ライフサイエンスコーパス: catalytic core

1 ydrolysis to conformational changes of their catalytic core.

2 rates is uncoupled from their binding to the catalytic core.

3 d 60 residues downstream (CRD) of the kinase catalytic core.

4 presenilin (PS1 or PS2), the gamma-secretase catalytic core.

5 one of three domains constituting the LigIII catalytic core.

6 s that associate with different parts of the catalytic core.

7 of its two most N-terminal helices from the catalytic core.

8 nduced structural rearrangements of the CRL1 catalytic core.

9 ng the co-folded hTERT-hTR ribonucleoprotein catalytic core.

10 he evolution of an ancestral RNAP two-barrel catalytic core.

11 e signal for branching is transmitted to the catalytic core.

12 dentified in our screen map to dynein's AAA+ catalytic core.

13 rticle, crosslinks extensively with this RNA catalytic core.

14 tical PDE6alpha' subunits form the cone PDE6 catalytic core.

15 , TER and p65 in the ribonucleoprotein (RNP) catalytic core.

16 n the TREX1 CTR and lysines within the TREX1 catalytic core.

17 unique extended loop that protrudes from the catalytic core.

18 docking of the P1 duplex into the ribozyme's catalytic core.

19 t, deubiquitination, and movement toward the catalytic core.

20 quires all four SEN complex subunits and the catalytic core.

21 SrrB and present the structure of the DHp-CA catalytic core.

22 3 of the Class II aminoacyl-tRNA synthetase catalytic core.

23 ck sensing by the ZnF to nick joining by the catalytic core.

24 ation increases the rate of switching in the catalytic core.

25 g the reactive site and buckling the DNAzyme catalytic core.

26 enzymatic activity to point mutations of the catalytic core.

27 modified by EGL-9, and mutation of the EGL-9 catalytic core.

28 ion, followed by a two-step unfolding of the catalytic core.

29 the same binding site as the DNA ligase III catalytic core.

30 ion of nucleotide identity in their putative catalytic core.

31 lleles in the stability of the spliceosome's catalytic core.

32 2 endonuclease/exonuclease/phosphatase (EEP) catalytic core.

33 y share a approximately 400 kDa five-subunit catalytic core.

34 rotein substrates through a highly conserved catalytic core.

35 DgkB and the mammalian diacylglycerol kinase catalytic cores.

36 .2 +/- 0.2) x 10(2) M(-1) s(-1)) or the MerA catalytic core (1.2 x 10(2) M(-1) s(-1)), establishing t

37 ication inhibits the recruitment of the PP2A catalytic core (A and C subunits).

38 PolD contains a unique two-barrel catalytic core absent from all other DNA polymerase fami

39 gh-resolution crystal structures of the RET1 catalytic core alone and in complex with UTP analogs.

40 ng a multidomain fold, with a (betaalpha)(8) catalytic core and a separate glucan binding domain with

41 A transcription and consists of a 10-subunit catalytic core and a subcomplex of subunits Rpb4 and Rpb

42 oloenzyme contains a ribonucleoprotein (RNP) catalytic core and additional proteins that modulate the

43 ar interactions occurring between the kinase catalytic core and autoinhibitory/regulatory region.

44 g in a different family, were located in the catalytic core and completely disrupted QARS aminoacylat

45 H domain (RH) of Prp8 near the spliceosome's catalytic core and demonstrate that prp8 alleles that ma

46 The catalytic core and dimer interface regions of H352Y clos

47 e of both variants ablating a portion of the catalytic core and dimer-interface contacts of native Ty

48 destabilizing the propeptide from the enzyme catalytic core and favoring conversion to mature forms o

49 lular protease complex consisting of the 20S catalytic core and its associated regulators, including

50 te-independent compound binding to the Sirt6 catalytic core and potent activation of Sirt6-dependent

51 t of metabolosomes, BMCs that share a common catalytic core and process distinct substrates via speci

52 non-catalytic core; contacts between the non-catalytic core and Rrp44, which inhibit exoribonuclease

53 key regulatory role by interacting with the catalytic core and scaffolding inactive heterotrimeric G

54 reveals the paths of TER in the TERT-TER-p65 catalytic core and single-stranded DNA exit; extensive s

55 typically long MKLP1 neck domain between the catalytic core and the coiled coil and thereby reconfigu

56 ng the PDE6 hetero-tetramer at both the PDE6 catalytic core and the PDEgamma subunits, driving extens

57 ntal structural properties of the OLD family catalytic core and the underlying mechanism controlling

58 hat occurs at a higher frequency than in the catalytic core and which correlates with the rate of pro

59 loited in vitro reconstitution of the enzyme catalytic core and/or a PCR-amplified activity assay rea

60 Although their catalytic cores and fundamental mechanisms of transcript

61 nsion, are affected by many mutations in the catalytic core, and also require a signal peptide.

