by linear discriminant analysis.

88 eported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extra

89 We evaluated Leptospira carriage by quantitative polymerase chain reaction among

90 ons to the discovery of resistant strains in carriage can potentially select against resistance in a

91 rst week of life have higher bifidobacterial carriage compared to exclusively breast-fed counterparts

92 PCV13"), and had nasopharyngeal pneumococcal carriage compared with 7-valent pneumococcal conjugate v

93 iables were positively associated with PnIST carriage compared with both groups: temperature >=39 deg

94 cine parameters were estimated by fitting to carriage data from 2001/2002 and post-PCV IPD data to 20

95 Carriage decay rate is analysed using non-linear regress

96 In children younger than 5 years, PCV10-type carriage declined between eras (age-standardised adjuste

97 PCV serotype carriage declined by 80%, while that of non-PCV serotype

98 PCV10-type carriage declined in children <5 years and adults post-P

99 The prevalence of PCV13 VT carriage decreased during the 10 years between CSS0 and

100 In adults, PCV10-type carriage decreased from 12.9% to 2.8% (HIV+) and from 11

101 Among infants, VT carriage decreased from 33.3% (113/339) in CSS1 to 11.4%

102 Pneumococcal carriage did not impact rates of lower respiratory tract

103 l toxin concentrations in groups with CDI vs carriage differed, but only when groups were defined by

104 in promoter-binding assays, and risk allele carriage diminished transcriptional correlations among I

105 Although risk factors for meningococcal carriage do not strongly impact most bacterial species i

106 substantial long-term effects on bla(CTX-M) carriage duration.

107 er lower protection against vaccine-serotype carriage during and beyond the first year of life.

108 without ESBL-E carriage, 238 (55%) acquired carriage during their hospital stay.

109 der" antibiotic exposure during asymptomatic carriage (e.g., the pneumococcus).

110 les from the Experimental Human Pneumococcal Carriage (EHPC) project.

111 lly, pneumococcal abundances were highest in carriage events newly-detected after ILI-onset (estimate

112 We therefore assessed meningococcal carriage following a MenB vaccination campaign in respon

113 nd (i) the rate of maternal rectovaginal GBS carriage, (ii) the rate of vertical transmission of GBS,

114 pAB5 confers niche specificity, as its carriage improves UPAB1 survival in a CAUTI model and de

115 rial efficacy, we set out to survey parasite carriage in 3 communities in North Sumatera Province.

116 ission (p<0.0001) was associated with MCRPEC carriage in 35 patients compared with 378 patients with

117 s post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influ

118 Given the approximate prevalence of HLA-B*53 carriage in African (20%) and Hispanic (6%) populations,

119 a relatively lower/ delayed bifidobacterial carriage in cesarean-born babies.

120 influenza-like illness (ILI) on pneumococcal carriage in community-dwelling older adults.

121 tamase producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%.

122 tamase-producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%.

123 Due to their heterogeneity and carriage in healthy individuals, identification of diagn

124 faecium (VREfm) is the driver for E. faecium carriage in hospitalized patients, which, in turn, is a

125 his study investigated Staphylococcus aureus carriage in patients with microbial keratitis (MK).

126 sion, use of qPCR suggests that pneumococcal carriage in Portuguese elderly is approximately 10%, and

127 The point prevalence of newly detected CRE carriage in post-acute care hospitals decreased from 12.

128 From 2009-2016, we monitored pneumococcal carriage in southern Israel, where children should recei

129 From 2009-2016, we monitored pneumococcal carriage in southern Israel, where children should recei

130 used to quantify PQ effect on (i) gametocyte carriage in the first two weeks post-treatment; (ii) the

131 The dynamics of ESBL-E carriage in the general Dutch population are characteriz

132 Asymptomatic carriage in the nasopharynx is a prerequisite for diseas

133 ld nutrition interventions on enteropathogen carriage in the WASH Benefits cluster-randomized control

134 nt phenotypes and multidrug-resistant E coli carriage in urban wildlife is linked to variation in eco

135 tegies to augment vaccine-induced control of carriage, including alternative schedules and catch-up c

136 d meningococcal carriage or risk factors for carriage, including male gender, smoking, and frequent s

137 o 0.26, 95% CI 0.19-0.35) and non-PCV10-type carriage increased (1.71, 1.47-1.99).

138 rrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration.

