ライフサイエンスコーパス: catalytic subunit

1 horylation of the activation loop within the catalytic subunit.

2 with Pi3k92e, the human ortholog of the p110 catalytic subunit.

3 s directly to the C2 domain of the p110alpha catalytic subunit.

4 rodimer and the DNA-dependent protein kinase catalytic subunit.

5 e two domains, creating room for binding the catalytic subunit.

6 the A/B charge-swap pair and the endogenous catalytic subunit.

7 onomers through the C-terminal domain of the catalytic subunit.

8 raction sites of the Pgamma subunit with the catalytic subunits.

9 its and smaller bodies contain predominantly catalytic subunits.

10 whereas rod PDE6 consists of two homologous catalytic subunits.

11 ous isoforms of scaffolding, regulatory, and catalytic subunits.

12 PP2R5E (B56epsilon, regulatory), and PPP2CA (catalytic) subunits.

13 ubsequent increases in glucose-6-phosphatase catalytic subunit-2 (G6PC2) levels contribute to lipotox

14 Apolipoprotein B mRNA-editing enzyme catalytic subunit 3 (APOBEC-3) enzymes are cytidine deam

15 POBEC3 (apolipoprotein B mRNA-editing enzyme catalytic subunit 3) proteins, which mutate viral nuclei

16 obec3A (apolipoprotein B MRNA editing enzyme catalytic subunit 3A, abbreviated "A3A") in maintaining

17 y), and apolipoprotein B mRNA-editing enzyme catalytic subunit 3C (APOBEC3C, a nucleic acid-editing d

18 e of the human ATP6V1A gene that encodes the catalytic subunit A of V-ATPase in GC.

19 athione reductase, glutamate-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin 1).

20 ed with a decrease of protein kinase A (PKA) catalytic subunit alpha (Calpha) expression both at the

21 osphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) gene.

22 mplexes and identified protein phosphatase 1 catalytic subunit alpha (PP1A) as a NACA-associated Ser/

23 (DNAJB1) with protein kinase cAMP-activated catalytic subunit alpha (PRKACA) and by dense desmoplasi

24 ions of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in en

25 DNAJB1) to the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedl

26 The two isoforms of the AMPK catalytic subunit (AMPKalpha1 and alpha2) are both expre

27 sociate with distinct surfaces of the larger catalytic subunit and influence the enzymatic properties

28 atory subunit MYPT1 bound to the phosphatase catalytic subunit and myosin.

29 ors: the metal within the MPc (M = Co vs Ni) catalytic subunit and the identity of the heteroatomic c

30 s of the PP1A holoenzyme complex: the PPP1CA catalytic subunit and the regulatory subunits PPP1R9B, P

31 loenzymes that contain a common scaffold and catalytic subunits and a variable regulatory subunit.

32 protein of p53) proteins associate with PP1 catalytic subunits and are implicated in multiple functi

33 interacts with the catalytic domains of both catalytic subunits and induces major changes in the inte

34 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-

35 exist between the composition of proteasome catalytic subunits and the cellular response to Cfz.

36 heme oxygenase-1, glutamate-cysteine ligase catalytic subunit, and NAD(P)H quinone oxidoreductase 1

37 All NATs contain at least one catalytic subunit, and some contain one or two additiona

38 f PBAF including the Swi/Snf-associated Brg1 catalytic subunit, and the other contains Baf180 but not

39 nits associate with and inhibit all class IA catalytic subunits, APDS2 mutations are expected to simi

40 ID) and apolipoprotein B mRNA-editing enzyme catalytic subunit (APOBEC) enzymes convert cytosines to

41 H(2)O(2) and a significant proportion of the catalytic subunits are glutathionylated on two cysteine

42 subunits are always in large molar excess of catalytic subunits (average approximately 17-fold).

43 t TIR-199 covalently binds each of the three catalytic subunits (beta1, beta2, and beta5) and reveale

44 ediated by induction of the immunoproteasome catalytic subunit beta5i.

