ライフサイエンスコーパス: causative

1 other diabetes-related alterations could be causative.

2 We previously identified the causative agent as a novel SARS-related coronavirus (SAR

3 rted in the liver to trimethylamine oxide, a causative agent for atherosclerosis.

4 sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi sarcoma (KS), primary effusio

5 ic pathogen, Acanthamoeba castellanii is the causative agent for the sight threatening infection Acan

6 fects 50 to 80% of the population and is the causative agent of a fatal demyelinating disease of the

7 uman beta(2)-microglobulin (beta(2)m) is the causative agent of a hereditary amyloid disease.

8 atory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associat

9 utionarily divergent Trypanosoma brucei, the causative agent of African sleeping sickness.

10 tozoan parasite Entamoeba histolytica is the causative agent of amebiasis, an infection that manifest

11 Bacillus anthracis is the causative agent of anthrax disease, presents with high m

12 e protection against Junin virus (JUNV), the causative agent of Argentine hemorrhagic fever, demonstr

13 been reported in bluetongue virus (BTV), the causative agent of bluetongue disease in livestock.

14 Machupo virus (MACV), the causative agent of Bolivian hemorrhagic fever (BHF), is

15 ion with an endemic Mycobacterium bovis (the causative agent of bovine/zoonotic tuberculosis, bTB) in

16 Brucella, the causative agent of brucellosis, is a stealthy intracellu

17 Yersinia pestis is the causative agent of bubonic, pneumonic, and septicemic pl

18 Human papillomavirus (HPV) is the causative agent of cervical and other epithelial cancers

19 IMPORTANCE Human papillomavirus (HPV) is the causative agent of cervical and some other epithelial ca

20 n papillomaviruses 16 (HPV16) is the primary causative agent of cervical cancer (CC).

21 Varicella zoster virus (VZV) is the causative agent of chickenpox and shingles.

22 e many other pathogens, Vibrio cholerae, the causative agent of cholera, can modulate its gene expres

23 Classical swine fever virus (CSFV) is the causative agent of classical swine fever, a notifiable d

24 The causative agent of coronavirus disease 2019 (COVID-19) i

25 ory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19),

26 ome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19),

27 ory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19),

28 ory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19),

29 ory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19),

30 y syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19).

31 ory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 illness, has caused millions

32 The rapid emergence of SARS-CoV-2, the causative agent of COVID-19, and its dissemination globa

33 SARS-CoV-2 virus is the causative agent of COVID-19.

34 tory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19.

35 cute respiratory syndrome coronavirus 2, the causative agent of COVID-19.

36 s and S. meliloti, and this bacterium is the causative agent of crown gall disease in plants.

37 didatus Liberibacter solanacearum (Lso), the causative agent of economically important diseases inclu

38 Aphanomyces invadans, the causative agent of epizootic ulcerative syndrome, is one

39 Salmonella is a major causative agent of foodborne illness and rapid identific

40 upper respiratory tract in pigs and also the causative agent of Glasser's disease, which causes signi

41 Neisseria gonorrhoeae, the causative agent of gonorrhea, is an exclusive human path

42 Dracunculus medinensis, the causative agent of Guinea worm disease in humans, is bei

43 Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and the leading

44 n intraerythrocytic parasite and the primary causative agent of human babesiosis.

45 Plasmodium falciparum is a causative agent of human malaria.

46 Coxiella burnetii is the causative agent of human Q fever, eliciting symptoms tha

47 the poly-P repeats of huntingtin exon 1, the causative agent of Huntington's disease.

48 her hand, although it has been reported as a causative agent of immediate allergy, most of them are a

49 MPORTANCE Infectious bronchitis virus is the causative agent of infectious bronchitis in chickens.

50 Schistosoma mansoni is the causative agent of intestinal schistosomiasis and infect

51 sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), an AIDS-defini

52 Lassa virus (LASV) is the causative agent of Lassa fever (LF), an often-fatal hemo

53 Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhag

54 erium leprae was thought to be the exclusive causative agent of leprosy until Mycobacterium lepromato

55 The causative agent of leptospirosis includes multiple serov

56 chete Borrelia burgdorferi sensu lato is the causative agent of Lyme disease (LD).

57 Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to ve

58 Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted by the b

59 Plasmodium spp., the causative agent of malaria, have a complex life cycle.

60 icularly Burkholderia pseudomallei (Bp), the causative agent of melioidosis in Thailand.

