ライフサイエンスコーパス: cathepsin B

1 rved in the presence of proteolytic enzymes (cathepsin B).

2 cross-reactivity with the cysteine protease cathepsin B.

3 VPE activity was independent of cathepsin B.

4 Then, this caused degradation of CTSDmat by cathepsin B.

5 racellular sensing of the lysosomal protease cathepsin B.

6 -expression or pharmacological inhibition of cathepsin B.

7 abel as the peptide molecules are cleaved by cathepsin B.

8 do not interact with DNA or inhibit protease cathepsin B.

9 chool whiting showed higher activity towards cathepsin B.

10 and lysosomal damage, leading to release of cathepsin B.

11 e (UPR) kinase PERK and the lysosomal enzyme cathepsin B.

12 ion, and by genetic co-deletion of lysosomal cathepsin B.

13 sequent degradation mediated by the protease cathepsin B.

14 e of cathepsin L, including cooperation with cathepsin B.

15 cells from lysosomal breakdown by inhibiting cathepsin B.

16 -ribosylation (ARF)-dependent trafficking of cathepsin B.

17 tem is applied to a screen of inhibitors for cathepsin B.

18 ysteine proteases calpain I, calpain II, and cathepsin B.

19 ed protein levels of the lysosomal protease, cathepsin B.

20 Gly-Ala-NH-CH(2)-Fc is the optimal probe for cathepsin B.

21 plasma membrane, resulting in the release of Cathepsin B.

22 ing the derepression of the lysomal protease cathepsin B.

23 n aspartic protease in Alzheimer's disease), cathepsin B (a cysteine protease in cancer), and Alp2 (a

24 re located upstream of CTSB, a gene encoding cathepsin B, a cysteine protease involved in keratinocyt

25 e VC(S) linker was designed to be cleaved by cathepsin B, a lysosomal cysteine protease.

26 inhibitor-binding site in cysteine protease cathepsin B, a potential drug target and prognostic mark

27 sponse of the formulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed

28 Cathepsin B abundancy in the model mimicked human diseas

29 Cathepsin B activates trypsinogen in these colocalized o

30 as not altered in the cathepsin B mutant and cathepsin B activation was independent of vacuolar proce

31 ty of T-cytotoxic memory cells, which resist cathepsin B activation, may distinguish rejection-free a

32 lysosomal dysfunction, lysosomal rupture and cathepsin B activation.

33 Tc seemed resistant to cathepsin B activation; (3) with increasing rATG concent

34 ructure of 5-nitro-8-hydroxyquinoline in the cathepsin B active site.

35 Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esoph

36 suring conditions, the limit of detection of cathepsin B activity and concentration can reach 2.49 x

37 mediated ARF1 inhibition resulted in reduced cathepsin B activity and consequently reduced trypsinoge

38 Trypsinogen activation, increased cathepsin B activity and inflammation around the pancrea

39 Trypsin activity, cathepsin B activity and myeloperoxidase activity on the

40 demonstrate that inhibitors of autophagy or cathepsin B activity and/or molecular targeting of p62/S

41 e-dependent increase in pH and a decrease in cathepsin B activity associated with bacterial survival.

42 rode array for rapid, multiplex detection of cathepsin B activity based on a simple electrochemical m

43 It inhibited cathepsin B activity by nearly 40% in vitro.

44 Mice and macrophages lacking cathepsin B activity had increased resistance to the cyt

45 The detections of cathepsin B activity in different concentrations of whol

46 to generate LG3 during normoxic conditions, cathepsin B activity was found to be important to genera

47 The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tum

48 reactive oxygen species (ROS) production and cathepsin B activity, accompanied by an up-regulation of

49 vation, blocking ATP signaling, K(+) efflux, cathepsin B activity, and lysosomal acidification all in

50 e oxygen species (ROS) led to an increase in cathepsin B activity, and pharmacological inhibition of

51 quires Ad endosomal membrane penetration and cathepsin B activity.

52 on pathways was evaluated by studying pH and cathepsin B activity.

53 We show that cathepsin-B activity in the lysosome is upregulated by R

54 actions among three cancer-related proteases cathepsin B, ADAM10, and ADAM17.

55 ppressed vesicle formation and knock down of cathepsin B-AIF significantly reduced neratinib lethalit

56 f inducible nitric oxide synthase (iNOS) and cathepsin B also reversed chlamydial killing.

57 icles that deliver antimicrobial peptide and cathepsin B (AMP-CatB) mRNA.

