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2 their DNA binding sites, leading to a xylose catabolic activation independent of catabolite repressio
3 in the joint cavity, which can increase the catabolic activities of chondrocytes and damage cartilag
4 ion factors mediate the growth-promoting and catabolic activities of the lysosome and undergo a compl
9 gonia are prevented from responding to RA by catabolic activity of cytochrome P450 family 26 enzymes.
11 to balance the benefits of the enhanced host catabolic activity with the risk of being eliminated by
13 ng of specific nutrients to engage them into catabolic and anabolic processes, and contributes to tem
17 and TNF-alpha, induce aberrant expression of catabolic and degradative enzymes and inflammatory cytok
20 vely impacts articular cartilage, triggering catabolic and inflammatory responses in chondrocytes.
22 tents of gene connectivity, are enriched for catabolic and muscle system processes respectively, and
23 uman IVD tissue and induced an inflammatory, catabolic and pro-angiogenic phenotype in bovine nucleus
25 r the identification of anabolic, transport, catabolic and regulatory portions of the cycloalternan p
26 nses energetic stress and, in turn, promotes catabolic and suppresses anabolic metabolism coordinatel
28 ulation represent much of the purpose of the catabolic arms of metabolism and then drive many anaboli
30 ations and the exoproteome of three aromatic-catabolic bacteria: Pseudomonas putida KT2440, Rhodoccoc
31 s, while PTs are especially characterized by catabolic/biosynthetic and transport processes including
35 ism observed may indicate that mitochondrial catabolic capacity is a key constraint setting an upper
36 nitrogen starvation to address the roles of catabolic carbon recycling, acyl chain redistribution, a
38 at AGGF1 activates autophagy, a housekeeping catabolic cellular process, in endothelial cells (ECs),
39 Macroautophagy (hereafter autophagy) is a catabolic cellular self-eating process by which unwanted
40 mmune and nervous systems drive anorexia and catabolic changes in adipose tissue and skeletal muscle,
41 otes reactive oxygen species (ROS) to induce catabolic changes through stabilization of IkappaB-zeta,
42 s, MV-induced diaphragm inactivity initiates catabolic changes via rapid activation of Smad3 signalin
48 dings enhance the understanding of microbial catabolic diversity during adaptive evolution in respons
49 fects suppressing osteoblastogenesis and pro-catabolic effects enhancing osteoclastogenesis, which dr
52 demonstrates that MCP-1 has a role in PTH's catabolic effects on bone including monocyte and macroph
55 ard direct competition for the same limiting catabolic electron donor substrate with subsequent niche
56 s of serine, histidine, and methionine; (iv) catabolic end products of lignin (pyruvate and oxaloacet
59 de (AEA) signaling through inhibition of its catabolic enzyme fatty acid amide hydrolase (FAAH) in th
61 x 10(-53)), a gene that encodes the primary catabolic enzyme for 1,25-dihydroxyvitamin D and 25-dihy
62 -molecule inhibitors of the tryptophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO) repre
67 ression of genes encoding putative cell wall catabolic enzymes (including those involved with pectin)
68 is consumed by this microorganism using the catabolic enzymes encoded by genes hpdH, hbdH and mmsA.
71 s, type 1 and 2, as well as biosynthetic and catabolic enzymes of the endocannabinoids N-arachidonoyl
72 uggests that coordinate targeting of the Trp catabolic enzymes tryptophan 2,3-dioxygenase (TDO) and I
73 atch a broad specificity of hydroxycinnamate catabolic enzymes while responding to toxic thioester in
74 gulated expression of genes for sphingolipid catabolic enzymes, pointing to additional mechanisms for
75 Dioxane metabolism can be initiated by two catabolic enzymes, propane monooxygenase (PRM) and tetra
77 rgely layered structure consisting of mostly catabolic enzymes; (iii) an anabolic module with a simil
79 with HMWHA was more effective in inhibiting catabolic events and stimulating anabolic events than P1
81 gest that P15-1 together with HMWHA inhibits catabolic events in articular chondrocytes via the inhib
82 identification of novel factors that reduce catabolic events in chondrocytes and enhances chondrogen
83 nflammatory properties of HMWHA and decrease catabolic events in interleukin-1beta (IL-1beta)-treated
84 , it can be presumed that PRF suppresses the catabolic events that are caused by osteoclastic bone re
85 ase expression of cytokines, chemokines, and catabolic factors that damage synovial tissues and can a
87 chondrial bioenergetics, biogenesis and fuel catabolic functions are distinct in cells harboring low
88 naling inhibits inflammatory stimuli-induced catabolic gene expression in human articular chondrocyte
89 triterpenoid biosynthetic and glucosinolate catabolic genes are up-regulated in jazQ independently o
91 mediation by flooding local populations with catabolic genes for petroleum hydrocarbon degradation.