45 This enzyme consists of four catalytic subunits: biotin carboxylase (BC), carboxyltra

46 /polymerase and C-terminal domains (CTDs) of catalytic subunits bound to indispensable B-subunits, wh

47 opy (cryo-EM) structures of DNA-PKcs (DNA-PK catalytic subunit) bound to a DNA end or complexed with

48 ulates sulfenylation of cysteines in the PKA catalytic subunit by H(2)O(2) and a significant proporti

49 tors, help to coordinate synthesis of OXPHOS catalytic subunits by the mitoribosomes with both the im

50 Prior to signaling, PKA-R holds the kinase's catalytic subunit (C) in an inactive state by exerting a

51 ly later in life, and this involves PKA, its catalytic subunit Calpha, and the Wnt/beta-catenin pathw

52 PRKACA and PRKACB code for two catalytic subunits (Calpha and Cbeta) of cAMP-dependent

53 We found that knockdown of these calcineurin catalytic subunits caused cardiac restriction under norm

54 binding induces a stepwise transition of the catalytic subunit cavity, converting a closed cavity tha

55 re, we describe a unique role for the orphan catalytic subunit CcoN4 in colony biofilm development an

56 thase adopts a different conformation with a catalytic subunit changing conformation substantially an

57 thase-II (Chs2) and chitin synthase-III (the catalytic subunit Chs3 and its activator Chs4), respecti

58 lly regulated by TNF-induced casein kinase 2 catalytic subunit (CK2alpha') phosphorylation of nuclear

59 verexpression of CK2, particularly the alpha catalytic subunit (CK2alpha, CSNK2A1), has been implicat

60 is a serine/threonine kinase composed of two catalytic subunits (CK2alpha and/or CK2alpha') and two r

61 Ca(2+)/CaM) to relieve autoinhibition of the catalytic subunit (CNA) by its C terminus.

62 Unique among DNA polymerases, the Pol3 catalytic subunit contains a 4Fe-4S cluster that may sen

63 osphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta) sites were associated with lung

64 s the ability to interact with the p110alpha catalytic subunit (Deltap85alpha) or expression of mutan

65 other features of PKA signaling for reducing catalytic subunit diffusion and increasing recapture rat

66 hese AHAS complexes form a core to which the catalytic subunit dimers are attached, adopting the shap

67 al inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, we found that it

68 tivation of the DNA-dependent protein kinase-catalytic subunit (DNA-PKcs) and nonhomologous end joini

69 ng the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with autoimm

70 The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has well-established roles

71 DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a central component of n

72 DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a key role in mediati

73 inhibition of DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) recruitment and activation,

74 a complex with DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) that carries out endonucleo

75 nd recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form DNA-dependent prote

76 lenging to identify inhibitors of the DNA-PK catalytic subunit (DNA-PKcs) with good selectivity versu

77 K), which comprises the KU heterodimer and a catalytic subunit (DNA-PKcs), is a classical non-homolog

78 composed of the KU heterodimer and the large catalytic subunit (DNA-PKcs), is a classical nonhomologo

79 ependent on the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), which can bind to and phos

80 ctors including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4-like factor (XLF), a

81 0-Ku80 (KU) heterodimer and the large DNA-PK catalytic subunit (DNA-PKcs).

82 (ATR), and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

83 etazoan also by DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

84 zation with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

85 omolog (SUZ12), but mutations in PRC2's main catalytic subunit enhancer of zeste homolog 2 (EZH2) hav

86 on of Ku70 and DNA-dependent protein kinase, catalytic subunit, essential DNA repair proteins in the

87 on dinucleosomes reveals how binding of its catalytic subunit EZH2 to nucleosomal DNA orients the H3

88 1 and H3K27me3, increased solubility of PRC2 catalytic subunit EZH2, and genome-wide deregulation of

89 Its catalytic subunit, EZH2, is responsible for the trimethy

90 Prothrombinase is composed of a catalytic subunit, factor Xa (fXa), and a regulatory sub

91 the expression of the non-ubiquitous AMPKa2 catalytic subunit, found to be important for both HCMV-m

92 sm caused by defective glucose-6-phosphatase catalytic subunit (G6PC) activity.