58 o used for turn-on fluorescence detection of cathepsin B, an enzyme known to be overexpressed in mamm

59 Moreover, they are sensitive to proteases (cathepsin B and asparagine endopeptidase) that are over-

60 Annexin A3 colocalized with cathepsin B and C, claudin-1, phosphorylated ERK1/2, and

61 sium, scavenging mitochondrial ROS, and both cathepsin B and caspase-1 inhibition.

62 Co-expression of cathepsin B and cathepsin B-resistant mutant LFABP in Mc

63 s regulated by a lysosomal pathway, in which cathepsin B and cathepsin D play redundant roles.

64 deficiency in these mice results in enhanced cathepsin B and D activities, indicating lysosomal dysfu

65 Furthermore, the lysosomal protease cathepsin B and HIV-1 induced production of reactive oxy

66 OMK ligands are suitable in vitro probes for cathepsin B and hold promise as a platform to develop mo

67 recruit Bim and Bax to lysosomes to release cathepsin B and induce apoptosis.

68 Cathepsin B and L activities were 90% (+/- SD) [2.4 +/-

69 mography was established, and an increase of cathepsin B and L activity after HP treatment was shown

70 14 +/- 0.08 compared with 0.04 +/- 0.04) and cathepsin B and L expressions in the vastus lateralis of

71 phagic vacuoles and was blocked by lysosomal cathepsin B and L inhibition.

72 hese mice express greater amounts of hepatic cathepsin B and lower amounts of liver fatty acid-bindin

73 ERSID is regulated positively by cathepsin B and negatively by PBA1, revealing a complex

74 usion activity triggered by the host factors cathepsin B and Niemann-Pick C1.

75 he expression of critical EBOV entry factors cathepsin B and NPC1.

76 ion were used to investigate the function of cathepsin B and PBA1 in ER-stress-induced PCD (ERSID).

77 L-1beta was also dependent on the release of cathepsin B and production of reactive oxygen species (R

78 lant proteases with caspase-3-like activity, cathepsin B and proteasome subunit PBA1, remains to be e

79 imal cerulein, and the cytosolic activity of cathepsin B and trypsin was evaluated.

80 cretion as compared with cells co-expressing cathepsin B and wildtype LFABP.

81 Activities of cathepsins B and B+L were higher than cathepsin H for al

82 Transcripts for cathepsins B and C were increased in FSGS glomeruli comp

83 y increasing cathepsin D activity, levels of cathepsins B and D and two proteins known to interact wi

84 to LC3-II conversion, and the activation of cathepsins B and D were assayed with Western blot analys

85 nzymes (acid lipase, beta-glucuronidase, and cathepsins B and D).

86 tides were released at the cleavage sites of cathepsins B and D, which thus play an important role.

87 utophagosome-associated lysosomal proteases, cathepsins B and D.

88 hepsin family by RNA interference identified cathepsins B and H as key mediators of TLR3 processing.

89 om lysosomal permeabilization and release of cathepsins B and L in autophagy-deficient cells.

90 Caco2 cells were also noted to produce cathepsins B and L, and inhibition of cathepsins suppres

91 ign nevi; we found up-regulation of cysteine cathepsins B and L, matrix metalloproteinase (MMP)-1 and

92 ipating in the processing were identified as cathepsins B and L.

93 n, bromelain, ficin, and mammalian lysosomal cathepsins B and L.

94 leavage assays, we demonstrate that cysteine cathepsins B and S can directly cleave Rip1.

95 for Leu-Leu-OMe-induced cell death, whereas cathepsins B and S were required for alum-mediated necro

96 thepsin inhibition and mediated partially by cathepsins B and S.

97 showed that the probe was very selective for cathepsins B and Z, two lysosomal cysteine proteases.

98 Apoptotic (caspase-3+, cathepsin B+) and inflammatory (CD154+) T-cell subsets w

99 ated by blockade of endosomal acidification, cathepsin B, and caspase 1, suggesting that virus intera

100 ike receptor protein 3 (NLRP3) inflammasome, cathepsin B, and caspase-1 and may play a role in the pa

101 block proteolytic activities of host furin, cathepsin B, and caspases that mediate toxin's lethality

102 tion, inhibitors of reactive oxygen species, cathepsin B, and K(+) efflux pathways, known to specific

103 lysate spiked with varied concentrations of cathepsin B, and the tissue lysate after immunoprecipita

104 role for the proteolytic cleavage of ENaC by cathepsin B, and we suggest two possible mechanisms by w

105 t of pre-slaughter stress, the activities of cathepsin B- and B/L-like enzymes increased and activiti

106 iple tissues (integrin alpha4/annexin A4 and cathepsin B/apolipoprotein E3) and the other two have a

107 -specific differences in the requirement for cathepsin B are correlated with sequence polymorphisms a

108 n close proximity to SNCA and CTSB (encoding cathepsin B) are the most significant contributors.

