ライフサイエンスコーパス: causal

1 ciation nor the nearest gene are necessarily causal.

2 sult in BMP9 loss of function and are likely causal.

3 remains unclear whether this association is causal.

4 d to determine whether such associations are causal.

5 , it is unclear whether the associations are causal.

6 r 10 further genes we judge them most likely causal.

7 han controls (EWAS P = 5.4e-7) and is likely causal (2SLS MR P = 9.8e-15).

8 sarcoma-associated herpesvirus (KSHV) is the causal agent for Kaposi's sarcoma (KS), the most common

9 sarcoma-associated herpesvirus (KSHV) is the causal agent for Kaposi's sarcoma (KS), the most common

10 ember, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, C

11 ory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID 19, continues to evolve since its

12 Phytophthora capsici Leonian, the causal agent of foliar blight, root rot, fruit rot and c

13 he fungal pathogen Sclerotinia sclerotiorum, causal agent of white mold diseases on hundreds of plant

14 The origin and emergence of its causal agent, SARS-CoV-2, in the human population remain

15 Suspect causal agents include the chemicals pyridostigmine (PB),

16 associated with colorectal cancer (CRC), but causal alterations preceding CRC have not been elucidate

17 We propose a new MR method, Causal Analysis Using Summary Effect estimates (CAUSE),

18 work, we must make social epidemiology more causal and causal inference more social.

19 While the causal and clinical links are well established, molecula

20 logists answer myriad questions that are not causal and hypothesize about and investigate causal rela

21 le presentation, heterogeneous or undetected causal antigens and lack of gold-standard biomarkers.

22 Whether this link has any causal aspects to it remains to be explored.

23 The MR analyses showed causal association of BMI on these 3 inflammatory biomar

24 ion estimate is consistent with a protective causal association of EIF-4E and EIF-4A on type 2 diabet

25 variants for MR analysis to investigate the causal association of the 25(OH)D metabolites with T2D (

26 sample of European ancestry do not support a causal association of total 25(OH)D or 25(OH)D metabolit

27 incident VTE and explored the potential of a causal association using Mendelian randomization (MR).

28 longitudinal studies are needed to determine causal associations between these molecular pathologies,

29 rmed strong evidence of previously suggested causal associations for several glucose- and lipid-relat

30 andomization (MR) study was to analyze their causal associations in both sex-combined and sex-specifi

31 nown associations and reported several novel causal associations providing important insights about t

32 -DQB1 genes have significant and potentially causal associations with autoimmune type 1 diabetes (T1D

33 luded, there was strong evidence of possible causal attribution for RSV (OR, 8.5 [95% CI, 3.9-18.5];

34 iratory distress syndrome (ARDS) lacks known causal biomarkers.

35 wo or more conditions were identified in the causal chain for 585 (63%) of 933 cases.

36 of risk factors located more distally in the causal chain from gene to disease.

37 ression via CRISPRi and CRISPRa can pinpoint causal changes.

38 rtant limitations on the validity of drawing causal conclusions from observational data, a plausible

39 lthough our analyses do not allow us to draw causal conclusions, we find no evidence of negative heal

40 Baseline causal connectivity differences between depressed patien

41 A methylation underlie biological embedding, causal data are lacking.

42 be used to elucidate disease mechanisms and causal determinants of cell type-selective vulnerability

43 The current study found causal detrimental effects of T2DM on several cancers.

44 egression model are proposed to estimate the causal direct effect of treatment and the causal mediati

45 Here we apply causal discovery algorithms to sea level pressure data f

46 there is a need for web-based tools to make causal discovery methods accessible.

47 nowledge regarding the relationships between causal DNA variants in ENG, ACVRL1, SMAD4 and GDF2, and

48 We found evidence of a possible causal effect for DNA methylation on FEV(1) at 18 CpGs (

49 iants as instrumental variables to infer the causal effect of a specific risk factor on an outcome.

50 fetime smoking behaviour) and an independent causal effect of alcohol consumption when controlling fo

51 ian randomization analysis did not support a causal effect of coffee drinking on IOP (P > 0.1).

52 monstrate strong evidence for an independent causal effect of smoking on oral/oropharyngeal cancer (I

53 To disentangle the causal effect of the expansions from confounding factors

54 erimental method was used to investigate the causal effect of the JUHI discount policy on dental visi

55 boembolism prevention trials to evaluate the causal effect of venous thromboembolism reduction on mor

56 her smoking-associated DNA methylation has a causal effect on lung function has not been thoroughly e

57 these associations underlie a consequence or causal effect within the scope of biological functionali

58 zation (MR) is a valuable tool for detecting causal effects by using genetic variant associations.

