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1 zes a novel decarboxylation that uses NAD(+) catalytically.
4 truct a robust nanoreactor that incorporates catalytically active [FeFe]-hydrogenases and functional
5 f a method for the specific visualization of catalytically active AC in intracellular compartments is
6 enesis in RPE-1 cells, which was restored by catalytically active ADAMTS9 or ADAMTS20 acting in trans
8 ur theoretical studies demonstrate that such catalytically active anatase-type solid-solution phases
9 d storage as a method for the preparation of catalytically active and durable metal nanoparticles.
10 silver(I) from [Ag(1)](+) and generates the catalytically active and fluorescent complex [Ag(2)](+).
11 selected mutant forms of uPlm that are both catalytically active and insensitive to alpha2-AP inhibi
14 s in the field, we explore a model system of catalytically active Bi-Sn nano-alloys produced using a
15 High calcium levels must exist to permit catalytically active calcineurin to function during epid
16 yst axial epimers are all converted into the catalytically active cationic gold catalyst owing to the
22 polydentate, bulky ligands to stabilize the catalytically active Co(I) oxidation state from deleteri
23 nergy harvesting devices, such as large area catalytically active coatings for the hydrogen evolution
25 e probe the hydrodynamic flow field around a catalytically active colloid using particle tracking vel
27 ecause unlike in stoichiometric reactions, a catalytically active compound may turn over many substra
34 trations, WT FAH is in equilibrium between a catalytically active dimer and a monomeric species, with
36 into the consequences of depleting the three catalytically active DNMTs in human pluripotent stem cel
37 site catalysis and are typically composed of catalytically active elements atomically dispersed in mo
40 te its lipid kinase activity, explaining why catalytically active Fig4 is required for maximal PI(3,5
41 embled into 2D superlattices and found to be catalytically active for the photooxidation of 2-chloroe
42 the proteome that contains enzymes in their catalytically active form can be interrogated by using p
43 ed only a few diffusion trajectories for the catalytically active form of OTUB1, whereas in OTUB2 the
45 nthesis of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B(6), takes place t
46 ata, together with the recent structure of a catalytically active fragment of PLCepsilon, provide the
47 be used to interrogate the nuclearity of the catalytically active gold site for reactions known to be
48 volves dissociation of molecular hydrogen at catalytically active graphene ripples, followed by adsor
51 7) and Plasmodium vivax (Pv-M17) function as catalytically active hexamers to generate free amino aci
54 al limitations of the active sites of the 12 catalytically active human carbonic anhydrase (CA) isofo
55 beta- and gamma-secretases and holo-APP was catalytically active in vitro and generated a full array
56 was severely compromised in vivo but remains catalytically active in vitro, was able to superficially
57 rmations that are analogous to those seen in catalytically active kinases and, in some cases, can als
63 ange of carbonyl compounds are combined with catalytically active metal halide Lewis acids under synt
64 e synthesized to incorporate a wide range of catalytically active metals in tailored surroundings.
