ライフサイエンスコーパス: caveolin

1 ssue, which is triggered by a dysfunction of caveolin 1 (CAV1) and subsequent uncoupling of feedback

2 Caveolin 1 (Cav1) is a required structural component of

3 e-like polygonal structures [7, 8] formed by caveolin 1 (Cav1) or Cav3 and one of the cavin proteins

4 roliferation, and invasion by downregulating caveolin 1 (CAV1) that plays a pivotal and versatile rol

5 We hypothesized that caveolin 1 (CAV1), a well-known eNOS interactor, regulat

6 ding protein and main component of caveolae, caveolin 1 (cav1), which was present in each epicardial

7 use embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular

8 YD1) and purified human Src kinase and human caveolin 1 or interactions between these proteins in nat

9 ydrophobic domain (FQRQVWLLF) interacts with caveolin 1 targeting Kv1.3 to caveolar rafts.

10 mbrane of microvascular endothelial cells in caveolin 1(-/-) mice is much more susceptible to acute r

11 Thus, overall, whereas a direct caveolin 1/Na,K-ATPase interaction is confirmed, the lac

12 beit with a low molar stoichiometry (1:15-30 caveolin 1/Na,K-ATPase).

13 g tissue, we identified the membrane protein caveolin -1 (Cav1) as a direct interaction partner of th

14 by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101) to the caveolin-binding

15 howed that overexpression of synapsin-driven caveolin-1 (Cav-1) (SynCav1) increases MLR localization

16 d overexpression of an MLR scaffold protein, caveolin-1 (Cav-1) (via a synapsin promoter, SynCav1), i

17 Caveolin-1 (Cav-1) ablation results in loss of caveolae

18 endocytosis of ALK-1, and it is mediated by caveolin-1 (CAV-1) and dynamin-2 (DNM2) but not clathrin

19 mily, is largely different from better known caveolin-1 (Cav-1) and thus might play distinct function

20 Occludin (ocln) and caveolin-1 (cav-1) are critical determinants of BBB inte

21 t the Na/K-ATPase alpha1 subunit, c-Src, and caveolin-1 (cav-1) are essential for the Na/K-ATPase sig

22 Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression i

23 t levels of the endothelial-enriched protein caveolin-1 (Cav-1) are reduced in the brains of T2DM pat

24 Hence, this study evaluated the role of caveolin-1 (Cav-1) in modulating P2Y2R subcellular distr

25 cells to assess the role of cholesterol and caveolin-1 (CAV-1) in the diffusion, expression, and fun

26 es this gap in knowledge by identifying that caveolin-1 (Cav-1) is a candidate mechanism-based biomar

27 Caveolin-1 (Cav-1) is a key organizer of membrane specia

28 Caveolin-1 (cav-1) is an important player in cell signal

29 We report that caveolin-1 (cav-1) is essential for sorting of selected

30 Here we show that the expression of caveolin-1 (Cav-1) is reduced in the brain in Type 2 dia

31 We hypothesized that caveolin-1 (Cav-1) participates in IOP maintenance via m

32 ions in the caveolar structural protein gene Caveolin-1 (CAV-1) were identified in two patients with

33 Evidence suggests that Caveolin-1 (Cav-1), a major component of caveolae which

34 to-oncogene tyrosine-protein kinase Src, and caveolin-1 (Cav-1), among others.

35 One LD coat protein is caveolin-1 (Cav-1), an essential component for caveola a

36 lasma membrane in DM, which colocalized with caveolin-1 (Cav-1), the key structural protein of caveol

37 yrosine kinase constitutively interacts with caveolin-1 (Cav-1), the key structural protein of caveol

38 s form a complex in membrane lipid raft with caveolin-1 (CAV1) and focal adhesion kinase (FAK) which

39 We show that caveolin-1 (Cav1) centrally regulates exosome biogenesis

40 idomic and gene array analyses revealed that caveolin-1 (CAV1) deficiency results in altered cellular

41 Caveolin-1 (Cav1) drives the formation of flask-shaped m

42 Caveolin-1 (CAV1) enhanced migration, invasion, and meta

43 holesterol-binding integral membrane protein caveolin-1 (Cav1) into the membrane, however, the precis

44 erapeutic stress-resistant tumor clones, and caveolin-1 (CAV1) is a main regulator of numerous signal