139 PCV impact on ANSP nasopharyngeal carriage is a dynamic, multicomponent process, highly de

140 S. aureus carriage is also known to be a precondition for its tran

141 Our results suggest that dermal CuV DNA carriage is associated with CTCL.

142 Approximately 97% lower Salmonella carriage is measured in a treated group, 14 days post-Sa

143 pathogen with relatively common asymptomatic carriage, is an effective intervention strategy, while o

144 Invasive and carriage isolates exhibited similar repeat numbers, but

145 cally distinct WGS data sets of pneumococcal carriage isolates.

146 2013 substrains, using multiple disease and carriage isolates.

147 to investigate the correlation between gene carriage, lineage and clinical outcome of IMI in a colle

148 ghly prevalent, largely inaccurate and their carriage may lead to unnecessary treatment and inferior

149 e, we use an experimental human pneumococcal carriage model (EHPC) to show that S. pneumoniae colonis

150 In multivariable analysis, ESBL-PE carriage more than doubled the risk of SSI (odds ratio [

151 ities were negatively associated with Pn-IST carriage (odds ratios, <1.0).

152 on rate of 2.83/year, an average duration of carriage of 0.35 years and an acquisition rate of 0.34/y

153 on rate of 2.83/year, an average duration of carriage of 0.35 years, and an acquisition rate of 0.34/

154 S. pneumoniae and find that the duration of carriage of a serotype is indeed positively correlated w

155 The relative risk for CDI with asymptomatic carriage of a toxin-encoding strain was 9.32 (95% CI=3.2

156 sex pilus-specific (SPS) phage to reduce the carriage of AMR plasmids.

157 nset autoimmunity; we show that heterozygous carriage of an African-predominant LRBA protein-altering

158 e airway microbiota, pathogen abundance, and carriage of antibiotic resistance genes.Methods: 16S rRN

159 Antibiotic use is the main driver for carriage of antibiotic-resistant bacteria.

160 Carriage of any of 3 coding NUDT15 variants was associat

161 demonstrate that asymptomatic nasopharyngeal carriage of Bordetella pertussis is inducible in humans

162 for developing active CDI from asymptomatic carriage of C. difficile are not well understood.

163 Detection of patients with gastrointestinal carriage of CPO is necessary to interrupt their spread w

164 enB vaccine had no discernible effect on the carriage of disease-causing meningococci, including grou

165 there was no difference in the prevalence of carriage of disease-causing N. meningitidis between the

166 At baseline, the risk factors for carriage of disease-causing N. meningitidis included lat

167 The primary outcome was oropharyngeal carriage of disease-causing Neisseria meningitidis (grou

168 The detection of intestinal carriage of ESBL-E through active surveillance cultures

169 Carriage of ESBL-E was common among neonates on admissio

170 Asymptomatic carriage of GAS in the human pharynx is commonplace and

171 rs and fishmongers were screened for enteric carriage of GBS.

172 tation characteristics in Hispanics and that carriage of high risk MC1R alleles occurs even among His

173 Associations between DRESS and carriage of HLA class I and II alleles were assessed by

174 patients lacking CD first-degree relatives, carriage of HLA-DQ2.5 with double dose of HLA-DQB1*02 se

175 Carriage of HSD17B13 rs72613567:TA attenuated the risk f

176 Carriage of HSD17B13 rs72613567:TA was associated with a

177 ase-control study to assess risk factors for carriage of MCRPEC in rectal swabs from inpatients with

178 independent method, to surveil the bacterial carriage of MGEs.

179 rointestinal antibiotic resistome, prolonged carriage of multidrug-resistant Enterobacteriaceae and d

180 s expressing protective HLA class I alleles, carriage of Nef codon 9 variants was also associated wit

181 on function in HIV-1 subtype C and show that carriage of Nef variants with enhanced MHC-B downregulat

182 Asymptomatic oropharyngeal carriage of Neisseria meningitidis peaks in adolescence

183 accines have likely contributed to increased carriage of nonencapsulated S. pneumoniae (NESp).

184 targeted qPCR and was independent of infant carriage of P. copri.

185 allergic disease, strongly predicts maternal carriage of P. copri.

186 The carriage of pathogens was also detected.

187 iant-specific antibody titers and subsequent carriage of pneumococcus expressing a particular antigen

188 CI, 0.68-0.89; P = 2.27 x 10(-4) ), whereas carriage of PNPLA3 rs738409:G was associated with an inc

189 se and to attenuate the risk associated with carriage of PNPLA3 rs738409:G.

