ライフサイエンスコーパス: caveola

1 density of the caveolin-1 in a flask-shaped caveola.

2 We show that up to 50 cavins associate on a caveola.

3 ludes the transvascular pumping space of the caveola.

4 at decorates the cytoplasmic surface of each caveola.

5 virus 40 into the same cells is dependent on caveola.

6 ic solutes are encapsulated in the budding h-caveola, and purified h-caveolae can be tailored to be t

7 hat compounds that block endocytosis of both caveola- and clathrin-derived vesicles have no effect on

8 d members of the polyomavirus subfamily, use caveola- and clathrin-mediated uptake pathways for entry

9 propose that the translocation of ICAM-1 to caveola- and F-actin-rich domains links the sequential s

10 veolin-1 (Cav-1), an essential component for caveola assembly in highly differentiated cells, includi

11 Within the PM mosaic environment, caveola assembly is unique as it requires progressive ol

12 We propose a model for caveola assembly whereby fuzzy electrostatic interaction

13 ing to SR-BI maintained the concentration of caveola-associated cholesterol by promoting the uptake o

14 o multifunctional complexes with the help of caveola-associated protein cavin-1.

15 The cavin proteins are essential for caveola biogenesis and function.

16 f the oligomerization domain/CSD for defined caveola biogenesis and furthermore, highlight the functi

17 Caveola biogenesis requires expression of both Cav1 and

18 w that Cav1 tyrosine phosphorylation induces caveola biogenesis via actin-dependent mechanotransducti

19 caveolae and a model prokaryotic system for caveola biogenesis.

20 a novel feedback regulatory loop to regulate caveola biogenesis.

21 We conclude that oxLDL-induced depletion of caveola cholesterol causes eNOS to leave caveolae and in

22 location of eNOS, on eNOS activation, and on caveola cholesterol in endothelial cells.

23 In addition, the pharmacological removal of caveola cholesterol with cyclodextrin mimicked the effec

24 hereby preventing oxLDL-induced depletion of caveola cholesterol.

25 The caveola coat protein Cavin1 is essential for shaping suc

26 generate membrane curvature and a metastable caveola coat.

27 he general structure and the localization of caveola components remain largely unchanged.

28 e that CD36 mediates the effects of oxLDL on caveola composition and eNOS activation.

29 Each caveola contains approximately 150 caveolin-1 proteins.

30 Caveola-deficient cavin-1(-/-) muscle fibers showed a st

31 evels are reduced, suggesting a link between caveola deformation and global protein expression.

32 elocalization of cavin-1 to the nucleus upon caveola deformation.

33 This pathway of entry is cholesterol and caveola dependent and requires intact microtubules as we

34 by an additional non-clathrin-dependent, non-caveola-dependent endocytic pathway.

35 HPV31) enters its natural host cell type via caveola-dependent endocytosis, a distinct mechanism from

36 with both clathrin-mediated endocytosis and caveola-dependent endocytosis, neither of these two inte

37 ing drugs that inhibit clathrin-dependent or caveola-dependent endocytosis, we showed that EHV-1 entr

38 rast, infection of cells by SV40 proceeds by caveola-dependent endocytosis.

39 re of plasma membrane caveolae and regulates caveola-dependent functions.

40 sferrin receptor (TfR) are internalized by a caveola-dependent pathway.

41 renergic receptor (betaAR), are localized to caveola domains.

42 iving cells to determine the role of Dyn2 in caveola dynamics.

43 ctor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal a

44 or the Rho GTPase Cdc42, in the mechanism of caveola endocytosis in endothelial cells (ECs).

45 The mechanistic understanding of caveola fission is, however, sparse.

46 lted in shorter duration times and increased caveola fission.

47 sordered domains of Cavin1 are essential for caveola formation and dynamic trafficking of caveolae.

48 ations for understanding the role of Cav1 in caveola formation and in regulating cellular signaling e

49 The fundamental principles of caveola formation are only slowly emerging.

50 olins, but not caveolin mutants defective in caveola formation in mammalian systems.

51 ssion of cav-3 in insect (Sf9) cells induces caveola formation, comparable in size with those observe

52 pressed PTRF, whose function is critical for caveola formation, compromised adipocyte differentiation

53 Methyl beta-cyclodextrin, an inhibitor of caveola formation, reduced EBV basolateral entry.

54 ions with signaling proteins, is crucial for caveola formation.