93 in coordinated up-regulation of chlorophyll catabolic genes, impairment of chloroplast biogenesis, a
94 ulates the expression of multiple methionine catabolic genes, including SAM synthetase (Sam-S), as we
101 We find that S47 cells exhibit decreased catabolic glycolysis but increased use of the pentose ph
102 is a key regulator of autophagy, a critical catabolic homeostasis pathway that involves sequestratio
104 Circulating concentrations of glucagon, a catabolic hormone that affects these metabolic pathways,
105 that Cyp26a1, which encodes a key enzyme for catabolic inactivation of RA required for tight control
106 producing N-gamma-ADABA but not the ectoine catabolic intermediate N-alpha-acetyl-l-2,4-diaminobutyr
107 to identify 3-hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, as a new para
109 e (C8:0-OH), putative hydrolysis products of catabolic intermediates for alpha-linolenic acid and lin
110 abolic organelles necessary for anabolic and catabolic lipid reactions whose numbers are highly dynam
113 nhibit ROS production and the suppression of catabolic markers including IL-6, COX-2, iNOS, MMP-3, MM
117 hagy (hereafter referred to as autophagy), a catabolic membrane trafficking pathway that degrades cel
118 flux into the anabolic pathway and maintains catabolic metabolism for energy production, thus prevent
119 oduce the biological infrastructure, whereas catabolic metabolism generates energy to fuel all biolog
120 ted hyaluronan respond by switching to a pro-catabolic metabolism that includes enhanced production o
121 ls metabolically shift from an ATP-producing catabolic metabolism to a metabolism that supports anabo
123 include the carboxysome for CO2 fixation and catabolic microcompartments found in many pathogenic mic
124 ed within the Staphylococcus aureus arginine-catabolic mobile element (ACME) that we hypothesized fun
125 e leukocidin (PVL), SCCmec IVa, the arginine catabolic mobile element (ACME), and a specific mutation
126 lular metabolic fluxes generally go from the catabolic module to the core for substantial interconver
127 sions among intermediate metabolites; (ii) a catabolic module, with a largely layered structure consi
128 protein regulates the expression of the hca catabolic operon in Acinetobacter and related bacterial
129 on in a transcriptional activator for xylose catabolic operons, either CRP or XylR, and these mutatio
130 eady state response of metabolic regulation (catabolic or anabolic) with respect to structural and in
131 lucose range, eventually making the response catabolic or unresponsive to increasing glucose levels.
134 lism of Escherichia coli; (iii) the vanillin catabolic pathway (which is the converging point of majo
135 The fact that the genes responsible for the catabolic pathway are separately located on plasmid and
136 al profile after SCI and highlight the lipid catabolic pathway as an important macrophage function th
137 al profile after SCI and highlight the lipid catabolic pathway as an important macrophage function th
138 expression analysis establishes the vanillin catabolic pathway as the major contributor of NAD(P)H sy
139 ations of the first 6 metabolites in the Trp catabolic pathway by LC-MS-MS in the community-based Hor
143 ish the production of GalOA or the full GalA catabolic pathway in Saccharomyces cerevisiae proved cha
146 resistance mechanism in Mtb and an l-leucine catabolic pathway that proceeds via an unprecedented (R)
147 complete genes that encode the conserved IPU catabolic pathway were revealed, based on comparative an
149 f the rate-limiting enzyme in the pyrimidine catabolic pathway, dihydropyrimidine dehydrogenase (DPYD
150 In the recently discovered bacterial L-AHG catabolic pathway, L-AHG is first oxidized by a NAD(P)(+
151 unctional comparisons to identify a putative catabolic pathway, thereby distinguishing RV1423 from a
152 ), the first intermediate of the fungal GalA catabolic pathway, which also has interesting properties
153 bioremediation requires knowledge of its BAM-catabolic pathway, which is currently restricted to the
160 as investigated in dependence of 2 different catabolic pathways (the Embden-Meyerhof-Parnas or the pe
161 n availability and specific transporters and catabolic pathways activated with increasing aerobiosis.
163 of mutations, and that anabolic rather than catabolic pathways are more stringently required, likely
165 that this pattern is caused by retention of catabolic pathways from the host during plastid secondar
169 luding proteins and amino acids; many of the catabolic pathways needed to assimilate these compounds
170 In response to low energy, AMPK stimulates catabolic pathways such as autophagy to enhance energy p
171 ge and understanding of the biosynthetic and catabolic pathways that are relevant to the complex trai
172 es the magnitude of mechanistically distinct catabolic pathways that ensure lysosomal clearance of a
174 ars and fats can feed into many anabolic and catabolic pathways(1), how our bodies handle nutrients d
175 e converging point of majority of the lignin catabolic pathways) is coupled with the tetrahydrofolate
176 SIRT1 plays in modulating both anabolic and catabolic pathways, allow us to propose the hypothesis t
177 by oral microbes, specifically via arginine catabolic pathways, is an essential factor in maintainin
178 glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid oxidation (FAO).
179 vating biosynthetic pathways and suppressing catabolic pathways, particularly that of macroautophagy.
