ライフサイエンスコーパス: catalytic cycle

1 al intermediate to the Ir(IV) species in the catalytic cycle.

2 dated alkylpalladium(II) intermediate in the catalytic cycle.

3 ack by a reactive enolate created during the catalytic cycle.

4 key role for a cationic Co(I) species in the catalytic cycle.

5 n agreement with the DFT calculations of the catalytic cycle.

6 d the highly reactive intermediates in their catalytic cycle.

7 ay during the N...N bond-forming step in the catalytic cycle.

8 rm NH(3) , regenerating H(-) and closing the catalytic cycle.

9 (ICH) conformational dynamics throughout its catalytic cycle.

10 e/molecule complex, therefore completing the catalytic cycle.

11 ns allow us to propose an alternative, truly catalytic cycle.

12 hat solvent dissociates from iron during the catalytic cycle.

13 P and assign them to particular steps in the catalytic cycle.

14 fferent oxidation states accessed within the catalytic cycle.

15 metal and the ligand in several steps of the catalytic cycle.

16 an external force that is adjusted within a catalytic cycle.

17 ase, Bronsted acid and Lewis base within the catalytic cycle.

18 substrate during sugar ring rotation in the catalytic cycle.

19 i(I)/Ni(III) redox steps were avoided in the catalytic cycle.

20 rticipate in a cooperative manner during the catalytic cycle.

21 ly capture the reaction intermediates in its catalytic cycle.

22 protons in different states relevant to the catalytic cycle.

23 site cap that must open and close during the catalytic cycle.

24 and the role that flexible loops play in the catalytic cycle.

25 with additional Pd precursor to re-enter the catalytic cycle.

26 ta-ketone intermediates assembled during the catalytic cycle.

27 ion of the Re catalyst and completion of the catalytic cycle.

28 involved in the rate-determining step of the catalytic cycle.

29 iron(III), substrate, and temperature to the catalytic cycle.

30 d amine in the generation of a more complete catalytic cycle.

31 ormational change is an integral part of the catalytic cycle.

32 ole of protein conformational entropy in its catalytic cycle.

33 l data are presented to support the proposed catalytic cycle.

34 ibility of each of the proposed steps of the catalytic cycle.

35 is possible and likely to participate in the catalytic cycle.

36 studies suggested a classical cross-coupling catalytic cycle.

37 catalyzed aerobic conditions to complete the catalytic cycle.

38 onal equilibrium for individual steps in the catalytic cycle.

39 reductive elimination is key for a potential catalytic cycle.

40 GK, two sequential enzymes in the glycolysis catalytic cycle.

41 ge kinetics in the first three states of the catalytic cycle.

42 vidence is provided for the key steps of the catalytic cycle.

43 compared states the enzyme visits during its catalytic cycle.

44 ing interactions during the native multistep catalytic cycle.

45 mperatures above 0 degrees C during a normal catalytic cycle.

46 Preliminary studies suggest a Ni(I)/Ni(III) catalytic cycle.

47 ire a reductive step for the turnover of the catalytic cycle.

48 hat Cl(-) is bound to SERT during the entire catalytic cycle.

49 site that changes shape and size during its catalytic cycle.

50 s, a plausible mechanism is proposed for the catalytic cycle.

51 alkyl chloroformates through a Pd(II)/Pd(IV) catalytic cycle.

52 erization of functional intermediates in the catalytic cycle.

53 dules, each revealing a distinct step in the catalytic cycle.

54 undergo the proposed elementary steps of the catalytic cycle.

55 roduct-released" states of the enzyme in the catalytic cycle.

56 the stereodetermining transmetalation in the catalytic cycle.

57 ns that mimic different steps in the overall catalytic cycle.

58 es support each of the proposed steps in the catalytic cycle.

59 ane followed by alkene binding completes the catalytic cycle.

60 tant to the decay of Co(I), thus closing the catalytic cycle.

61 d HBpin, which acts to drive turnover of the catalytic cycle.

62 ion states and intermediates involved in the catalytic cycle.

63 tion appears to proceed via a Ni(I) -Ni(III) catalytic cycle.

64 yl-phosphate intermediate of the phosphatase catalytic cycle.