66 y achieved by employing tertiary amines with catalytically active N, N-dimethyl groups as the base ca
68 MCF-7 cells were engineered to overexpress a catalytically active or a catalytically inactive SIRT6 f
69 entities, it is limited by requirement of a catalytically active particle impacting an inert electro
70 fficient procedure to achieve a high load of catalytically active Pd nanosheets inside exosomes, with
74 l theory (DFT) calculations to elucidate the catalytically active phase, reaction center and the OER
75 changes the chemical environment around the catalytically active Pmh moiety, so that the light-induc
76 melanogaster female meiosis and suggest that catalytically active Polo is a distinct subset of the to
78 successful expression and purification of a catalytically active recombinant hGFAT2 (rhGFAT2) in Esc
80 ia the template-independent pathway, and the catalytically active replicator that mediates the templa
81 vivo Mice with targeted knockout of the more catalytically active SDR16C6 enzyme have no obvious phen
82 to different molecular classes: those with a catalytically active serine and those with at least one
86 JAK inhibitors that traditionally target the catalytically active site of this kinase family has been
89 nalyze the hydrogen evolution reaction (HER) catalytically active sites of 1H-MoS(2) nanosheets, MoS(
95 ) (1 is a chiral N(2)P(2) macrocycle) is the catalytically active species in the asymmetric transfer
101 o a controlled reduction to selectively form catalytically active styrene-stabilized iron(0)-alkyl co
105 temperature at 800 degrees C was found more catalytically active than that at 700 degrees C due to t
106 issing-cluster defects were shown to be more catalytically active than their missing-linker counterpa
107 proteolysis by binding to PMN surfaces in a catalytically active tissue inhibitor of metalloproteina
108 e utility of this synthetic route to prepare catalytically active TMC NPs, we evaluated the thermoche
110 in guiding the nucleation and growth of the catalytically active ultrasmall Ni nanoclusters, and fur
117 deoxycytidine deaminase with two domains, a catalytically active, weakly ssDNA binding C-terminal do
119 An N-Lip C-Lip fusion of mouse lipin-2 is catalytically active, which suggests mammalian lipins fu
120 bis(pyridine)Au(I) complexes are shown to be catalytically active, with their reactivity being modula
124 he formation of active forms of drugs can be catalytically assembled remotely via two-photon irradiat
126 sts in multiple conformations, including the catalytically competent closed state independent of the
127 unforeseen details about how NMT1 reaches a catalytically competent conformation in which the reacti
128 microscopy structure of a ternary complex of catalytically competent DNMT3A2, the catalytically inact
130 ium-( R)-PhanePhos complex, Ir-PP-I, that is catalytically competent for allene-fluoral reductive cou
132 m of the dimeric protein absorbed at 448 nm (catalytically competent form), whereas the monomeric for
136 mes bound these less-phosphorylated IPs in a catalytically competent manner, suggesting that IP hydro
137 effects of nucleotides on the assembly of a catalytically competent maturation complex on viral DNA,
140 st, the protease domain is "locked" into the catalytically competent trypsin-like configuration upon
143 essive deletion of these interactions led to catalytically compromised proteins that fail to bind NAD
145 s host, which can effectively immobilize and catalytically convert polysulfide intermediates during c
146 However, BthA is not MauG-like in that it catalytically converts H(2)O(2) to water, and a 1.54- an
147 CsPbI(3) is stable to oxygen but rapidly and catalytically converts to non-perovskite delta-CsPbI(3)
149 iosensor uses the gene-targeting capacity of catalytically deactivated CRISPR-associated protein 9 (C
150 broadly expressing a single guide RNA and a catalytically dead Cas9 fused to the KRAB repressor doma
151 cerbated in DOT1L knockout cells, but not in catalytically dead DOT1L cells, revealing a role of DOT1
152 eloped a CRISPR/Cas9-based system to express catalytically dead PfClpP, which showed that PfClpP olig
154 for CRISPR interference (CRISPRi) by binding catalytically dead SpCas9 (dSpCas9) to the region upstre
156 ted a Grp94 heterodimer with one arm that is catalytically dead, to extend the lifetime of the ATP/AD
158 hosphine ligand, leading to the formation of catalytically dormant palladium complexes that reactivat
159 ral catabolism of charged amino acids with a catalytically efficient and thermodynamically favorable
160 Variations in the protein folding needs of catalytically efficient red algae Rubisco prevent their
161 estigated another Asn residue (N140) that is catalytically essential and strictly conserved in the TD
164 We present an atom-economic strategy to catalytically generate and intercept nitrile anion equiv
165 strain release and the templating effect of catalytically generated metallacycles can be harnessed t
167 ter, [eta(4)-Ge(9)(Hyp)(3)]Rh(COD), that can catalytically hydrogenate cyclic alkenes such as 1,5-cyc
169 using a single guide RNA (sgRNA)-guided and catalytically impaired Campylobacter jejuni CRISPR-assoc
170 nformation into a specified DNA site using a catalytically impaired Cas9 endonuclease fused to an eng
171 rs use DNA-modifying enzymes targeted with a catalytically impaired CRISPR protein to precisely insta
172 soform of UBA1 and in expression of a novel, catalytically impaired isoform initiated at p.Met67.