190 6S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly p

191 ic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that

192 The carriage of resistance markers was not associated with p

193 ssessment of parasite species present or the carriage of resistance markers, because parasite DNA can

194 R expression strongly associate with allelic carriage of rs6897932, a disease-associated IL7R polymor

195 Carriage of rs738409:G in patatin-like phospholipase dom

196 to DEPs disrupts asymptomatic nasopharyngeal carriage of S pneumoniae in mice, leading to disseminati

197 ients with recurrent MK have higher rates of carriage of S. aureus suggesting endogenous site colonis

198 Intestinal carriage of Salmonella Enteritidis (SE) in the chicken h

199 We investigated whether the carriage of selected single nucleotide polymorphisms (SN

200 chlorhexidine increased (4-fold) but plasmid carriage of smvA alone was detrimental to the cell.

201 e progression of asymptomatic nasopharyngeal carriage of Streptococcus pneumoniae to invasive pneumoc

202 underly epidemiological studies showing that carriage of the KIR3DS1 homozygous genotype is more freq

203 Carriage of the TLR4-rs7873784 was associated with highe

204 h CM, but due to the clustering within CC of carriage of these genes, it was not possible to differen

205 Significant carriage of these serotypes remains in all age groups.

206 Carriage of this genotype is associated with a reduced r

207 dlots was not sufficient to impact the fecal carriage of this organism in cattle.

208 ments of CDI relative risk from asymptomatic carriage of toxin-encoding strains and highlight the com

209 o childhood vaccination programs has reduced carriage of vaccine serotypes and pneumococcal disease.

210 We measured PCV-conferred protection against carriage of vaccine-serotype pneumococci via the relativ

211 Carriage of variants in PNPLA3 and HSD17B13 differential

212 ch acute care inpatients are tested for MRSA carriage on admission, unit-to-unit transfer, and discha

213 tudies, PQ reduced PCR-determined gametocyte carriage on days 7 and 14, most apparently in patients p

214 standing the effect of intestinal Salmonella carriage on the microbiome and metabolome of developing

215 s (i) invasive disease and (ii) asymptomatic carriage on the palatine tonsils of pigs on UK farms.

216 t specimens, which may indicate asymptomatic carriage or a less severe syndrome, such as upper respir

217 We found no impact of PCV13 on serotype 3 carriage or disease, and emergence of non-PCV13-serotype

218 B-FHbp does not rapidly reduce meningococcal carriage or prevent serogroup B carriage acquisition.

219 rial community composition and meningococcal carriage or risk factors for carriage, including male ge

220 ns unknown whether this vaccine will prevent carriage or transmission, key aspects in long-term vacci

221 (diagnosed per US guidelines), asymptomatic carriage, or non-CDI diarrhea.

222 are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense

223 no significant differences in the secondary carriage outcomes.

224 Despite evidence of reduction in VT carriage over the study period, there is high persistent

225 a 73% (95% CI 24-90) reduction in gametocyte carriage (P = .013).

226 However, PCV10-type and PNSP carriage persisted in children regardless of catch-up va

227 esistance in transmissible gastrointestinal (carriage) populations of E. faecium.

228 ts display distinctive patterns of S. aureus carriage, positively associated with Acinetobacter speci

229 Livestock-associated S. aureus nasal carriage predominated among IHO workers.

230 meningococcal and genotypically serogroup B carriage prevalence among sampled students were stable,

231 Secondary outcomes included carriage prevalence and acquisition of all N. meningitid

232 mpact of viruses on Streptococcus pneumoniae carriage prevalence and load remains poorly understood.

233 We estimated pneumococcal carriage prevalence and serotypes among Portuguese elder

234 VT carriage prevalence half-life is similar among PCV-vacci

235 013 through August 2014, we estimated ESBL-E carriage prevalence on admission using rectal swab cultu

236 Carriage prevalence on campus remained stable, suggestin

237 tal model of pneumococcal carriage to annual carriage prevalence surveys and invasive pneumococcal di

238 MDRSA nasal carriage prevalence was similar among IHO workers and CR

239 d to detect meningococcal colonisation and a carriage rate of 32.6% was observed.

240 biont species exhibited remarkably different carriage rates and density profiles.

241 ven influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants bo

242 Carriage rates for all three bacterial species declined

243 While carriage rates have been recently shown to remain stable

244 MRSA hand carriage rates in patients, nurses, and dentists were 9.

245 c patients have been reported to have higher carriage rates of M pneumoniae compared with nonasthmati

246 Overall carriage rates remain stable owing to replacement by non

247 At housing, high carriage rates were observed for P. multocida (95%), and

248 ering density of pneumococcal nasopharyngeal carriage, reducing phagocytic killing, and resulting in

249 No carriage reduction was observed over time or with more M

250 nsusceptible Streptococcus pneumoniae (ANSP) carriage: reduction of PCV serotypes, increase of non-PC

251 However, pneumococcal carriage remained comparable due to an expansion of non-

252 aviour following challenge, with low-density carriage representing the most stable ecological state.

