ライフサイエンスコーパス: catalytic center

1 modifying the helical pitch adjacent to the catalytic center.

2 cyclase complex or even a large multienzyme catalytic center.

3 om the bulk and promptly positioned near the catalytic center.

4 cid (Glu-141), suggesting flexibility in the catalytic center.

5 l L-serine dehydratases that utilize an Fe-S catalytic center.

6 isease, target residues that are part of the catalytic center.

7 s exclusively on the nonreducing side of its catalytic center.

8 he nicotinamide ring well ordered within the catalytic center.

9 controlled at a docking site remote from the catalytic center.

10 omplex and reversibly expose and conceal the catalytic center.

11 -strand RNAs (+RNAs) and guide them into the catalytic center.

12 2 duplex and its positioning relative to the catalytic center.

13 was Gly244Val, a novel mutation close to the catalytic center.

14 the RNase H primer grip and into the RNase H catalytic center.

15 downstream from the ribonuclease H (RNase H) catalytic center.

16 sidues and five water molecules in the PDP1c catalytic center.

17 ry domains and promotes self-assembly of the catalytic center.

18 substrate structure in order to assemble the catalytic center.

19 predicted to bind poorly at the spliceosome catalytic center.

20 hang immediately ahead of the DNA polymerase catalytic center.

21 on the opposite side of the RHbetaH from the catalytic center.

22 for INS2 in a surface cleft adjacent to the catalytic center.

23 r(337) involves direct contact with the PKAc catalytic center.

24 at the SRD is in close proximity to the EF-G catalytic center.

25 ion complex and that occur downstream of the catalytic center.

26 oncomplementary nucleotide to the polymerase catalytic center.

27 tate analogs and therefore distinct from the catalytic center.

28 "thumb" domain, about 30 A from the enzyme's catalytic center.

29 ate groups can be decarboxylated at the same catalytic center.

30 can be disrupted without an effect on either catalytic center.

31 is brought to the immediate vicinity of RNAP catalytic center.

32 mutations had little or no effect on either catalytic center.

33 3 RT approximately 12-13 bp from its RNase H catalytic center.

34 tory of the template relative to the RNase H catalytic center.

35 text of a preorganized and solvent-excluding catalytic center.

36 channel and blocking substrate access to the catalytic center.

37 ace of the RNase T monomer opposite the DEDD catalytic center.

38 ng that connects the enzyme surface with the catalytic center.

39 ularly clear view of the four coppers at the catalytic center.

40 lytic cysteine in the aldehyde dehydrogenase catalytic center.

41 es, aspartate and histidine, in the putative catalytic center.

42 YP4 family of mammalian P450s and their heme catalytic center.

43 rings the two HKD domains together to form a catalytic center.

44 lymerase to displace the 3' OH away from the catalytic center.

45 fluence on the electronic environment of the catalytic center.

46 nclear, undergo positional shifts toward the catalytic center.

47 that excludes external solvent access to the catalytic center.

48 nH2 domain, which acts as a scaffold for the catalytic center.

49 f an electron transfer site distant from the catalytic center.

50 ith USP12 at two distinct sites far from its catalytic center.

51 elis complex, substrate does not contact the catalytic center.

52 s that contain at least one iron atom in the catalytic center.

53 he RNA:DNA hybrid and in the vicinity of the catalytic center.

54 the pocket (-2* subsite) that abuts onto the catalytic center.

55 udies support a binuclear copper site as the catalytic center.

56 urally differentiated heme that provides the catalytic center.

57 hly electrophilic single-site d(0) Zr-benzyl catalytic center.

58 by their adduction to Cys521 proximal to its catalytic center.

59 coupling between the dimer interface and the catalytic center.

60 r the active site and controls access to the catalytic center.

61 state with Glu-288 positioned away from the catalytic center.

62 inds to the enzyme in close proximity to the catalytic center.

63 onic effect of the ligand arrangement at the catalytic center.

64 s the pKa values of the acid residues at the catalytic center.

65 active leads binding to site 4, outside the catalytic center.