173 ned in proximity to the bound substrate, the catalytically impaired Phe61Ala with an elevated activat
174 growth factor receptor-3 (HER3 or ERBB3), a catalytically impaired RTK whose phosphorylation by MET
175 ated dose and temporal control of SpCas9 and catalytically impaired SpCas9 technologies, including tr
176 of a conformation that is associated with a catalytically impaired state through structural changes;
177 luster may prove beneficial for labeling the catalytically important belt region, which could in turn
178 ely stimulates reversible modifications on a catalytically important cysteine, whereas zinc binds at
180 s experiments, we demonstrated that all four catalytically important loops-the WPD, Q, E, and substra
183 rmed organometallic reagents to be conducted catalytically in a byproduct-free manner from inexpensiv
185 sine (A-to-I) RNA editing approach by fusing catalytically inactivate RNA-targeting CRISPR-Cas13 (dCa
187 plex of catalytically competent DNMT3A2, the catalytically inactive accessory subunit DNMT3B3 and a n
189 e and thiourea stations is converted between catalytically inactive and active states by pulses of a
190 N-acetyltransferase activity, yeast NAA50 is catalytically inactive and positions NatA at the ribosom
191 of OGA in elementary learning, we generated catalytically inactive and precise knockout Oga alleles
192 le-knockout infectivity, while expression of catalytically inactive APX drastically reduced virulence
195 tic site of its Nudix domain that renders it catalytically inactive but does not influence its abilit
196 arget site selection of SB by fusing it to a catalytically inactive Cas9 (dCas9) and by providing a s
198 ation of the CRISPR/Cas9 system that directs catalytically inactive Cas9 (dCas9) to target loci for s
199 an adeno-associated virus (AAV9) carrying a catalytically inactive Cas9 (dCas9), VP64 transactivator
200 al regulation of Cebpe, we targeted it using catalytically inactive Cas9 fused to Kruppel-associated
201 e method of blocking gene expression using a catalytically inactive Cas9 protein (dCas9) and programm
204 Here we show that knock-in mice that express catalytically inactive caspase-8(C362A) die as embryos o
208 nscribed, RNAP rearranges into an elemental, catalytically inactive conformer unable to load NTP subs
213 PR-ubiquitinated substrates, we exploited a catalytically inactive DupA mutant to trap and identify
214 ally downregulated protein) 4-1, but not its catalytically inactive form NEDD4-1-C867A, increased Cav
215 expression of wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibits cell dif
218 ls was rescued by reintroduction of HDAC4 or catalytically inactive HDAC4, but not HDAC1 or HDAC5.
219 111)In-PA-WT(K563C), or (111)In-LF(E687A) (a catalytically inactive LF mutant) in tumor and normal ti
221 , a collagen-binding discoidin domain, and a catalytically inactive metallocarboxypeptidase domain.