109 Data indicate cathepsin B as a key molecule mediating neurodegeneratio

110 we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosoma

111 rk further confirmed CDK6, RICTOR, and CTSB (cathepsin B) as targets of miR-218 and examined the func

112 cells apically express the cysteine protease cathepsin B, as indicated by two-dimensional gel electro

113 ysteine protease CPR-4, a homologue of human cathepsin B, as the first RIBE factor in nematodes, to o

114 enzymes with barracouta showing the highest cathepsins B, B+L, D and H activities.

115 This study compared the activities of cathepsins B, B+L, D, H and calpain-like enzymes in crud

116 is hydrolyzable by the proteases plasmin and cathepsin B, both strongly linked with cancer progressio

117 subunit fusion protein was cleaved by active cathepsin B but not the full-length beta or gamma subuni

118 le of trypsin in AP and shows that cytosolic cathepsin B but not trypsin activates cell death pathway

119 Cytosolic cathepsin B but not trypsin activates the intrinsic path

120 istant acid phosphatase histoenzymology, and cathepsin B (CATB) and matrix metalloproteinase 9 (MMP9)

121 iously, we showed that the cysteine protease cathepsin B (CatB) degrades Abeta, most likely by C-term

122 ifically causes a leak of lysosomal protease cathepsin B (CatB) into the cytoplasm.

123 Cathepsin B (CatB) proteolytically degrades Abeta into n

124 s and angiogenesis are mediated by activated cathepsin B (CatB), a cysteine protease that translocate

125 HIV-infected macrophages secrete cathepsin B (CATB), and serum amyloid p component (SAPC)

126 Cathepsin B (cathB) was subsequently confirmed to be dif

127 IHC showed that glomerular tuft staining for cathepsin B, cathepsin C, and annexin A3 in cFSGS was si

128 tophagosome numbers, expression of lysosomal cathepsin B, cathepsin D, Beclin-1, and microtubule-asso

129 , and either an acid-sensitive bond (1) or a cathepsin B cleavable bond (3) for ensuring an effective

130 Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-

131 cers were used in the design: a lysosomally (cathepsin B) cleavable tetrapeptide GFLG spacer conjugat

132 ) containing photosensitizer (Ce6) through a Cathepsin B-cleavable peptide.

133 1 activity was assayed following an in vitro cathepsin B cleavage reaction.

134 Whereas cathepsin B cleaved chemokines especially in the C-termi

135 Interestingly, cathepsin B combined with its enzymatic inhibitors led t

136 rs show DNA release by 4 h of treatment with cathepsin B; comparatively, polyplexes formed with pHCat

137 itation showed that there is ~13.4 nM higher cathepsin B concentration in 29.1 microg mL(-1) of whole

138 ate of the endosomal/lysosomal endopeptidase cathepsin B, connected to oligo-(L)-lysine for nucleic a

139 Moreover, cathepsin B contributes to NAIP5/NLRC4 inflammasome-indu

140 sylated and thereby inactivated caspase 3 or cathepsin B could be reactivated through either Trx1- or

141 we suggest two possible mechanisms by which cathepsin B could regulate ENaC.

142 Cathepsin B (CTB) is a cysteine protease believed to be

143 dependent effects of simultaneously deleting cathepsin B (CtsB) and CtsS in a murine pancreatic neuro

144 demonstrate a direct involvement of cysteine cathepsin B (CtsB) and L (CtsL).

145 Cathepsin B (CtsB) contributes to atherosclerosis and ca

146 The lysosomal hydrolase cathepsin B (CTSB) is a known activator of trypsinogen,

147 The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human

148 Cathepsin B (CTSB) is present in both normal and CF epit

149 e intracellular activation of trypsinogen by cathepsin B (CTSB), which can be induced directly via G

150 gen activation) or by the lysosomal protease cathepsin B (CTSB).

151 The lysosomal proteases cathepsin B, D, and L have been identified as regulators

152 tivator of various lysosomal enzymes such as cathepsin B, D, and L.

