ライフサイエンスコーパス: casein kinase 1

1 in of eIF2Bepsilon, can be phosphorylated by casein kinase 1.

2 iotic division is coordinated by a conserved casein kinase 1.

3 mRNA encoding another core clock component, casein kinase 1.

4 y for calcineurin and decreased affinity for casein kinase 1.

5 e Ser45 and Thr41, independent of priming by casein kinase-1.

6 ral putative phosphosite mutations abrogated casein kinase 1.2 activity on HSP90, only Ser(289) could

7 HSP90 is a substrate for casein kinase 1.2-catalysed phosphorylation in vitro.

8 this need, new small molecule inhibitors of casein kinase-1 acting through ATP-competitive and ATP-n

9 Strikingly, loss of casein kinase 1 activity causes constitutive activation

10 Deregulation of CK1 (casein kinase 1) activity can be involved in the develop

11 Casein kinase 1 alpha (CK1 alpha) was shown to directly

12 ary identified HRZ-1 derivatives that target casein kinase 1 alpha (CK1alpha) and Wee-like protein ki

13 discovered a series of molecules that induce casein kinase 1 alpha (CK1alpha) degradation.

14 protein stability of FOXO3A is regulated by Casein Kinase 1 alpha (CK1alpha) in an oncogenic RAS-spe

15 Casein kinase 1 alpha (CK1alpha) is a serine/threonine k

16 sense mutations of the CSNK1A1 gene encoding casein kinase 1 alpha (CK1alpha) occur in a subset of my

17 Here, we report that casein kinase 1 alpha (CK1alpha) phosphorylates Cdc25A o

18 the transcription factor Helios (IKZF2) and casein kinase 1 alpha (CK1alpha).

19 We found that casein kinase 1 alpha (Csnk1a1), a serine-threonine kina

20 ung cancer (NSCLC) cell lines, we identified casein kinase 1 alpha (CSNK1A1, CK1alpha).

21 expressing the more distantly related human casein kinase 1 alpha 2 could not.

22 We found that MDMX binds to the casein kinase 1 alpha isoform (CK1alpha) and is phosphor

23 elates with the ability of Foxd1 to regulate casein kinase 1, an NF-AT inhibitory kinase; the latter

24 inus by protein kinase A and subsequently by casein kinase 1 and glycogen synthase kinase 3.

25 rimes subsequent phosphorylation of adjacent casein kinase 1 and glycogen synthase kinase 3.

26 dependent protein kinase and subsequently by casein kinase 1 and glycogen synthase kinase 3.

27 iled a unique mechanism of dual targeting of casein kinase 1 and phosphatidyl inositol 3-kinase isofo

28 old selectivity against calmodulin kinase 2; casein kinase-1 and -2; CDK1 and -4; mitogen-activated p

29 ing cascade involving Frizzled, Dishevelled, Casein kinase 1, and Glycogen synthase kinase 3 that reg

30 quential phosphorylation of LRP6 by GSK3 and casein kinase 1, and this dual phosphorylation promotes

31 ae, the redundant YCK1 and YCK2 genes (Yeast Casein Kinase 1) are required for viability.

32 Our results describe a role for casein kinase 1 as a direct regulator of sterol homeosta

33 beta-catenin involves its phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen synth

34 se (FASP) serine cluster embedded within the Casein Kinase 1 binding domain (CK1BD) of mammalian PER1

35 contained a single open reading frame termed casein kinase-1 binding protein (CK1BP).

36 nstrated that Ser(568) was phosphorylated by casein kinase 1 both in vitro and in vivo.

37 signaling pathway that leads from mGluRs to casein kinase 1 (CK1) activation.

38 ubiquitylation were blocked by disruption of casein kinase 1 (CK1) activity, and mass spectrometry an

39 inetics rely on site-specific recruitment of Casein Kinase 1 (CK1) and access of intrinsically disord

40 lation was reduced by specific inhibitors of casein kinase 1 (CK1) and casein kinase 2 (CK2) (10 muM

41 ometry approach were carried out to identify casein kinase 1 (CK1) and glycogen synthase kinase 3 (GS

42 such as phosphorylation of clock proteins by casein kinase 1 (CK1) and glycogen synthase kinase 3 (GS

43 untered by distinct NFAT kinases, among them casein kinase 1 (CK1) and glycogen synthase kinase 3 (GS

44 ligase complex upon dual phosphorylation by casein kinase 1 (CK1) and glycogen synthase kinase 3beta

45 In the absence of a Wnt signal, casein kinase 1 (CK1) and glycogen synthase kinase-3beta

46 n shown to interact with various isoforms of casein kinase 1 (CK1) and keratins and to mediate organi

47 (VRK1) and the delta and epsilon isoforms of casein kinase 1 (CK1) are linked to various disease-rele

48 under physiological conditions and identify Casein Kinase 1 (CK1) as an upstream effector that bidir

49 Casein kinase 1 (CK1) delta and epsilon share 97% sequen

50 rylation and that both were inhibited by the casein kinase 1 (CK1) delta/epsilon inhibitor IC261.

