ライフサイエンスコーパス: catechol-O-methyltransferase

1 to the active site of a promiscuous enzyme, catechol O-methyltransferase.

2 e modified by variation in the gene encoding catechol O-methyltransferase.

3 thionine ([3H]SAM) in presence of endogenous catechol-O-methyltransferase.

4 od substrates for recombinant and endogenous catechol-O-methyltransferase.

5 hylation of select tyrphostins by endogenous catechol-O-methyltransferase.

6 In genetically modified mice with reduced catechol-O-methyltransferase activity there was selectiv

7 Inhibition of catechol-O-methyltransferase activity with tyrphostin AG

8 ethylated to less polar monomethyl ethers by catechol-O-methyltransferase, an enzyme present in many

9 e its application for drug discovery using a catechol O-methyltransferase and its inhibitors entacapo

10 of the methyl-transfer reaction catalyzed by catechol O-methyltransferase and modeled by hybrid QM/MM

11 ently reported isotope-effect variations for catechol-O-methyltransferase and its mutant structures.

12 e involves three enzymes: monoamine oxidase, catechol O-methyltransferase, and sulfotransferase.

13 receptor, ATP-binding cassette subfamily B, catechol-O-methyltransferase, and cytochrome 2D6 current

14 mechanism of inhibition by quercetin of the catechol O-methyltransferase-catalyzed O-methylation of

15 Catechol-O-methyltransferase catalyzes the methylation o

16 allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behav

17 The human gene for catechol O-methyltransferase (COMT) contains a common po

18 Human catechol O-methyltransferase (COMT) contains three commo

19 The catechol O-methyltransferase (COMT) gene affects how lon

20 ional polymorphism (Val(108/158) Met) in the catechol O-methyltransferase (COMT) gene and eye trackin

21 etween the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophren

22 tional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene underlies some

23 could result from haploinsufficiency of the catechol O-methyltransferase (COMT) gene, located within

24 tional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene.

25 uenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene.

26 Human catechol O-methyltransferase (COMT) has emerged as a mod

27 Catechol O-methyltransferase (COMT) inhibitors are an es

28 In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the m

29 Catechol O-methyltransferase (COMT) is the enzyme respon

30 Catechol O-methyltransferase (COMT) plays important role

31 The catechol O-methyltransferase (COMT) Val158Met polymorphi

32 Catechol O-methyltransferase (COMT), the major enzyme de

33 Catechol O-methyltransferase (COMT)-catalyzed methylatio

34 Using catechol O-methyltransferase (COMT, EC 2.1.1.6) and thio

35 in Parkinson's disease, namely the genes for catechol-O-methyltransferase (COMT Val(158)Met) and micr

36 The catechol-O-methyltransferase (COMT) 158Val --> Met polym

37 ltransferase activity, the methyltransferase catechol-O-methyltransferase (COMT) and a known selectiv

38 ies of genetic variation in these systems in catechol-O-methyltransferase (COMT) and in metabotropic

39 otransmitters (dopamine, serotonin), such as catechol-O-methyltransferase (COMT) and monoamine oxidas

40 he genotype of the Val158Met polymorphism in catechol-O-methyltransferase (COMT) as an index of relat

41 Participants were genotyped for catechol-O-methyltransferase (COMT) at the Val158Met loc

42 Human catechol-O-methyltransferase (COMT) catalyzes a methyl t

43 Catechol-O-methyltransferase (COMT) catalyzes the methyl

44 Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-meth

45 i) to determine whether polymorphisms in the catechol-O-methyltransferase (COMT) gene affect the rela

46 The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activit

47 methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associ

48 ect of the Val108/158Met polymorphism in the catechol-O-methyltransferase (COMT) gene in children bef

49 The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is an important

50 functional polymorphism (Val(158)Met) in the catechol-O-methyltransferase (COMT) gene is associated w

51 The catechol-O-methyltransferase (COMT) gene is located in t

52 Functional genetic variants in the catechol-O-methyltransferase (COMT) gene result in a dif

53 In particular, the catechol-O-methyltransferase (COMT) gene, located on chr

54 ional polymorphism (Val(108/158) Met) in the catechol-O-methyltransferase (COMT) gene, which accounts

55 a functional polymorphism (Val158Met) in the catechol-O-methyltransferase (COMT) gene, whose protein

56 fficacy might be modified by variants of the catechol-O-methyltransferase (COMT) gene.