153 ious findings revealed that ASMase activates cathepsins B/D (CtsB/D), our aim was to investigate the

154 ry CD8(+) T cells was rescued by concomitant cathepsin B deficiency, demonstrating that cathepsin B w

155 However, reports that cathepsin B-deficient macrophages have no defect in part

156 mice treated with a cathepsin inhibitor and cathepsin B-deficient mice suffer limited intestinal inj

157 or four doxorubicin, respectively, through a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu

158 Cathepsin B degraded copolymers pHCathK(10) and pHCath(D

159 f rats or mice (wild-type, trypsinogen 7, or cathepsin B-deleted) were stimulated with supramaximal c

160 cies Bundibugyo, containing D47 and I584, is cathepsin B dependent and that ebolavirus Zaire-1995, th

161 trong association of acinar cell injury with cathepsin B-dependent intracellular activation of trypsi

162 Mice lacking cathepsin B display aberrant follicular architecture, a

163 ic deletion or pharmacological inhibition of cathepsin B down-regulated mechanistic target of rapamyc

164 Cathepsin B downregulation reduced reactive oxygen speci

165 derived neurons were shown to have decreased cathepsin B expression compared to controls.

166 Surprisingly, suppression of cathepsin B expression via CRISPR-Cas9 gene deletion or

167 myelin build-up induces lysosomal damage and cathepsin B extracellular release by lysosomal exocytosi

168 calcium binding protein A8 (S100A8), S100A9, cathepsin B, fibronectin, and galectin-3-binding protein

169 uggest that activity-dependent exocytosis of Cathepsin B from lysosomes regulates the long-term struc

170 nterruption of either CCL2-CCR2 signaling or cathepsin B function significantly impaired PNI in vivo

171 ediated knock-down of genes belonging to the cathepsin B gene family.

172 Knock-down of cathepsin B genes reduced aphid fitness, but only on the

173 on of cystatin B, an endogenous inhibitor of cathepsins B, H and L, on the development of NPC neuropa

174 Now, a chemiluminescent probe for cathepsin B has been developed that provides a 16,000-fo

175 Human cathepsin B has many house-keeping functions, such as pr

176 posed to active recombinant histidine-tagged cathepsin B (His-CATB).

177 ntial role of cytosolic trypsin vs cytosolic cathepsin B in activation of apoptosis.

178 metastasis to bone that is coexpressed with cathepsin B in bone metastases.

179 sefulness against the deleterious effects of cathepsin B in cancer progression.

180 indings established a prometastatic role for cathepsin B in distant metastasis and illustrated the th

181 Leukocytes were the source of cathepsin B in drain fluid.

182 ified the activity of the lysosomal protease cathepsin B in macrophages as a rate-limiting factor in

183 siRNA-mediated knockdown of cathepsin B in McA-RH7777 cells resulted in a 39% increa

184 f their possible target enzymes legumain and cathepsin B in MDA-MB-435S, A375, and C8161 melanoma cel

185 ntified a fundamental biological function of cathepsin B in providing a checkpoint for homeostatic ma

186 containing antimicrobial peptides linked to cathepsin B in the lysosomes (MACs) can be applied for t

187 ion of CTSB, as well as stronger staining of cathepsin B in the stratum granulosum of affected indivi

188 ction and therapeutic targeting potential of cathepsin B in this setting of advanced disease.

189 RNA interference-mediated knockdown of cathepsin B in tumor cells reduced collagen I degradatio

190 ting the ability to effectively label active cathepsin B in vitro.

191 Cathepsin B increased the activity of matrix metalloprot

192 vealed an inflammatory infiltrate expressing cathepsin B, independent of the presence of pancreatic f

193 Purified lysosomal enzymes, specifically cathepsin B, inhibited cryptococcal growth.

194 Sensitivity to chloroquine, cathepsin B inhibition, and a G-rich inhibitory oligodeo

195 escence, AlphaLISA, and enzymatic assays for cathepsin B inhibition.

196 oneal administration of the highly selective cathepsin B inhibitor CA-074 reduced metastasis in tumor

197 activity decreases with the application of a cathepsin B inhibitor directly onto the apical side of 2

198 Prior studies have found that the cathepsin B inhibitor, Ca074Me, suppresses this response

199 Taking advantage of previous studies of cathepsin B inhibitor-resistant viruses, we found that v

200 r, lysosomal acidification inhibitors, and a cathepsin B inhibitor.

