ライフサイエンスコーパス: catastrophic

1 systemic autoimmune diseases (SAD-APS), and catastrophic.

2 of the central nervous system (CNS) could be catastrophic.

3 Injudicious biopsy is potentially catastrophic.

4 pies of these mutants within a receptor were catastrophic.

5 e reduction without parameter adjustment was catastrophic.

6 uberculosis through costs to patients can be catastrophic.

7 Different attack rate scenarios for catastrophic (30.15%), strong (21.96%), and moderate (11

8 system disturbance and recovery, sustained a catastrophic 50-foot free-fall from the top of the rainf

9 a global public health problem resulting in catastrophic accidents, increased mortality, and hundred

10 s a form of cell death that results from the catastrophic accumulation of lipid reactive oxygen speci

11 vo, allowing Poldelta exonuclease to prevent catastrophic accumulation of Pole-P301R-generated errors

12 range from the hoped-for rapid success to a catastrophic adverse influence on vaccine uptake general

13 We show that, despite producing a catastrophic amount of replication errors in vivo, the y

14 ts with total parenteral nutrition-dependent catastrophic and chronic GF were referred for surgical i

15 The world's most catastrophic and deadly thunderstorm asthma epidemic str

16 as, or supervolcanoes, are sites of the most catastrophic and hazardous events on Earth, yet the temp

17 Time-lapse microscopy reveals catastrophic and highly heterogeneous mitoses, suggestin

18 ountries, out-of-pocket spending can be both catastrophic and impoverishing at all income levels, but

19 tem beyond its planetary boundaries, risking catastrophic and irreversible global environmental chang

20 >1.5 degrees C as dangerous; >3 degrees C as catastrophic; and >5 degrees C as unknown, implying beyo

21 ch as atypical hemolytic uremic syndrome and catastrophic antiphospholipid antibody syndrome.

22 Catastrophic antiphospholipid syndrome (CAPS) is a poten

23 with severe systemic lupus erythematosus or catastrophic antiphospholipid syndrome.

24 g C5b-9 deposition) were present in 85.7% of catastrophic APS (CAPS), 35.6% of APS (and 68.5% of samp

25 Catastrophic arrhythmias and sudden cardiac death can oc

26 Dam1 is not phosphorylated are not nearly as catastrophic as when Mps1 is inactivated.

27 chaotic plastic flows consisting of several catastrophic avalanches under the applied loading.

28 material to the extracellular space prior to catastrophic axon degeneration.

29 te post-spheroid rupture events that lead to catastrophic axon disassembly.

30 Catastrophic battery failure due to internal short is ex

31 DR TB-related costs were catastrophic before and after TB-specific or TB-sensitiv

32 In an era of catastrophic biodiversity loss, robust indicators produc

33 existing predictions of either stability or catastrophic biomass loss, the Amazon forest's response

34 events are short-lived and characterized by catastrophic biosphere collapse and subsequent reorganiz

35 cted changes in seawater chemistry will have catastrophic biotic effects due to ocean acidification h

36 Particularly catastrophic bleaching-induced coral mortality events in

37 o objects near the Sun arises from the super-catastrophic breakup (that is, almost complete disintegr

38 hree decades, with the LPHI warming becoming catastrophic by 2050.

39 dwide; however, the incidence of potentially catastrophic cardiac or aortic complications has not dec

40 The possible occurrence of catastrophic cascades due to MP pollution is predominant

41 model is an efficient method for predicting catastrophic cascading events with potential application

42 II binding, which causes septal defects and catastrophic cell envelope damage.

43 am followed by phenytoin died as a result of catastrophic cerebral oedema unrelated to either treatme

44 This work reports a controllable catastrophic change of poly-Si NWs by thermally-assisted

45 Given the catastrophic changes befalling coral reefs, understandin

46 er forecasts can be expected to help prevent catastrophic changes in vegetation states by identifying

47 he direct and real time observation of these catastrophic changes of poly-Si nanowires for the first

48 Given the slow unfolding of what may become catastrophic changes to Earth's climate, many are unders

49 Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizure

50 We also identify multiple cases of catastrophic chromosomal rearrangements known as chromoa

51 ng global warming below 2 degrees C to avoid catastrophic climate change will require atmospheric car

52 We will need collective action to avoid catastrophic climate change, and this will require valui

53 y for reductions in the risk associated with catastrophic climate change.