93 mal mutations in glucose-6-phosphatase alpha catalytic subunit (G6PC) and can present with severe hyp

94 nase 1 (PCK1), and the glucose-6-phosphatase catalytic subunit (G6PC).

95 osphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (Pi3kgamma), was highly expresse

96 hermore, we identified protein phosphatase 1 catalytic subunit gamma (PPP1CC) as the upstream enzyme

97 Variants near the calcineurin catalytic subunit gamma gene PPP3CC and the polypeptide

98 gets serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, neurofilament light cha

99 ygenase 1 (Hmox1), glutamate-cysteine ligase catalytic subunit (Gclc) and paraoxonase 1 (PON1).

100 fering with the association of ADA2 with the catalytic subunit GCN5.

101 We show that the catalytic subunit gene Brg1 has a specific role in cardi

102 ated by hypoxia, and although the AMPKalpha1 catalytic subunit has been implicated in angiogenesis, l

103 ated by hypoxia, and although the AMPKalpha1 catalytic subunit has been implicated in angiogenesis, l

104 The catalytic subunits have similar biochemical activity, ho

105 rs targeting the active site cysteine of the catalytic subunit HOIP using fragment-based covalent lig

106 non-viral vector to transfect the telomerase catalytic subunit (hTERT) and the simian virus 40 large-

107 1 or PKM2, the knocking down of AMPKalpha1/2 catalytic subunit in H1299 cells induced apoptosis.

108 0 encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetyltransferase A

109 mTOR primarily functions as a catalytic subunit in two structurally related but functi

110 distinct regulatory subunits with conserved catalytic subunits in holoenzyme complexes.

111 plies that the retention of the -AAX in PDE6 catalytic subunits in Rce1(-/-) mice is responsible for

112 binds the telomerase reverse transcriptase (catalytic subunit) in some cell lines, raising the possi

113 he stability of PP2Ac (protein phosphatase 2 catalytic subunit) in vitro and in vivo, which dephospho

114 -related gene 1 (BRG1, SMARCA4), the SWI/SNF catalytic subunit, in the endometrial epithelium.

115 incorporates two different paralogs of each catalytic subunit into active proteasomes.

116 ase-activating Sli15/INCENP scaffold and the catalytic subunit Ipl1/Aurora B.

117 nge is to understand how the activity of PKA catalytic subunits is directed in cells.

118 major differences in the interactions of the catalytic subunit Isw1 with the acidic pocket of nucleos

119 The catalytic subunit large protein (L) and cofactor phospho

120 Apolipoprotein B mRNA editing enzyme catalytic subunit-like protein 3B (APOBEC3B or A3B), as

121 found that YU102, a dual inhibitor of the iP catalytic subunit LMP2 and the cP catalytic subunit Y, a

122 ith RIalpha suggests that PKA regulatory and catalytic subunits may fine-tune P-REX1 activity or thos

123 Disruption of the catalytic subunit, MTA1, in the ciliate Oxytricha leads

124 The core NatA complex consists of the catalytic subunit NAA10 and the ribosome-anchoring subun

125 A is a heterodimeric complex consisting of a catalytic subunit (Naa10/ARD1) and an auxiliary subunit

126 teine desulfurase complex that consists of a catalytic subunit (NFS1), LYR protein (ISD11), and acyl

127 Presenilin (PSEN, catalytic subunit), Nicastrin (NCT), Presenilin Enhancer

128 previously unknown role of the NADPH oxidase catalytic subunit NOX5 in cerebral infarction.

129 onate, suggesting that this gene encodes the catalytic subunit of a respiratory antimonate reductase,

130 Five contigs encoding homologs of the catalytic subunit of alkylsuccinate synthase (assA) were

131 BRD4S directly bound BRG1, a catalytic subunit of BAF, via its bromodomain and extrat

132 studied the conformational landscape of the catalytic subunit of cAMP-dependent protein kinase A, a

133 The catalytic subunit of DNA Polymerase alpha (Polalpha) has

134 POLA1 encodes the p180 catalytic subunit of DNA polymerase alpha-primase.

135 sed DNA damage and reduced expression of the catalytic subunit of DNA polymerase alpha.

