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1 an extended beta-ketoacyl chain (ACP = acyl carrier protein).
2 ozoite surface protein 8 (MSP8) as a vaccine carrier protein.
3 a chain linker to a diphtheria toxin mutant carrier protein.
4 array of tertiary and heteroaryl amines to a carrier protein.
5 th siderophores conjugated to an immunogenic carrier protein.
6 l length polysaccharide for conjugation to a carrier protein.
7 sence of a prior immune response against the carrier protein.
8 ratase, a decarboxylase and a dedicated acyl carrier protein.
9 gnition of peptides derived from the coupled carrier protein.
10 vaccine that used SIIL tetanus toxoid as the carrier protein.
11 shear conditions FVIII is released from its carrier protein.
12 surrogate of BDE-47 covalently attached to a carrier protein.
13 exclusive of the native substrate, acyl-acyl carrier protein.
14 harides of varying chain length to CRM197 as carrier protein.
15 ation of the identified minimal epitope on a carrier protein.
16 ith favourable dynamic properties of an acyl carrier protein.
17 ons ready for activation and coupling to the carrier protein.
18 supercomplex (termed III-IV) and the ADP/ATP carrier proteins.
19 sponses to Pfs25 when coupled to immunogenic carrier proteins.
20 nd NFU5 proteins with the ISCA class of Fe-S carrier proteins.
21 f genes encoding mitochondrial dicarboxylate carrier proteins.
22 fits to including non-conserved pneumococcal carrier proteins.
23 h CD45 expression, were examined for SC-PNAL carrier proteins.
24 along with a reduction in mitochondrial acyl carrier proteins.
25 ting functional overlap between BSH and Fe-S carrier proteins.
26 of B. pseudomallei and covalently linked to carrier proteins.
27 ately being incorporated into essential acyl carrier proteins.
28 FabZ dehydratase subunits with six AcpP acyl carrier proteins.
29 (Ppt) from coenzyme A (CoA) to diverse acyl carrier proteins.
30 nd that the evaluated proteins are potential carrier proteins.
31 chondrial presequence-containing but not for carrier proteins.
32 f novel fentanyl-based haptens conjugated to carrier proteins.
33 other mitochondrial proteins such as ADP/ATP carrier proteins.
35 t function in vivo, we focused on the Sterol Carrier Protein 2 (scp2), a multifunctional protein that
37 H-Asn-Phe-Gly-Ala-Ile-Leu-Gly-NH2) and acyl carrier protein (65-74) fragment (H-Val-Gln-Ala-Ala-Ile-
38 ssion of uncoupling protein (UCP) 3, ADP/ATP carrier protein (AAC) 1 and AAC2, and pyruvate dehydroge
41 ucing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketide int
43 an acyl-adenylate and ligation onto the acyl carrier protein (ACP) domain of MbtB to form covalently
45 a reaction chamber for the intramodule acyl carrier protein (ACP) domain that carries building block
48 s DSF by dehydration of a 3-hydroxyacyl-acyl carrier protein (ACP) fatty acid synthetic intermediate
50 le for the C2-methylation of 3-ketoacyl-acyl carrier protein (ACP) intermediates to give the correspo
53 d a candidate gene encoding a beta-keto acyl carrier protein (ACP) reductase (BKR) putatively associa
55 many complex biosynthetic pathways, the acyl carrier protein (ACP) shuttles substrates to appropriate
57 ia esterification by the bacterial acyl-acyl carrier protein (ACP) synthase AasC but inhibitors of th
59 ich BioZ proteins catalyze a 3-ketoacyl-acyl carrier protein (ACP) synthase III-like reaction to prod
60 polyketide biosynthesis, beta-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this proc
61 parate domains of the bifunctional acyl-acyl carrier protein (ACP) synthetase/2-acylglycerolphosphoet
63 specialized acyl-transferase that uses acyl carrier protein (ACP) to covalently link fatty acids, vi
64 er of an R-3-hydroxyacyl chain from its acyl carrier protein (ACP) to the 3-OH group of UDP-GlcNAc.