59 ariants, each with very small effects, whose causal effects could not be individually identified.

60 We first investigated the causal effects of 474 smoking-associated CpGs on forced

61 We also examined potential causal effects of a morning preference on objectively ca

62 iated with coffee intake to assess potential causal effects of coffee consumption on IOP.

63 To understand possible causal effects of dietary intake on the risk of metaboli

64 of intergenerational relationships may have causal effects of opposite sign on the diffusion of COVI

65 Causal effects of PCOS on risks of CHD and stroke were e

66 We searched for potential causal effects of SHBG in UK Biobank (N = 334 977) and f

67 Interpreting the causal effects of these genetic modifications is crucial

68 MR suggested that seven traits have causal effects on ACR, highlighting the role of adiposit

69 dividual's life but evidence relating to the causal effects on health is limited.

70 When estimating causal effects, careful handling of missing data is need

71 gate causal relationships without estimating causal effects.

72 r understand the mechanisms underlying these causal effects.

73 This article introduces a formal theory of causal emergence in multivariate systems, which studies

74 In support, we discover a causal enhancer variant (rs6060369) present in billions

75 Causal evidence for a double dissociation between LOC an

76 ncement of emotional action control provides causal evidence for phase-amplitude coupling mechanisms

77 aking has long been hypothesized, but direct causal evidence in humans is still lacking.

78 erall pattern of results provides consistent causal evidence of the two-way functional significance o

79 (total n = 800), one preregistered, provide causal evidence that drawing attention to prosocial (vs.

80 t current stimulation (HD-tDCS) and provided causal evidence that the right temporoparietal junction

81 that SFAs increase LDL cholesterol, a major causal factor in the development of cardiovascular disea

82 urable at the scale of in vivo MRI, may be a causal factor in the development of cortical folding.

83 d strategies to address most effectively its causal factors and improve diagnosis, treatment, and pre

84 C virus (HCV) infection is one of the major causal factors for hepatocellular carcinoma (HCC).

85 For 27 genes we infer they are causal for CAD, and for 10 further genes we judge them m

86 ndomization studies assessing whether T2D is causal for CHD); and then turn to the implications of th

87 hibition, regulated by amino acid levels, is causal for diapause metabolism and epigenetic state.

88 uropsychiatric disorders and, more recently, causal frameworks for these epidemiological associations

89 SCN8A is a novel causal gene for early infantile epileptic encephalopathy

90 We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep thr

91 The goal of such effort is to identify the causal genes and have a complete understanding of the mo

92 enomic loci associated with AD; however, the causal genes and variants remain unidentified in most lo

93 cal eQTL and GWAS data prioritised 13 likely causal genes for differential fibre quality in a transcr

94 Objective: To identify candidate causal genes for IR, we screened regional and biological

95 single- and multi-SNP models for identifying causal genes in GWAS data for 46 circulating metabolites

96 insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging.

97 However, revealing the causal genes responsible for the observed associations i

98 ollaborative Cross mice to identify putative causal genes that contribute to the risk of fractures.

99 We identified 13 shared causal genes, 16 shared causal pathways between AD and T

100 rable advances have been made in identifying causal genes, relatively little progress has been made t

101 port, which can be used for inferring likely causal genes.

102 erative reserve in blood-cell progenitors is causal has important public-health implications.

103 ile this quasi-experiment does not allow for causal identification, each policy's effect on reducing

104 decades has involved examining the potential causal impact of educational attainment (schooling years

105 ity acceleration and hence is unlikely to be causal in aging.

106 ly a causal network, which can be learned by causal inference algorithms.

107 Here we report a causal inference analysis investigating the effects of p

108 to dissect function or use associations for causal inference analysis.

109 ngagement of social epidemiology with formal causal inference approaches." The formidable, but not in

110 ., outcomes-wide analysis) used to establish causal inference between religion and health, epidemiolo

111 iology, social epidemiology and quantitative causal inference have been seemingly at odds over the ye

112 Causal inference methods (Interrupted Time Series and Di

113 ust make social epidemiology more causal and causal inference more social.

114 f forces that are "above the skin." Although causal inference should be a key goal for social epidemi

115 aired, cell-specific transcriptomic data and causal inference testing, we identify examples where sit

116 This is the first study to use causal inference to measure the impact of longer shifts

117 With literature-guided causal inference tools, >300 site-specific signaling rel

118 nsidered natural experiments that strengthen causal inference when assessing the association between

119 sociation study interpretation) and performs causal inference with type I error control.