54 For catastrophic coastal flooding, when wind-driven storm su

55 in myosin II hyperactivation accompanied by catastrophic cofilin-dependent decreases in actin filame

56 act with warming oceans may be vulnerable to catastrophic collapse even with little atmospheric warmi

57 calized bands of high stress emerge, causing catastrophic collapse of the mechanical strength of the

58 The massive star ends its life with a catastrophic collapse to leave a black hole-a promising

59 mistic estimate, to survive without facing a catastrophic collapse.

60 Fomalhaut b appears to be a directly imaged catastrophic collision between two large planetesimals i

61 Periprosthetic joint infection (PJI) is a catastrophic complication of shoulder arthroplasty.

62 body-positive patients could ameliorate this catastrophic complication.

63 in patients with AF before they present with catastrophic complications like heart failure or stroke.

64 mbrane oxygenation interaction to avoid such catastrophic complications.

65 the other hand, genomic instability can have catastrophic consequences for age-related diseases such

66 ained activity at ruptured micronuclei, with catastrophic consequences for genome stability.

67 of artisanal-scale gold mining (ASGM), with catastrophic consequences for human and ecological healt

68 often floods during the monsoon season, with catastrophic consequences for people throughout the regi

69 single cytokine in the mammalian thymus has catastrophic consequences in cases of congenital deficie

70 distorted our health care systems and caused catastrophic consequences in our affected communities.

71 ess the threat of antibiotic resistance, the catastrophic consequences of inaction, and the need for

72 uses and protecting meiotic progeny from the catastrophic consequences of their derepression.

73 er, misplaced meiotic recombination can have catastrophic consequences on genome stability.

74 tribute to the decline that is bound to show catastrophic consequences very soon.

75 tion of specific cellular subpopulations has catastrophic consequences.

76 ingly common, often unheralded, and can have catastrophic consequences.

77 ic aortic wall can degenerate over time with catastrophic consequences.

78 hanges in the number of households incurring catastrophic costs and were assessed by quintiles of hou

79 as effective or affordable for preventing TB catastrophic costs as a TB-specific cash transfer approa

80 We defined tuberculosis-related catastrophic costs as the sum of direct medical, direct

81 ould decrease household tuberculosis-related catastrophic costs by 5-20%, but gains would be seen lar

82 of households incurring tuberculosis-related catastrophic costs by 6-19%.

83 they would be insufficient to prevent DS TB catastrophic costs in 4 out of 6 countries, and when inc

84 uld be insufficient to prevent DS TB-related catastrophic costs in any of the 6 countries, and when i

85 Preventing DR TB-related catastrophic costs will require considerable additional

86 imated the reduction in tuberculosis-related catastrophic costs with an aggressive expansion of tuber

87 , and when increased enough to prevent DS TB catastrophic costs would require a budget between $298 m

88 , and when increased enough to prevent DS TB catastrophic costs would require a budget between $3.8 m

89 these 2 cash transfer approaches to prevent catastrophic costs.

90 cash transfers, are endorsed to help prevent catastrophic costs.

91 nstead of 20% as the threshold for measuring catastrophic costs.

92 ansion of tuberculosis services might reduce catastrophic costs.

93 mo-Triassic Mass Extinction (PTME), the most catastrophic crisis in Phanerozoic history.

94 ive disease management strategies to prevent catastrophic crop losses require rapid, sensitive, and m

95 al T -cell response leading to a potentially catastrophic "cytokine storm".

96 ehind incinerated vegetation, which can fuel catastrophic debris flows.

97 ses to infection that range from recovery to catastrophic decline and extirpation.

98 Catastrophic decline is rarely seen in patients on combi

99 nteraxonal degenerative signal that promotes catastrophic degeneration among trophically deprived axo

100 Before catastrophic degeneration, we observed an increase in in

101 drive death receptor 6 and calpain-dependent catastrophic degeneration.