65 roduct in solution and thereby establishes a catalytic cycle.

66 ts a contribution of the metal center in the catalytic cycle.

67 conformational changes required for the VKOR catalytic cycle.

68 allow for an unambiguous identification of a catalytic cycle.

69 states sampled during the calcium transport catalytic cycle.

70 series of conformational changes during the catalytic cycle.

71 nt deprotonation are rate-determining in the catalytic cycle.

72 al for the two electron transfers within the catalytic cycle.

73 etal carbene intermediate is not part of the catalytic cycle.

74 that occur in the enzyme complex during the catalytic cycle.

75 analyses, which shed light on the postulated catalytic cycle.

76 anions that resemble a primary step of MCR's catalytic cycle.

77 tive and are consistent with a Ni(I)/Ni(III) catalytic cycle.

78 )(IMes)(2)Cl] and [Ni(IMes)(2)] for the next catalytic cycle.

79 revealing a catalyst migration to the second catalytic cycle.

80 proposed oxidative TEMPO(.) /TEMPO(+) redox catalytic cycle.

81 d steps and, moreover, potentially different catalytic cycles.

82 ) halide or aryl species are proposed in the catalytic cycles.

83 osed to occur by the union of three distinct catalytic cycles.

84 reactions and intermediates involved in the catalytic cycles.

85 n arrested at the same point in their rotary catalytic cycles.

86 the dominant halogen, hydrogen, and nitrogen catalytic cycles.

87 s sample multiple conformations during their catalytic cycles.

88 the catalytic recycling experiments in five catalytic cycles.

89 ve been discovered and explained in terms of catalytic cycles.

90 ple active sites during the courses of their catalytic cycles.

91 contain and is notably increased by internal catalytic cycles.

92 he (beta/gamma)-C(sp(3))-H functionalization catalytic cycles.

93 TP, enhances ligation by supporting multiple catalytic cycles.

94 idated and are active complexes in Pd(II/IV) catalytic cycles.

95 d that Mo-bpy maintains its structure during catalytic cycling.

96 usters give rise to an exponentially growing catalytic cycle, a specific realization of Dyson's notio

97 A mechanism comprising a nickel catalytic cycle, a zirconium catalytic cycle, and Zr-->N

98 -dependence of ATP hydrolysis and blocks the catalytic cycle after formation of the aspartyl phosphat

99 e can be regenerated and introduced into the catalytic cycle again.

100 late group allows water to bind early in the catalytic cycle, allowing intramolecular proton-coupled

101 e oxime as a triplet sensitizer in the first catalytic cycle and a reductant toward the cyanoarene in

102 alone and in complex with key ligands of its catalytic cycle and antiviral iminosugars, including two

103 talytic reaction as well as each step in the catalytic cycle and by low-temperature detection of inte

104 Ir(ppy)(3) deactivates the nickel catalytic cycle and creates more dehalogenated side prod

105 olve the redox and protonation events in the catalytic cycle and determine their intrinsic thermodyna

106 e highest free-energy barrier of the overall catalytic cycle and hence governs the turnover rate of t

107 To elucidate their catalytic cycle and inhibitory mechanism, we report 11 x

108 reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues resp

109 rformed to trace the elementary steps of the catalytic cycle and provide the end-user with a clear an

110 This conformation provides insight on IRAP's catalytic cycle and reveals significant active-site plas

111 nsufficient to account for the complete NRPS catalytic cycle and that the loaded state of the PCP mus

112 ling both a proposed intermediate in the CDO catalytic cycle and the essential NHase Fe-S(O)(Cys114)

113 active site during the oxidative half of the catalytic cycle and then being rapidly reduced by T(SH)(

114 mall reaction barriers for most steps in the catalytic cycle and, therefore, predict fast product for

115 compounds are present in two interconnected catalytic cycles and react with hydrazine and base or hy

116 olecular heterodimer, kinetic studies on the catalytic cycle, and a thorough analysis of transition s

117 nformational states of human P-gp during the catalytic cycle, and demonstrate that, following ATP hyd

118 f inactive enzyme molecules to return to the catalytic cycle, and thus, enables a steady-state NO syn

119 rising a nickel catalytic cycle, a zirconium catalytic cycle, and Zr-->Ni transmetalation is proposed

120 ikely that Mo changes valency throughout the catalytic cycle; and (ii) two distinctive E(4)(4H) (57)F

121 ra of the molecular species formed along the catalytic cycle are modeled using a combination of molec

122 h only the intrinsic behaviors of the nickel catalytic cycles are observed.