57 r (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated

58 hisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes.

59 or placebo (n = 537) and were stratified by catechol-O-methyltransferase (COMT) genotype activity (h

60 A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to af

61 Catechols are O-methylated by catechol-O-methyltransferase (COMT) in a SAM consuming r

62 Administering L-dopa with a catechol-O-methyltransferase (COMT) inhibitor to block i

63 Healthy individuals (n = 35) received the catechol-o-methyltransferase (COMT) inhibitor tolcapone

64 Catechol-O-methyltransferase (COMT) inhibitors delay the

65 Catechol-O-methyltransferase (COMT) is a key enzyme for

66 Catechol-O-methyltransferase (COMT) is a key enzyme in t

67 Catechol-O-methyltransferase (COMT) is a key regulator o

68 Catechol-O-methyltransferase (COMT) is a major enzyme co

69 O-Methylation catalyzed by catechol-O-methyltransferase (COMT) is a Phase II metabo

70 The gene encoding catechol-O-methyltransferase (COMT) is a strong candidat

71 Catechol-O-methyltransferase (COMT) is one of the major

72 The Val158Met polymorphism of human catechol-o-methyltransferase (COMT) is one of the most w

73 Catechol-O-methyltransferase (COMT) metabolizes dopamine

74 Catechol-O-methyltransferase (COMT) modulates dopamine l

75 human TR3 gene overlapped with the gene for catechol-O-methyltransferase (COMT) on a complementary D

76 Catechol-O-methyltransferase (COMT) plays an important r

77 Catechol-O-methyltransferase (COMT) plays both a regulat

78 uals homozygous for the met158 allele of the catechol-O-methyltransferase (COMT) polymorphism (val158

79 Additionally, catechol-O-methyltransferase (COMT) polymorphism has bee

80 our-hour urinary hydroxytyrosol and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes wer

81 Here we show that pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia

82 as a function of baseline PFC DA [indexed by catechol-O-methyltransferase (COMT) Val(158)Met genotype

83 al relationship between the BOLD(SV) and the catechol-O-methyltransferase (COMT) Val(158)Met polymorp

84 cortex plasticity, while additionally taking catechol-O-methyltransferase (COMT) Val158Met and kidney

85 authors assessed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphi

86 The catechol-O-methyltransferase (COMT) val158met polymorphi

87 t study, we address the role of the gene for catechol-O-methyltransferase (COMT), a key modulator of

88 els are associated with genetic variation in catechol-O-methyltransferase (COMT), a regulatory enzyme

89 und a dramatic increase in the expression of catechol-O-methyltransferase (COMT), along with a lower

90 oratory has identified an early reduction in catechol-O-methyltransferase (COMT), an enzyme responsib

91 Catechol-O-methyltransferase (COMT), an important therap

92 he DAT1 VNTR and functional polymorphisms in catechol-O-methyltransferase (COMT), DRD2, and DRD4 were

93 O-Methylation, catalyzed by catechol-O-methyltransferase (COMT), inactivates catecho

94 metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of

95 Enzymatic methyl transfer, catalyzed by catechol-O-methyltransferase (COMT), is investigated usi

96 in inactivating and packaging NE, including catechol-O-methyltransferase (COMT), monoamine oxidase-A

97 is amplified by allelic variants in a gene, catechol-O-methyltransferase (COMT), regulating catechol

98 Inhibition of catechol-O-methyltransferase (COMT), the enzyme primaril

99 For catechol-O-methyltransferase (COMT), the Val(158)Met pol

100 (OPRD1), cannabinoid receptor 1 (CNR1), and catechol-o-methyltransferase (COMT), was strongly associ

101 enols are very rapidly O-methylated by human catechol-O-methyltransferase (COMT), we are interested i

102 ion of a fungal tyrosinase and the mammalian catechol-O-methyltransferase (COMT), which can effect th

103 he enzymes proline dehydrogenase (PRODH) and catechol-O-methyltransferase (COMT), which modulate the

104 r (DAT), which predominates in striatum, and catechol-O-methyltransferase (COMT), which predominates

105 s and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylati

106 he rs4680 single-nucleotide polymorphism for catechol-O-methyltransferase (COMT).