62 d side chains, limiting accessibility of the catalytic core, and interfering with homodimerization.

63 specific C-terminal extension, the conserved catalytic core, and the presence of a signal peptide.

64 ple sites on APC/C including the cullin-RING catalytic core; and (ii) the outcomes of these interacti

65 ious works, both the allosteric receptor and catalytic core are designed, rather than evolved.

66 reciated and that domains outside the tandem catalytic core are essential for proficient substrate de

67 ovide evidence that enhanced dynamics in the catalytic core are linked to catalysis.

68 is observed when the hairpin stems of enzyme catalytic cores are open under UV irradiation.

69 Outside their catalytic cores are two regions unique to HO2: a 20-amin

70 the class I ligase, which contains the same catalytic core as the polymerase.

71 motif-containing betabetaalpha-metal finger catalytic core augmented by an interesting 'finger-loop'

72 ufficient to revert the structure of the CRL catalytic core back to its unmodified form.

73 o unwrap, which facilitates insertion of the catalytic core between the histone octamer and the unwra

74 ing two conserved internal domains forming a catalytic core but a highly divergent N terminus.

75 The two share a catalytic core but diverge in their tail regions.

76 ide bonds that reside outside the beta-sheet catalytic core but likely assist the folding of the TIKI

77 hrough the nascent protein to the ribosome's catalytic core, but only a few biological consequences o

78 The NTR is attached to the catalytic core by hydrogen bonds and stacking forces alo

79 om MerB by the N-terminal domain (NmerA) and catalytic core C-terminal cysteine pairs of its coevolve

80 nly K9 DON was able to block modification of catalytic core C409 near the dimer interface.

81 Unique structural elements outside of the catalytic core called "cap domains" are thought to provi

82 minal extension (NED), amino terminus (NTD), catalytic core (CCD), and carboxyl terminus domains (CTD

83 The PduL structure, in the context of the catalytic core, completes our understanding of the struc

84 one of the complexes was found to be the 20S catalytic core complex of the proteasome.

85 iquitin chain assembly complex, of which the catalytic core component is heme-oxidized iron regulator

86 Human Argonaute 2 (hAgo2), the catalytic core component of the RNA-induced silencing co

87 have a modular structure in which a central catalytic core composed of nucleotidyltransferase and ol

88 Members of class I deoxyribozymes carry a catalytic core composed of only 15 conserved nucleotides

89 crystal structure of the intact cytoplasmic catalytic core [comprising the dimerization and histidin

90 NA path to Rrp6 that penetrates into the non-catalytic core; contacts between the non-catalytic core

91 SCF enzymes share a common catalytic core containing Cul1Rbx1, which is directed to

92 On the opposite side of the APC, the dynamic catalytic core contains the cullin-like subunit APC2 and

93 helix removes the branch adenosine from the catalytic core, creates a space for 3' exon docking, and

94 The activity of its catalytic core, cyclin-dependent kinase 8 (CDK8), is con

95 A weak interaction with the catalytic core domain (CCD) and a strong interaction wit

96 and HIV integrase predominantly involves the catalytic core domain (CCD) and the C-terminal domain (C

97 ibrary of 971 fragments against the HIV-1 IN catalytic core domain (CCD) followed by a fragment expan

98 e most potent IN inhibitor 11j within the IN catalytic core domain (CCD) is described as well as its

99 The x-ray crystal structure of the catalytic core domain (CCD) of IN in complex with the IN

100 By dissecting the catalytic core domain (CCD) of IN into short structural

101 three domains: the N-terminal domain (NTD), catalytic core domain (CCD), and C-terminal domain (CTD)

102 (CTD) and a structural homology model of the catalytic core domain (CCD).