66 stitution, immediately adjacent to the beta' catalytic center.

67 NA from reaching the active site in the RNAP catalytic center.

68 pend on the two SH2 domains and on an intact catalytic center.

69 h predicts substrate interactions beyond the catalytic center.

70 that the enzyme has a unique bimetal Mg(2+) catalytic center.

71 d to deliver multiple electrons/holes to the catalytic centers.

72 , 13 A away from the Mg(2+) positions in the catalytic centers.

73 of Fe(II) ions with O(2) at multiple di-iron catalytic centers.

74 se of a loose fit of substrates bound in the catalytic centers.

75 formational change to toggle between the two catalytic centers.

76 assembly containing six copies of all eight catalytic centers.

77 y functional sites such as binding motifs or catalytic centers.

78 relationship between these N- and C-terminal catalytic centers.

79 mational shift that does not perturb the two catalytic centers.

80 three catalytic activities but has only two catalytic centers.

81 an increased spatial separation between the catalytic centers.

82 the unnatural reactivity of transition-metal catalytic centers.

83 iates in the hydrophilic microenvironment of catalytic centers.

84 on of alternate activation/inhibition of the catalytic centers.

85 strates, high mobility, and stability of the catalytic centers.

86 he bulky N-methylanthraniloyl-CoA within the catalytic centers.

87 substrate phosphorylation sequence into the catalytic center, (2) there is minimal allosteric commun

88 hates predicted to be in the vicinity of the catalytic center (A207, C208, A304, U305, and A306) with

89 hen an iron-sulfur cluster is present in its catalytic center, aconitase displays enzymatic activity;

90 ognized family of metalloproteases that have catalytic centers adjacent to or within the membrane.

91 om the helical scaffold, the position of the catalytic center along the peptoid backbone, and the deg

92 that autophosphorylation, while exposing the catalytic center, also produces a conformer less stable

93 y of first and second step substrates at the catalytic center alter efficiency of the two steps of sp

94 odulin-binding domain (CBD), which block the catalytic center and a conserved substrate-binding groov

95 gest that Cys(343) and Tyr(345) are near the catalytic center and affect the active site conformation

96 was completely inactivated by abolishing the catalytic center and C-terminal regulatory domain, produ

97 disrupting a metal-ligand interaction at the catalytic center and discovered that, when the DEAH box

98 -jaw" region of RNAP II is downstream of the catalytic center and distal to the site of RNAP II-TFIIB

99 However, little is known about its catalytic center and how it interacts with these two typ

100 in tandem into the DNA template ahead of the catalytic center and investigated whether they induce pa

101 Cys-110 is near the zinc-binding catalytic center and is normally buried.

102 tive to the step of subunit placement at the catalytic center and potentially to the reaction status

103 losely to the spatial separation between the catalytic center and RNase H primer grip.

104 --a relatively nonspecific activation of the catalytic center and specific selection of water as a nu

105 ming NTP substrates are thought to reach the catalytic center and the 3' end of the nascent RNA is li

106 tin-like gelatin binding region flanking the catalytic center and the carboxyl hemopexin-like region.

107 ed by a long-range communication between the catalytic center and the coenzyme-binding domain and poi

108 on the outer surface of RNAP, away from the catalytic center and the nucleic acid binding path.

109 Trp-332, situated near the catalytic center and the nucleotide-binding area of TG2,

110 Mini-RAG1 consists primarily of the catalytic center and the residues N-terminal to it, but

111 cts with product RNA located upstream of the catalytic center and the RNA-DNA hybrid, a view consiste

112 rol the access of substrates to the embedded catalytic center and thereby modulate the outcome of che

113 Substitution of amino acids at the catalytic center and/or groove substantially improved th

114 ong-lived radical ion pair states that power catalytic centers and, consequently, the production of s

115 wo zinc ions instead of two iron ions in the catalytic center, and as a result, the enzymes are inact

116 e CBR class that target the enzyme's complex catalytic center are attractive leads for new antimicrob

117 Although the overall fold and catalytic center are conserved relative to other NPPs, a

118 ations in or surrounding the metalloprotease catalytic center are properly assembled into CSN complex

119 rotationally symmetric cosN precisely to the catalytic center are proposed to rely on an ~60 residue

120 cate that it is capable of forming an active catalytic center as a monomer.