123 Dual catalytic cycles are proposed, with a relatively fast en

124 The metal-free flavin/NO(x)/TEMPO catalytic cycles are uniquely compatible, especially com

125 last acyl-thioesterase intermediates in the catalytic cycle as DAP conjugates, we provide structural

126 in a polymerase in order to complete a full catalytic cycle as well as prepare for DNA translocation

127 ates two states (open and closed) during the catalytic cycle, as reported for specific ADP-PFK.

128 least one substrate is bound throughout the catalytic cycle, as the rate of (18)O-labeled water inco

129 steps involved in reactions directly on the catalytic cycle, as well as off-cycle processes.

130 identified several key intermediates in the catalytic cycle, as well as those related to catalyst de

131 rm of ATP hydrolysis and coordination of the catalytic cycles between the leading and the trailing he

132 ial role in the rate determining step of the catalytic cycle, but the exact nature of this complex is

133 in the resting state but revealed within the catalytic cycle by cleavage of the MS-Fe(NO)2 bond from

134 the sequence of events in the bidirectional catalytic cycle can be elucidated on the basis of the vo

135 that both reductive and oxidative quenching catalytic cycles can be operative, although the reductiv

136 This shows how coupled catalytic cycles can create a metabolic network that all

137 crystal structures of the protein along the catalytic cycle capture, for the first time in an HP2P,

138 mplexes, leaving some doubt that a canonical catalytic cycle consisting of an initial oxidative addit

139 cesses and essential steps in many important catalytic cycles, controlling redox chemistry-in particu

140 n of active sites and their evolution in the catalytic cycle during CO and alcohol oxidation reaction

141 A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Mark

142 gage in either Pd(II)/Pd(IV) or Pd(II)/Pd(0) catalytic cycles, enabling access to a diverse range of

143 ation of the phenoxazine catalyst during the catalytic cycle encourages the synthesis of well-defined

144 density oscillations that govern the overall catalytic cycle, facilitate the product formation, and r

145 A catalytic cycle featuring regeneration of the metal cata

146 mechanistic pathways for the entirety of the catalytic cycle for asymmetric decarboxylative allylic a

147 On the basis of these data, a redox catalytic cycle for carnitine monooxygenase was proposed

148 Based on (77)Se NMR spectroscopy, a catalytic cycle for diselenide 8b, involving aminoebsele

149 The turnover-limiting step in the catalytic cycle for hydroboration of the internal alkene

150 nown kinetics of the elementary steps of the catalytic cycle for methanol coupling, using scaling met

151 The proposed general catalytic cycle for methanol synthesis is supported by m

152 Comparison with the proposed catalytic cycle for tantalum-doped silica catalysts reve

153 responding alkoxide followed by entering the catalytic cycle for the iron-catalyzed hydrosilylation.

154 sity functional theory studies, we propose a catalytic cycle for the process that is facilitated by m

155 The turnover-limiting step in the catalytic cycle for the reaction of vinylarenes is the b

156 A novel catalytic cycle for the reaction with formic acid is pro

157 The mechanistic details of the catalytic cycles for all the individual processes are es

158 of 2, indicating that 5 and 2 share the same catalytic cycles for both metathesis and isomerization,

159 xes through elementary reactions proposed in catalytic cycles for C(sp(2) )-C(sp(3) ) bond formation.

160 tal formate is a key elementary step in many catalytic cycles for CO(2) conversion.

161 tive steps that occur in sequence within the catalytic cycle, giving rise to a composite selectivity

162 A detailed catalytic cycle has been derived for typical 2-Cys Prxs,

163 vated alkenes proceeding via a Pd(II)/Pd(IV) catalytic cycle has been developed.

