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1 ine production from innate immune cells, but cast doubt on a different study, which suggests that thi
3 equency, detectable regulatory polymorphisms cast doubt on a model in which cis-acting variation is a
4 ults, which contradict previous evidence and cast doubt on a widely accepted model for the mtPTP, war
5 ily of transcription factors are infrequent, casting doubt on a direct role for E2Fs in driving cance
6 sults are observed with ectopic plakoglobin, casting doubt on a normal role for plakoglobin in axis s
9 This observation has sometimes been used to cast doubt on applicability of the Turing mechanism to c
13 ognising abstract shapes, a conclusion which casts doubt on cognitive explanations of fly behaviour i
14 e importance of NMR spectroscopy studies and cast doubts on drawing conclusions mostly based on singl
15 s have largely confirmed this view(4)(,)(5), casting doubt on earlier observations using capillary tu
17 ting the original igneous precursor, thereby casting doubt on evidence for a Palaeoproterozoic conver
18 s mitral regurgitation in cardiomyopathy and casts doubt on FMR being purely "functional" in etiology
19 be accommodated in the H. habilis holotype, casting doubt on H. rudolfensis as a biologically valid
21 The difficulties inherent in such controls cast doubt on how effective miRNAs are in driving phenot
22 rowth habit and wall strength of mur2 plants casts doubt on hypotheses regarding roles of xyloglucan
23 ty; however, variable results across studies cast doubt on its claimed capacity to enhance performanc
27 er for prostate cancer, further studies have cast doubt on its utility to diagnose this condition.
31 with hypertrophic or dilated cardiomyopathy, casting doubt on its acceptance as a distinct disease en
32 a natural amphi-North Atlantic distribution, casting doubt on its non-native status in the NW Atlanti
35 serve a solvent effect on radical stability, casting doubt on key aspects of the captodative effect.
37 of large collaborative outcome studies have cast doubt on many traditional 'common sense' practices.
38 r (CC) and Quantum Monte Carlo (QMC) methods casts doubt on many benchmarks for larger non-covalent s
39 s of rare familial forms of the disease have cast doubt on our understanding of the role of genetics
40 s is known about the use of such language to cast doubt on patient clinical history in hospital setti
44 resented by phenyl to naphthyl substitution, casting doubt on previous reports of predicted binding o
45 -positive cells in standard assay conditions casts doubt on previous inferences that the vast majorit
46 observed in Earth's stratigraphic record and casts doubt on previously hypothesized links between mar
50 (HGT) between distantly related rrn operons casts doubt on reconstructions of phylogenetic relations
51 se source localisation techniques, therefore casting doubt on reported differences in brain generator
53 hain" gating mechanism, but conflicting data cast doubt on such a mechanism, and thus the structure o
57 r-like cells in the slug posterior, however, cast doubt on that ability, and more recent experiments
58 ssociated with shear thinning and thickening cast doubt on that conclusion and leave unsettled whethe
60 rther research on spontaneous transformation cast doubt on that interpretation, and motivated re-exam
61 ndividual from subsequent infections and has cast doubt on the ability to develop effective vaccines.
62 spheres are of malignant origin, our results cast doubt on the assumption that adherent tumor-derived
65 results from a large multi-center study have cast doubt on the benefit of the broad application of hy
66 e functional consequences of their mutations cast doubt on the causal role of NL4 mutations in these
68 teraction between storage medium and filler, cast doubt on the clinical relevance of in vitro studies
69 ormalized left ventricular ejection fraction cast doubt on the complete reversibility of this conditi
73 pre-travel advice on malaria prevention, but cast doubt on the effectiveness of current strategies to
74 ficient to preserve vegetation condition and cast doubt on the effectiveness of protection elevation
78 ory and experiment in these paradigm systems cast doubt on the existence of LBHBs, as currently defin
79 nce from priming and aggregate turnover that cast doubt on the existence of SOC with profound intrins
80 mportance of temporal discharge patterns and cast doubt on the functional significance of call-select
84 ally distal environmental factors, then they cast doubt on the hypothesis that such factors have larg
86 idely among different leukemia specimens but cast doubt on the hypothesis that this variation is a ma
87 ld-type in phenotype [7]; these two findings cast doubt on the idea of a function for activin in earl
88 gnificant proliferative capacity in vivo and cast doubt on the idea that adult stem cells have a sign
89 required for meiosis in the genome has also cast doubt on the idea that Giardia is primitively asexu
91 hough recent findings by several groups have cast doubt on the importance of canonical disulfide pair
96 ecent estimates on younger OJN eruption ages cast doubt on the link between OJN volcanism and OAE1a.