45 Caveolin-1 (CAV1) is a multifunctional protein and a maj

46 Caveolin-1 (CAV1) is an essential component of caveolae

47 The plasma membrane organizing protein caveolin-1 (Cav1) is increased in a variety of cancers,

48 Caveolin-1 (Cav1), a major Src kinase substrate phosphor

49 The absence of PTEN leads to caveolin-1 (CAV1)-dependent beta-catenin transcriptional

50 revious studies demonstrated that absence of caveolin-1 (Cav1)/caveolae in hyperlipidemic mice strong

51 o characterize the structure and dynamics of caveolin-1 (D82-S136; Cav182-136) in a DMPC bilayer usin

52 Complete backbone assignments of caveolin-1 (residues 62-178) were made, and it was deter

53 Caveolin-1 acts as a scaffolding protein to functionally

54 tor light responses, indicating that lack of caveolin-1 affects photoreceptor function in a non-cell-

55 xpression of claudin 2, increased binding of caveolin-1 and claudin 2, and increased trafficking of c

56 sion molecule-1 and the transcytosis protein Caveolin-1 and promoting endothelial transcytosis.

57 ke is dependent on host cell cholesterol and caveolin-1 and that internalization proceeds via clathri

58 further demonstrate that ShcA interacts with Caveolin-1 and the costameric protein plasma membrane Ca

59 Correspondingly, significant increases of caveolin-1 and vascular endothelial growth factor (VEGF)

60 of the Na(+),K(+)-ATPase with ankyrin B and caveolin-1 are expected to result in changes in plasma m

61 Caveolin-1 associates with the endo/lysosomal machinery

62 ound in caveolae and directly phosphorylated caveolin-1 at Tyr14 in vitro and in vivo This modificati

63 vin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened by immunohistochemistry in

64 ely through inactivation of the NAD(+)-SIRT1-caveolin-1 axis, which limits an important fuel source f

65 re and driver-gene mutations, and the cavins/caveolin-1 axis.

66 A heterozygous caveolin-1 c.474delA mutation has been identified in a f

67 A heterozygous Caveolin-1 c.474delA mutation has been identified in a f

68 in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

69 in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

70 ischemic penumbra of rat brains, and whether caveolin-1 changes correlated with reduced brain injury

71 odification regulated the generation of TIE2/caveolin-1 complexes and was essential for TIE2/caveolin

72 on and confocal microscopy demonstrated TIE2/caveolin-1 complexes in the nucleus, and using inhibitor

73 Caveolin-1 exhibits a stage-dependent, functional fluctu

74 We identified caveolin-1 expression as a crucial step in adipose cell

75 In contrast, manipulation of caveolin-1 expression did not affect the actions of E2 o

76 We demonstrate that a lack of caveolin-1 expression inhibits oncogenic K-Ras (K-Ras(G1

77 at the mRNA and protein levels, and that low caveolin-1 expression is associated with poor survival.

78 human sample analysis in which we show that caveolin-1 expression is dramatically down-regulated in

79 Cavin-1 stabilizes caveolin-1 expression or activity by inhibiting its inte

80 We found that depletion of caveolin-1 expression promotes primary cilia formation t

81 lial nitric oxide synthase (eNOS) and alters caveolin-1 expression to decrease nitric oxide bioavaila

82 mature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesi

83 Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell sene

84 e expansion response correlated with initial caveolin-1 expression.

85 reduced enzyme activity and upregulation of caveolin-1 expression.

86 emodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' (Goetz

87 emodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' by Goet

88 po-osmotic tension induced the dispersion of caveolin-1 from the caveolae, possibly through flattened

89 Here we studied how this mutation alters caveolin-1 function using patient-derived fibroblasts.

90 Here we studied how this mutation alters caveolin-1 function, using patient-derived fibroblasts.

91 Ligand 1 will permit targeted study of caveolin-1 function.

92 was to screen subjects for variation in the Caveolin-1 gene (Cav1), previously shown to correlate wi

93 Like mice lacking caveolin-1 globally, (RPE)CAV1(-/-) mice developed a nor

94 Neuron-targeted caveolin-1 improves neuromuscular function and extends s

95 roximately one-quarter of the density of the caveolin-1 in a flask-shaped caveola.

96 The caveolin-1 in a flattened caveola is assumed to have app

97 tion of Sirt1 expression or re-expression of caveolin-1 in caveolin-1 null MEFs restores reactive oxy

98 Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed t

99 critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation by dam

100 critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation throug

101 esults reveal a novel role for intracellular caveolin-1 in modulating phagolysosomal function.