120 and visual stimulus locations), decisional (causal inference), and motor response dimensions.

121 Using G-computation, a causal inference-based method, we then estimated changes

122 ntrolling for confounding bias is crucial in causal inference.

123 of these generalized case-control methods to causal inference.

124 The observational design limits causal inference.

125 -harm using multivariate genetic designs for causal inference.

126 onfounding (e.g., genetic liability), and no causal inferences can be made based on this study alone.

127 The appreciation of the causal interactions among distinct anatomical units in t

128 at an episode of mental disorder arises from causal interactions among its symptomatic elements has e

129 ntimicrobial resistance (AMR), but they lack causal interpretation.

130 These findings provide a causal link between ABN activity during REM sleep and me

131 Our data suggest a causal link between Ca(2+) dysregulation and primary, no

132 ight damage in our mouse model, supporting a causal link between decreased chromatin accessibility an

133 These results establish a causal link between early visual areas and the modulator

134 s neither the existence nor the absence of a causal link between intergenerational relationships and

135 ther causes serious bleeding, establishing a causal link between partial agonism and impaired hemosta

136 These results provide further evidence of a causal link between sensorimotor beta bursts and movemen

137 onal studies (studies 6 and 7) demonstrate a causal link between the two constructs: A purchase decis

138 is evident (e.g. high altitude); however, a causal link is not established.

139 Importantly, a causal link to CVD for these and other specific gut micr

140 eruptions in the geological record and their causal link to the mass extinction events during the pas

141 -1R1 signaling prevents disease, providing a causal link.

142 Experimental work has revealed causal links between physical cleansing and various psyc

143 MS-fMRI approach provides an opportunity for causal manipulations of human memory consolidation.

144 ll play a leading role in driving the use of causal manipulations with optogenetic tools to study hig

145 e further discover and replicate a potential causal mechanism behind this interaction related to S. p

146 interneuron activity represents an important causal mechanism for conditioned fear.

147 s of these results, we propose the following causal mechanism for induced seismicity: pore pressure i

148 Here, we propose a multi-process causal mechanism for injection-induced earthquakes throu

149 cardiac sodium channel expression is a known causal mechanism in AF.

150 Here, we investigate a potential causal mechanism of this effect driven by the neuropepti

151 The causal mechanisms and the relative contributions of mate

152 Causal mechanisms for fluid injection-induced earthquake

153 Collectively, our studies uncover causal mechanisms for the class II phenotype and highlig

154 ing the corresponding wakeful behaviour, the causal mechanisms underlying specific dream contents rem

155 ing and sphingolipid metabolism as molecular causal mechanisms.

156 nce), urgently require the identification of causal mechanisms.

157 th outcomes, and to delineate the underlying causal mechanisms.

158 Our study establishes a causal mechanistic link between microbiome-level competi

159 sophila neurogenetics, our results provide a causal, mechanistic account for a long-known visual illu

160 effects modeling, network construction, and causal mediation analysis, we identified genes, CpGs, an

161 We also investigated potential causal mediation by air pollution.

162 he causal direct effect of treatment and the causal mediation effects of microbiome at both the commu

163 However, there are no existing causal mediation methods specifically designed to handle

164 We propose a rigorous Sparse Microbial Causal Mediation Model (SparseMCMM) specifically designe

165 a possible lack of ability to single out the causal mediators.

166 c tools such as LbNOX to empower studies of 'causal metabolism'.

167 and applied network-based and probabilistic causal methods to identify severe asthma genes and their

168 oposed model framework to identify signature causal microbes.

169 Dynamic causal modeling evidence suggested that treatment decrea

170 tatistical learning errors, and used dynamic causal modeling to tap into the underlying neural circui

171 gs demonstrate that population-level dynamic causal modelling can disclose a core pathophysiological

172 sue using a novel technique-spectral dynamic causal modelling-that estimates the effective connectivi

173 These probabilistic causal models enabled detection, prioritization and repl

174 grangian furnishes a normal form for dynamic causal models-state space models based upon differential

175 ion of intrinsic functional networks and the causal modulation of human behaviour and experience with

176 he findings from our observational study and causal MR analyses, together with data from RCTs, do not

177 the near-Mendelian haplotype reveals eleven causal mutation candidates.

178 example, the tremendous number of loci with causal mutations.

179 However, the causal nature of single-nucleotide variants and small in

180 A phosphorylation network is essentially a causal network, which can be learned by causal inference

181 We demonstrate how the resulting causal networks (fingerprints) offer an objective pathwa

182 connected to both AD and T2DM in multi-omics causal networks.