97 entists conducted research which appeared to cast doubt on the link between smoking and p53 mutations
98 eam (GS) to the subpolar gyre (SPG) and have cast doubt on the mechanism underlying an apparent pathw
100 ized cyclic (amino)(aryl)carbene (CAArC), we cast doubt on the most common carbene trapping reactions
103 r closest living relatives likely exists and cast doubt on the notion that stable function representa
104 spective epidemiological data in humans have cast doubt on the possibility of a strong relationship.
106 create human liver diseases in mice, and has cast doubt on the potential of iPSC-Heps for liver cell
113 er hand, several arguments have emerged that cast doubt on the relevance of EF effects as a conceptua
115 ermination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported
123 ot from activation of the death pathway, and cast doubt on the utility of anti-apoptotic therapies to
124 l edema and subsequent anatomic changes have cast doubt on the utility of edema-weighted MR imaging a
125 tism in the phase diagram has for many years cast doubt on the validity of conventional models of mag
128 analysis of the proposed frameshifting site cast doubt on the validity of this claim and prompted us
129 However, recent behavioral studies have cast doubt on the validity of this dichotomy, showing th
130 ugated) genistein in certain strains of mice cast doubt on the value of the use of these rodents for
131 level in the Veterans Health Administration cast doubt on the value of using 30-day RSMRs as a means
136 n vary widely within and among lineages have cast doubts on the existence of a single "molecular cloc
137 sediments, but lower opal accumulation rates cast doubts on the importance of the EEP as an oceanic r
139 ron firing observed during other motor tasks cast doubts on the proposed mechanisms of movement regul
140 re was no such expansion in the simulations, casting doubt on the accuracy of methods that infer demo
141 lation of viral mutagens has been difficult, casting doubt on the clinical viability of this strategy
142 d and Waterborne disease (FWD) surveillance, casting doubt on the comparability of their results and
143 the lockdown measures in several countries, casting doubt on the effectiveness or on the implementat
144 n of the phenyl ring interaction to binding, casting doubt on the extent of the cation-pi effect.
145 he former can be retrieved associatively and casting doubt on the general consolidation hypothesis.
146 de of replication occurs in tissues, thereby casting doubt on the general validity of the "orthodox,"
147 of somewhat arbitrarily selected strategies, casting doubt on the generalizability of conclusions.
148 about sensory and motor variables is small, casting doubt on the hypothesis that correlations betwee
149 s in single-crystal absorbance measurements, casting doubt on the idea that ground state conformation
150 ne) even 24 h beyond a single exercise bout, casting doubt on the importance of nutrient timing vs. s
151 ed in two of the three BLUF domains studied, casting doubt on the importance of the formation of a po
152 cross a wide variety of tasks code modality, casting doubt on the notion that these regions embody a
153 etween the synthetic and the natural product casting doubt on the originally proposed structure.