103 mined the three-dimensional structure of its catalytic core domain (CCD).

104 ains (NmerA) that can transfer Hg(2+) to the catalytic core domain (Core) for reduction to Hg(0).

105 RT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct exp

106 2 conjugating enzyme UBE2K has a 150-residue catalytic core domain and a C-terminal ubiquitin-associa

107 ally, in our model, the junction between the catalytic core domain and C-terminal domain adopts a hel

108 erization of IN via interactions between the catalytic core domain and the CTD and that understanding

109 n vitro The full-length Rev1 protein and its catalytic core domain are similar in their ability to su

110 structure of the Cronobacter sakazakii RecQ catalytic core domain bound to duplex DNA with a 3' sing

111 ibitor binding at the dimer interface of the catalytic core domain but at the same time markedly impa

112 erse biological functions but share a common catalytic core domain composed of six membrane-spanning

113 cence-based studies on the recombinant MMP-2 catalytic core domain demonstrated that anacardic acid d

114 tures have shown that ALLINIs bind at the IN catalytic core domain dimer interface and bridge two int

115 e three-domain organization, consisting of a catalytic core domain flanked by amino- and carboxy-term

116 about enzyme mechanisms, but to date the IN catalytic core domain has proven resistant to such an an

117 We report three structures of the catalytic core domain of hPus1 from two crystal forms, a

118 Here we show that the conserved catalytic core domain of SIRT1 has very low catalytic ac

119 activity, induces structural changes in the catalytic core domain of the enzyme.

120 f one monomer with the C-terminal domain and catalytic core domain of the second monomer as well as d

121 e most C-terminal beta-barrel domain and the catalytic core domain of tTG.

122 In this format, the IN catalytic core domain produced a K(i) of 15.2 nm while c

123 ed the X-ray structure of the drug-resistant catalytic core domain protein, which provides means for

124 C-terminal region stably associates with the catalytic core domain to form a SIRT1 holoenzyme.

125 nd we use this system to select mutations in catalytic core domain V (DV) that partially rescue retro

126 in cis because of evolutionarily restrictive catalytic core domain-carboxy-terminal domain linker reg

127 itors that are known to function through the catalytic core domain.

128 the N- and C-terminal domains that flank the catalytic core domain.

129 irst NMR studies of a soluble variant of the catalytic core domain.

130 tween the IN C-terminal domain (CTD) and the catalytic core domain.

131 ive site to the C-terminal segment of Rev1's catalytic core domain.

132 quantitatively screened the activity of the catalytic core domains from subfamily 4 (GH5_4) and clos

133 fragments, in which interactions between the catalytic core domains play a prominent role.

134 udies based on both the HIV-1 IN and RNase H catalytic core domains provided new structural insights

135 eir effect on the orientations of the PH and catalytic core domains relative to the lipid membranes.

136 r, characterized by interactions between two catalytic core domains.

137 we present the crystal structure of the CBP catalytic core encompassing the bromodomain (BRD), CH2 (

138 A polymerase (RNAP) holoenzyme consists of a catalytic core enzyme (alpha(2)betabeta'omega) in comple

139 rial RNA polymerase holoenzyme consists of a catalytic core enzyme in complex with a sigma factor tha

140 erial RNA polymeras holoenzyme consists of a catalytic core enzyme in complex with a sigma factor tha

141 ing efficient transfer of Hg(2+) to the MerA catalytic core for reductive detoxification.

142 we determined crystal structures of the XPD catalytic core from Sulfolobus acidocaldarius and measur

143 G-quadruplex RNA evicts the PRC2 catalytic core from the substrate nucleosome.

144 We have shown that the p50-bound RNP catalytic core has a relatively low rate of tandem repea

145 more complete model of the human telomerase catalytic core illustrates how domains of TER and TERT,

146 udding yeast telomerase, which consists of a catalytic core in association with two regulatory protei

147 eostasis has been linked to presenilins, the catalytic core in gamma-secretase complexes cleaving the

148 work thus suggests a role of the Pol epsilon catalytic core in replisome formation, a reliance of Pol

149 We present here the structure of Pol kappa catalytic core in ternary complex with DNA and an incomi

150 association with the recombinant telomerase catalytic core increases enzyme activity.