136 hic Arabidopsis thaliana mutant of the POL2A catalytic subunit of DNA polymerase epsilon and show tha

137 ic mutations in REV3L, the gene encoding the catalytic subunit of DNA polymerase zeta involved in tra

138 s the expression of POLA1, which encodes the catalytic subunit of DNA polymerase-alpha.

139 sease, and here we report PRIM1 encoding the catalytic subunit of DNA primase as a novel disease gene

140 ere we show that ATM is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-P

141 poly(ADP-ribose) polymerases (PARP) and the catalytic subunit of DNA-dependent protein kinase (DNA-P

142 ownregulation impairs phosphorylation of the catalytic subunit of DNA-PK at serine 2056 in response t

143 Presenilin 1 (PS1) is the catalytic subunit of gamma-secretase, an enzyme complex

144 Conditional gene targeting of the catalytic subunit of glutamate cysteine ligase (Gclc) bl

145 e early genes and phosphorylates INTS11, the catalytic subunit of Integrator.

146 We discovered a mutation in the catalytic subunit of liver glycogen phosphorylase kinase

147 this CUG governs the ratio between POLG (the catalytic subunit of mitochondrial DNA polymerase) and P

148 iers of this ratio and identified one as the catalytic subunit of mtDNA polymerase gene (POLG), tam.

149 ed expression of Cybb, the gene encoding the catalytic subunit of NADPH oxidase gp91phox.

150 mutations in PIK3CD, encoding the p110delta catalytic subunit of phosphoinositide 3-kinase (PI3K), h

151 have an activating mutation in p110alpha, a catalytic subunit of phosphoinositide 3-kinase.

152 The PIK3CA gene, which encodes the p110alpha catalytic subunit of PI3 kinase (PI3K), is mutationally

153 PIK3CA encodes the p110alpha catalytic subunit of PI3K and is frequently mutated in h

154 c mutations in PIK3CA, the gene encoding the catalytic subunit of PI3K, PI3K inhibitors have yielded

155 PIK3CG resulting in absence of the p110gamma catalytic subunit of PI3Kgamma.

156 vity of most of these kinases, including the catalytic subunit of PKA (PKAc).

157 nism in which binding and stabilization of a catalytic subunit of PKA by hydralazine lead to improved

158 1 Among the DDX3 regulon, Prkaca encodes the catalytic subunit of PKA, a potential activator of Rac1

159 ars upon deleting the REV3 gene encoding the catalytic subunit of Pol zeta.

160 s of enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2

161 rs Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2

162 Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2

163 Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressive Complex 2 (PRC2

164 that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that

165 action with enhancer of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, and

166 ress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2)

167 istically, Chaer directly interacts with the catalytic subunit of polycomb repressor complex 2 (PRC2)

168 Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2)

169 itional knockout of the alpha isoform of the catalytic subunit of PP2A (PP2ACalpha).

170 specific modification and degradation of the catalytic subunit of PP2A when bound to microtubules.

171 m1 methylates and alters the activity of the catalytic subunit of PP2A, shifting the balance of Gcn4

172 of a pronounced peptide-binding cleft on the catalytic subunit of PPPs suggests that these enzymes ar

173 the stem cell population, RNF2, the dominant catalytic subunit of PRC1, activates transcription of Sa

174 in CPA with somatic mutations in either the catalytic subunit of protein kinase A (PRKACA) or the gu

175 ocalization and substrate specificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dic

176 searched for proteins that interact with the catalytic subunit of protein phosphatase 2A (PP2Ac).