61 C is Burkholderia pseudomallei, which is the causative agent of melioidosis, a serious disease that o

62 mallei is an intracellular bacterium and the causative agent of melioidosis, a severe disease in trop

63 Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease in

64 Burkholderia pseudomallei, the causative agent of melioidosis, possesses at least three

65 omallei is a Gram-negative bacterium and the causative agent of melioidosis.

66 is an oncogenic gammaherpesvirus that is the causative agent of multiple human cancers.

67 Yersinia enterocolitica (Ye), as well as the causative agent of plague, Yersinia pestis (Yp).

68 Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis (TB), is respo

69 an obligate intracellular bacterium and the causative agent of Q fever.

70 netic variation in a pathogen, including the causative agent of salmonellosis, Salmonella enterica, c

71 llular bacterium Orientia tsutsugamushi, the causative agent of scrub typhus.

72 RTANCE Herpes simplex virus 1 (HSV-1) is the causative agent of several pathologies ranging in severi

73 Tick-borne encephalitis virus (TBEV) is the causative agent of severe human neuroinfections that mos

74 ost-transcriptionally tRNAs in Shigella, the causative agent of shigellosis.

75 ism underpins the pathogenic strategy of the causative agent of TB, Mycobacterium tuberculosis (Mtb),

76 SARS-CoV-2 is the causative agent of the 2019-2020 pandemic.

77 corporated an additional crRNA to detect the causative agent of the 2020 COVID-19 pandemic.

78 Vibrio cholerae, the causative agent of the acute diarrheal disease cholera,

79 ory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-1

80 st reported in late 2019 in China and is the causative agent of the coronavirus disease 2019 (COVID-1

81 The causative agent of the coronavirus disease 2019 (COVID-1

82 SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 millio

83 y syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic.

84 of the antibody response to SARS-CoV-2, the causative agent of the COVID-19 pandemic.

85 Plasmodium falciparum is the causative agent of the deadliest human malaria.

86 y syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the devastating COVID-19 lung disease

87 The causative agent of the disease, the coronavirus SARS-CoV

88 sidiomycete fungus Rigidoporus microporus, a causative agent of the disease.

89 lity to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive int

90 strains.IMPORTANCE Mumps virus (MuV) is the causative agent of the highly infectious disease mumps.

91 ae is a Gram-negative human pathogen and the causative agent of the life-threatening disease cholera.

92 leading cause of noncongenital blindness and causative agent of the most common sexually transmitted

93 Congo hemorrhagic fever virus (CCHFV) is the causative agent of the most widespread tick-borne viral

94 y syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019

95 y syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019

96 The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory

97 the intestinal pathogen Vibrio cholerae, the causative agent of the severe diarrheal disease cholera.

98 he protozoan parasite Toxoplasma gondii, the causative agent of toxoplasmosis, includes both CBS and

99 cellular bacteria Chlamydia trachomatis, the causative agent of trachoma and sexually transmitted dis

100 d with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).

101 n pathogen Mycobacterium tuberculosis is the causative agent of tuberculosis resulting in over 1 mill

102 (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3).

103 ycolipids in Mycobacterium tuberculosis, the causative agent of tuberculosis, are important virulence

104 Mycobacterium tuberculosis complex (MTC), a causative agent of tuberculosis.

105 ed a model using Francisella tularensis, the causative agent of tularemia, in which pathways triggere

106 sarcoma-associated herpesvirus (KSHV) is the causative agent of two B-cell lymphoproliferative diseas

107 or of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be r

108 The causative agent was identified as the species Severe acu

109 ion resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely rel

110 The complete genome of the causative agent, a variant from the Zaireebolavirus spec

111 by the diversity ofclinical isolates of the causative agent, Mycobacterium tuberculosis, has recentl

112 escribed, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus

113 The causative agent, severe acute respiratory syndrome coron

114 Cellular entry into the causative agent, the protozoan parasite Trypanosoma bruc

115 h antibodies-regardless of what virus is the causative agent-it will be essential to depend on carefu

116 udy of the full transmission dynamics of its causative agent-severe acute respiratory syndrome corona

117 he human oncogenic viruses, is the principal causative agent.

118 The causative agents for the current national outbreak of el

119 and levels of interferon alpha, two proposed causative agents in neuropsychiatric systemic lupus eryt

120 Noroviruses are the main causative agents of acute viral gastroenteritis, but the

121 gh-risk human papillomaviruses (HPV) are the causative agents of cervical cancer.

122 ORTANCE Human papillomaviruses are the major causative agents of cervical, oral, and anal cancers.

123 Trypanosoma protozoan parasites are the causative agents of Chagas disease and sleeping sickness

124 ug resistant S. aureus is now one of the key causative agents of community-acquired infections.