151 at a conserved domain within the Pol epsilon catalytic core influences both of these replication step

152 ough variable regions that determine how the catalytic core is activated and recruited to phosphoryla

153 Thus, the ISWI ATPase catalytic core is an intrinsically active DNA translocas

154 Rod PDE6 catalytic core is composed of two distinct subunits, PDE

155 anchors the flexible activation loop to the catalytic core is frequently mutated in disease patients

156 RNA, TLC1, is rapidly evolving, the central catalytic core is largely conserved, containing the temp

157 A model for the assembly pathway of the catalytic core is proposed.

158 The activity of the proteasome 20S catalytic core is regulated by protein complexes that bi

159 While PolD has an ancestral RNA polymerase catalytic core, its active site has evolved the ability

160 ingle residue in the last alpha helix of the catalytic core, kinesin-7 (CENP-E) exhibited this same b

161 mon SNPs are randomly distributed within the catalytic core, known disease SNPs consistently map to r

162 regulatory components of Epac2 away from the catalytic core, making the later available for effector

163 nt mutations into the highly conserved DD35E catalytic core motif of the foamy virus integrase sequen

164 5NT also interacts with the catalytic core of AC, mainly via the C1 domain, to enhan

165 evidence that the GAUT1:GAUT7 complex is the catalytic core of an HG:GalAT complex and that cell wall

166 mTOR forms the catalytic core of at least two distinct signaling comple

167 15th nucleotide of a duplex, while the DDDE catalytic core of AtAGO2 is important for recognition of

168 The catalytic core of ATP-dependent DNA ligases consists of

169 iously undefined functional nodes within the catalytic core of CESA.

170 rystal structure of the AUM cap fused to the catalytic core of chronophin to 2.65 A resolution and pr

171 interconversion of DNA-binding sites in the catalytic core of condensin, forming the basis of the DN

172 ic catalytic subunits (alphabeta), while the catalytic core of cone PDE6 (alpha') is a homodimer.

173 al function is to add two copper ions to the catalytic core of cytochrome c oxidase (COX).

174 d that the C-terminal extension flanking the catalytic core of Dbp4 plays an important role in the re

175 smin) regulates TLS via interaction with the catalytic core of DNA polymerase-eta (poleta), and that

176 the dehydratase domain of CylM resembles the catalytic core of eukaryotic lipid kinases, despite the

177 deletion of presenilin1 and presenilin2, the catalytic core of gamma-secretase, in Ngn3- or Pax6-expr

178 er disease mutations in presenilin (PS), the catalytic core of gamma-secretase, invariably increase t

179 is cavity is large enough to accommodate the catalytic core of group II intron RNA.

180 Here we report the crystal structure of the catalytic core of HOIP in its apo form and in complex wi

181 t biochemical and structural analysis of the catalytic core of hpol eta.

182 determine a substrate-bound structure of the catalytic core of human AFG3L2.

183 Here we report the crystal structure of the catalytic core of human DNA polymerase alpha (Pol alpha)

184 have determined the crystal structure of the catalytic core of human MEC-17 in complex with its cofac

185 the purification and characterization of the catalytic core of human RecQ4.

186 We also show that the catalytic core of human Rev1 is uniquely augmented by tw

187 The catalytic core of ligase III is the second DNA nick-bind

188 We conclude that the catalytic core of MERS PLpro, i.e. without the Ubl2 doma

189 are TM glycines and that TM4, located at the catalytic core of MFS proteins, forms a helix that surfa

190 The catalytic core of MRN/X comprised of the Mre11 nuclease

191 talytic activity; however, the ZIP-sensitive catalytic core of PKC is known to participate in the enz

192 the autoinhibitory X/Y-linker region of the catalytic core of PLC-epsilon markedly activates the enz

193 Pol2, called Pol2core, that consists of the catalytic core of Pol and retains both polymerase and ex

194 eaf (clf) allele, carrying a mutation in the catalytic core of PRC2, strongly enhanced the clf phenot

195 d the Linker connecting those domains to the catalytic core of Rabex5.