65 We reveal that subunit B22 anchors an acyl carrier protein (ACP) to the complex, replicating the LY
67 ype I PKS module minimally contains AT, acyl carrier protein (ACP), and ketosynthase (KS) domains.
68 esulfurase (NFS1), LYR protein (ISD11), acyl-carrier protein (ACP), and the iron-sulfur cluster assem
69 he PKS and NRPS modules mediated by the acyl carrier protein (ACP), condensation (C) and ketoreductas
70 on a thioesterase specific for butyryl-acyl carrier protein (ACP), which allows native fatty acid bi
71 , we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in FA
72 enosyl-l-methionine and either cellular acyl carrier protein (ACP)-coupled fatty acids or CoA-aryl/ac
80 l transcriptional regulator Fis and the acyl carrier protein AcpP, were identified in P. aeruginosa.
81 selects from the bacterial pool of acyl-acyl carrier proteins (ACPs) an acyl chain of a specific leng
85 ratory has developed methods to prepare acyl carrier proteins (ACPs) loaded with substrate mimetics a
86 Prior work showed that expression of acyl carrier proteins (ACPs) of a diverse set of bacteria rep
87 is highly selective for two specialized acyl carrier proteins (ACPs) that deliver the donor and accep
88 se (AT), which loads monomer units onto acyl carrier proteins (ACPs), small, flexible proteins that s
89 tics are positioned on the actinorhodin acyl carrier protein (actACP) to probe the underpinnings of s
90 n is laid for defining the dynamic action of carrier-protein activity in primary and secondary metabo
92 Cyanobacteria possess two enzymes, acyl-acyl carrier protein (acyl-ACP) reductase (AAR) and aldehyde-
94 generally consists of an integrated peptidyl carrier protein, an amino acid-loading adenylation domai
95 terase-mediated offloading reaction from the carrier protein and activates the biosynthetic intermedi
97 only when present at the amino-terminus of a carrier protein and even conservative peptide amino acid
98 ocking crosslinking of Escherichia coli acyl carrier protein and FabA, a direct mimic of the biologic
99 g (SAXS), the positions of the flanking acyl carrier protein and ketosynthase domains have been ident
100 cular level and is performed by at least one carrier protein and two channels in Arabidopsis (Arabido
101 dent tailoring enzymes, a free-standing acyl carrier protein and two hypothetical proteins in oocydin
102 ng to transfer clusters between scaffold and carrier proteins and in the final stages of FeS protein
103 g enzyme can adenylate each of these sulphur-carrier proteins and probably also catalyses the subsequ
104 ol-linker to serve as a conjugation point to carrier proteins and surfaces for immunological experime
105 me this limitation, including conjugation to carrier proteins and/or formulation with potent adjuvant
106 protein domain of the synthase to a separate carrier protein, and a non-ribosomal peptide synthetase
107 oesterase that hydrolyzes beta-ketoacyl acyl-carrier protein, and ShMKS1 is a decarboxylase that conv
108 olysaccharides were conjugated to the CRM197 carrier protein, and the resulting glycoconjugates were
110 osphate (S1P) is present in plasma, bound to carrier proteins, and involved in many physiological pro
111 nstable mutant variants of the mitochondrial carrier protein, Ant1, also induces aggresomes despite a
113 s identified four stable complexes: the acyl-carrier proteins ApeE and ApeF bound to the thioesterase
114 ing, and its ability to interact with acidic carrier proteins are critical steps for proper enamel de
116 e reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual reaction
119 oforms interact with the two biotin carboxyl carrier protein (BCCP) isoforms of A. thaliana ACCase.