180 sis is achieved via complex biosynthetic and catabolic pathways, whose exact activities remain to be
188 herefore, therapies targeted at reducing the catabolic phenotype may protect against degenerative joi
189 etic modifications that imparts a persistent catabolic phenotype to the FLS, despite their dissociati
190 firmed the presence of distinct anabolic and catabolic phenotypes, and identified differential expres
191 ocean, and is highest in the sediment.s DMSP catabolic potential is present throughout the trench wat
192 A wide range of therapeutics including anti-catabolic, pro-anabolic factors and chemo-attractants th
193 and biological processes, such as transport, catabolic process and small molecule metabolic process,
196 IAA oxidation by DAO1 is the principal auxin catabolic process in Arabidopsis and that localized IAA
198 irect lipid sources for autophagy, a central catabolic process in homeostasis and stress response.
200 that LRRK2 can act to regulate the cellular catabolic process of macroautophagy, although the precis
202 utophagy ("autophagy") is the main lysosomal catabolic process that becomes activated under nutrient-
203 s a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macr
205 ion in autophagy, an intracellular lysosomal catabolic process that regulates protein homeostasis and
208 croenvironment and can activate autophagy, a catabolic process which provides nutrients during starva
210 ic process, negative regulations of cellular catabolic process, and regulation of cellular protein lo
212 nalling pathway, ubiquitin-dependent protein catabolic process, ion transport, abiotic and biotic str
213 teasome-mediated ubiquitin-dependent protein catabolic process, negative regulations of cellular cata
214 folding, response to stress, single-organism catabolic process, regulation of peptidase activity, and
216 ains how CDK4 promotes anabolism by blocking catabolic processes (FAO) that are activated by AMPK.
217 on feedback loop that separates anabolic and catabolic processes across the Earth's 24-h light-dark c
218 , two proteins involved in mitochondrial RNA catabolic processes and both negatively correlated with
219 c intermediate acetyl-CoA links anabolic and catabolic processes and coordinates metabolism with cell
220 rocal effect of methotrexate on anabolic and catabolic processes and implicate AMPK activation as a m
222 onal protein targeting to membrane, and mRNA catabolic processes are the top biologic processes respo
223 al leaf senescence, mitochondria orchestrate catabolic processes by becoming increasingly central ene
224 WNT/beta-catenin signaling is a regulator of catabolic processes in cancer cells, which varies depend
225 reased expression of VEGF is associated with catabolic processes in chondrocytes and synovial cells.
230 Strikingly, a strong upregulation of various catabolic processes was observed in the absence of autop
240 raminidases 3 and 4, play important roles in catabolic processing of brain gangliosides by cleaving t
242 g brain, and an increase in H(13)CO(3)(-), a catabolic product of KIC through the mitochondrial BCKDC
244 show that at least three separate potential catabolic products of allyl-GSL or closely related compo
247 Faulty execution of lysosomal growth and catabolic programmes drives cancer, neurodegeneration an
249 in the urea kinetic-based normalized protein catabolic rate (nPCR), an indicator of protein intake in
250 eatures that enable their persistence at low catabolic rates for millions of years, remain unknown.
254 ates to determine the energy yields of other catabolic reactions at environmentally relevant conditio
255 ses and the stimulation of energy-generating catabolic reactions by transcriptional reprogramming and
257 ssure and chemical composition for microbial catabolic reactions, including a discussion of the effec
261 review, we summarize current knowledge about catabolic reductive dehalogenases and the electron trans
263 4 host gene expression profiles, among which catabolic remodeling, associated with high expression of
264 atrix synthesis or degradation (anabolic and catabolic remodeling, respectively) was quantified by re
266 e utility of these tools by examining ADP1's catabolic repression regulation, creating a strain with
268 CM)-treated C2C12 myotubes underwent a rapid catabolic response in a TLR4-dependent manner, including
269 by SGs indicates a role in IL-1beta-mediated catabolic response that could be therapeutically targete
270 en AKT and PDE3 is responsible for efficient catabolic response under low glucose condition; the cros
271 nduced activation of the C/EBPbeta-dependent catabolic response, which included upregulation of E3 li
274 tory, the immunosuppressive, and the protein catabolic responses individually, successful treatment o
275 SCs, AM hydrogels and AM-ADSCs inhibited the catabolic responses of IL-1beta and inhibited the Wnt/be
276 tic effect of AM with ADSC in preventing the catabolic responses of inflammation in stimulated chondr
281 composition, protein synthesis, anabolic and catabolic signalling, mitochondrial phenotype and gene e
283 e availability, resident species with a high catabolic similarity with the invader efficiently reduce
285 c changes consistent with the induction of a catabolic state that was not rescued by inositol supplem
286 ficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contribu
291 (HX), and gelsolin (GSN), and tested against catabolic stimulation for their effects on glycosaminogl
292 n of a Microbacterium maritypicum riboflavin catabolic strain, and the cloning of the riboflavin cata
294 dings indicate that analytes associated with catabolic stress were altered in infants with HIE; howev
295 bserved activity within a complex eukaryotic catabolic system remains one of the most significant cha
296 opose that, by determining the fate of these catabolic systems, this hierarchical switch regulates th
297 hese responses were also linked to decreased catabolic (TNF-alpha, TWEAK/Fn14 axis; FOXO-1, Atrogin-1
298 ent signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell
299 hich critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyc
300 ible for ensuring ultrasensitive response in catabolic zone (glucose <4.5 mmol); the crosstalk betwee