196 Here, we identify basic amino acids in the catalytic core of Rag1 specifically important for transe

197 The catalytic core of rod PDE6 is a unique heterodimer of PD

198 yQ-expanded ataxin-7 directly bound the Gcn5 catalytic core of SAGA while in association with its reg

199 The crystal structure of the catalytic core of SAMHD1 reveals that the protein is dim

200 As the catalytic core of SHP-2 shares extremely high homology t

201 Telomerase contains a catalytic core of telomerase reverse transcriptase (TERT

202 The catalytic core of Tetrahymena telomerase comprises a ter

203 The catalytic core of the [FeFe]-hydrogenase (HydA), termed

204 Presenilin-1 (PS1) is the catalytic core of the aspartyl protease gamma-secretase.

205 ernary complex and appear to function as the catalytic core of the Cas system to process CRISPR RNA i

206 gion, and propose how they interact with the catalytic core of the complementary subunit to regulate

207 The catalytic core of the complex can be either of two close

208 ecruited by the MTA1 corepressor to form the catalytic core of the complex.

209 bone bond in the substrate, we find that the catalytic core of the DNAzyme unwinds and the overall co

210 findings yielded detailed insights into the catalytic core of the EctA enzyme that laid the foundati

211 cate that at the pH of optimal activity, the catalytic core of the enzyme adopts a structure in which

212 ndicates that the DHHC motif constitutes the catalytic core of the enzyme required for autopalmitoyla

213 ues to probe the electronic structure of the catalytic core of the enzyme.

214 ignal peptide and the start of the conserved catalytic core of the enzyme.

215 op of Cdk9 to allow substrates to access the catalytic core of the enzyme.

216 each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase.

217 the putative substrate-docking site and the catalytic core of the gamma-secretase.

218 Since residue 17 is buried within the catalytic core of the hammerhead in the X-ray structure,

219 oss-linking strategy was explored within the catalytic core of the Hammerhead ribozyme (HHRz).

220 the nuclease-null dCas9 protein fused to the catalytic core of the human acetyltransferase p300.

221 Here we report the crystal structure of the catalytic core of the human m(6)A writer complex compris

222 present the first structural detail into the catalytic core of the human system and reveal that the c

223 the phosphodiester backbone of the conserved catalytic core of the intron RNA, allowing the protein t

224 Drosha, the catalytic core of the microprocessor complex, has a crit

225 The catalytic core of the monomer is accommodated only near

226 Flavocytochrome b(558), the catalytic core of the phagocytic NADPH oxidase, mediates

227 rucial insights into the organization of the catalytic core of the replisome and form an important st

228 This robustness suggests that the catalytic core of the ribosome is an ancient construct t

229 To generate the open complex, the conserved catalytic core of the RNAP combines with initiation fact

230 3' position of the deoxycytidine C13 in the catalytic core of the same DNAzyme caused significant de

231 HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-represso

232 SF3B1, which functions at the catalytic core of the spliceosome, was the second most f

233 a distance by pulling substrate RNA from the catalytic core of the spliceosome.

234 Formation of catalytic core of the U12-dependent spliceosome involves

235 for the mechano-chemical cycle of the common catalytic core of these helicases.

236 ase RNA for TERT that is crucial to form the catalytic core of this biomedically important RNP enzyme

237 , cleavage kinetics, and conformation of the catalytic core of this hammerhead, leading to a ribozyme

238 The catalytic core of this protein-RNA complex is a 250-kDa

239 The catalytic core of VKOR is a four transmembrane helix bun

240 lomerase is a ribonucleoprotein complex, the catalytic core of which includes the telomerase reverse

241 Here we report crystal structures of the catalytic core of yeast Pol alpha in unliganded form, bo

242 Our results reveal that heme binding to the catalytic cores of HO1 and HO2 causes similar dynamic an

243 ediates, provided detailed insights into the catalytic cores of the EutD and EutE enzymes.

244 e, we detected conformational changes in the catalytic core only in one state of the catalytic cycle-

245 In the active state, the catalytic core oscillates between open, intermediate, an

246 The catalytic core (p65-TER-TERT) is assembled with a three-

247 The Tetrahymena telomerase holoenzyme catalytic core (p65-TER-TERT) was recently modeled in ou

248 unanticipated role as a hub between the RNP catalytic core, p75-p19-p45 subcomplex, and the DNA-bind

249 ry gamma-subunits (Pgamma) which bind to the catalytic core (Palphabeta) to inhibit catalysis and sti

250 s, but that regions N- and C-terminal to the catalytic core potentiate catalytic efficiency by betwee

251 to specific mRNAs where regions outside the catalytic core promote the formation of different comple

252 ase and selected peptidase activities of the catalytic core proteasome at low micromolar concentratio

253 th the PA200 proteasome activator to the 20S catalytic core proteasome.