102 re complex picture and a gradual rather than catastrophic demographic movement.

103 Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy

104 a critical reservoir enabling recovery from catastrophic DG damage.SIGNIFICANCE STATEMENT Adult hipp

105 This method exploits the catastrophic disassembly, at the acidic pH of the tumour

106 tients with acute type A aortic dissection-a catastrophic disease that requires prompt intervention-t

107 systems commonly experience and recover from catastrophic disturbances (e.g., forest fires, traffic j

108 uption of this cell cycle arrest can lead to catastrophic DNA damage for the host.

109 We find that catastrophic DNA damage occurs during S-phase of the cel

110 with global perturbations resulting from the catastrophic drainage of proglacial Lake Agassiz at ca.

111 These data are consistent with a catastrophic driver for the extinction, such as bolide i

112 and difficulty of predicting the location of catastrophic drought years in advance.

113 could be particularly useful for diagnosing catastrophic ecological responses to global change.

114 he 66 Ma Chicxulub crater had a profound and catastrophic effect on Earth's environment, but the impa

115 ic methods that can mitigate the potentially catastrophic effects of infectious outbreaks in farmed a

116 the absence of these mechanisms can lead to catastrophic effects on genome stability and cell viabil

117 hat tip the balance in favor of EBV can have catastrophic effects.

118 This has increased the risk of incidents and catastrophic emergencies during the transportation of un

119 osome length homeostasis and protection from catastrophic end-to-end chromosome fusions.

120 erspective, the question is whether averting catastrophic environmental impacts through an accelerate

121 ous volcanoes on Earth, capable of large and catastrophic eruptions, yet their low eruptive frequency

122 storically derived demographic data from the catastrophic European Black Death/bubonic plague (Yersin

123 Stroke is a catastrophic event for patients and their families.

124 ome instability by which a presumably single catastrophic event generates extensive genomic rearrange

125 i) Neither the occurrence nor the costs of a catastrophic event in any one year are precisely predict

126 vention or additional glaucoma surgery, or a catastrophic event such as loss of light perception.

127 At the time, this catastrophic event was considered unprecedented and spar

128 cancer genome may instead undergo a one-time catastrophic event, such as chromothripsis, where a larg

129 ents previously thought to occur as a single catastrophic event-is frequent and may occur multiple ti

130 enon of chromosome fragmentation in a single catastrophic event.

131 espond quickly to and recover from the final catastrophic event.

132 underestimate the probability and impact of catastrophic events (e.g., economic crises, natural disa

133 port extinction models that incorporate both catastrophic events as drivers of environmental deterior

134 This combination of catastrophic events clearly threatened the sustainabilit

135 ion of critical infrastructure systems after catastrophic events is an important issue, inspiring wor

136 While the impacts of catastrophic events on the biophysical attributes of com

137 rocesses, and therefore to better anticipate catastrophic events such as phreato-magmatic eruptions o

138 Marine oil spills are catastrophic events that cause massive damage to ecosyst

139 d that many bacteria have evolved to survive catastrophic events using a variety of mechanisms, which

140 mpening possible perturbations might lead to catastrophic events when those perturbations exceed cert

141 While regular earthquakes are catastrophic events with rupture velocities governed by

142 OC), a model wherein occasionally occurring "catastrophic events" are necessary in order to maintain

143 the acceleration toward failure exhibited by catastrophic events.

144 as the occurrence of >=1 moderate, major, or catastrophic events.

145 ion strategy is vulnerable to unpredictable, catastrophic events.

146 scenario 1 and scenario 2), and the risk of catastrophic expenditure significantly increased from a

147 expenditure, and proportion of women facing catastrophic expenditure.

148 d income were considered to have experienced catastrophic expenditure.

149 9.4% of the population) individuals to incur catastrophic expenditures in 2007.

150 ibutions, and (3) likelihood of experiencing catastrophic expenditures, defined as out-of-pocket plus

151 index and the complement of the incidence of catastrophic expenditures.

152 points; 95% CI: -14.9 to -1.7; P = 0.01) of catastrophic expenditures.