121 ctive transformations at an embedded achiral catalytic center, as illustrated by the oxidative kineti

122 HP (PDB entry 2DHN), four snapshots for the catalytic center assembly along the reaction pathway can

123 uring catalysis: together, they organize the catalytic center assembly, and individually, each plays

124 r in the structure, forming the endonuclease catalytic center at cosN, the nicking site.

125 on mutagenesis was performed near the diiron catalytic center at positions I100, G103, and A107 of th

126 consists of only two domains that define the catalytic center at the bottom of the nucleoside triphos

127 could aid in positioning the ribonuclease H catalytic center at the PPT/U3 junction and also provide

128 further showed that His28 and His114 in the catalytic center bind a variety of divalent metal ions w

129 The DNA minor groove is compressed at the catalytic center, bringing the two scissile phosphodiest

130 s does not contribute directly to the enzyme catalytic centers but is crucial for 10-formyltetrahydro

131 NPP), have nearly identical binuclear Zn(2+) catalytic centers but show tremendous differential speci

132 cilitate exiting of the Gla product from the catalytic center by ionic attraction.

133 tivity, probably due to the occlusion of its catalytic center by LARP7.

134 ong-range chemical environment surrounding a catalytic center can be readily achieved.

135 Finally, we show that a site remote from the catalytic center can control this checkpoint, which occu

136 template strand two nucleotides ahead of the catalytic center can interrupt DNA synthesis.

137 l relationship between its N- and C-terminal catalytic centers compared with HIV-1 RT.

138 cling [NiFe] hydrogenases harbor a dinuclear catalytic center composed of nickel and iron ions, which

139 wo electrons have to be transferred into the catalytic center, composed of heme a(3) and Cu(B), befor

140 We noted that the oxidized catalytic center contains a Cu(II) coordinated by two Hi

141 e-phosphate isomerase (TIM) barrel fold, the catalytic center contains a divalent cation-binding site

142 ituted glutathiones or by mutagenesis of the catalytic center Cys(32) to alanine.

143 ll-death-inducing activities depend on their catalytic center cysteine residues as well as caspase-li

144 that one NBS1 residue, Arg(13), sits at the catalytic center despite being on the opposite side of t

145 e in some vertebrate NP receptors, harbors a catalytic center diagnostic for guanylyl cyclases and th

146 , comprising Tyr-161 through Ser-178, of the catalytic center dimerization domain of VanS, a sequence

147 ecifically, residues 148-151 interact at the catalytic center, displacing essential metal ions, accou

148 Of the five residues targeted at the catalytic center, E159D resulted in substantial loss of

149 ucleotides reveal, at the atomic detail, the catalytic center embraced by the ATPase domain and the l

150 s to a site on fXa that is distinct from the catalytic center (exo-site).

151 The catalytic centers face the inner canal confining protein

152 possible conformational coupling between the catalytic center (Fe(a3)(3+)-Cu(B)(2+)) and a protein si

153 Modeling of the putative hydrolase catalytic center/folate-binding site suggested that the

154 docking site and the ATP binding site in the catalytic center for activated JNK2alpha2, and (3) the r

155 se as an example, we placed mutations in the catalytic center for editing at residues strongly conser

156 sites by creating mutations that disrupt the catalytic center for editing but not for aminoacylation

157 e(2+) fails to replace Mg(2+) in the RNase H catalytic center for localized generation of hydroxyl ra

158 lease domains to dimerize to form the active catalytic center for the induction of the DSB.

159 inuities in the lipid continuum can serve as catalytic centers for a previously unseen microscale agg

160 of Escherichia coli DNA polymerase I houses catalytic centers for both polymerase and 3'-5' exonucle

161 erminal strand of RbcL, which stabilizes the catalytic center, for access to the Rca hexamer pore.

