ライフサイエンスコーパス: catalytic region

1 distinct subdomains on the periphery of the catalytic region.

2 d DNA substrate nucleotides to the N(40) DNA catalytic region.

3 unique domain between the two halves of the catalytic region.

4 elices, devoid of ATP, enter the alpha3beta3-catalytic region.

5 affects the conformational state of the hTS catalytic region.

6 pon ligand binding but still retains a wider catalytic region.

7 to bring substrates into the vicinity of the catalytic region.

8 ons cluster in three TPRs and the C-terminal catalytic region.

9 II, contains both SH2 and SH3 domains but no catalytic region.

10 lized to the N-terminal lobe (N-lobe) of the catalytic region.

11 e product at the product release side of the catalytic region.

12 al domains relative to the substrate-binding catalytic region.

13 common amino acid residues that lie near the catalytic region.

14 atures that promote water removal from polar catalytic regions.

15 te having remarkably similar folds for their catalytic regions.

16 binding pocket toprim (E179A, D229A, D231A), catalytic region 5Y-CAP (R94A, D95A, Y98F) and the DNA-b

17 Expression of the catalytic region alone yields a protein with a reduced c

18 For example, within the catalytic region an aspartate in Mnk2 plays a key role.

19 ultidomain protein composed of an N-terminal catalytic region and a C-terminal region that organizes

20 restins, one associated with the common PDE4 catalytic region and the other located within its unique

21 these mutation sites are near the predicted catalytic region, and the confluence of other mutation s

22 in, followed by a large conserved C-terminal catalytic region approximately 300 amino acids long comp

23 TPRs 8 and 9 and the catalytic region are also important for modulating trich

24 of the protein both N- and C-terminal to the catalytic region are required for Fat facets function.

25 Furthermore, predicted catalytic regions are shown to lie between major areas o

26 enesis identified Met(132) in the N-terminal catalytic region as affecting the substrate specificity

27 IP1 narrowed the phosphorylation site to the catalytic region between residues 400 and 866.

28 Additionally, modelling of the catalytic region bound to a hexasaccharide tripentapepti

29 binding domain in NCX1, whereas the calpain catalytic region bound to the catenin-like domain in NCX

30 suggest that the local structure around the catalytic region can be different from that revealed by

31 sive interactions, whereas the intracellular catalytic regions can modulate the phosphorylation state

32 otubule-binding configuration of its central catalytic region compared to VASH1-SVBP.

33 These enzymes share a common catalytic region comprising a DNA-binding domain, a nucl

34 The N-terminal domain, which contains the catalytic region defined by random mutagenesis, did not

35 dentify here a mutation in the Rne protein's catalytic region (E429G), as well as a bacterial cell wa

36 The catalytic region encircles nicked DNA with each of the d

37 esidues within the coenzyme binding fold and catalytic regions found in SDR enzymes.

38 a COOH-terminal PKGI fragment containing the catalytic region (now termed PKGIgamma) was observed in

39 oMA) was used to identify nucleotides in the catalytic region of 9F7 that are essential for ligation

40 domain revealed a limited homology with the catalytic region of a newly identified GTPase-activating

41 detected a chromodomain embedded within the catalytic region of a predicted Arabidopsis DNA methyltr

42 residues (Asp 32 and Asp 228) present in the catalytic region of BACE that can adopt multiple protona

43 yeast, Mps1 phosphorylation of a central non-catalytic region of Bub1 promotes its association with t

44 if reminiscent of a critical sequence in the catalytic region of calcineurin-type phosphatases; surpr

45 binding to the substrate binding site in the catalytic region of CaMKIIdelta.

46 The unique segments adjacent to the catalytic region of eukaryotic DNA ligases are involved

47 ns for specific conserved amino acids in the catalytic region of Fat facets and also indicate that re

48 agenesis, we have mapped an exosite to a non-catalytic region of LF.

49 tent with the structural similarities of the catalytic region of motor proteins and G proteins.

50 Finally, the catalytic region of nSMase2 where palmitoylation occurs

51 the carboxyl terminus of Asp2 resembles the catalytic region of numerous enzymes that function throu

52 action epitope of Evolocumab, located in the catalytic region of PCSK9, the binding epitope of VHH-B1

53 sults suggest a novel model in which the non-catalytic region of PKCmu acts as a scaffold for assembl

54 al change caused by PI(4,5)P2 binding to the catalytic region of PLD.

