ライフサイエンスコーパス: casein kinase I

1 iod being exquisitely sensitive to levels of casein kinase I.

2 e identify the major phosphorylation site of casein kinase I.

3 phosphorylation of specific sites on axin by casein kinase I.

4 ties of the purified kinase identified it as casein kinase I.

5 a consensus sequence for phosphorylation by casein kinase I.

6 hia coli could be phosphorylated in vitro by casein kinase I.

7 inactivated by Cki1, the S. pombe homolog of casein kinase I.

8 evidence is presented indicating that it is casein kinase I.

9 Casein kinase I-alpha (CKI-alpha) was identified as an N

10 ulted in the amplification of cDNAs encoding casein kinase I-alpha and -gamma, while an in-gel casein

11 is consistent with the 36 to 40-kDa size of casein kinase I-alpha in other animal species.

12 ensus sequence for the acidotrophic kinases, casein kinase I and casein kinase II.

13 dation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-

14 ce, and the prospective Ser residue-specific casein kinase I and II phosphorylation sites for this pu

15 endent protein kinase, casein kinase II, and casein kinase I and not at all phosphorylated by MAPK.

16 trate of two red blood cell protein kinases, casein kinase I and p72syk protein tyrosine kinase.

17 ctivity; phosphopeptide analysis showed that casein kinase I and the connexin49 protein kinase activi

18 ation of optimal peptide substrates of CDK5, casein kinases I and II, NIMA, calmodulin-dependent kina

19 ing the phosphorylation of Vac17 via Yck3, a casein kinase I, and likely another unknown kinase.

20 nt galectin-3 was phosphorylated in vitro by casein kinase I, and separated from the native species b

21 ial and additive action of protein kinase A, casein kinase I, and the Fused (FU) kinase.

22 horylates Fas ligand, in which two conserved casein kinase I binding sites regulate NFAT activation a

23 n49 was shown to be a substrate for purified casein kinase I but not for casein kinase II; the endoge

24 us of Rho, as observed by phosphorylation by casein kinase I, but did not affect phosphorylation by R

25 We also show that casein kinase I, but not casein kinase II, can phosphory

26 Purified casein kinase I can also hyperphosphorylate DAH in the i

27 We have demonstrated that casein kinase I can attenuate TRAIL-induced apoptosis in

28 I alpha L proteins were demonstrated to have casein kinase I catalytic properties.

29 r axonemes has implicated the protein kinase casein kinase I (CK1) in regulation of dynein.

30 To assess the role of casein kinase I (CK1) in the regulation of dopamine sign

31 jacent Glycogen Synthase Kinase 3 (GSK3) and Casein Kinase I (CK1) sites.

32 Casein kinase I (CK1), a ubiquitous Ser/Thr protein kina

33 This region functions as a casein kinase I (CK1)-binding domain (CK1BD) mediating s

34 the FRQ-interacting RNA helicase (FRH), and Casein-Kinase I (CK1) form the FFC complex that represse

35 ested the ability of the acidotropic kinases casein kinase I (CKI) and casein kinase II (CKII) to pho

36 Recently, casein kinase I (CKI) and protein phosphatase 2A (PP2A)

37 Activity of the major clock kinase casein kinase I (CKI) epsilon is regulated by inhibitory

38 quential phosphorylation by PKA, GSK3, and a casein kinase I (CKI) family member(s).

39 Recent studies suggest that casein kinase I (CKI) family members play pivotal roles

40 Although members of the casein kinase I (CKI) family phosphorylate alphaSyn at S

41 Finally, disruption of a Neurospora casein kinase I (CKI) gene, ck-1b, showed that it is not

42 CK3, a gene that encodes a vacuolar membrane casein kinase I (CKI) homolog that nonredundantly functi

43 resulted in PER2 being hypophosphorylated by casein kinase I (CKI) in vitro.

44 is established that Ser45 phosphorylation by casein kinase I (CKI) initiates phosphorylation at Thr41

45 Casein kinase I (CKI) is a family of serine/threonine pr

46 Casein kinase I (CKI) is a family of widely expressed pr

47 veral approaches were used to determine that casein kinase I (CKI) is physically anchored in the flag

48 Casein kinase I (CKI) is required in both invertebrates

49 osophila melanogaster, mutations affecting a casein kinase I (CKI) ortholog called doubletime (dbt) c

50 iew these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of

51 Inhibition of casein kinase I (CKI) phosphorylation events in HT29, HC

52 We found that two casein kinase I (CKI) proteins, Yck1 and Yck2, previousl

53 Here we show that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell-surface accumula

54 to growth signals, and in collaboration with casein kinase I (CKI), generates a phosphodegron that bi

55 t Pah1 is phosphorylated by the YCK1-encoded casein kinase I (CKI), regulating Pah1 catalytic activit

56 A widely studied mutation in casein kinase I (CKI), the CKIepsilon(tau) mutant, has b

57 RQ), FRQ-interacting RNA helicase (FRH), and casein kinase I (CKI), which inhibits the activity of th

58 Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression

59 utation in a phosphorylation site within the casein kinase I (CKI)-binding domain of the human PER2 g

60 biquitination and destruction of VEGFR2 in a casein kinase I (CKI)-dependent manner.