162 electrons per NO, which are supplied to the catalytic center from NADPH through reductase domains in

163 ubstrate recognition site, while leaving the catalytic center fully accessible.

164 s that are considered to be crucial for RNAP catalytic center function.

165 The functional groups at the catalytic center have clearly undergone H-D exchange des

166 fine turning the electronic structure of the catalytic centers, hence their activity and selectivity.

167 sting the modifications likely disrupted the catalytic center, illustrating the significance of the H

168 dicating that they probably form the RNase T catalytic center in a manner similar to that found in ot

169 peration between the RNase H primer grip and catalytic center in achieving this cleavage.

170 alpha-hydroxylating monooxygenase (PHM) or a catalytic center in copper nitrite reductase (CuNiR).

171 lows the formation of an optimally organized catalytic center in the heterodimer.

172 ta provide compelling evidence for an ATPase catalytic center in the N-terminal half of the large ter

173 might form a putative cysteine endopeptidase catalytic center in the proteolytic cleavage of AgrD at

174 imer thereby positioning the U8 close to the catalytic center in the pyrophosphatase domain of the ot

175 nal analysis allowed us to identify a unique catalytic center in this class of DNA glycosylases.

176 These results reveal a view of the catalytic center in which an inner shell of conserved nu

177 of reaction and showed that the majority of catalytic centers in this MOF are redox-accessible where

178 which carries an amino acid exchange in the catalytic center, increases the DNA methylation rate by

179 It has been hypothesized that the two catalytic centers interact functionally, perhaps by shut

180 e-deleted subunits, activity of the affected catalytic center is fully restored when the Nat1-Ard1 Na

181 The catalytic center is housed mainly within a (beta/alpha)8

182 hat removal of the branch structure from the catalytic center is in competition with binding of the 3

183 ransfer from reduced heme a and Cu(A) to the catalytic center is inhibited and both heme a3 and Cu(B)

184 The catalytic center is known to contain two Mg(2+) ions, an

185 l a (beta/alpha)(8) barrel fold in which the catalytic center is present in a long substrate-binding

186 nding of cyanide to heme a3 in this oxidized catalytic center is, however, dependent on the redox sta

187 ed that residue G121, which is 19 A from the catalytic center, is involved in catalysis, and long dis

188 ghly conserved 9 amino acid stretch in their catalytic center known as the RNase III signature motif.

189 +) forms of BFR showed that the intrasubunit catalytic center, known as the ferroxidase center, is pr

190 isomerism dependent oxidative activation of catalytic center leads to a nonprecious molecular cataly

191 by positioning the RING-E2 approximately UBL catalytic center, licensing the acceptor lysine, and inf

192 The functional dimer contains two catalytic centers located at the interface between subun

193 bstrate within gamma-secretase such that its catalytic center must start proteolysis at the known ini

194 The crystal structure based model of the catalytic center of Ago2 revealed that the siRNA and the

195 Because the catalytic center of all Dus enzymes is conserved, it is

196 anism for CO oxidation by the C-cluster, the catalytic center of an environmentally important enzyme.

197 We also find that the catalytic center of bRT plays an essential role in site-

198 hesis of heme a, the prosthetic group of the catalytic center of COX.

199 The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His

200 a network of metal binding sites within the catalytic center of INPP1.

201 In essence, the catalytic center of mouse 38C2, which encompasses a deep

202 ability of p22phox, another component of the catalytic center of NAD(P)H oxidase.

203 The catalytic center of nitric-oxide synthase (NOS) consists

204 The catalytic center of nitrogenase, the [Mo:7Fe:9S:C]:homoc

205 The structure of 6 and the catalytic center of one DMSO reductase isoenzyme have si

206 vidence clearly advances the notion that the catalytic center of oxygen evolution is a Mn-Ca heteronu

207 e membrane-binding (regulatory) site and the catalytic center of PLA(2), which contributes to the int

208 11p (C11) mediates RNA 3'-5' cleavage in the catalytic center of pol III during pausing.