102 and formed a continuous population with the caveolin-1 in the caveolae of cells under isotonic cultu

103 ng with insulin receptor isoforms binding to caveolin-1 in the PM.

104 of this study was to investigate the role of caveolin-1 in treadmill-exercise-induced angiogenesis in

105 the EPA-induced lipid raft disorganization, caveolin-1 inactivation, and cellular cytotoxicity were

106 The proportion of one-quarter-density caveolin-1 increased after increasing the tension of the

107 In addition, overexpression of caveolin-1 induces stress induced premature senescence i

108 demonstrate that the combination of TIE2 and caveolin-1 inhibitors resulted in significant radiosensi

109 show that the lipid raft scaffolding protein caveolin-1 interacts with the STIM1-Orai1 complex to inc

110 These results suggest that caveolin-1 is a mediator of nonestrogenic SPI effects on

111 Caveolin-1 is a target for academic and pharmaceutical r

112 Caveolin-1 is an integral membrane protein that is the p

113 While caveolin-1 is known to participate in a myriad of vital

114 These data show that caveolin-1 is necessary for optimal KSR1-dependent ERK a

115 tosis required dynamin but was unaffected by caveolin-1 knockdown or cholesterol depletion.

116 in endothelial transport of macromolecules: caveolin-1 knockout (Cav1-/-) and FcRn knockout (FcRn-/-

117 Therefore, by inhibiting Sirt1, caveolin-1 links free radicals to the activation of the

118 n of caveolin-1 with claudin 2 suggests that caveolin-1 may act as a shuttle for the internalization

119 eolin-1 complexes and was essential for TIE2/caveolin-1 nuclear translocation.

120 expression or re-expression of caveolin-1 in caveolin-1 null MEFs restores reactive oxygen species-in

121 nd premature senescence in wild-type but not caveolin-1 null mouse embryonic fibroblasts (MEFs).

122 vital cellular processes, structural data on caveolin-1 of any kind is severely limited.

123 small, high-affinity, selective disrupter of caveolin-1 oligomers.

124 Phosphorylation of caveolin-1 on tyrosine 14 promotes the sequestration of

125 ma membrane domains structurally composed of caveolin-1 or -3 along with other proteins.

126 r or small interfering RNAs (siRNAs) against caveolin-1 or Tie2 inhibited their trafficking.

127 Neuron-specific caveolin-1 overexpression improves motor function and pr

128 and showed that combination of cavin-1 with caveolin-1 predicted worse survival in pancreatic cancer

129 olar deformation by measuring the density of caveolin-1 projected onto a two-dimensional (2D) plane.

130 oximately 2.5-fold) or decrease (by half) of caveolin-1 protein levels in RPE cells in culture was su

131 We show that halving caveolin-1 protein levels significantly alkalinized lyso

132 This frameshift mutation leads to a caveolin-1 protein that contains all known functional do

133 This frameshift mutation leads to caveolin-1 protein that contains all known functional do

134 Each caveola contains approximately 150 caveolin-1 proteins.

135 Phosphorylation of tyrosine 14 on caveolin-1 regulates CRAC channel-evoked c-fos activatio

136 a subcutaneous xenograft model that stromal caveolin-1 remodels the intratumoral microenvironment, w

137 ression of wild-type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.

138 ression of wild type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.

139 Interestingly, overexpression of caveolin-1 restores cellular senescence in both A549 and

140 Treatment with the caveolin-1 scaffolding domain peptide (CSP) reversed the

141 her, inhibition of Src kinase activity using caveolin-1 scaffolding domain peptide suppressed bleomyc

142 reveal that structurally distinct domains of caveolin-1 selectively regulate the ability of local cal

143 extent of caveolar formation and the role of caveolin-1 signalling were evaluated by immunohistochemi

144 ey show, for the first time, that organellar caveolin-1 significantly affects tissue functionality in

145 Therefore, eliminating caveolin-1 specifically impairs phagolysosomal degradati

146 Here we explored mice lacking caveolin-1 specifically in the retinal pigment epitheliu

147 A mutant form of caveolin-1 that fails to reach the cell surface augmente

148 cally to augmented interaction of BMPR2 with caveolin-1 via elafin-mediated stabilization of endothel