120 domain-containing (BADC) and biotin carboxyl carrier protein (BCCP) subunits from Arabidopsis indicat
121 ion reaction of the acceptor biotin carboxyl carrier protein (BCCP), through the expected biotinoyl-A
124 is able to provide selectivity for both the carrier protein-bound amino acid and the amine substrate
125 hydroxylates C5 of norvaline appended to its carrier protein but can either chlorinate or hydroxylate
126 f the thioester bond to the structure of the carrier protein by using solution NMR spectroscopy and m
127 In addition, we show that different vaccine carrier proteins can be glycosylated using this system.
129 oduced, to our knowledge, a novel carotenoid carrier protein, COCP, which consists of dimerized C-dom
130 al description of transport by mitochondrial carrier proteins, consistent with an alternating-access
134 njugate vaccines, consisting of an antigenic carrier protein coupled to the capsular polysaccharide o
136 on the chemical equilibrium of Fa binding to carrier proteins Cp, like albumin in plasma and intersti
137 ction of these compounds via functionalizing carrier proteins (CPs) of biosynthetic megaenzymes.
141 es consisting of hexasaccharide 2 coupled to carrier protein CRM197 stimulates a T-cell-dependent B-c
142 is of either FabZ (3-R-hydroxymyristoyl acyl carrier protein dehydratase), slrA (novel RpoE-regulated
147 ormed on plants mutated in the stearoyl-acyl carrier protein desaturase (sacpd-c) gene, which were pr
149 the castor (Ricinus communis) stearoyl-Acyl Carrier Protein desaturase (T117R/G188L/D280K) that, in
150 ation of the soluble castor Delta9-18:0-acyl carrier protein desaturase, specifically, the hypothesis
152 trait loci to a region containing ACYL-ACYL CARRIER PROTEIN DESATURASE1 (AAD1) and AAD3 We found tha
153 obo H antigens were then conjugated with the carrier protein diphtheria toxoid cross-reactive materia
154 ers the polyketide chain from the final acyl carrier protein domain of the synthase to a separate car
155 -shaped structure capable of caging the acyl carrier protein domain proximal to each active site.
158 n, suggesting that chemical modifications to carrier proteins during NRPS synthesis may impart direct
160 ures of three forms of Escherichia coli acyl carrier protein engaging LpxD, which represent stalled s
161 e centers of malonyl-CoA and malonyl- S-acyl carrier protein, essential to fatty acid, polyketide and
163 t the interface that optimally position acyl carrier protein for acyl delivery and that directly invo
164 o damaged endothelium and also serves as the carrier protein for coagulation factor VIII (FVIII), pro
165 t the use of highly immunogenic rPfMSP8 as a carrier protein for leading vaccine candidates rPfMSP1(1
167 preferred acyl donors, while acyl-ACP (acyl carrier protein), free fatty acids, or galactolipid-boun
168 acterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis thaliana, NFU4 and NFU
169 f structural information on substrate-loaded carrier proteins has hindered our understanding of NRPS
170 U1, a late-acting iron-sulfur (Fe-S) cluster carrier protein, has a key role in the pathogenesis of t
171 the inherent conformational mobility of acyl carrier protein have stymied previous attempts to visual
172 ctivation of apo-ACPP to generate holo-(acyl carrier protein) (holo-ACPP) in an early step of fatty a
173 ies of an adenylation domain and its partner carrier protein in apo-, holo-, and substrate-loaded for
176 arrier conjugates: protease digestion of the carrier protein in the endosome and presentation of a re
177 staining or to the expression levels of iron-carrier proteins in cells or bronchoalveolar lavage flui
179 hondrial NAD is imported from the cytosol by carrier proteins, in mammals, the mechanism of how this
181 of insulin-like growth factor type 1 and its carrier protein insulin-like growth factor binding prote
182 nthetic intermediates tethered to their acyl carrier proteins interact with multiple active sites dur
183 We infer that similar principles underlie carrier protein interactions with other enzymes of the S
184 , are required to convert beta-ketoacyl acyl-carrier protein intermediates of the fatty acid biosynth
186 rmylating oxygenase (ADO) converts acyl-Acyl Carrier Proteins into corresponding n-1 alkanes via alde
187 2 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane.