55 Upon loss of caveola function, vacuolated cells collapse at discrete

56 elial cells via an endocytic pathway that is caveola-independent (as well as clathrin-independent).

57 evidence that BDV uses a clathrin-mediated, caveola-independent cell entry pathway.

58 A biotin assay for caveola internalization indicated a significant decrease

59 tions as an accessory protein that restrains caveola internalization.

60 The caveolin-1 in a flattened caveola is assumed to have approximately one-quarter of

61 ts an endoplasmic reticulum contaminant-free caveola isolation protocol; describes the presence of fu

62 did not fractionate with detergent-insoluble caveola-like membranes as cholera toxin receptors do.

63 phipathic helix preferentially interact with caveola-like model membranes.

64 Thus, Golgi-associated caveolins and caveola-like vesicles could represent part of the transp

65 t had no effect on the clathrin-dependent or caveola/lipid raft-mediated endocytic mechanisms.

66 hways, including both clathrin-dependent and caveola/lipid raft-mediated endocytosis.

67 opose that anandamide uptake may occur via a caveola/lipid raft-related endocytic process in RBL-2H3

68 these data suggest that following uptake via caveola/lipid raft-related endocytosis, anandamide is ra

69 BKV colocalizes with the caveola-mediated endocytic marker cholera toxin subunit

70 virus 40 (SV40) is taken up into cells by a caveola-mediated endocytic process that delivers the vir

71 protein 8, Arp2, cortactin, and calmodulin), caveola-mediated endocytosis (caveolin-1, dynamin-2, Arp

72 hat RVFV strain MP-12 uses dynamin-dependent caveola-mediated endocytosis for cell entry.

73 ate that BKV entry into Vero cells occurs by caveola-mediated endocytosis involving a pH-dependent st

74 Caveola-mediated endocytosis is responsible for the upta

75 In support of this, caveola-mediated endocytosis of labeled cholera toxin B

76 ell-surface abundance of TRPV5 by inhibiting caveola-mediated endocytosis of the channel.

77 hat HS-binding FMDV enters the cells via the caveola-mediated endocytosis pathway and that caveolae c

78 In contrast, inhibitors of caveola-mediated endocytosis, and RNAi targeted to caveo

79 d by inhibitors of clathrin-mediated but not caveola-mediated endocytosis, indicating that RRV enters

80 volved in Chlamydia entry, whereas those for caveola-mediated endocytosis, phagocytosis, and macropin

81 with cholera toxin B, which enters cells by caveola-mediated endocytosis.

82 rts tonic inhibition of TRPV5 by stimulating caveola-mediated endocytosis.

83 ve previously shown that BKV enters cells by caveola-mediated endocytosis.

84 , virus did not colocalize with a marker for caveola-mediated endocytosis.

85 Consistent with a caveola-mediated entry pathway for HPV31, the virions as

86 nce that HS internalizes bound ligands via a caveola-mediated mechanism, it was of interest to analyz

87 efective DH-PH, resulting in 62% increase in caveola-mediated uptake compared with controls.

88 asma membrane-enriched material that yielded caveola membranes free of endoplasmic reticulum and nonr

89 P4 stimulates signaling molecules located in caveola microdomains.

90 e filovirus pseudotypes colocalized with the caveola protein marker caveolin-1 but that VSV pseudotyp

91 The caveola protein, caveolin-1, binds to cholesterol and is

92 th caveolae and is directly regulated by the caveola protein, caveolin.

93 terol causes the concentration of pERK1/2 in caveola/raft lipid domains and the cytosol of human fibr

94 Inhibitors of caveola-related (clathrin-independent) endocytosis reduc

95 c analysis of precipitated material revealed caveola-sized vesicular profiles that could be double-la

96 s independent of its GTPase activity and the caveola stabilizing protein EHD2.

97 by beta-cyclodextrin results in the loss of caveola structure in myeloma cells, as shown by transmis

98 We observed that specific inhibitors of the caveola system, including cholesterol-sequestering drugs

99 l formation in vitro and results in aberrant caveola trafficking through the endosomal system.

100 dium vivax and P. cynomolgi produce numerous caveola-vesicle complex (CVC) structures within the surf

101 TRAgs are, at least in part, associated with caveola-vesicle complexes, a unique structure of P. viva