149 Endogenous caveolin-1 was recruited to maturing phagolysosomes in R

150 The one-quarter-density caveolin-1 was soluble in detergent and formed a continu

151 The distinct, dispersed lower-density caveolin-1 was soluble in detergent and increased after

152 Co-immunoprecipitation of caveolin-1 with claudin 2 suggests that caveolin-1 may a

153 that K-Ras(G12V) promotes the interaction of caveolin-1 with MTH1, which results in inhibition of MTH

154 However, coexpression of wild-type caveolin-1 with mutated caveolin-1 restored the ability

155 However, co-expression of wild type caveolin-1 with mutated caveolin-1 restored the ability

156 ive critical molecules (cavin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened

157 Notably, caveolin-1, a lipid raft protein, is exclusively detecte

158 We found that caveolin-1, a structural protein component of caveolar m

159 ment of cavin-1 on the prognostic potency of caveolin-1, and showed that combination of cavin-1 with

160 Notably, caveolin-1, caveolin-2, and annexin A2, which are protei

161 ucture analysis of a functional construct of caveolin-1, containing the intact C-terminal domain, was

162 ycin signaling; reduced protein abundance of caveolin-1, dystrophin, epidermal growth factor receptor

163 nt of endothelial nitric oxide synthase from caveolin-1, leading to an impairment of nitric oxide sig

164 2 cells exhibited a strong association among caveolin-1, p53, and mouse double minute 2 homologue (md

165 ICs expressed caveolin-1, podoplanin and receptor for advanced glycati

166 can be increased by blocking its binding to Caveolin-1, the main coat protein of caveolae, using a h

167 and-induced TIE2 trafficking is dependent on caveolin-1, the main component of caveolae.

168 membranes and the interaction of Sirt1 with caveolin-1, which lead to inhibition of Sirt1 activity.

169 hat we find compartmentalizes exclusively to caveolin-1-associated detergent-resistant membrane (DRM)

170 e translocation of RIPK1, RIPK3, and MLKL to caveolin-1-containing DRM vesicles without fully blockin

171 lmonary arteries via elastase inhibition and caveolin-1-dependent amplification of BMPR2 signaling.

172 echanism that involves recruitment of KIT to caveolin-1-enriched microdomains.

173 d TRPV5 activity by impairing dynamin-2- and caveolin-1-mediated endocytosis of TRPV5.

174 reted by senescent fibroblasts following the caveolin-1-mediated inhibition of Sirt1.

175 The caveolin-1-mediated secretion of IL-6 by senescent fibro

176 Consistent with these data, caveolin-1-null mice overexpressing K-Ras(G12D) display

177 K-Ras(G12D)-induced premature senescence in caveolin-1-null mice results in the formation of more ab

178 r senescence in the lung of wildtype but not caveolin-1-null mice.

179 Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed to induce forma

180 cancer cells, which could not be restored by caveolin-1-rescue construct.

181 nd prevents the translocation of ICAM-1 into caveolin-1-rich membrane domains.

182 ion and induces translocation of ICAM-1 into caveolin-1-rich membrane domains.

183 We also identified IL-6 as a caveolin-1-specific cytokine that is secreted by senesce

184 T domain mutant displayed reduced binding to Caveolin-1.

185 pid raft-associated proteins VE-cadherin and caveolin-1.

186 detergent-resistant membranes (rafts) and to caveolin-1.

187 surface augmented degradation like wild-type caveolin-1.

188 accompanied by increased LD localization of caveolin-1.

189 colocalized with clathrin far more than with caveolin-1.

190 D1) cofactor during endolysosomal sorting of caveolin-1.

191 ins rich in the membrane raft marker protein caveolin-1.

192 ediated stabilization of endothelial surface caveolin-1.

193 r the lipid raft markers ganglioside GM1 and Caveolin-1.

194 ature senescence induced by the depletion of caveolin-1.

195 n impaired the antiproliferative function of caveolin-1.

196 impaired the anti-proliferative function of caveolin-1.

197 were associated with down-regulation of the caveolin-1/p53-mediated senescence pathway in bone.

198 e formation of lipid rafts and activation of caveolin-1; however, no such observations were made upon

199 In native renal membranes, a specific caveolin 14-5 oligomer (95 kDa) was found to be in direc

200 les is in a approximately 1:1 complex with a caveolin 14-5 oligomer.