189 a proline-derived pyrrolyl group bound to a carrier protein is first halogenated and then elaborated
191 attachment of polysaccharide antigens to the carrier protein is thought to be imperative to the immun
192 y of BexX to selectively distinguish sulphur-carrier proteins is given a structural basis using X-ray
193 ort of presequence-containing precursors and carrier proteins is impaired in PC-deficient mitochondri
195 provide evidence that covalent attachment to carrier proteins is not required for conversion of T-ind
196 nocytogenes encode two functional enoyl-acyl carrier protein isoforms based on their ability to compl
198 usion peptide (FP8) - when conjugated to the carrier protein, keyhole limpet hemocyanin (KLH) - to be
199 Cryptosporidium ACS (and related acyl-[acyl-carrier-protein]-ligases) as pharmacological targets but
201 present the first structure of an NRPS aryl carrier protein loaded with its substrate via a native t
202 nzyme contains four subunits, having an acyl-carrier protein (MdcC subunit) with a distinct prostheti
203 ays and rewiring acyl-CoA and acyl-ACP (acyl carrier protein) metabolism in Yarrowia lipolytica hold
204 s indicated that covalent modifications to a carrier protein modulate domain communication, suggestin
205 on and thus activation of mitochondrial acyl carrier protein (mtACP) of mitochondrial fatty acid synt
206 Escherichia coli iron-sulfur (Fe-S) cluster carrier protein NfuA efficiently reconstitutes the auxil
207 Recently, it was shown that the Fe-S cluster carrier protein NfuA from Escherichia coli can regenerat
212 which a molecular antigen is conjugated to a carrier protein, offer the opportunity to circumvent the
213 e vaccines by fusing the peptide epitopes to carrier proteins optimizes vaccine immunogenicity in mic
214 have been used as mimics of the natural acyl carrier protein pathway intermediates to assay FASII enz
215 delivered between enzyme centers by peptidyl carrier protein (PCP) domains, which makes PCP interacti
216 le tethered to a conserved, type II peptidyl carrier protein (PCP), as exemplified by PltL in the bio
217 re sorted according to their affinity to the carrier protein PDE6delta and the ability of Arl3 but no
219 ding protein 4 (FABP4) is a leaderless lipid carrier protein primarily expressed by adipocytes and ma
220 Apolipoprotein E is a 299-residue lipid carrier protein produced in both the liver and the brain
221 rmational differences among the stalled acyl carrier proteins provide the molecular basis for the ass
222 f the bacterial capsular polysaccharide to a carrier protein provides CD4(+) T cells with epitopes th
224 (MT) is fused with an N-terminal pseudo-acyl carrier protein (psiACP), in which the apo state of the
226 tool to specifically inhibit the enoyl-acyl carrier protein reductase (FabI) of C. trachomatis to de
227 acterial target of 6-OH-BDE-47 as enoyl-acyl carrier protein reductase (FabI), an essential and widel
228 ridone compound that inhibits the enoyl-acyl carrier protein reductase (FabI), has recently been show
231 anobacterial pathway consisting of acyl-Acyl Carrier Protein reductase and an aldehyde-deformylating
234 , namely potent inhibition of the enoyl-acyl carrier protein reductase FabI, as validated by in vitro
235 lts show that FabI is the primary enoyl-acyl carrier protein reductase of type II bacterial fatty aci
238 Acquired haem is distributed by haemolymph carrier protein(s) and sequestered by vitellins in the d
239 in which the target region is presented on a carrier protein scaffold with preserved structural prope
240 ss requires DRAM-1, which binds the membrane carrier protein SCAMP3 and the amino acid transporters S
242 ring lipid A synthesis (Raetz pathway), acyl carrier protein shuttles acyl intermediates linked to it
244 We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the
245 d molecular motors, identified as the solute carrier protein SLC26a5, that drive somatic motility at
246 ember of a very interesting family of solute carrier proteins (SLCs), some of which have been suggest