107 ough a functional epistatic interaction with Catechol-O-methyltransferase (COMT).

108 ent in humans is the Val/Met polymorphism in catechol-O-methyltransferase (COMT).

109 ulated by the dopamine transporter (DAT) and catechol-O-methyltransferase (COMT).

110 n the expression of tyrosine hydroxylase and catechol-O-methyltransferase (COMT).

111 he frontal cortex is critically dependent on catechol-O-methyltransferase (COMT).

112 em and how our genetic profile (specifically catechol-O-methyltransferase [COMT] polymorphisms) impac

113 ith a functional polymorphism (Val158Met) in catechol-O-methyltransferase [COMT], a gene that indexes

114 estradiols to methoxyestradiols (mediated by catechol-O-methyltransferase, COMT).

115 that integrated clinically relevant genetic (catechol-O-methyltransferase; COMT knockdown) and enviro

116 gle gene regions (e.g. opioid receptor mu-1, catechol-O-methyltransferase, cytochrome P450 2D6) and o

117 y of properties is observed between GNMT and catechol O-methyltransferase, despite significant differ

118 unctional polymorphism (val(158)-met) in the catechol O-methyltransferase gene, which has been shown

119 enotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsiv

120 The COMT (catechol-O-methyltransferase) gene has been linked to a

121 r common mutations in the human factor V and catechol-O-methyltransferase genes.

122 Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at in

123 le nucleotide tandem repeat, and the Val/Val catechol-O-methyltransferase genotype had greater decrea

124 ormance (p < 0.002) and with the val(158)met catechol-O-methyltransferase genotype.

125 a proof-of-concept, we study three enzymes (catechol-O-methyltransferase, glucose-6-phosphate dehydr

126 hydroxyestradiol by hamster kidney cytosolic catechol O-methyltransferase (IC50 approximately 10-14 m

127 in which we administered the brain penetrant catechol-O-methyltransferase inhibitor tolcapone or plac

128 a novel, once-daily, potent third-generation catechol-O-methyltransferase inhibitor.

129 g several other medications, such as MAOBIs, catechol-O-methyltransferase inhibitors, or dopamine ago

130 ibution of ER proteins, such as calnexin and catechol-O-methyltransferase, into a large centrosomal a

131 te to changes in cortical dopamine levels as catechol-O-methyltransferase is the main mode of inactiv

132 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMT(L

133 the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered pr

134 es, including APOE (apolipoprotein E), COMT (Catechol-O-Methyltransferase), MDR1 (multi-drug resistan

135 enosyl-L-homocysteine, a potent inhibitor of catechol-O-methyltransferase-mediated methylation of 3,4

136 oncompetitive inhibitor of DNMTs) during the catechol-O-methyltransferase-mediated O-methylation of t

137 enes also implicated in schizophrenia (e.g., catechol-O-methyltransferase, neuregulin-1).

138 10 homozygous for Val/Val and 10 for Met/Met catechol-O-methyltransferase polymorphisms) underwent (1

139 e-derivatives like 3-iodothyronamine (T1AM), catechol-O-methyltransferase products like 3-methoxytyra

140 A common polymorphism in the human gene for catechol-O-methyltransferase results in replacement of V

141 r O-methylation by human recombinant soluble catechol-O-methyltransferase (S-COMT) is a feasible deto

142 aken together, we concluded that CTOMT1 is a catechol-O-methyltransferase that produces guaiacol in t

143 We used the well-characterized enzyme catechol O-methyltransferase to demonstrate that the ass

144 hic Parkinson's disease as a function of the catechol-O-methyltransferase Val(158)Met polymorphism us