201 tric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction

202 Caveolin-2 (Cav-2), a member of caveolin protein family,

203 sing the anti-tumor immune response and that caveolin-2 could be a potential target for cancer immuno

204 ith the latter, transfer and co-injection of caveolin-2 deficient bone marrow (origin of TAMs) suppre

205 ltrating CD8 T cells and tumor regression in caveolin-2 deficient mice, suggesting that an early incr

206 our data suggest that lung cancer cells use caveolin-2 expressed in bone marrow-derived cell types i

207 ovel mechanism, via which host deficiency in caveolin-2 inhibits tumor growth.

208 Here, we demonstrate that host deficiency in caveolin-2, a member of caveolin protein family, increas

209 Notably, caveolin-1, caveolin-2, and annexin A2, which are proteins associate

210 Cav-1-F92A was measured by stabilization of caveolin-2, sucrose gradient, and electron microscopy.

211 with a reduction in the scaffolding protein caveolin-3 (Cav-3), altered Ca(2+) cycling, increased pr

212 Mutations in the CAV3 gene encoding caveolin-3 (Cav3), a scaffolding protein integral to cav

213 tations in the caveolae scaffolding protein, caveolin-3 (Cav3), have been linked to the long QT type

214 nges can be correlated with modifications in caveolin-3 and L-Type Ca(2+) channel distributions acros

215 Caveolin-3 co-localizes with and affects the expression

216 Reintroduction of caveolin-3 in the failing myocytes is able to normalize

217 laments is associated with downregulation of caveolin-3 in the hypertrophic failing rabbit myocytes.

218 Reintroduction of caveolin-3 is able to confine beta2 adrenergic receptor

219 Caveolin-3 is the major structural protein of caveolae i

220 in-1 or expression of a dystrophy-associated Caveolin-3 mutant both led to sarcolemmal damage but onl

221 MD1A (myotilin), LGMD1B (lamin A/C), LGMD1C (caveolin-3), LGMD1D (desmin), LGMD1E (DNAJB6), and more

222 levels of myosin heavy and light chains and caveolin-3.

223 ng functional caveolae through expression of caveolin-3.

224 Purified caveolin 8S oligomers assumed disc-shaped arrangements o

225 Functional interference of caveolin abrogated LCs superior ability to cross-present

226 cells that could be independent of clathrin, caveolin, actin, and lipid phase separation.

227 duced the internalization of IL-12Rbeta1 via caveolin and caused cancer cell death via the IL-12-IFN-

228 sma membrane, are comprised predominantly of caveolin and cavin proteins and can respond to mechanica

229 perimentation reveal that complex effects of caveolin and cortical actin on Ras nanoclustering are si

230 inical role of lipid raft-specific proteins, caveolin and flotillin, in assessing patient prognosis a

231 The clustering and activation of caveolin and signaling proteins further stabilize raft s

232 ion of Rac1 is accelerated in the absence of caveolin and that, when caveolin is knocked down, polari

233 In cells that lack caveolins and caveolae, cavin1 is cytosolic and rapidly

234 We show that caveolins and caveolin dependent endocytosis are necessa

235 caveolae: integral membrane proteins termed caveolins and cytoplasmic coat proteins called cavins.

236 Oligomers of membrane-embedded caveolins and peripherally attached cavins form the cave

237 olae by a complex consisting of Na,K-ATPase, caveolin, and Src kinase.

238 discovered, HPV entry occurs by a clathrin-, caveolin-, and dynamin-independent endocytosis via tetra

239 We suggest caveolin as one such molecule that serves as a regulator

240 A sequestered TGF-beta receptor complexes to caveolin-associated membrane compartments, and reducing

241 RAI1 colocalizes with clathrin, but not with caveolin, at the apical membrane of PTECs, which determi

242 Our results identify a caveolin-binding domain in Kv1 channels and highlight th

243 Kv1 channels share a putative caveolin-binding domain located at the intracellular N-t

244 in of caveolin-1 (amino acids 82-101) to the caveolin-binding domain of Sirt1 (amino acids 310-317).

245 region containing aromatic amino acids, the caveolin-binding motif.

246 ol binders by a single point mutation in the caveolin-binding motif.

247 vo demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrowth receptors, and, when o

248 sduction and signaling, we hypothesized that caveolin (Cav) proteins might regulate integrins in the

249 lding and cholesterol binding proteins named caveolin (Cav).

250 Caveolin (Cav)1, a widely expressed transmembrane protei

251 We then found that caveolins (CAV1 and CAV2) and the membrane sculpting F-B

252 nique membrane architecture generated by the caveolin-cavin system.