183 Abdominal adiposity may trigger causal pathological processes, partially independent fro

184 sitivity (CS) as an intermediary step in the causal pathway between macular damage and impairment of

185 We also apply this approach to study the causal pathway from smoking to overall survival among lu

186 identified 13 shared causal genes, 16 shared causal pathways between AD and T2DM, and 754 gene expres

187 edge of blood pressure genomics, explore the causal pathways for hypertension identified in Mendelian

188 It highlighted putative causal pathways to diabetes mediated by BMI for four gen

189 Causal pathways to disruptive behavior disorders, even w

190 A causal perspective on these issues allows decisions abou

191 Developing a causal physics-based model that ultimately links descend

192 ne-mapped variant-trait pairs with posterior causal probability >0.95, a >32% improvement versus SuSi

193 Understanding the causal processes that contribute to disease onset and pr

194 youth with conduct disorders who have unique causal processes underlying their problem behavior and a

195 We aimed to identify causal protein biomarkers for MPV and PLT among 71 CVD-r

196 Identifying potential drug targets, i.e. causal protein-coding genes, therefore, requires crossin

197 e, but not insurmountable, tensions call for causal reasoning and effect estimation in social epidemi

198 Causal reasoning can shed new light on the major challen

199 cians to analyze transcriptome data, predict causal regulations, assess network topology and identify

200 However, the identification of individual, causal regulatory variants is challenging.

201 followed by Mendelian randomization to infer causal relations of proteins for PLT/MPV.

202 included (1) drugs with prior evidence for a causal relationship (e.g., megestrol); (2) drugs without

203 in reuptake inhibitors (SSRIs) confirmed the causal relationship between amygdala serotonin transport

204 , longitudinal experiment, demonstrating the causal relationship between authentic posting and positi

205 In addicted populations, however, the causal relationship between biobehavioral phenotypes of

206 However, the causal relationship between GPe neuron classes and movem

207 explore current perspectives on the possible causal relationship between hearing loss, neural reorgan

208 Our results support a potentially causal relationship between higher physical activity lev

209 However, the causal relationship between MPO and the development and

210 al to trial, offering a means of testing the causal relationship between network activity and human t

211 the cerebral cortex; however, evidence of a causal relationship between network interactions and cor

212 These data do not suggest a causal relationship between osimertinib and cardiac fail

213 Mendelian randomization identified a causal relationship between psoriasis and T2D (P = 1.6 x

214 to investigate associations in support of a causal relationship between smoking and alcohol consumpt

215 Furthermore, we establish a direct, causal relationship between the three-dimensional genome

216 However, it is not known whether there is a causal relationship between these phenomena.

217 However, it remains unclear whether a causal relationship exists between lipids and BC.

218 trate a concordant, positive and potentially causal relationship of lymphocyte count with systolic BP

219 However, the causal relationship of such observation remains unclear.

220 However, the causal relationship of these events remains unclear.

221 Our findings revealed a more nuanced causal relationship than previously suggested, providing

222 rol); (2) drugs without prior evidence for a causal relationship, but potentially worth further explo

223 ontal disease if further studies establish a causal relationship.

224 now stores almost 23 000 manually-annotated causal relationships between proteins and other biologic

225 based study (42,112 patients) and tested for causal relationships with multivariable Mendelian random

226 causal and hypothesize about and investigate causal relationships without estimating causal effects.

227 alysis is an important tool to elucidate the causal relevance of environmental and biological risk fa

228 gh-density lipoprotein cholesterol level are causal risk factors for changes in prognostically import

229 -6), and C-reactive protein (CRP) are likely causal risk factors for depression.

230 Identifying causal risk factors for self-harm is essential to inform

231 rease in body mass index was associated with causal risk ratios for aortic valve stenosis and replace

232 l developmental windows can therefore play a causal role and have a profound impact on the excitatory

233 Our results implicate a causal role for accumbal MFN2 on the regulation of anxie

234 Yet a causal role for alpha in attention is debated.

235 Furthermore, we established a causal role for AR in ALD by showing that the genetic de

236 ultures.Conclusions: These results support a causal role for ER stress and resulting epithelial dysfu

237 sary for normal behavior in this task, but a causal role for human OFC in outcome-guided behavior has

238 n in excitatory cells, indicating a dominant causal role for SOM(+) cells in the integration of infor

239 s, and the core network more broadly, play a causal role in episodic simulation and divergent thinkin

240 Until the discovery of DUX4 and its causal role in FSHD, most trials were untargeted with li

241 ecessary to gain insight into their possible causal role in human aging and disease.