209 To map the Mg(2+) binding site in the catalytic center of primase, we have employed the iron c

210 id residues that chelated Mg(2+) ions in the catalytic center of primase.

211 T) instead of the conserved histidine in the catalytic center of retroviral RTs such as at position 5

212 though Argonaute2 has been identified as the catalytic center of RISC, the RISC polypeptide compositi

213 acilitate the chelation of metal ions in the catalytic center of target enzymes.

214 Certain structural features at the catalytic center of TbetaR-I are characteristic of tyros

215 321, and Glu-489), are predicted to form the catalytic center of the active site, where the n1 site i

216 nd 17 introns with exons 9 to 14 forming the catalytic center of the enzyme and exons 1 to 3 encoding

217 ure appears integral to the formation of the catalytic center of the enzyme and this arrangement stro

218 The binuclear site, which is the catalytic center of the enzyme, possesses two conformati

219 ng" onto the protein some 12 A away from the catalytic center of the enzyme, resulting in the creatio

220 ough different forms of PARPi all target the catalytic center of the enzyme, they have variable abili

221 ting to an interaction of BYK191023 with the catalytic center of the enzyme.

222 ace and the electrostatic environment in the catalytic center of the enzyme.

223 211, Lys229, and Lys241 were involved in the catalytic center of the enzyme.

224 base of this loop and remotely modulates the catalytic center of the enzyme.

225 PS1) in its active heterodimeric form is the catalytic center of the gamma-secretase complex, an enzy

226 Three-dimensional homology models of the catalytic center of the HBV reverse transcriptase (RT)-D

227 with the dNTPase activity (D137N) or in the catalytic center of the histidine-aspartate (HD) domain

228 , the first three of which occur at a single catalytic center of the intein.

229 ion does not affect protein folding, but the catalytic center of the mutant is not fully assembled ev

230 d to facilitate the access of cyanide to the catalytic center of the oxidized bovine enzyme.

231 RNA 3' end and transcribed DNA strand at the catalytic center of the pol III elongation complex.

232 lele encoding an M435I point mutation in the catalytic center of the protease, and M2 cells produced

233 nserved amino acid, and appears to be in the catalytic center of the protein, PUS1p.

234 n allosteric link between the tunnel and the catalytic center of the ribosome.

235 consistent with an open conformation for the catalytic center of the spliceosome during first-to-seco

236 ly uncharacterized function for Brr2p in the catalytic center of the spliceosome.

237 6 snRNA duplex to allow U6 snRNA to form the catalytic center of the spliceosome.

238 the five residues mentioned above, form the catalytic center of this enzyme.

239 Subsequent spatial reorientation of the catalytic centers of both enzymes might facilitate the t

240 This combination allows the two catalytic centers of HIVRT to work simultaneously at sim

241 nusual Fe(II)(CN)(CO) moieties that form the catalytic centers of hydrogenases, which are thought to

242 Selenocysteine (Sec) is found in the catalytic centers of many selenoproteins and plays impor

243 DNA topoisomerases, but is unrelated to the catalytic centers of other DNA or RNA polymerases.

244 onding and dynamics of hydrogen atoms in the catalytic centers of proteins are essential for catalysi

245 under lipid environmental conditions, where catalytic centers of the observed type are common, key p

246 Moreover, the catalytic centers on the nanoparticle surface were found

247 maller numbers of amino acids constituting a catalytic center or a binding site that may be remote fr

248 dues forming an active site, whether it is a catalytic center or interaction interface, are frequentl

249 he integrin-binding site did not include the catalytic center or the M-type receptor-binding site.

250 Catalytic centers or protein-protein interaction domains

251 te 5' vicinity, thereby locating the RNase H catalytic center over the PPT-U3 junction, a notion stre

252 as well as two other amino acids outside the catalytic center play important roles in CSN derubylatio

253 (SABRE) of a substrate and parahydrogen at a catalytic center promises to overcome the inherent insen

254 of a diverse assortment of embedded achiral catalytic centers, promising a generation of synthetic f

255 The ATP binding pocket and the catalytic center reside at the interface of the two lobe

256 The catalytic center resided partially in an inactive Niu-A-

257 The CSN's derubylation catalytic center resides in its subunit 5, which in Arab

258 Although the catalytic center resides in the N-terminal 75-kDa subuni

259 se transcriptase thumb subdomain and RNase H catalytic center, respectively.