247 are covalently attached to the heterodimeric carrier protein SoxYZ through conjugation to a cysteine
249 ALT proteins used endogenous fatty acyl-acyl carrier protein substrates to generate fatty acids that
250 d concomitant loss of the mitochondrial acyl carrier protein subunit ACPM1 from the enzyme complex an
251 lia through the coordinated actions of cargo carrier proteins such as Unc119 or PDE6delta, as well as
254 ndrial fatty acid synthesis by ketoacyl-acyl carrier protein synthase is not vital for protein lipoyl
255 ains provided by mitochondrial ketoacyl-acyl carrier protein synthase to meet the high lipoate requir
257 iosynthetic pathway, the beta-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme PqsBC c
258 nes (putatively encoding beta-ketoacyl-(acyl-carrier-protein) synthases, peroxisomal acyl-activating
259 ar fatty acids are activated by an acyl-acyl carrier protein synthetase (AasN) and validate type II f
260 eria harbor an enzyme known as the acyl-acyl carrier protein synthetase (AasS), which allows them to
262 for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of the m
263 ted cardiolipin by acyltransferase/acyl-acyl carrier protein synthetase, demonstrating the first evid
264 ative substrate, l-threonine appended to the carrier protein, SyrB1, but hydroxylates C5 of l-norvali
265 the biosynthetic operon for NOS, as an acyl carrier protein that delivers 3-methylindolic acid (MIA)
266 rate that SLC25A46, like Ugo1, is a modified carrier protein that has been recruited to the outer mit
267 helix-coiled-coil-helix domain 4 (CHCHD4), a carrier protein that mediates p53 import into the mitoch
268 s by coupling bacterial polysaccharides to a carrier protein that recruits heterologous CD4 T cells t
269 al absorption is thought to be mediated by a carrier protein that still remains to be identified.
271 ncing uncovered a few genes encoding sulphur-carrier proteins that are probably involved in the biosy
272 ng the 4 most prevalent FP8 sequences with 4 carrier proteins: the aforementioned KLH and rTTHC; the
274 tic up-regulation of a specialized acyl-acyl carrier protein thioesterase paralog and the concerted r
275 with cDNAs for various Cuphea FatB acyl-acyl carrier protein thioesterases (FatB) that produce a vari
277 tween the substrate and product forms of the carrier protein through differences in their interaction
278 e a comprehensive molecular description of a carrier protein throughout its life cycle and demonstrat
279 ious attempts to visualize structurally acyl carrier protein tied to an overall catalytic cycle.
280 the utility of PfMSP8 as a parasite-specific carrier protein to enhance the production of complex mal
281 studied calmodulin (CaM) as a more universal carrier protein to express many types of AMPs in E. coli
282 ear ribonucleoprotein (hnRNP) A1 serves as a carrier protein to modulate nucleocytoplasmic shuttling
283 accharide and used its tetanus toxoid as the carrier protein to produce the now-licensed, highly effe
284 site at the core of the enzyme, allowing two carrier proteins to dock with Cy and deliver their subst
285 ved by the covalent conjugation of CPSs with carrier proteins to produce glycoconjugate vaccines.
286 tation p.L81R and pR212W in malonyl CoA-acyl carrier protein transacylase (MCAT), a mitochondrial pro
287 s well as decarboxylase (MdcD-MdcE) and acyl-carrier protein transferase (MdcA) catalytic activities.
289 rticular, we show in immunized mice that the carrier protein transthyretin simultaneously optimizes t
291 The affinity between myristoylated cargo and carrier protein, Unc119, varies between subnanomolar and
295 atter case, only peptides generated from the carrier protein were critical for helper T cell recognit
296 ody response against the human albumin-based carrier protein, which was prevented by using a mouse al
297 ovalently attach purified polysaccharides to carrier proteins, which is widely considered to be techn
299 of the structure and dynamics of an apo-aryl carrier protein with those of its modified forms reveale
300 bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properti