153 A low incidence of catastrophic expenses sometimes reflects low service cov

154 rom a volcanically-induced tsunami since the catastrophic explosive eruption of Krakatau in 1883 and

155 ra, El Salvador, which has a long history of catastrophic explosive eruptions.

156 Identifying the early warning signals of catastrophic extinctions has recently become a central f

157 o restore form and function of patients with catastrophic facial defects.

158 ial (tensile or compressive) tests, prevents catastrophic failure and leads to higher ultimate flow s

159 in shear bands, and is associated with early catastrophic failure in tension.

160 lastic strain on each shear band so that the catastrophic failure is prevented or delayed, and promot

161 Catastrophic failure occurs only when the slip surface i

162 that loss of Merlin in these cells causes a catastrophic failure of axonal regeneration and remyelin

163 to defects or damage that typically lead to catastrophic failure of conventional dielectric electroa

164 of dielectric materials, and ultimately, to catastrophic failure of the devices(3-5).

165 ia, USA, prior to its rapid acceleration and catastrophic failure on May 20, 2017.

166 es to transition via runaway acceleration to catastrophic failure.

167 less slide slowly for months or years before catastrophic failure.

168 ughening at critical strains, while avoiding catastrophic failure.

169 es, resulting in both poor reversibility and catastrophic failure.

170 sustain a compressive strain of ~50% without catastrophic failure; larger ones exhibit brittle fractu

171 ternal hearts and kidneys be more subject to catastrophic failures during pregnancy than at other tim

172 Natural hazards including floods can trigger catastrophic failures in interdependent urban transport

173 Much like in ecological systems, catastrophic failures of SM networks are difficult to pr

174 ectrodes and Joule heating can result in the catastrophic failures such as thermal runaway, which is

175 with a strong resilient capability to resist catastrophic failures.

176 al alarm because it has been associated with catastrophic fetal abnormalities, including microcephaly

177 ca could lessen, although not eliminate, the catastrophic financial burden on affected households.

178 ate threshold conditions for high-intensity, catastrophic fires during nondrought years.

179 been increasingly affected by intense, often catastrophic, flash floods that deliver significant amou

180 and with sediment; however, they also create catastrophic flood hazards.

181 as that will eventually experience increased catastrophic flooding and land loss.

182 is characterized by features associated with catastrophic flooding indicates final breaching of the S

183 Catastrophic floods cause deaths, injuries, and property

184 4 billion years ago an ocean fed by enormous catastrophic floods covered most of the Martian northern

185 This extreme event is accompanied by a catastrophic force drop as observed in the experimental

186 via carbon starvation, causing more frequent catastrophic forest die-offs than the present projection

187 plasticity in SmNiO3 perovskites to address catastrophic forgetting in a dynamic learning environmen

188 of this and it has been widely thought that catastrophic forgetting is an inevitable feature of conn

189 The brain has evolved mechanisms to prevent catastrophic forgetting of old knowledge during new trai

190 lly - and surprisingly efficiently - prevent catastrophic forgetting on toy examples even in a class-

191 Artificial neural networks suffer from catastrophic forgetting.

192 Volatile depletion is consistent with catastrophic formation, such as a giant impact, whereas

193 nal research findings on several of the most catastrophic forms of pediatric epilepsy.

194 d chemo-mechanical stresses can also lead to catastrophic fracture of electrolyte membranes.

195 climate backgrounds, which demonstrates that catastrophic freshwater outburst floods were not a prere

196 king), and uncertainty about possible, often catastrophic, future events.

197 be tempted to biopsy, which could lead to a catastrophic gastrointestinal haemorrhage.

198 Whole-genome sequencing uncovered a catastrophic genome rearrangement in TB that caused the

199 Our findings show that catastrophic genome rearrangements arise spontaneously a

200 Recent analyses have reported catastrophic global declines in vertebrate populations(1

201 by sill complexes are more likely to trigger catastrophic global environmental change than their floo

202 rovide important lessons for a planet facing catastrophic global warming and environmental change.