260 mutation (Gly64Ser) that is remote from the catalytic center results in a higher fidelity polymerase

261 Structural details of the catalytic center revealed specific roles for individual

262 of mixed-valence Ti(3+)/Ti(4+) intermediate catalytic centers revealed by electron spin resonance (E

263 t interestingly, two mutations affecting the catalytic center (rpb1-N488D) and the homology box G (rp

264 rate and the flexible F bridge domain of the catalytic center serve as two separate ratchet devices t

265 olecules bind in a single orientation at the catalytic center suitable for two distinct reductions.

266 anization and confinement of isolated Ti(IV) catalytic centers supported on silicates is investigated

267 ite located approximately 30 A away from the catalytic center that anchors the N-terminus of substrat

268 row, basic channel that ends at the putative catalytic center that is completely enclosed within the

269 merases have lipase activity, they do have a catalytic center that resembles that of lipases.

270 Some aminoacyl-tRNA synthetases have two catalytic centers that together achieve fine-structure d

271 -insertion site prior to its delivery to the catalytic center, the bacterial RNAPs likely recognize t

272 Two components of the RNA polymerase (RNAP) catalytic center, the bridge helix and the trigger loop

273 e of these is in the highly conserved active catalytic center; the other is near the carboxyl terminu

274 allosterically alters the properties of the catalytic center, thereby predisposing the ribosome for

275 ding site is located 75 A away from the RNAP catalytic center, these results strongly indicate that R

276 peting functions: as the key residues in the catalytic center, they enable Tau auto-acetylation; and

277 The capacity for sites remote from the catalytic center to alter fidelity suggests new possibil

278 ructural changes in OAS1 that reorganize its catalytic center to promote synthesis of 2'-5'-oligoaden

279 a phosphatase-like Cys(X)(5)Arg motif as the catalytic center to reduce arsenate to arsenite.

280 ssibility of an exquisite sensitivity of the catalytic center to subtle changes in substrate position

281 cally organize light-harvesting antennae and catalytic centers to achieve solar energy conversion.

282 rimers bind and align with eIF2B's bipartite catalytic centers to catalyze nucleotide exchange.

283 motif and in the NYN domain proximal to the catalytic center, to bind and cleave pre-tRNA.

284 The substrate analogue extends away from the catalytic center toward the distal end of the internal c

285 s by an unusual mechanism: while leaving the catalytic center unaffected, it induces product release

286 ion initiation shifted further away from the catalytic center upon increasing the GC content of promo

287 changed from predominant hole reservoirs to catalytic centers upon modulation of the applied bias.

288 A secondary binding site remote from the catalytic center was identified that is distinct from on

289 chanism of concerted primer synthesis by two catalytic centers was an enigma for over three decades.

290 proximately 3-6 bp behind the DNA polymerase catalytic center, was identified between amino acids 290

291 containing a His-47 --> Gln mutation (at the catalytic center) were transfected into BHK cells and ce

292 e is a possible auxiliary iron source to the catalytic center when it is lost during catalysis in a p

293 rotein particular in regions remote from the catalytic center where high conservation across protein

294 paired by the mutations, indicating that the catalytic center where O(2) is reduced is intact.

295 se, RuC(2)N(2) stands out as the most active catalytic center, where both ruthenium and adjacent carb

296 Linezolid binds the 50S A-site, near the catalytic center, which suggests that inhibition involve

297 ng metal-binding sites within the RNase IIIb catalytic centers, which are critical for microRNA inter

298 ng a subset of binding interactions near the catalytic center with conserved characteristic chemical

299 Thus, the structurally defined catalytic center with genetic unnatural tyrosine substit

300 iron ions toward the ferritin cavity and the catalytic centers within the protein.