253 Caveolins (CAVs) are structural proteins of caveolae tha

254 redict that, in the presence of fibronectin, caveolin defines regions of the cell that are resistant

255 We show that caveolins and caveolin dependent endocytosis are necessary for proper

256 APs) enters cancer cells and normal cells by caveolin-dependent endocytosis and macropinocytosis, res

257 ll proliferation depended upon clathrin- and caveolin-dependent translocation of the IR to the nucleu

258 ation via activation of Rho/ROCK, CDC42, and caveolin endocytosis-dependent pathways, resulting in lo

259 impaired nitric oxide production and altered caveolin expression in hyperhomocysteinemia (HHcy), lead

260 se pathway and toward a lipid raft-dependent caveolin-Fyn-Shc pathway.

261 g process, a function similar to that of the Caveolin genes (CAV1 and CAV2) which have previously bee

262 olae, specific lipid rafts which concentrate caveolins, harbor signaling molecules and their targets

263 s internalised via a clathrin-dependent, but caveolin-independent, route.

264 intramembrane domain and the CSD for defined caveolin-induced membrane deformation.

265 ineering applications, which is required for caveolin-induced vesicle formation in a bacterial system

266 We have identified the key steps in cavin/caveolin interplay regulating adipocyte caveolae dynamic

267 ed in the absence of caveolin and that, when caveolin is knocked down, polarization of active Rac1 is

268 Caveolin is traditionally thought of as a membrane-local

269 ion and brush border fanning, which preceded caveolin-mediated bacterial internalization through chol

270 s EIPA, blebbistatin, and wortmannin and the caveolin-mediated endocytosis inhibitors nystatin and fi

271 ion of another receptor endocytosis pathway, caveolin-mediated endocytosis, did not affect Wnt pathwa

272 In the absence of coronin-1C, the effect of caveolin-mediated endocytosis, which targets Rac1 for pr

273 y sensitive to perturbation of clathrin- and caveolin-mediated endocytosis.

274 onstitutive coronin-1C-mediated trafficking, caveolin-mediated Rac1 endocytosis is induced by engagem

275 homocysteinylation of eNOS and disruption of caveolin-mediated regulation leads to ECM remodeling and

276 t protein kinase type II) and development of caveolin-mediated signaling compartmentalization.

277 tely we focus on two non-canonical roles for caveolin - membrane repair and regulation of mitochondri

278 ins, such as caveolae, and their constituent caveolins, modulate receptor signaling in astrocytes; ye

279 e without releasing a significant portion of caveolin molecules.

280 ant proteins, ABCA3, GM-CSF, podoplanin, and caveolin mRNA after 7 days, temporal induction of CCAAT/

281 s involved in Na/K-ATPase signaling, such as caveolin, phospholipase C, Src, and the IP3 receptor.

282 lular senescence and ageing and propose that caveolin plays a distinct role in each of these processe

283 eolar functions from those supported by mere caveolin presence and also demonstrated that neither cav

284 t host deficiency in caveolin-2, a member of caveolin protein family, increases M1-polarized tumor-as

285 Caveolin-2 (Cav-2), a member of caveolin protein family, is largely different from bette

286 and sphingolipid content; they also contain caveolin proteins in their structure.

287 patially resolved assemblies of clathrin and caveolin, Rab5a in early endosomes, and alpha-actinin, o

288 rent structural conformations can impair the caveolin recognition, thereby altering channel's spatial

289 How B lymphocytes, lacking any known form of caveolin, repair membrane injury is unknown.

290 We discover that both coronin-1C and caveolin retrieve Rac1 from similar locations at the rea

291 lyRs are closely associated with cholesterol/caveolin-rich domains at subcellular levels.

292 adhesion impacts receptor enrichment through Caveolin-rich membrane domains.

293 ation of AQP3 and phospholipase D2 (PLD2) in caveolin-rich membrane microdomains.

294 We have speculated that insertion of the caveolin scaffolding domain (CSD), a conserved amphipath

295 tains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82-101).

296 ccessibility by extracellular matrix probes, caveolin structure in a bilayer remains elusive.

297 We have previously found that caveolin, the main structural component of caveolae, spe

298 The loss of caveolae and caveolin was in accordance with the decrease in HCN chan

299 between purified human Na,K-ATPase and human caveolin was obtained, albeit with a low molar stoichiom

300 ion of endophilin B1 vesicles also contained caveolin, whereas clathrin was almost undetectable on th