177 We identify the catalytic subunit of protein phosphatase 6 (PP6c) as the

178 Together with suppression of the catalytic subunit of pyruvate dehydrogenase phosphatase

179 This nuclear gene encodes the catalytic subunit of replicative mitochondrial DNA polym

180 39del mutations in POLR2A, which encodes the catalytic subunit of RNA polymerase II, hijack this esse

181 tify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path.

182 one deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repre

183 overexpressors of KIN10 (AKIN10/SnRK1.1), a catalytic subunit of SnRK1.

184 hallenged with a hybrid toxin containing the catalytic subunit of Stx1a and the cell-binding subunit

185 hallenged with a hybrid toxin containing the catalytic subunit of Stx2a and the cell-binding subunit

186 decrease the expression of GLT-1 and xCT (a catalytic subunit of Sxc) to determine the relative impo

187 o glutamate transporter 1 (GLT-1) and xCT (a catalytic subunit of Sxc)/Sxc upregulation in the nucleu

188 of human telomerase reverse transcriptase, a catalytic subunit of telomerase that was reversed by JNK

189 The catalytic subunit of telomerase, human telomerase revers

190 e indicates that the expression of TERT, the catalytic subunit of telomerase, is a biological marker

191 Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of the CDK-activating kinase complex.

192 ded mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 has a

193 APUM9 directly interacts with DCP2, the catalytic subunit of the decapping complex and DCP2 over

194 cells, REV3L (3130 residues) is the largest catalytic subunit of the DNA polymerases.

195 DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded b

196 RNase P RNA (RPR), the catalytic subunit of the essential RNase P ribonucleopro

197 (2+) cluster in the C-terminal domain of the catalytic subunit of the eukaryotic B-family DNA polymer

198 Presenilin 1 (PS1), the catalytic subunit of the gamma-secretase complex, cleave

199 In addition to its known role as the catalytic subunit of the gamma-secretase complex, select

200 In addition to its known role as the catalytic subunit of the gamma-secretase complex, select

201 actors, including Bcl10, MALT1, and the HOIP catalytic subunit of the linear ubiquitin chain assembly

202 n cells upon genetic ablation of METTL3 (the catalytic subunit of the major m(6)A methyltransferase c

203 Brahma-related gene 1 (Brg1), a catalytic subunit of the mammalian SWI/SNF chromatin-rem

204 DIS3 encodes a catalytic subunit of the nuclear RNA exosome complex tha

205 1) phosphorylated a threonine residue on the catalytic subunit of the phosphatase PP2A, which disrupt

206 ste homolog 1 (EZH1) gene, which codes for a catalytic subunit of the polycomb complex.

207 T domains in Enhancer of Zeste 2 (EZH2), the catalytic subunit of the Polycomb Repressive Complex 2 (

208 r of zeste homolog 2 (EZH2) is the enzymatic catalytic subunit of the polycomb-repressive complex 2 (

209 eningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2

210 A deficiency in BRG1, the catalytic subunit of the SWI/SNF chromatin remodeling co

211 were dependent on the function of SMARCA4, a catalytic subunit of the SWI/SNF complex.

212 ized MANTIS lncRNA interacted with BRG1, the catalytic subunit of the switch/sucrose nonfermentable c

213 C alpha (PKCalpha) interacts with TRM61, the catalytic subunit of the TRM6/61 tRNA methyltransferase.

214 uinazolines that covalently modify a soluble catalytic subunit of V-ATPase with high potency and exqu

215 ely, implicating these genes as encoding the catalytic subunits of a respiratory arsenate reductase (

216 E4B are lost in hepatocytes deleted for both catalytic subunits of AMPK.

217 Since the discovery that the catalytic subunits of APC/C are conformationally dynamic

218 Interestingly, expression of the catalytic subunits of both the standard and immunoprotea

219 Brg1 (Smarca4) and Snf2h (Smarca5) are catalytic subunits of distinct ATP-dependent chromatin r

220 ntains 14 genes that are predicted to encode catalytic subunits of DMSOR family enzymes.