51 An increase of casein kinase 1 (CK1) expression has been described in t

52 lated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen synthase ki

53 Members of the casein kinase 1 (CK1) family are evolutionarily conserve

54 Members of the casein kinase 1 (CK1) family are important regulators of

55 Members of the casein kinase 1 (CK1) family have emerged as key regulat

56 azolopyridine, GW461484A (GW), which targets casein kinase 1 (CK1) family member Yck2.

57 e tau protein kinases include members of the casein kinase 1 (CK1) family of phosphotransferases, whi

58 dies to show that Ser-247 is a target of the casein kinase 1 (CK1) family of protein kinases.

59 Casein kinase 1 (CK1) has been implicated in a variety o

60 Here, the casein kinase 1 (CK1) Hrr25 is shown to be an endocytic

61 Yck2, a casein kinase 1 (CK1) in C. albicans, is targeted by ant

62 We have examined the role of casein kinase 1 (CK1) in connexin-43 (Cx43) gap junction

63 Casein kinase 1 (CK1) is a highly conserved serine/threo

64 Casein kinase 1 (CK1) is one such enzyme; it stimulates

65 r of kinases, including the serine-threonine casein kinase 1 (CK1) isoforms CK1d/e, regulate the timi

66 Casein kinase 1 (CK1) isoforms epsilon and delta, key ci

67 The cDNA for casein kinase 1 (CK1) of Plasmodium falciparum was clone

68 y protein kinase A (PKA) sites and secondary casein kinase 1 (CK1) or glycogen synthase kinase 3 (GSK

69 We have recently shown that Casein Kinase 1 (CK1) promotes timely progression throug

70 Phosphorylation of Cx43 by Casein Kinase 1 (CK1) regulates gap junction assembly.

71 ee specific PKA sites or adjacent PKA-primed casein kinase 1 (CK1) sites are replaced by alanine resi

72 protein kinase C (PKC) site Cx43(S368A), the casein kinase 1 (CK1) sites Cx43(S325A/328Y/330A), and t

73 Casein kinase 1 (CK1) was identified as the major kinase

74 ength Ci (Ci-155) by protein kinase A (PKA), casein kinase 1 (CK1), and glycogen synthase kinase 3 (G

75 at Ser680 promotes Ser683 phosphorylation by casein kinase 1 (CK1), and these phosphorylation events

76 Phosphorylation of the COPII coat by casein kinase 1 (CK1), Hrr25, contributes to the directi

77 nes; rephosphorylation by kinases, including casein kinase 1 (CK1), restores NFAT to its latent state

78 elsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymph

79 Casein kinase 1 (CK1)-mediated phosphorylation of Cx43 p

80 he PERIOD proteins, regulated by isoforms of casein kinase 1 (CK1).

81 ent manner by the plasma membrane-associated casein kinase 1 (CK1).

82 er-174 and Ser-175 by the nuclear isoform of casein kinase 1 (CK1).

83 egulated by the phosphorylation at Ser(6) by casein kinase 1 (CK1).

84 ain-derived tau filaments are members of the casein kinase-1 (CK1) family of protein kinases.

85 In this study, we determined the role of casein kinase-1 (CK1) in regulating NMDAR activity in th

86 Arsenite also recruited a TDP-43 kinase, casein kinase-1 (CK1), to GADD34.

87 dence that the delta and epsilon isoforms of casein kinase 1 (CK1delta and CK1epsilon) show identical

88 ly regulated by multisite phosphorylation by casein kinase 1 (CK1delta/epsilon).

89 Two such regulators, casein kinase 1 (CKI) and F-box and leucine-rich repeat

90 Here, we show that the Casein Kinase 1 (CKI) family is required for Expanded ph

91 atalytic domain of Schizosaccharomyces pombe casein kinase-1 complexed with CK17, refined to a crysta

92 Human casein kinase 1 delta (CK1delta) and epsilon (CK1epsilon

93 Both casein kinase 1 delta (CK1delta) and epsilon (CK1epsilon

94 Casein kinase 1 delta (CK1delta) and its closest homolog

95 Inhibition of casein kinase 1 delta (CK1delta) blocks primary ciliogen

96 A mutation in casein kinase 1 delta (CK1delta) was identified in non-h

97 hanced PASP IR also showed diminished IR for casein kinase 1 delta (Ck1delta), a marker of granulovac

98 can play an important role in dissection of casein kinase-1-dependent processes.

99 rane recruitment by Frizzled (FZD) and (iii) Casein kinase 1 e (CK1e) has a key regulatory function i

100 Casein kinase 1 epsilon (CK1epsilon) and its closest hom

101 requires both non-canonical Wnt5a ligand and casein kinase 1 epsilon (CK1varepsilon), and that this e

102 species, events that are highly dependent on casein kinase 1 epsilon (termed DOUBLETIME [DBT] in Dros

103 self-renewal, by inducing the expression of casein kinase 1 epsilon.