125 . are important plant pathogens that are the causative agents of crown gall or hairy root disease.

126 um is a genus of apicomplexan parasites, the causative agents of cryptosporidiosis in humans and/or a

127 m subsp pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws-endemic

128 s are important human pathogens that are the causative agents of epidemics and pandemics.

129 Bacteria are major causative agents of eye infections that can lead to loss

130 Species of the protozoan Leishmania are causative agents of human leishmaniasis, a disease that

131 lity to provide timely identification of the causative agents of lower respiratory tract infections c

132 Plasmodium spp. parasites are the causative agents of malaria in humans and animals, and t

133 ew drugs that target Plasmodium species, the causative agents of malaria, are needed.

134 Parasites from the genus Plasmodium are the causative agents of malaria.

135 bolome contains a plethora of biomarkers and causative agents of various diseases, some of which are

136 The causative agents, schistosomes, are intravascular flatwo

137 Despite involving the same causative allergens, allergy immunotherapy (AIT) treatme

138 Together our data supports a causative association of the identified ADAM17 variant i

139 The causative bacteria can be found in patients' intestinal

140 timing, inoculum, route of infection and the causative bacterial species in different wild-type mouse

141 The causative chemicals responsible for nitrile rubber glove

142 To identify the causative compounds, effect-directed analysis was succes

143 s biological function and establish a direct causative connection between amyloid formation and its p

144 Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multip

145 NDM and their unaffected parents to identify causative de novo variants.

146 The causative disease mechanism is largely unknown, and no t

147 nherited variants to the 32 individuals with causative DNM in ANKRD11 using only growth z-scores high

148 ed significantly in fine-mapping potentially causative domains within these genes.

149 nding further credence to the penetrance and causative effect of the identified variants.

150 ical subtypes, pathogenic genes and putative causative environmental agents.

151 ise into prominence has focused attention on causative environmental factors and their interplay with

152 sarcoma of HNFS, ultraviolet damage may be a causative factor and that immune checkpoint inhibition m

153 l mutations in the gene encoding SNAP25 as a causative factor for developmental and epileptic encepha

154 us perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked di

155 n is not only an outcome but also possibly a causative factor for liver pathology.

156 the human mutations revealed that each is a causative factor for the associated NTD.

157 study, we sought to characterize Nurr1 as a causative factor in LID expression.

158 not clear; defects in iron management are a causative factor in the cell-death pathway known as ferr

159 abolic stressor such as APOE4 may point to a causative factor in the pathogenesis of AD.

160 Hepatitis B virus (HBV) is the major causative factor of chronic viral hepatitis, liver cirrh

161 llular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain un

162 ctivity, and IOL optic design are additional causative factors for PD.

163 y and reveals type I IFNs and CD8 T cells as causative factors of intestinal leakage during chronic i

164 als hypoxia and neighboring vessels as major causative factors of the beneficial function.

165 The causative factors underlying conformational conversion o

166 nagement, including treatments targeting the causative factors, and continuation of treatment after h

167 ibed in COVID-19 patients, discuss potential causative factors, and describe differential diagnostic

168 likely gene-disrupting variants in SCAF4 are causative for a variable neurodevelopmental disorder ass

169 nd FOXC1, which have been demonstrated to be causative for AML.

170 methylation on the promoter of CDKL5, a gene causative for an infantile epilepsy, from the silenced X

171 wo human genes, ERCC8/CSA and ERCC6/CSB, are causative for CS and their protein products, CSA and CSB

172 Of 17 genes reported as being causative for LQTS, 9 (AKAP9, ANK2, CAV3, KCNE1, KCNE2,

173 K, an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia (SCAR10), is an int

174 Probably these somatic changes are causative for the observed male fertility defect.

175 muscle involvement, and establish TRIP4 as a causative gene for several congenital muscle diseases, i

176 ackaging a fragment of human mutant HTT, the causative gene mutation in Huntington's disease.

177 ted loss of function of Hoxc13, which is the causative gene of the ectodermal dysplasia 9 (ECTD9) in

178 The main causative gene of this disease - lissencephaly-1 (LIS1)

179 d that variants in prosaposin (PSAP), a rare causative gene of various types of lysosomal storage dis

180 We performed exome sequencing to uncover the causative gene, and functional experiments in the cell m

181 a lysosomal storage disease, all 13 of NCL's causative genes affect endolysosomal function, and at le

182 In recent years, numerous causative genes and risk factors for amyotrophic lateral

183 s, which were previously suggested as likely causative genes at respective AMD susceptibility loci.