61 Casein kinases I (CKI) are serine/threonine protein kina

62 ycolytic enzymes, phosphorylation of CDB3 by casein kinase I could conceivably impact erythrocyte str

63 ytic region of the mammalian protein kinase, casein kinase I delta (CKI delta), has been solved by X-

64 Casein kinase I delta (CKIdelta) and casein kinase I eps

65 r a critical requirement for the centrosomal casein kinase I delta (CKIdelta) in centrosome transloca

66 We also provide in vivo evidence that casein kinase I delta is a second clock relevant kinase.

67 Set8 for ubiquitination and degradation in a casein kinase I-dependent manner, which is activated by

68 Casein kinase I epsilon (CKI epsilon) is a member of the

69 ant for phosphorylation of Drosophila PER by casein kinase I epsilon (CKI epsilon; doubletime protein

70 ns, the cryptochromes (mCRY1 and mCRY2), and casein kinase I epsilon (CKIepsilon) form multimeric com

71 Casein kinase I delta (CKIdelta) and casein kinase I epsilon (CKIepsilon) have been implicate

72 The Drosophila double-time gene product, a casein kinase I epsilon (CKIepsilon) homolog, has been r

73 The serine/threonine protein kinase casein kinase I epsilon (CKIepsilon) is a key regulator

74 Casein kinase I epsilon (CKIepsilon) is a known componen

75 Casein kinase I epsilon (CKIepsilon) is a widely express

76 has suggested that phosphorylation of Dsh by Casein Kinase I epsilon (CKIepsilon) may act as a molecu

77 The tau locus is encoded by casein kinase I epsilon (CKIepsilon), a homolog of the D

78 Casein kinase I epsilon (CKIvarepsilon) is a Wnt-regulat

79 (CSNK1 epsilon, encoding the Ser/Thr kinase casein kinase I epsilon; DLG1, encoding a membrane-assoc

80 Multiple members of the casein kinase I family of serine/threonine protein kinas

81 (Nicotiana tabacum) PAPK is a member of the casein kinase I family.

82 siRNAs targeting casein kinase I gamma 3 (CSNK1G3) or the inositol polyph

83 ne MTA1s-interacting proteins, we identified casein kinase I-gamma 2 (CKI-gamma2, a ubiquitously expr

84 MP-dependent kinase A, protein kinase C, and casein kinase I had no effect.

85 In both mammals and fruit flies, casein kinase I has been shown to regulate the circadian

86 hemical evidence suggests involvement of the casein kinase I homolog doubletime (dbt) in the Drosophi

87 sphorylate Crz1p in vitro and identified the casein kinase I homolog Hrr25p.

88 of the interaction between FRQ and CK-1a (a casein kinase I homolog) results in the hypophosphorylat

89 Mutants defective in yeast casein kinase I homologues are unable to internalize alp

90 Activating beta-catenin through Casein Kinase I inhibition or Wnt3A addition increased b

91 Both GSK3 and casein kinase I inhibitors alleviate collagen repression

92 nd surveys of kinase inhibitors suggest that casein kinase I is a primary SV2 kinase.

93 ng to the growing list of processes in which casein kinase I is involved.

94 Protein kinase CK1 (formerly termed casein kinase I) is ubiquitous in eukaryotic cells and c

95 to vertebrate epsilon and delta isoforms of casein kinase I, is essential for circadian rhythmicity

96 scription-PCR using total ovine lens RNA and casein kinase I isoform-specific oligonucleotide primers

97 her, upon Fas ligand-mediated costimulation, casein kinase I phosphorylates Fas ligand, in which two

98 es, we show that Hrr25p, an isoform of yeast casein kinase I, phosphorylates Tif6p both in vitro and

99 ic acid (S6E) mutations were produced at the casein kinase I phosphorylation site in galectin-3.

100 Potential casein kinase I phosphorylation sites in Mth1 and Std1 a

101 this sequence not only showed two consensus casein kinase I phosphorylation sites, but also provided

102 een characterized, little is known regarding casein kinase I phosphorylation.

103 We propose that casein kinase I plays a similar role in both nutritional

104 talyzes the phosphorylation of connexin49 is casein kinase I, probably the alpha isoform.

105 protein kinase A, CDK2, Erk2, twitchin, and casein kinase I, provide a structural basis for the subs

106 expressed in Chinese hamster ovary cells and casein kinase I readily phosphorylated the immunopurifie

107 In vitro, purified casein kinase I selectively phosphorylates the beta3A an

108 n DARPP-32 at the PKA (Thr34) but not at the casein kinase I (Ser130) phosphorylation site.

109 a 12-amino acid leader sequence containing a casein kinase I serine phosphorylation site, which is pr

110 phosphorylation of CIITA by GSK3 relies on a casein kinase I site three amino acids C-terminal to the

111 lens membranes with KCl was inhibited by the casein kinase I-specific inhibitor, N-(2-aminoethyl)-5-c

112 Using isolated components, casein kinase I was found to phosphorylate the cytoplasm

113 ucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi

114 ed to the membrane-associated protein kinase casein kinase I (Yck1).

115 -induced phosphorylation of its prodomain by casein kinase I (Yck1/2).

116 ion is dependent on Ptr3 and the integral PM casein kinase I (Yck1/2).

117 res downstream assistance from an inhibitory casein kinase I, Yck3.

118 When HOPS is phosphorylated by the vacuolar casein kinase I, Yck3p, tethering only takes place when