55 gineering studies, we have identified in the catalytic region of PLDbeta a new PI(4,5)P2 binding regi

56 on deletion mutants, TEFM interacts with the catalytic region of POLRMT, and in vitro TEFM enhanced P

57 The structure of the catalytic region of proenzyme MASP-1 R448Q was solved at

58 P-REX2 inhibits PTEN by interacting with the catalytic region of PTEN, and the inositol polyphosphate

59 vesicle breakdown induced by the C-terminal catalytic region of Raf-1.

60 e of cells supplied with only the N-terminal catalytic region of RNase E and that mitigation of RNase

61 hat precisely overlaps the carboxyl-terminal catalytic region of seprase-l.

62 entified a cysteine residue in the conserved catalytic region of sirtuin 1 as target for glutaredoxin

63 ht of the recently reported structure of the catalytic region of TdT.

64 modium, Eimeria, and several plants, and the catalytic region of the Ca2+/calmodulin-dependent protei

65 nucleotide binding arms that flank the 40-nt catalytic region of the deoxyribozyme.

66 , His290, Lys134, and Lys368 in the putative catalytic region of the formylglycine at position 75, wi

67 The three-dimensional structure for the catalytic region of the mammalian protein kinase, casein

68 osine phosphorylations in the N-terminal non-catalytic region of the molecule, which contains an SH3

69 n-of-function mutations map to the conserved catalytic region of the PLD protein.

70 e second one is located in the middle of the catalytic region of the protein.

71 The structure of the C2 catalytic region of type II rat adenylyl cyclase has an

72 the DNA primer can facilitate a step in the catalytic region of yeast telomerase that leads to great

73 698 residues) has sequence similarity to the catalytic regions of bovine GTPase-activating protein an

74 Although the catalytic regions of DsbA and DsbC are composed of struc

75 nases containing both the NH(2)-terminal and catalytic regions of Lck.

76 carboxy-terminal region with homology to the catalytic regions of mammalian PDEs.

77 o-acid signature that is associated with the catalytic regions of members of the tyrosine recombinase

78 ted the effect of mutations within conserved catalytic regions of MNK on intracellular localization a

79 now show that Ca(2+) also interacts with the catalytic regions of PLD.

80 ely facilitates D5 engaging both binding and catalytic regions of the ribozyme, and these may be a co

81 Contacts between the catalytic regions of the two enzymes suggests that RDR2

82 th alanine at position 426 in the C1 domain (catalytic region) of AC6.

83 actions between gamma and the regulatory and catalytic regions on alphabeta are not well understood.

84 C1a and C1b activator binding domains of the catalytic region or to the C1 domains of two adjacent PK

85 d R1162A, or the metal binding C1168A in the catalytic region, resulted in catalytically impaired enz

86 on to an N-terminal SH2 domain and a central catalytic region, SHIP2 (like SHIP1) possesses both pote

87 We found that the N-terminal SPRTN catalytic region (SprT) possesses a ubiquitin-binding do

88 een shown to correspond to a wide variety of catalytic regions, substrate-binding sites and protein i

89 with alanine replacing threonine 402 in the catalytic region (T402A), it was determined that the two

90 construct harboring the signal + prodomain + catalytic region (TACE-SPCdeltaDETCy), expressed in bacu

91 e one or two highly conserved C-terminal non-catalytic regions, termed polo boxes.

92 eractive site was mapped to a C-terminal non-catalytic region that is conserved in the PP1(C)2 isofor

93 s (E3s) of the HECT family share a conserved catalytic region that is homologous to the E6-AP C termi

94 ribonucleoprotein-type RNA-binding domain, a catalytic region that may be related to the polymerase m

95 three tyrosines within the head domain, the catalytic region that mediates movement along microtubul

96 nformations correspond to alterations in the catalytic region that reveal the active site to NAD(+).

97 synthetic peptides which contained putative catalytic regions that were associated with the beta5 (E

98 by interacting with a site in the RNase III catalytic region, that expression of YmdB is transcripti

99 nslational modifications of apoB100 near the catalytic region, we performed data-independent, paralle

100 z2p, and Sal6p) share >59% identity in their catalytic region with Glc7p.