104 ut not other PI3Kdelta inhibitors, inhibited casein kinase-1 epsilon (CK1epsilon).

105 C compared to the other carcinomas, included casein kinase 1, epsilon and frizzled-7, both members of

106 Csnk1e, the gene encoding casein kinase 1-epsilon, has been implicated in sensitiv

107 be our isolation and characterization of the casein kinase 1 family member Hhp2 as a novel regulator

108 We demonstrate that Casein kinase 1 family members, including isoforms of Ta

109 he Hedgehog pathway are redundant with other Casein kinase 1 family members.

110 s showed that MPAK, which is a member of the casein kinase 1 family of Ser/Thr protein kinases, is re

111 icted protein-serine/threonine kinase in the casein kinase 1 family.

112 ropose that adoption of this conformation by casein kinase-1 family members stabilizes a delocalized

113 Members of the casein kinase-1 family of protein kinases play an essent

114 CK1delta, a member of the ubiquitous casein kinase-1 family, is implicated in the progression

115 Depletion of casein kinase 1 gamma (CSNK-1) in Caenorhabditis elegans

116 a multifaceted approach, we have found that casein kinase 1 gamma 1 (CK1gamma1) carries out this fun

117 ugh a yeast two-hybrid screen, we identified casein kinase 1 gamma 2 (CKIgamma2) as a novel Smad3-int

118 Here, we establish that the casein kinase 1 gamma CSNK-1 and a PIP(2) synthesis enzy

119 involves SOD1-mediated stabilization of two casein kinase 1-gamma (CK1gamma) homologs, Yck1p and Yck

120 ing protein (IQGAP); and three NFAT kinases, casein kinase 1, glycogen synthase kinase 3, and dual sp

121 ts G2 mode by blocking Srs2 DNA helicase and Casein Kinase 1 (Hhp1).

122 We also show casein kinase 1 (Hrr25) is a key kinase that phosphoryla

123 rotein interactions, and the pivotal role of Casein Kinase 1 in clock regulation.

124 Ser(9) was phosphorylated by casein kinase 1 in vitro in a phosphoserine 6-dependent

125 The structure reveals that IC261 stabilizes casein kinase-1 in a conformation midway between nucleot

126 We show that casein kinase-1 inhibition increases NMDA receptor activ

127 Conversely, pharmacological Casein Kinase-1 inhibition stabilizes REST, which in coo

128 We further evaluated whether D4476, a casein kinase 1 inhibitor, would exhibit selective antil

129 Because casein kinase 1 is associated with sites of polar growth

130 Casein kinase 1 is responsible for most of the hyperphos

131 Casein kinase-1 is a family of ubiquitous eukaryotic pro

132 Yck2 protein is a plasma membrane-associated casein kinase 1 isoform that attaches to membranes via p

133 creen was performed with human Ckidelta (the casein kinase-1 isoform most closely linked to granulova

134 s paralogs in humans may function to recruit casein kinase-1 isoforms to protein complexes involved i

135 e inhibitor with differential activity among casein kinase-1 isoforms, in complex with the catalytic

136 oline-8-sulfonamide (CK17), is selective for casein kinase-1 isolated from a variety of sources.

137 psis (Arabidopsis thaliana) CK1 member named casein kinase 1-like 6 (CKL6) associates with cortical m

138 Inhibition of casein kinase 1 may also contribute to the antitumoral a

139 in 90 and glycogen synthase kinase 3 but not casein kinase 1 nor LATS in YAP-mediated TAZ loss.

140 glycogen synthase kinase 3beta (GSK3beta) or casein kinase 1 or 2 (CK1/2) markedly slowed the decay o

141 tion was not modulated by the mTOR kinase or casein kinase 1 or 2, indicating ARP101 engages other ki

142 ists of two independent domains that contain casein kinase 1 phosphorylation sites.

143 New studies show that casein kinase 1 primes beta-catenin for subsequent phoph

144 Casein kinase 1 protein kinases are ubiquitous and abund

145 depends on the ubiquitin ligase Rsp5 and the casein kinase 1 redundant pair Yck1/Yck2.

146 x with the catalytic domain of fission yeast casein kinase-1 refined to a crystallographic R-factor o

147 he protein kinase A site, Thr-34, and at the casein kinase-1 site, Ser-137, and decreases phosphoryla

148 hosphorylation state of Ser137-DARPP-32, the casein kinase-1 site.

149 n synthase kinase and protein kinase A or of casein kinase 1 slowed the decay of nuclear NFATc1 after

150 sites for cAMP-dependent protein kinase and casein kinase 1 suggest a role for these kinases in Smo

151 e sensitive to pharmacological inhibition of Casein kinase 1, suggesting the possibility of shared cl

152 with FRQ-interacting RNA helicase (FRH) and casein kinase 1 to form the FRQ-FRH complex (FFC) which

153 Our data indicate that casein kinase-1 tonically regulates NMDA receptor activi