221 Presenilins 1 and 2 (PS1 and 2) are the catalytic subunits of gamma-secretase, a multiprotein pr

222 t1 and Pmt2 share a structural fold with the catalytic subunits of oligosaccharyltransferases, confir

223 ecific knockout of the p110alpha or p110beta catalytic subunits of PI3K.

224 ain Enhancer-of-zeste enzymes, which are the catalytic subunits of Polycomb Repressive Complex 2 (PRC

225 of methylation on PP2Ac is conserved in the catalytic subunits of PP4 and PP6, and PP4 is also methy

226 ify 158 interactions including those between catalytic subunits of sequential enzymes and between sub

227 and SMARCA2/BRM, the two mutually exclusive catalytic subunits of the BAF complex, display a well-es

228 e in which T cells lacked expression of both catalytic subunits of the inhibitor of kappaB kinase (IK

229 probes for studying two of the three active catalytic subunits of the plant proteasome.

230 study the activity and role of the different catalytic subunits of the proteasome in different plant

231 We selected one of the catalytic subunits of the subfamily I, StPP2Ac2b, to dev

232 ) is a regulatory protein which inhibits the catalytic subunits of Type 2A phosphatases.

233 specific deletion of the alpha subunit (main catalytic subunit) of Ac.

234 rine/threonine-protein phosphatase PP1-alpha catalytic subunit or protein kinase A activation.

235 and p85beta are dispensable, the PI3-kinase catalytic subunit p110alpha requires interaction with Ra

236 ) and Ile(597)) in the helical domain of the catalytic subunit (p110beta) of PI3Kbeta whose mutation

237 Further studies showed that the catalytic subunit p110delta of class I PI3K played a rol

238 on mutations in the PIK3CD gene encoding the catalytic subunit p110delta of PI3K-delta (referred to a

239 The mutation in PIK3CD gene that encodes the catalytic subunit p110delta of the PI3K significantly re

240 between the small GTPase Kras and the PI(3)K catalytic subunit p110delta.

241 encodes the phosphoinositide 3-kinase (PI3K) catalytic subunit, p110delta, a lipid kinase linked to n

242 ion of various mutant forms of the PI3Kgamma catalytic subunit (p110gamma) in cells lacking PI3Kgamma

243 In addition to its catalytic subunit (p125), pol delta comprises three regu

244 Activation of NOX4 requires catalytic subunit p22(phox), which is upregulated follow

245 l B-subunit (p59) in complex with CTD of the catalytic subunit (p261C).

246 Each of the two catalytic subunits (Palpha and Pbeta) contains a catalyt

247 The rod PDE6 holoenzyme consists of two catalytic subunits (Palphabeta) whose activity is suppre

248 tein expression of phosphoinositide 3-kinase catalytic subunit PI3K(p110alpha), which can promote tum

249 (R) domain by cAMP-dependent protein kinase catalytic subunit (PKA).

250 romyces cerevisiae (S.c.) is composed of the catalytic subunit Pol3 along with two regulatory subunit

251 A small C-terminal domain of the catalytic subunit Pol3 carries both iron-sulfur cluster

252 a complex is a heterotetramer comprising the catalytic subunit POLD1 and the accessory subunits POLD2

253 establish the role of DNA polymerase delta1 catalytic subunit (POLD1) as the cause of a primary immu

254 he Pol gamma holoenzyme consists of the p140 catalytic subunit (POLG) and the p55 homodimeric accesso

255 s the alpha-isoform of protein phosphatase 1 catalytic subunit (PP1alpha) and eIF2alpha to assemble a

256 loenzyme consisting of protein phosphatase-1 catalytic subunit (PP1c) and MP target subunit-1 (MYPT1)

257 ty of molecular techniques, we show that PP1 catalytic subunit (PP1c) co-localized, co-fractionated,

258 MST1/2 and MAP4Ks by the STRIPAK phosphatase catalytic subunit PP2AC.

259 Overexpression of the PP2A catalytic subunit (PP2Ac) by lentiviral transduction in

260 re-induced expression of the pertussis toxin catalytic subunit (PTXa).