164 the intermediate palladium complexes in the catalytic cycle have been prepared and characterized, an

165 omplexes representing different steps of the catalytic cycle, implying that these stretches of the pr

166 propriate reductants and acids to access the catalytic cycle in a stepwise fashion, permitting direct

167 t catalytic activity revealed that an intact catalytic cycle in both protomers is required for enhanc

168 Termination of the catalytic cycle in this way impairs communication betwee

169 We present a simplified model for the catalytic cycle in which capture of the transported DNA

170 ceeds through a formally Ti(II)/Ti(IV) redox catalytic cycle, in which an azatitanacyclobutene interm

171 s that contribute to different stages of the catalytic cycle, including the catalytic step and produc

172 on mechanisms, energy profiles of the entire catalytic cycles, including the reduction steps have to

173 s typically involved the Pd(II)/Pd(0)/Pd(II) catalytic cycle incorporating an external oxidant and of

174 alysis provides a seamless continuum for the catalytic cycle, incorporating large motions by four loo

175 inetics characterization of the complete SQR catalytic cycle indicates that GSH serves as the physiol

176 first crystal structure of AMSDH and several catalytic cycle intermediates.

177 ion of a catalyst, which introduces a second catalytic cycle into the metabolic network, was used to

178 tial Diels-Alderases; however, whether their catalytic cycles involve a concerted or stepwise cycliza

179 We have shown previously that the NOS enzyme catalytic cycle involves a large number of reactions but

180 on a comprehensive kinetic investigation, a catalytic cycle involving a ternary complex that binds t

181 ctants with and without NAD(+), we propose a catalytic cycle involving formation of an intermediary N

182 4 degrees C and under ambient pressure in a catalytic cycle involving the formation of a peroxodiiro

183 The accepted mechanism of HALS comprises a catalytic cycle involving the rapid combination of a nit

184 and isotopic labeling studies corroborate a catalytic cycle involving turnover-limiting alcohol dehy

185 the AC assistance should be well-suited for catalytic cycles involving reductive elimination or oxid

186 As a result of a fundamentally different catalytic cycle, iodine yields the bis-bisulfate ester o

187 is system initiates a rearrangement, and the catalytic cycle is completed by reduction of the new eno

188 of intermediate steps are minimized and the catalytic cycle is devoid of high transition-state barri

189 ifurcating flavin site, the proposed EtfABCX catalytic cycle is distinct from that of the genetically

190 uantum chemistry calculations, show that the catalytic cycle is driven via the redox activity of both

191 , CO2 dissociates on the oxide surface and a catalytic cycle is established without coke deposition.

192 Au with the redox properties of Pd within a catalytic cycle is particularly appealing for the synthe

193 Furthermore, all reaction flux in the closed catalytic cycle is predicted to flow through an O-O bond

194 A plausible catalytic cycle is proposed based on informative mechani

195 A catalytic cycle is proposed for the intermolecular/intra

196 A catalytic cycle is proposed in which NH2-CAM reacts with

197 A catalytic cycle is proposed with Si-H insertion as the r

198 onditions were adjusted such that the nickel catalytic cycle is saturated with excited photocatalyst.

199 is initiated by ortho C-H activation and the catalytic cycle is terminated by C-2 protonation.

200 First, the rate-limiting step in the catalytic cycle is the formation of the reactive Fe-H in

201 The first step in several catalytic cycles is P-H oxidative addition to yield inte

202 DFT calculations, a mechanism involving two catalytic cycles is proposed wherein the alternating cop

203 ve site conformations that appear during the catalytic cycle may allow fine-tuning of inhibitor disco

204 linear because the rate-limiting step of the catalytic cycle, nucleotide release, scales linearly wit

205 The two redox events in the catalytic cycle occur on the [4Fe-4S]H subcluster at sim

206 Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs.

207 e key intermediates, their relevance for the catalytic cycle of [FeFe] hydrogenase, and novel strateg

208 l data, we proposed a model for the complete catalytic cycle of AAR.

209 pecies are key reaction intermediates in the catalytic cycle of both enzymes (e.g., oxygenases) and s

210 energy barrier of rate-limiting steps of the catalytic cycle of Ca(2+) transport.