184 Mutagenomics identified likely causative genes for many of the mutant lines analyzed fr

185 diagnosis and the aetiological variants and causative genes for more than half such disorders remain

186 ve somatic mutations in the gene CTNNB1, but causative genes from germline and the underlying pathoph

187 Identifying genotype-phenotype links and causative genes from quantitative trait loci (QTL) is ch

188 mal investigation, implying that a number of causative genes have not yet been recognized.

189 ic low-frequency variants reveals putatively causative genes in restless legs syndrome.

190 n of CAG repeats in the coding region of the causative genes that are otherwise unrelated.

191 To identify putatively causative genes, we searched for highly significant muta

192 PD has several known causative genes, with one directly linked to retromer an

193 having limited or disputed evidence as LQTS-causative genes.

194 heterogeneity, complicating the discovery of causative genes.

195 AD has over 25 causative genes/risk factors, with several of them linke

196 etic risk loci have been identified, but the causatives genes at these loci are largely unknown, so t

197 eading to gain-of-function of PLCdelta1 as a causative genetic defect in familial multiple pilomatric

198 dies for a proper diagnosis, to search novel causative genetic defects or investigate environmental f

199 of these biological processes, including the causative genetic mutations, and of the influence of env

200 ng the V2F challenge requires us to identify causative genetic variants, relevant cell types/states,

201 egulation of PDE4 activity/expression may be causative in a subset of patients.

202 genetic alterations of endocytic proteins as causative in high incidence human cancers.

203 Mycobacterium tuberculosis (Mtb), the causative infectious agent of tuberculosis (TB), kills m

204 ng only growth z-scores highlighted 5 likely causative inherited variants and two unrecognized DNM re

205 However, a causative link between serum HBsAg levels and impairment

206 s during organismal development and can be a causative mechanism for initiation and progression of ca

207 However, the causative mechanisms behind these effects have yet to be

208 researchers need to identify pathobiological causative mechanisms for the 50% of patients with unprov

209 ambiguation of these effects to identify the causative mechanisms of cell death is extremely challeng

210 of chromosomal aberrations and knowledge of causative mechanisms would represent an important step t

211 study aimed to describe the epidemiology of causative microorganisms of catheter-related infection a

212 The causative microorganisms, comorbidities, and durations o

213 diagnosis in terms of identification of new causative/modifier genes and polygenic conditions.

214 herapies is our limited understanding of the causative molecular and cellular mechanisms.

215 Variant c.833T>C is a known causative mutation for homocystinuria, but is not pathog

216 The causative mutation is a 78-kb tandem duplication of PLAU

217 The causative mutation maps to a gene orthologous with the t

218 complementation experiments established the causative mutation of repp12 as a single amino acid exch

219 m pathogenicity of the previously identified causative mutation of spondylolysis and investigate the

220 as lost to the research community before the causative mutation was identified.

221 The causative mutation was in Ncstn, an essential gene encod

222 The causative mutation was in Pdia6, an essential gene encod

223 To identify the causative mutation, a fibroblast cell line, derived from

224 edicted mode of inheritance) to identify the causative mutation.

225 Moreover, causative mutations can be difficult to pinpoint because

226 provide a framework for elucidating how BBS-causative mutations interfere with the biogenesis of the

227 axia of speech, a rare disorder enriched for causative mutations of large effect.

228 However, the impact of ALS-causative mutations on splicing has not been fully chara

229 Causative mutations were identified for three lines usin

230 In contrast with CYLD cutaneous syndrome-causative mutations, CYLDM719V exhibited significantly i

231 In conclusion, a causative NAGLU variant in Schipperke dogs with MPS IIIB

232 is not clear whether anti-VEGF treatment is causative of atrophy versus being associated with atroph

233 ns can template protein-protein interactions causative of cellular toxicity.

234 ne dinucleotide (NAD) synthesis pathway, are causative of congenital malformation and miscarriage in

235 , generates molecular mechanisms potentially causative of disease, and returns interpretable pathogen

236 , DAMpred correctly recognized the mutations causative of Li-Fraumeni-like syndrome with a Matthews c

237 as gingivalis(Pg), keystone oral-pathobiont, causative of PD, efficiently invades human gingival epit

238 pping, we identified 11 mutations presumably causative of retinal phenotypes in genes previously know

239 sequences in mice and, therefore, may not be causative of retinitis pigmentosa in humans.