201 structure-based design and synthesis of new cathepsin B inhibitors using the cocrystal structure of

202 on of lysosomal membranes and the release of cathepsin B into the cytoplasm are required for Ad-induc

203 ut not ts1, induces the release of lysosomal cathepsin B into the cytoplasm of infected cells.

204 Finally, excessive release of cathepsin B into the cytosol can lead to cell death thro

205 of these organelles resulting in leakage of cathepsin B into the cytosol leading to acinar cell deat

206 proteins Bim and Bax to lysosomes, releasing cathepsin B into the cytosol where it mediates mitochond

207 sted particles disrupt lysosomes and release cathepsin B into the cytosol, somehow activating NLRP3.

208 ite for AP only because it causes release of cathepsin B into the cytosol.

209 Accurate activity of cathepsin B is derived with an improved fitting algorith

210 teolytic activity of a cancer-related enzyme cathepsin B is measured with alternating current voltamm

211 Cathepsin L, but not cathepsin B, is an important contributor in this process

212 h inhibits the cysteine proteases papain and cathepsins B, K and L up to 2 times more potently than 1

213 ated that it was a potent inhibitor of human cathepsins B, K, and L ( Ki = 6.87, 0.49, and 0.34 nM, r

214 nd non-ELR (CXCL9-12) chemokines by cysteine cathepsins B, K, L, and S at neutral pH by high resoluti

215 The cathepsin B knockdown and 24-h treatment with OA resulte

216 Cathepsin B knockdown was accompanied by a 74% increase

217 on correlates with loss of the expression of cathepsin B, known to be essential for EBOV entry.

218 ated with texture (r(2) = 0.4), as also were cathepsin B&L and sex.

219 ling and tiger flathead demonstrated higher cathepsin B+L activity, whereas gemfish and eastern scho

220 The cathepsin B+L and B activities increased significantly w

221 derate to excellent selectivity versus human cathepsins B, L, and S and showed no apparent toxicity t

222 macrophages, singly or multiply deficient in cathepsins B, L, C, S and X.

223 Pharmacological inhibition of cathepsin B/L enhanced EPO-induced red cell formation in

224 phagosomes and late endosomes to SiNP-filled cathepsin B/L-containing lysosomes rather than elevated

225 Spi2A defects were ameliorated by cathepsin-B/L inhibition, and by genetic co-deletion of

226 The mRNA levels of cathepsins B/L and plasminogen activators, but not MMPs,

227 testing inhibitors of TGF-beta signaling and cathepsins B/L in the therapy of invasive/metastatic mel

228 ted by cell membrane-permeable inhibitors of cathepsins B/L, but not by wide-spectrum inhibitors of M

229 y monocytes, and inhibition of phagocytosis, cathepsin B leakage, generation of reactive oxygen speci

230 n vivo studies have suggested that during AP cathepsin B leaks into the cytosol from co-localized org

231 Our results showed that digestion with cathepsin B led to nanoparticle size reduction.

232 Reducing cathepsin B levels via siRNA following TNFalpha exposure

233 te that inhibition of the lysosomal protease cathepsin b-like blocks endocytosis, causing cell death.

234 can be attributed to inhibition of lysosomal cathepsin b-like protease activity.

235 otease subfamilies: aleurain-like proteases, cathepsin B-like proteases, and vacuolar processing enzy

236 namic activities of aleurain-like proteases, cathepsin B-like proteases, and vacuolar processing enzy

237 ed by a direct activity assay of recombinant cathepsin b-like protein.

238 Cathepsin B may cleave ENaC extracellularly after being

239 Cathepsin B may execute its function after tonoplast rup

240 that multiple redundant cathepsins (not just cathepsin B) mediate this process by evaluating IL-1beta

241 Cathepsin B-mediated CD18 shedding regulates leukocyte r

242 tes joint inflammation in arthritis, induces cathepsin B-mediated cleavage of SirT1, resulting in red

243 ages and potentiate nerve invasion through a cathepsin B-mediated process.

244 The prototype for this phenomenon is cathepsin B-mediated trypsin generation.

245 the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by c

246 Using the system, a label-free screen for cathepsin B modulators against 1280 chemicals was comple

247 Tonoplast rupture was not altered in the cathepsin B mutant and cathepsin B activation was indepe

248 hepsin B, and IL-6 concentrations as well as cathepsin B, myeloperoxidase and trypsin activities were

249 gen, such as trypsinogen-7-null (T(-/-)) and cathepsin B-null (CB(-/-)) mice, have been used to study

250 Simultaneous detection of the proteolysis of cathepsin B on the microelectrode array functionalized w

251 enhanced excretion of peptides derived from cathepsin B or C.