254 nclear whether the CTD communicates with the catalytic core region of Rpb1 and thus must be physicall

255 While the U6 snRNA catalytic core remains firmly held in the active site ca

256 teractions are coupled to yield an activated catalytic core remains unknown.

257 At its catalytic core resides the activated splicing complex Ba

258 t homology to nSMase2 and possesses the same catalytic core residues as members of the extended N-SMa

259 The enhancement is greater for hTDG catalytic core (residues 111-308 of 410), indicating the

260 we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed w

261 , sigma factors (sigmas), associate with the catalytic core RNA polymerase to guide it through the es

262 or LipB reside both in the lipoyl domain and catalytic core sequences.

263 The structure reveals a conserved stable catalytic core shared with other GCN5 superfamily acetyl

264 hin the system, without interfering with the catalytic core, similar to structural rearrangements tha

265 The catalytic core sits on top of PCNA in an open configurat

266 vealing that its Ct-extension folds onto the catalytic core, sits atop the active site, and precludes

267 Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions betw

268 vity of cMLCK appears to be intrinsic to its catalytic core structure rather than an autoinhibitory s

269 They also share catalytic core structures, including the heme-binding si

270 the biogenesis of the mitochondrion-encoded catalytic core subunit 2 (COX2) result in myopathies.

271 atalytic domains, DNA-binding regions, and a catalytic core targeting the histone tails, LSD1-CoREST

272 e tandem repeat synthesis and bridge the RNP catalytic core, Teb1, and the p75 subunit of the holoenz

273 tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, reveal

274 ilt a pseudoatomic model of human telomerase catalytic core that accounts for almost all of the cryoe

275 y Pol31-Pol32N subunits relative to the Pol3 catalytic core that best agrees with the experimental sc

276 nuclear RNA exosome includes a 9-subunit non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subunits

277 an autoregulatory segment C terminus of the catalytic core that blocks myosin regulatory light chain

278 Other mutations in the catalytic core that generated CCTs with reduced solubili

279 generated a predicted structure of the XTUT7 catalytic core that indicated histidine 1269 was likely

280 2, within a C-terminal (Ct) extension of its catalytic core that is only present in higher eukaryotes

281 between the cellulose binding domain and the catalytic core that only changes subtly.

282 This deoxyribozyme contains a 14-nucleotide catalytic core that preferentially catalyzes RNA cleavag

283 bridize to 16S rRNA to form 32 deoxyribozyme catalytic cores that produce a fluorescent signal.

284 rminal domain to clamp parts of the intron's catalytic core, that at least one C-terminal domain inse

285 needed for RNA replication contain at their catalytic core the class I RNA ligase, an artificial rib

286 centers around a cullin-RING-like E3 ligase catalytic core; the "Arc Lamp" is a hub that mediates tr

287 Although the proteins share a common catalytic core, they have different specificities and co

288 ding WD40, or DWD proteins) to the CUL4-ROC1 catalytic core to constitute a potentially large number

289 roteins that modulate the ability of the RNP catalytic core to elongate telomeres.

290 It tethers the catalytic core to the flexibly attached C-terminal domai

291 with the Arg-128 residues positioned in the catalytic cores to facilitate melting of dsDNA and gener

292 communication between four different kinase catalytic cores to mediate activation and how in molecul

293 ch are converted to helical rotations in the catalytic core via an intervening HAMP-like domain.

294 th a homology-based chain trace of the CesA8 catalytic core, were modeled into a previously determine

295 ilon rotation within the F(1)alpha(3)beta(3) catalytic core where substrates are bound and products a

296 iphosphate (ADP) suggest that motions of the catalytic core, which are required for ATP binding, are

297 ognition of a phylogenetically-conserved RPR catalytic core, whose minimal attributes we further defi

298 Proteasomes are composed of a 20S catalytic core with or without one or two activator comp

299 erase holoenzyme requires association of the catalytic core with the telomere adaptor subcomplex (TAS

300 nector loop into a hydrophobic pocket of the catalytic core, with the coiled-coil aligned near the en