154 ed in most cases after performing nested PCR casting doubt on the physiologic relevance of these spli
155 ne is not conserved between mouse and human, casting doubt on the proposed function of this proline r
156 e Sahara, which most ESMs fail to reproduce, casting doubt on the representation of land-atmosphere c
157 erent from both extant reptiles and mammals, casting doubt on the reptilian model for early synapsid
158 eported within myelinated tracts of the CNS, casting doubt on the role myelin-associated inhibitors p
159 press binding sites for factor VIII (fVIII), casting doubt on the role of exposed PS as the determina
160 ten found after more intense nerve activity, casting doubt on the role of rapid endocytosis at synaps
161 biogeographical differences between species, casting doubt on the speculation that the spectral sensi
162 c/dysoxic events did not affect seep faunas, casting doubt on the suggested anoxic nature and/or glob
163 n patterns in the circulation or in tissues, casting doubt on the usefulness of plasma nitrite/nitrat
164 was observed on nonhuman primate cell lines, casting doubt on the utility of nonhuman primates as mod
165 P assay conditions has never been published, casting doubt on the validity of previous calibrations.
166 ffects as the source of the catalytic power, casting doubt on the validity of the electrostatic idea,
168 ed the HCO(3)(-)-dependent oxidation of DCF, casting doubt on the validity of using DCF oxidation as
169 hat most NETs resemble intergenic sequences, casting doubts on the quality of such UniGene clusters.
170 mpR (OmpR-P) is unable to bind to EnvZ, thus casting doubts on the role of the EnvZ phosphatase activ
171 ntial for proton translocation by complex I, casting doubts on the suggestion of an asynchronous oper
175 considered to be important for those models, casts doubt on the current hypothesised mechanisms of ex
176 e of cervical loss of tooth structure, which casts doubt on the currently popular concept of abfracti
180 interpretation of data from previous studies casts doubt on the existence of sympathetic vasodilator
182 assumption creates an obvious confound that casts doubt on the feasibility of first-spike latency co
183 modulate short-term glucose homeostasis, but casts doubt on the general usefulness of the inhibition
184 etectable expression in the germ line, which casts doubt on the generality of the duplication model.
185 elta activity during conscious states, which casts doubt on the hypothesis that high amplitude delta
189 m Turkmenistan following the USSR's collapse casts doubt on the long-standing hypothesis regarding th
190 ent nucleosynthesis for realistic conditions casts doubt on the nup process being the explanation for
191 ct role in the etiology of this disorder and casts doubt on the previously proposed role of this prot
192 erably larger than previously recognized and casts doubt on the reliability of A(I) estimation by sur
193 ave not been adequately characterized, which casts doubt on the results reported in many scientific p
194 nitiated or spontaneous vocalizations, which casts doubt on the role of the frontal cortex of the Old
195 oxemia in the portal blood of trauma victims casts doubt on the role of the gut in the generation of
196 A recent report, using transgenic mice, casts doubt on the specificity of three antibodies commo
198 ciences and from clinical research, however, casts doubt on the validity of such criteria for clinica
200 the basal liverwort lineage Haplomitriopsida casts doubt on the widely held view that Glomeromycota f
202 -income backgrounds, but recent studies have cast doubt on their ability to substantially increase th
210 er, recent randomized controlled trials have cast doubt on these assumptions.Considering results from
222 tyle-associated factors and disease severity casts doubt on this association, and whether the risk is
228 t function for Rhomboid, an observation that casts doubt on this prevailing model of Rhomboid functio
231 ting the findings to human (patho)physiology casts doubt on using a single strain to address many que
233 is only at z = 3.2, and recent results have cast doubt on whether dust and molecules can be found in
234 ients have elevated VTE risk; recent studies cast doubt on whether GCS confers additional protection
237 ce sizes required to generate these dynamics cast doubt on whether they might be observable in annual
238 e of easily observable glycogen granules has cast doubt on whether this fuel store is operational, ev
240 environment selects"[4, 5], this hypothesis casts doubt on whether geographic divergence promotes sp
241 bias compared with the other methods, which casts doubt on whether its reconstructions should be fav
242 Furthermore, the solubility of C, O, and N casts doubt on whether rocky cores can exist in giant pl
246 otherwise nearly normal in its development, casting doubt on xyloglucan's role in wall structure.