252 , or NLRP3 deficiency, but are unaffected by cathepsin B or caspase-1 inhibitors.

253 ategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibod

254 ncreases the activity of cathepsin D but not cathepsins B or L.

255 However, discovering probes selective to cathepsin B over other cysteine cathepsins is a signific

256 rm organization of autophagosomes as well as cathepsin B overactivity).

257 A cathepsin B/pH dual-sensitive block copolymer with a mol

258 appears, as is the case of C99, in enlarged cathepsin B-positive structures, while extracellular Abe

259 stigated the subcellular distribution of the cathepsin B precursor, procathepsin B.

260 and secreted proteins, including Tenascins, Cathepsin-B precursor, cystatin, and numerous Variant-sp

261 Inhibition of cathepsin B prevents neuronal death and behavioural anom

262 ic groups to generate a library of candidate cathepsin B probes.

263 he specific proteolysis of the Fc-peptide by cathepsin B produces decay in the ACV peak current versu

264 studies in human specimens demonstrated that cathepsin B-producing macrophages were enriched in invad

265 dition that was also associated with greater cathepsin B production.

266 Herein, we show that T. gondii cathepsin B protease (TgCPB) does not undergo self-matur

267 lithography show a much faster kinetics for cathepsin B proteolysis with kcat/KM = 9.2 x 10(4)M(-1)s

268 whereas several specific inhibitors against cathepsin B, reactive oxygen species, or ubiquitin-media

269 y, and pharmacological inhibition of ROS and cathepsin B reduced iNOS expression.

270 Finally, cathepsin B regulated TGF-beta production/signaling, whi

271 Together, these data indicate that cathepsin B regulates VLDL secretion and free fatty acid

272 ccumulation of non-functional autophagosome, cathepsin B release and pineoblastoma cell death.

273 tion of either lysosomal Ca(2+) signaling or Cathepsin B release prevented the maintenance of dendrit

274 omal Zn, which activated lysosomal swelling, cathepsin B release, and LCD.

275 Co-expression of cathepsin B and cathepsin B-resistant mutant LFABP in McA-RH7777 cells r

276 molecular targeting of p62/SQSTM1, Atg7, or cathepsin B result in partial reversal of the suppressiv

277 Overexpression of cathepsin B resulted in decreased OA uptake and VLDL sec

278 fied alphabetaI with the cysteine proteinase cathepsin B results in the specific proteolysis of the H

279 -induced IL-1beta generation have questioned cathepsin B's involvement.

280 SIRT1 is an important substrate of cysteine cathepsins B, S, and L.

281 conjugated ex vivo to Cys34 of albumin via a cathepsin B-sensitive dipeptide linker to ensure that al

282 Knock down of Beclin1, ATG16L1, Rubicon or cathepsin B significantly lowered the ability of neratin

283 Cathepsin B small interfering RNA (siRNA) was transfecte

284 A cathepsin B-specific cleavable substrate (KGRR) conjugat

285 The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host protein

286 CXCL13 solubilization requires the protease cathepsin B that cleaves CXCL13 into a stable product.

287 rogrammed cell death through upregulation of cathepsin B, Tnf and Bid in a neutrophil-independent man

288 f primary melanomas and benign nevi revealed cathepsin B to be predominantly expressed by melanoma ce

289 through impairing the proteolytic cascade of cathepsin B/urokinase-type plasminogen activator (uPA)/m

290 t cathepsin B deficiency, demonstrating that cathepsin B was a physiological target of Spi2A in memor

291 Cathepsin B was identified as the TNFalpha-responsive pr

292 Co-localization of LFABP and cathepsin B was observed in a distinct Golgi apparatus-l

293 .68 +/- 0.50) x 10(4)M(-1)s(-1) for purified cathepsin B was obtained.

294 The lysosomal protease cathepsin B was required for IL-1beta release but not pr

295 in neuronal media, and both cathepsin L and cathepsin B were demonstrated to be important for increa

296 biquitin, p62/sequestosome1, cathepsin D and cathepsin B were detected with co-localizations of ubiqu

297 Transcript level and activity labelling of cathepsin B were used to assess activation.

298 ies of Th subsets, which expressed activated cathepsin B, were similarly increased with combined stim

299 and Cote d'Ivoire are strongly dependent on cathepsin B, while the ebolaviruses Sudan and Reston and

300 In addition, inhibition of cathepsin B with different drugs or microglia from CatB-