211 ate that it is possible to mimic the natural catalytic cycle of CYP101Fe(3+) by using pulse radiolysi

212 The rate-determining step in the catalytic cycle of E. coli dihydrofolate reductase is te

213 Our findings indicate that the catalytic cycle of E. coli gyrase operates at high therm

214 A key question concerning the catalytic cycle of Escherichia coli dihydrofolate reduct

215 on can have significant consequences for the catalytic cycle of H6H.

216 der daylight irradiation and can support the catalytic cycle of horseradish peroxidase (HRP) without

217 the first time the transient response of the catalytic cycle of human sulfite oxidase immobilized on

218 gaps in the elucidation of key steps in the catalytic cycle of kinesin.

219 te-to-disulfide conversion that sustains its catalytic cycle of methane formation in the energy savin

220 H(2)S was able to complete the catalytic cycle of MtAhpE and, according to kinetic cons

221 2) binding and C-C-bond formation during the catalytic cycle of nature's most efficient CO(2)-fixing

222 erved bound heme-iron-PN intermediate in the catalytic cycle of nitric oxide dioxygenase (NOD) enzyme

223 tic parameters k(1) and k(3) involved in the catalytic cycle of peroxidases were calculated.

224 g loops-work in dynamic unity throughout the catalytic cycle of PTP1B.

225 s of nucleic acid handling that underlie the catalytic cycle of repeat synthesis derive from both act

226 igatory succession of steps that make up the catalytic cycle of RG.

227 or the analogous conversion of P to Q in the catalytic cycle of sMMO.

228 t cleaves strong C-H bonds of methane in the catalytic cycle of soluble methane monooxygenase (sMMO).

229 teine thiols to a disulfide bond, during the catalytic cycle of the N-terminal domain of the key bact

230 des, allowing us to identify the most likely catalytic cycle of the reaction.

231 To gain insight into the steps of the catalytic cycle of this unusual oxidation reaction, a se

232 Possible hydroxylating intermediates in the catalytic cycle of this well-characterized enzyme have b

233 es for functionalization of C-H bonds in the catalytic cycles of a range of O2-activating iron enzyme

234 proposed key oxidizing intermediates in the catalytic cycles of heme-containing enzymes (P-450s, per

235 -peroxo intermediates are key species in the catalytic cycles of nonheme metalloenzymes, but their ch

236 precedents for proposed intermediates in the catalytic cycles of O(2)-activating cobalt enzymes.

237 urns our new hydrated electron source into a catalytic cycle operating in pure water over a wide pH r

238 possible to correlate these states with the catalytic cycle or the activity of the enzyme.

239 al small-molecule activation, and in several catalytic cycles proposed for nickel-containing enzymes,

240 ikely proceeds through a Se(II)/Se(IV) redox catalytic cycle reminiscent of the syn-dichlorination re

241 ese structures suggest successive steps in a catalytic cycle revealing that AC undergoes large confor

242 ves, a computational examination of the full catalytic cycle reveals that a benzoic acid byproduct ch

243 have long been hypothesized as being part of catalytic cycles, such as gold(III) alkene, alkyne, CO a

244 tic selectivity in the reduction step of the catalytic cycle suggests that Grx1 uses preferentially a

245 Detailed evaluation of potential catalytic cycles supports oxidation of the cyclized Os(I

246 n reactions, as well as the development of a catalytic cycle that has subsequently allowed the prepar

247 metric and NMR mechanistic studies support a catalytic cycle that involves a well-defined eta(6)-aren

248 six-coordinate Ru species is integral to the catalytic cycle that produces MeOH.

249 vent-exposed hydrophobic sites, breaking the catalytic cycle that promotes alphaS self-association.