203 eal that decreased fitness can result from a catastrophic growth arrest caused by unexpected darkness

204 with a significantly increased likelihood of catastrophic health expenditure (for the overall populat

205 drive up cost, place many people at risk of catastrophic health expenditure and pose high opportunit

206 a), financial protection by the incidence of catastrophic health expenditures (those exceeding 10% of

207 The effect of physical multimorbidity on catastrophic health expenditures persisted even among th

208 multimorbidity, health-care service use, and catastrophic health expenditures; and whether these asso

209 ween 2000 and 2010, and associations between catastrophic health spending and macroeconomic and healt

210 We aimed to estimate the global incidence of catastrophic health spending, trends between 2000 and 20

211 lobally, 808 million people in 2010 incurred catastrophic health spending.

212 dent parallel adaptive change in response to catastrophic human disturbance.

213 lone-driven flood events since 1999, causing catastrophic human impacts from flooding and leading to

214 ng following JAK/STAT inhibition may control catastrophic hyperinflammation in MAS.

215 Subacute potentially catastrophic illnesses in three diverse ICU populations

216 ICUs are susceptible to subacute potentially catastrophic illnesses such as respiratory failure, seps

217 disease 2019 (COVID-19) pandemic is having a catastrophic impact on human health(1).

218 weeks, which offers hope in mitigating their catastrophic impact on life, agriculture and property.Ag

219 the combined exposures simulated had mild to catastrophic impacts on ovulation.

220 ore cash transfers, DS TB-related costs were catastrophic in 6 out of 7 countries.

221 and >5 degrees C as unknown, implying beyond catastrophic, including existential threats.

222 The COVID-19 pandemic is causing a catastrophic increase in US mortality.

223 n a class II condensed history scheme, i.e., catastrophic inelastic scattering and Bremsstrahlung eve

224 the high-risk 65+ years subpopulation in the catastrophic influenza pandemic, and highest among the h

225 onsequently, prevention of these potentially catastrophic injuries is vital, and practitioners need t

226 rdial infarction with evidence of widespread catastrophic intravascular red-cell sickling.

227 Catastrophic landslides cause billions of dollars in dam

228 w the dangerous level and the LPHI below the catastrophic level, both in the near term (<2050) and in

229 a chytridiomycosis epizootic leading to the catastrophic loss of amphibians, a food source for snake

230 ion of the SPMTs which likely results in the catastrophic loss of APR and conoid.

231 cting specificity residues to mutate without catastrophic loss of DNA binding.

232 re projections indicating that a potentially catastrophic loss of global biodiversity is on the horiz

233 development of hyperglycemia related to the catastrophic loss of insulin, hep-tg mice continued to h

234 degeneration of motor neurons resulting in a catastrophic loss of motor function.

235 tment of P. aeruginosa with AB569 revealed a catastrophic loss of the ability to support core pathway

236 In the face of catastrophic loss, organizations around the world are de

237 Catastrophic losses of habitat-forming seagrass meadows

238 C1/mTORC2 inhibitors OSI-027 and PP242 cause catastrophic macropinocytosis in rhabdomyosarcoma (RMS)

239 crease cartilage growth, but instead lead to catastrophic malformations resembling chondrodysplasia o

240 atic spinal cord compression (MSCC) can be a catastrophic manifestation of advanced cancer that cause

241 zed, enhances tensile ductility and inhibits catastrophic mechanical failure(1,2).

242 ons in the conserved kinase, Mps1, result in catastrophic meiotic segregation errors but mild mitotic

243 Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with c

244 ich was carved during the Pleistocene by the catastrophic Missoula floods in eastern Washington, USA.

245 , symbiont-induced sperm modifications cause catastrophic mitotic defects in the fertilized embryo an

246 misalignment in metaphase, often leading to catastrophic mitotic failure.

247 This combination of phenotypes underlies the catastrophic MMR defect seen with the mutant MutLalpha i

248 The results are consistent with a catastrophic mode of disassembly, not enhanced severing

249 has long been thought to be the result of a catastrophic Moon-forming giant impact event.