223 n the catalytic activity of the enzyme, as a catalytically inactive mutant form of sPLA(2)-X does not
224 ow that the LSD1(K661A) frequently used as a catalytically inactive mutant in vivo (based on in vitro
226 the X-ray crystallographic structures of two catalytically inactive mutants of protein-tyrosine phosp
228 parated, which were significantly absent for catalytically inactive point mutant (E219Q) of MMP1 and
233 both cell lines and animals, as long as the catalytically inactive RNASEH1 can be expressed to study
234 , R-ChIP involves expression of an exogenous catalytically inactive RNASEH1 in cells to bind RNA-DNA
235 d to overexpress a catalytically active or a catalytically inactive SIRT6 form or were engineered to
237 it that Map3k8(D270A/D270A) mice, expressing catalytically inactive TPL-2 and physiologic ABIN-2, sho
238 Similarly, murine myoblasts overexpressing a catalytically inactive TRIM32 mutant aberrantly accumula
239 act as a potent catalyst poison, yielding a catalytically inactive tris-ligated [Ru(dtbpy)(2)(dtbpy
240 , named dm6ACRISPR, was created by linking a catalytically inactive Type VI-B Cas13 enzyme from Prevo
242 Proteolytically active ADAMTS9, but not a catalytically inactive variant, disrupted fibronectin fi
243 howed the AD domain of both ADADs was likely catalytically inactive, similar to known negative regula
245 ssDNA binding C-terminal domain (CTD) and a catalytically inactive, strongly ssDNA binding N-termina
250 to mediate increases in [Ca(2+)] (i) Because catalytically-inactive BTK is insensitive to active-site
251 which may occur in individual CLL patients, catalytically-inactive BTK restored the ability of the B
253 found that stable expression of WT, but not catalytically-inactive MUTYH, enhances MNNG cytotoxicity
254 cture-function analyses reveal TASOR bears a catalytically-inactive PARP domain necessary for targete
256 alogues and HIV-1 reverse transcriptase (RT) catalytically incorporates the TFV part as the chain ter
257 y, we report the first FVIIa variant that is catalytically independent of sTF and provide evidence su
258 Consequently, the rapid formation of the catalytically inert isomer kick-starts replication throu
260 a key conformational equilibrium between the catalytically inert product, formed via the template-ind
261 stability relation can be broken by alloying catalytically inert strontium zirconate with the other c
264 Pase) and by SopF, a bacterial effector that catalytically modifies the V-ATPase to inhibit LC3B lipi
267 tane; Ar(F) =3,5-(CF(3) )(2) C(6) H(3) ), to catalytically oxidize NH(3) to dinitrogen under ambient
269 terated at the heteroatom position have been catalytically prepared in 50-70% isolated yield, through
270 closure to position the nucleotide in a more catalytically productive conformation relative to inacti
271 y shifting conformational ensembles to favor catalytically-productive sub-states, and suggest improve
273 singlet ambiphilic carbene activates CO and catalytically promotes the carbonylation of an o-quinone
274 TiO(2) in the dark or under UV irradiation catalytically reacted with the SOM, increasing its O/C b
280 steps enabled structural characterization of catalytically relevant intermediates after O-insertion,
281 udies, and isolation and characterization of catalytically relevant intermediates were used to gain i
282 re, pseudo-single-turnover reactions between catalytically relevant iron intermediates and excess nuc
283 nd-order perturbation theory analysis of the catalytically relevant Ni(II) intermediate indicates tha
284 transfer from an iridium photocatalyst to a catalytically relevant Ni(II)(aryl) acetate acceptor was
285 tion and spectroscopic characterization of a catalytically relevant oxoiron(IV) intermediate in chemi
286 his field, the Pd(II/0) redox potentials for catalytically relevant Pd complexes have never been dete
287 nds the active site, yet the exact nature of catalytically relevant protein motions remains largely u
291 leavage assay (SPBCA) reported strain in the catalytically relevant unwound state, suggesting that th
293 d within the LFC, owing to displacement of a catalytically required arginine in FLCN from the RagC nu
295 extracting agent, beta-cyclodextrin, acts by catalytically tipping the equilibrium in favor of crysta
296 ation technique that uses a metal complex to catalytically transfer magnetization from parahydrogen t
298 tch can be isomerized to the more stable one catalytically upon reduction, permitting the optimizatio
299 8 , 1054 - 1060 ) was reported to produce H2 catalytically via EECC mechanism through a Ni-centered h