250 e PR --> F transition is the first step in a catalytic cycle that requires proton transfer from the b

251 ate mechanism consists of two interdependent catalytic cycles that operate in sequence: a fast Cu(II)

252 After each catalytic cycle the active site contains a disulfide, wh

253 bsorption reveals that, for each step in the catalytic cycle, the sacrificial reductant, 3-mercaptopr

254 During the catalytic cycle, the transported cations become transito

255 During the catalytic cycle, the two subclusters change oxidation st

256 ing the critical roles that NBE plays in the catalytic cycle, the use of structurally modified NBEs (

257 ity, relies on the interplay of two distinct catalytic cycles: the aminocatalytic electron-relay syst

258 ferent series of final steps in one Rh-based catalytic cycle, thereby enabling access to the otherwis

259 hematite surface oxygen first, followed by a catalytic cycle through a molecular-dioxygen-assisted pa

260 e coupling of transition-metal to photoredox catalytic cycles through single-electron transfer steps

261 eductant toward the cyanoarene in the second catalytic cycle to achieve the synthesis of hindered pri

262 to rapidly supply the second electron of the catalytic cycle to camphor-bound CYP101[FeO2](2+) Judgin

263 formed by C-C cleavage merge with the nickel catalytic cycle to create the challenging C(sp(3))-C(sp(

264 bond-breaking and bond-forming steps of the catalytic cycle to enable the use of many previously ine

265 edirecting the C(P)SOH intermediate from the catalytic cycle to the hyperoxidation/inactivation pathw

266 This methodology simultaneously uses three catalytic cycles to achieve hydridic C-H bond abstractio

267 catalyzed HAT and thiol radical trapping HAT catalytic cycles to be essential for effective catalysis

268 affect nvTRPM2 channel currents, reporting a catalytic cycle uncoupled from gating.

269 tarting point for a theoretical study of the catalytic cycle using DFT calculations.

270 tu can be reintroduced as phosphine into the catalytic cycle using mild and selective silane reagents

271 oxide is regenerated and activated in every catalytic cycle via intramolecular dehydration/cyclizati

272 A plausible catalytic cycle was characterized by DFT/B3LYP-D3 and in

273 Furthermore, hydrogen transfer of the catalytic cycle was experimentally probed and monitored

274 gether with the DFT calculations, a possible catalytic cycle was proposed.

275 The ON/OFF catalytic cycle was run three times in situ.

276 Each step of the interconnected catalytic cycles was confirmed separately.

277 he processes of PARP activation and the PARP catalytic cycle we describe can explain mechanisms of re

278 variation to support different stages of the catalytic cycle, we show that KSI utilizes cooperative s

279 lysis methodology suggested two steps in the catalytic cycle were involved as turnover determining.

280 Plausible activation pathways and catalytic cycles were computed in the gas phase (M06-L/d

281 Two distinct catalytic cycles were proposed for the Cu/Fe and Cu/Mn c

282 Different alternatives for the three catalytic cycles were tested to identify unambiguously t

283 the catalytic core only in one state of the catalytic cycle-when Fe(3+)-heme is bound to the HRMs an

284 pped-flow kinetics to provide evidence for a catalytic cycle where dioxygen binds prior to NO to gene

285 hydrides and dihydrogen complexes, including catalytic cycles where these reactions are proposed or o

286 me c oxidase is the first redox state in its catalytic cycle, where proton transfer through the K-cha

287 al PCs operates via a single photoexcitation/catalytic cycle, where the TM complex plays a "double du

288 itory effect by the carboxylate anion on the catalytic cycle, whereas 2-ethyl hexanoate minimizes thi

289 es within the H-cluster occurring during the catalytic cycle, whereas the CN(-) signals seem to be re

290 Preliminary studies allude to a catalytic cycle whereby the excited state of the organop

291 oach is predicated on a biomolecule-inspired catalytic cycle wherein high levels of asymmetric induct

292 We propose a plausible catalytic cycle, which involves a pentacoordinate silico

293 hance the rates of multiple steps within the catalytic cycle while serving as an ammonia surrogate.

294 which generally preserves the oxo palladium catalytic cycle widely accepted in the literature, is pr

295 catalyst to recycle byproducts back into the catalytic cycle will provide unique opportunities for th

296 potentiates a scenario for a possible cross-catalytic cycle with amplification.

297 The reactivity of catalytic cycles with and without methoxy migration is c

298 formed via the connection of two unexpected catalytic cycles, with acetate being only the precatalys

299 the breakdown of the last relevant directed catalytic cycle within a dynamical system.

300 The Pd-BNP has been recycled up to 5 catalytic cycles without any loss in reaction yields and