242 nd that somatic mutations potentially play a causal role in IBD pathogenesis.

243 These results suggest that the vmPFC plays a causal role in the acquisition of new learning and not j

244 ere, we show that the vmPFC actually plays a causal role in the acquisition of pavlovian threat condi

245 nderlying pathophysiology, or does it play a causal role in the progression of kidney disease?

246 rate that the mouse SC of both sexes plays a causal role in visual perceptual decision-making by tran

247 y transplantation experiments demonstrated a causal role of a properly assembled leaf bacterial commu

248 The causal role of alcohol consumption for other cardiovascu

249 Here we determined the causal role of CeL PKCdelta and SOM in incubation using

250 This study explored the causal role of complicated (American Heart Association-l

251 phic effect of ACC2 deletion demonstrating a causal role of elevated aspartate level in cardiomyocyte

252 disease in 2010, unequivocal evidence of the causal role of fine particulate matter air pollution (PM

253 f Suv39h1 and Suv39h2 enzymes to examine the causal role of heterochromatin loss in hematopoietic cel

254 domization (MR) allows the evaluation of the causal role of markers by minimizing the risk of biases

255 These findings support a causal role of pulmonary impairment in lung cancer etiol

256 rain patients' stepping rhythm, suggesting a causal role of the STN in dynamic gait control.

257 - and between-subjects design, we tested the causal role of this brain region in problem-solving, by

258 Evidence for a causal role of variants in presbycusis was provided by p

259 Dopamine neurons played a causal role only after outcome, when they encoded reward

260 nhibition of VTA TH neurons to show distinct causal roles for VTA subregions in distinct forms of rel

261 base editing of endogenous AGS loci revealed causal roles of one AGS-specific amino acid substitution

262 In testing for causal significance, we found that rhythmic optogenetic

263 The causal SNP (Chr12:5520945) likely endows GmPRR3b(H6) a m

264 Together the 14 putatively causal SNPs explained ~38% of NMR variation, a substanti

265 We discover three causal SNPs of EPAS1, the key adaptive gene for Tibetans

266 alidated framework and the generally complex causal structure of high-dimension data, analysis of hig

267 ring and making explicit decisions about the causal structure that generates sensory signals in our e

268 spatial correspondence cues and the inferred causal structure the frontal eye field and the intrapari

269 By contrast, informed by observers' inferred causal structure, the FEF-IPS circuitry integrates audit

270 e-factor (treatment, microbiome and outcome) causal study design.

271 Even if causal, the effect of beta-adrenoceptor antagonists on t

272 Assessing the causal tissues of human traits and diseases is important

273 we show that neuronal activity in the OFC is causal to economic choices.

274 s understanding of the task and its relevant causal variables.

275 nisms and highlights efforts to identify the causal variant and effector transcripts at T2DM GWAS sus

276 fine-mapping of that locus reveal a putative causal variant in a cardiac muscle specific regulatory r

277 e second intron of the CDH1, as the putative causal variant.

278 regions containing more than 13,000 credible causal variants (CCVs).

279 within noncoding regions of the genome where causal variants affect gene expression by altering the a

280 (GWAS) link >60 loci with SLE risk, but the causal variants and effector genes are largely unknown.

281 In contrast, <10% of the causal variants for schizophrenia, bipolar disorder and

282 y can substantially improve the detection of causal variants from existing molecular data.

283 -associated signals with the set of credible causal variants in each one.

284 rrying combinations of this and other likely causal variants in M1AP.

285 variation can be used to fine map potential causal variants of sQTLs and their associated neurologic

286 ethod could reduce the number of potentially causal variants to consider for follow-up, and found tha

287 SparkINFERNO prioritizes causal variants underlying GWAS association signals and

288 Causal variants were also enriched for alterations in tr

289 Causal variants were enriched at conserved nucleotides,

290 Potentially causal variants were significantly over-represented in a

291 n (CLU) locus to identify a subset of likely causal variants, and employ GenIE to understand the impa

292 as suggested cell-type-specific contexts for causal variants, implicating CD4 + effector memory T cel

293 otypes substantially differ in the number of causal variants, their localization in the genome and th

294 We identified 451 causal variants, which underlie genetic loci known to af

295 associated loci, and perform fine mapping of causal variants.

296 tatistically significant, ability to predict causal variants.

297 this is the likely modus operandum for many causal variants.

298 etic studies and limited knowledge of shared causal variants.

299 ing these SVs identify a number of candidate causal variants.

300 ted from brain were used for identifying the causal variants.