250 mblage was formed by a local single event of catastrophic mortality, which affected different members

251 er genomes alongside chromothripsis, another catastrophic mutational phenomenon.

252 ns of mushy silicic magma are among the most catastrophic natural events on Earth.

253 Flash flood is among the most catastrophic natural hazards which causes disruption in

254 Catastrophic oil spills stimulate these organisms to "bl

255 chanisms, including: the origination of bulk catastrophic optical damage (COD) due to locally high en

256 s limited by insufficient infrastructure and catastrophic out-of-pocket costs.

257 in large bedrock canyons that were carved by catastrophic outburst floods.

258 surements for the first time, preventing the catastrophic outgassing, precipitation and sample degrad

259 as reaching the stratosphere would result in catastrophic ozone depletion, extending the surface cool

260 phic payment incidence was positive whatever catastrophic payment incidence measure was used.

261 ion-weighted median annual rate of change of catastrophic payment incidence was positive whatever cat

262 spent on health is not sufficient to reduce catastrophic payment incidence; rather, what is required

263 Incidence of catastrophic payments was correlated positively with GDP

264 eceptor, is required for transition into the catastrophic phase in response to conditioned media but

265 are capable of hastening transition into the catastrophic phase of degeneration.

266 ison disassembly of axons over the next 3 h (catastrophic phase).

267 sis by which axons transition from latent to catastrophic phases of degeneration following trophic wi

268 co suggest that insects may be in a state of catastrophic population collapse: the German data descri

269 ed with control animals, Trib1-/- mice had a catastrophic prognosis, with frequent cardiac rupture, a

270 considered that these terrains formed due to catastrophic quakes and ejecta fallout produced by the a

271 ts in the represented position, resulting in catastrophic readout errors.

272 esistance in malaria vectors could presage a catastrophic rebound in disease incidence and mortality.

273 episodes may predispose the HFEV(1) group to catastrophic reductions in airflow.

274 , and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury

275 us for much of its earlier history, prior to catastrophic runaway greenhouse warming.

276 ischarging, which lead to short lifespan and catastrophic safety hazards.

277 Here, we describe the rapid climate-driven catastrophic shift in 2014 from a previously robust kelp

278 rse treatment outcomes and have been termed "catastrophic." Social protection initiatives, including

279 acier lake outburst floods (GLOFs) can cause catastrophic societal and geomorphic impacts.

280 he relation between a country's incidence of catastrophic spending and gross domestic product (GDP) p

281 The global incidence of catastrophic spending at the 10% threshold was estimated

282 he high-risk 0-19 years subpopulation in the catastrophic, strong and moderate influenza pandemics.

283 e high-risk 20-64 years subpopulation in the catastrophic, strong and moderate influenza pandemics.

284 her than among the adults and seniors in the catastrophic, strong, and moderate influenza pandemic sc

285 y of the polymeric calsequestrin network and catastrophic structural changes in the SR.

286 It is concluded that avoidance of catastrophic structural failure, as initiated in these s

287 lure (ALF).((1)) Their report highlights the catastrophic suddenness in which dengue ALF commonly pre

288 structures or financial networks can lead to catastrophic system collapse.

289 omote rapid telomere resection, resulting in catastrophic telomere loss and the generation of telomer

290 Individuals with more catastrophic thinking about pain and with low mindfulnes

291 myloid-beta oligomers also recapitulated the catastrophic tissue loss that is a hallmark of late AD.

292 ventually lead to impaired organ function or catastrophic transformation such as cancer.

293 heating, the helicoidal copolymers undergo a catastrophic transition into amorphous coaggregates via

294 marine environment, most notably leading to catastrophic tsunamis.

295 In 1965, a catastrophic underground blowout occurred during the dri

296 glioblastoma cells and induces cell death by catastrophic vacuolization.

297 ation, including elevated blood ammonia, and catastrophic weight loss, which, in Mut(ki/ki) mice, is

298 We defined health spending as catastrophic when it exceeded 10% or 25% of household co

299 specification pathways makes it particularly catastrophic when they malfunction, both during developm

300 of standing dead wood, raising concern over catastrophic wildfire and other hazards.