253 alysis, S. suis is divided into asymptomatic carriage, respiratory and systemic strains with distinct

254 and microarray, which adds multiple-serotype carriage, should be considered at regional reference lab

255 The overall (all serotypes) pneumococcal carriage significantly declined (33% and 11% in Bedouin

256 As a summation of all 4 processes, ANSP carriage significantly decreased among both Bedouin and

257 idemiologically associated with asymptomatic carriage (ST31) and diarrhoeal disease (ST40).

258 ever, even in asymptomatic people, a Babesia carriage state can be established that can last up to a

259 rsistent and non-persistent gastrointestinal carriage states in genetically identical mice.

260 o 12 different clonal complexes belonging to carriage strains.

261 nd binding activity compared to normal nasal carriage strains.

262 we analysed data from a one-year prospective carriage study in a Cambodian neonatal intensive care un

263 nd DNA microarray for samples from community carriage surveillance in Blantyre, Malawi.

264 ion of RD-informed strategies to incorporate carriage surveillance information and illustrate that co

265 to infection control, patient crowding, and carriage surveillance is warranted.

266 In 2016, we conducted a cross-sectional carriage survey (CSS5) in a community where PCV7 was fir

267 ge using rolling, prospective nasopharyngeal carriage surveys between 2015 and 2018, 3.6-7.1 years af

268 erformed annual cross-sectional pneumococcal carriage surveys in 2 sites: Kibera (children <5 years)

269 cimens and completed questionnaires during 4 carriage surveys over 11 months.

270 f the literature of penicillin allergy label carriage, the adverse effects of penicillin allergy labe

271 is associated with maternal rectovaginal GBS carriage, the single most important risk factor for GBS

272 and examined the factors associated with CRE carriage through a detailed questionnaire.

273 dynamic compartmental model of pneumococcal carriage to annual carriage prevalence surveys and invas

274 gainst progression of vaccine serotypes from carriage to CAAP via the relative association of vaccine

275 umococcal serotype-specific progression from carriage to disease before and after rollout of PCV7/13,

276 carriers under contact precautions transmit carriage to other patients at half the rate of undetecte

277 lves from one of asymptomatic nasopharyngeal carriage to overt disease.

278 confronted age-structured dynamic models of carriage transmission and disease with detailed IPD inci

279 Here we assess PCV carriage using rolling, prospective nasopharyngeal carri

280 In 2013, PCV10-type carriage was 10.3% (Lwak) to 14.6% (Kibera) in children

281 CMV carriage was associated with an expansion of phenotypica

282 Pneumococcal carriage was associated with exposure to young children

283 Further, (T) allele carriage was associated with lower MICA expression in li

284 ively, and found higher density P. multocida carriage was associated with slower clearance (p = 0.036

285 almost twofold increase in the prevalence of carriage was estimated over the study period, in 2015 re

286 The rate of decline in gametocyte carriage was faster when PQ was combined with artemether

287 ence and antimicrobial resistance (AMR) gene carriage was highly associated with CC.

288 on between delayed disease onset and HLA-DQ8 carriage was observed (p < 0.001), besides an influence

289 Transmissibility and duration of ESBL-E carriage was quantified using a transmission model also

290 The transmissibility and duration of ESBL-E carriage was quantified using a transmission model, whic

291 SE sensitization, but not S. aureus carriage, was associated with poly-sensitization to food

292 Risk factors for carriage were assessed at baseline.

293 nd nontypeable Haemophilus influenzae (NTHi) carriage were assessed prevaccination and at 4 and 9 mon

294 esident characteristics associated with MDRO carriage were assessed using multivariable models cluste

295 al cross-sectional surveys of nasopharyngeal carriage were done from 2009 to 2016.

296 Risk factors for long-term ESBL-E carriage were travel and hygiene related .

297 The risk factors for long-term ESBL-E carriage were travel- and hygiene-related.

298 The risk factors for long-term carriage were travelling to Asia, swimming in a sea/ocea

299 Risk factors for long-term carriage were travelling to Asia, swimming in sea/ocean,

300 Immunization effectively prevented carriage with only 1 of 4 single antigen-matched strains