261 ciated with increased mRNA expression of Nox catalytic subunits, reactive oxygen species (ROS) levels

262 sion of islet-specific glucose-6-phosphatase catalytic subunit-related protein-specific CD8(+) T cell

263 refute the recently proposed theory that PKA catalytic subunits remain tethered to regulatory subunit

264 e oxidase and respiratory arsenate reductase catalytic subunits represent a more ancient lineage of D

265 ephosphorylation site preference of the PP2A catalytic subunit, resulting in unique patterns of kinas

266 utation in a highly conserved residue of the catalytic subunit, Rnaseh2a(G37S/G37S) (G37S), to unders

267 ding the RNA exosome, specifically, with its catalytic subunit Rrp6 and with the exosome-associated R

268 -rRNA processing through the activity of its catalytic subunits, Rrp6 and Rrp44.

269 rative multibranching contacts with the PP2A catalytic subunit, selective for the unmethylated tail a

270 Although rod and cone PDE6 catalytic subunits share a similar domain organization c

271 matin remodeling complex, including its core catalytic subunit, SMARCA4.

272 The compound targets the catalytic subunit Spt14 (also referred to as Gpi3) of th

273 Fission yeast AMPK catalytic subunit Ssp2 is phosphorylated at Thr-189 by t

274 r slides and ejects nucleosomes, utilizing a catalytic subunit (Sth1) with DNA translocation activity

275 tivated potato (Solanum tuberosum), six PP2A catalytic subunits (StPP2Ac) were identified.

276 PP2A in tuberization, demonstrating that the catalytic subunit StPP2Ac2b positively modulates tuber i

277 PP2A in tuberization, demonstrating that the catalytic subunit StPP2Ac2b positively modulates tuber i

278 ells lacking STT3B-OST activity (missing the catalytic subunit STT3B or the oxidoreductase subunits m

279 The new arrangement of catalytic subunits suggests that the mechanism of ATP ge

280 To synthesize telomeric repeats, the catalytic subunit telomerase reverse transcriptase (TERT

281 intramolecular disulfide formation in their catalytic subunits that inhibits their activity.

282 finity receptors while FGFRs function as the catalytic subunits that mediate intracellular signaling.

283 n RNA-dependent RNA polymerase composed of a catalytic subunit, the L protein, and a cofactor, the P

284 Whilst they contain a common catalytic subunit, they have diverse modes of action det

285 -terminase protomer is composed of one large catalytic subunit tightly associated with two DNA recogn

286 ory subunit, facilitating the access of PP2A catalytic subunit to CK1varepsilon and its activation, w

287 its directing the myristylated N terminus of catalytic subunits toward the membrane for release and r

288 In human it consists of the catalytic subunits TSEN2 and TSEN34, as well as the non-

289 d fold and related catalytic mechanism, each catalytic subunit uses unique elements to mediate substr

290 esses downstream of PKA, we deleted both PKA catalytic subunits using CRISPR-Cas9, followed by a "mul

291 Alterations in the composition of proteasome catalytic subunits via interferon-gamma treatment or siR

292 PI3KC3-C1 consists of the lipid kinase catalytic subunit VPS34, the VPS15 scaffold, and the reg

293 de 3-kinase (PI3K) comprised of the p110beta catalytic subunit was recruited to the gB/EGFR complex d

294 Binding to the PP2A catalytic subunit was significantly impaired, disrupting

295 lated; CHK1/2; DNA-dependent protein kinase, catalytic subunit; WEE1; CDC7), or effector proteins for

296 A) is typically thought of in regards to the catalytic subunit, which is inhibited by the regulatory

297 e decreased expression of DNA-protein kinase catalytic subunit, which we have previously identified a

298 DMSORs compared to aerobic arsenite oxidase catalytic subunits, which evolved from the assimilatory

299 ors ARTEMIS and DNA-dependent protein kinase catalytic subunit, with defects in the hairpin opening s

300 of the iP catalytic subunit LMP2 and the cP catalytic subunit Y, ameliorates cognitive impairments i