240 We identified causative or probable causative variants in 135 (19%) of

241 Despite this, SF culture fails to identify a causative organism in ~50% of cases.

242 valence of ocular Chlamydia trachomatis, the causative organism of trachoma.

243 The causative organism plays an important role in prognosis

244 Common causative organisms are Streptococcus pneumoniae and Sta

245 nt in vitro activities against the principal causative organisms of AAT: Trypanosoma congolense, and

246 l acuity, larger corneal ulcer diameter, and causative organisms were not associated with endophthalm

247 In the causative parasite of the most deadly form of malaria in

248 iratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a ma

249 African swine fever virus (ASFV) is the causative pathogen of the recent African swine fever epi

250 bined with a failure to clearly identify the causative pathogen results in administration of empirica

251 disease, incited by different strains of the causative pathogen-Erwinia amylovora.

252 syndrome, a constellation of symptoms whose causative pathogenesis is unclear.

253 Predominant causative pathogens are S. pneumoniae and H. influenzae.

254 We test isolates of the 3 causative pathogens of CRE infections using ceftriaxone

255 Little is known on causative pathogens of intravascular catheters infection

256 iseases and accurate identification of their causative pathogens play a crucial role in disease preve

257 se and treat due to biofilm formation by the causative pathogens.

258 cherichia coli (E. coli) is one of the major causative pathogens.

259 th high antimicrobial resistance rates among causative pathogens.

260 rdium and prompting immediate search for the causative pathologic process.

261 III transcription is observed in cancer and causative Pol III mutations have been described in neuro

262 ssembly of amyloid-beta peptide (Abeta) is a causative process in Alzheimer's disease, has driven man

263 Mutant huntingtin (mHTT), the causative protein in Huntington's disease (HD), associat

264 This work suggests a causative relationship between a strain-specific structu

265 However, a causative relationship between KCNQ1 antibodies and the

266 The causative relationship between the clearance of infectio

267 A sequential and positive causative relationship is exhibited among the storage pe

268 We demonstrate the causative relevance of locally rewired as well as compen

269 o move the field forward from associative to causative results.

270 These studies define a causative role for OGA in tumor progression and reveal P

271 A causative role for plasmin (ogen) as a "second hit" in k

272 EGF therapy, prompting questions regarding a causative role for these therapies in atrophy developmen

273 the evidence that cellular senescence has a causative role in multiple diseases associated with agei

274 Despite evidence for a causative role in several important diseases, the functi

275 however, it is not known whether C4 plays a causative role in this brain disorder.

276 ggesting that chromophore deficiency plays a causative role in visual defects in early DR.

277 Recently, a causative role of deoxysphingolipids in MacTel disease h

278 increases imagery strength, demonstrating a causative role of visual cortex excitability in controll

279 lkyl isothiocyanate might also have played a causative role.

280 KGROUNDCeramides are sphingolipids that play causative roles in diabetes and heart disease, with thei

281 dance of many disease-related proteins, with causative roles in neoplasia, neurodegeneration, hepatos

282 with an SDHC epimutation, did not reveal any causative sequence anomalies.

283 as present (Epuyen/18-19) was similar to the causative strain (Epilink/96) in the first known person-

284 hree strategies: prevention, symptomatic and causative therapy.

285 er incomplete SCI and are at least partially causative to the observed recovery of function, which ca

286 f normalizing hyperglycemia in diabetes as a causative treatment strategy for late diabetic complicat

287 Moving from a correlative to a causative understanding of the role of neuroanatomical p

288 ng genomic methods to identify the potential causative variant are conducted along with variant impac

289 ding sequence of SlHAK20 was found to be the causative variant associated with Na(+) /K(+) ratio and

290 Herein we report the causative variant in the NAGLU gene in Schipperke dogs a

291 We identified causative or probable causative variants in 135 (19%) of 728 families, involvi

292 ted proportions with disease attributable to causative variants in each gene.

293 To find causative variants in known disorder-associated genes, a

294 r autosomal dominant (AD) and recessive (AR) causative variants.

295 SARS-CoV-2 is the causative viral agent of COVID-19, the disease at the ce

296 -19) often continue to test positive for the causative virus by polymerase chain reaction (PCR) even

297 The causative virus of the COVID-19 pandemic, SARS-CoV-2, us

298 The causative virus was later sequenced from a RT-PCR-positi

299 d mechanism is direct renal infection by the causative virus, SARS-CoV-2.

300 hogenic mechanism and route of spread of the causative virus, severe acute respiratory syndrome coron