ライフサイエンスコーパス: cell

1 the detailed electrical activity inside the cell.

2 phase and the SPB that remains in the mother cell.

3 ctivity of chimeric antigen receptor (CAR) T cells.

4 r injection of both syngeneic and xenogeneic cells.

5 icular, ET were enriched in polyfunctional T cells.

6 various epithelial, mesenchymal, and immune cells.

7 of P-Rex1 is required for its activation in cells.

8 ication-competent virus cultured from CD4+ T cells.

9 d stably integrated the library into HEK293T cells.

10 atterns on the surface of mucosal epithelial cells.

11 ained by the presence of nonfiring pacemaker cells.

12 f monitoring in-situ activity of LAP in live cells.

13 entiation of resident mesenchymal progenitor cells.

14 ecific sfRNAs in both mammalian and mosquito cells.

15 on of phospholipid synthesis into artificial cells.

16 CS network of CLL cells, but also of healthy cells.

17 th the potential to differentiate into tumor cells.

18 ments on both atrial and ventricular cardiac cells.

19 irus particles produced from MT-4 than SupT1 cells.

20 activation in IL-17(+) gammadelta and T(H)17 cells.

21 n dermal fibroblasts were used as comparator cells.

22 ertoire diversity of virus-specific CD8(+) T cells.

23 ory objectives included tracking of edited T cells.

24 tumor-bearing host, and persisted as memory cells.

25 ress might induce senescence in joint tissue cells.

26 e myeloblast 32D and human promyelocytic NB4 cells.

27 D-PerIg CD8(+) T cells but required CD4(+) T cells.

28 stroma following alpha3 deletion from tumor cells.

29 ng of H3K27me3-demarcated genes in mammalian cells.

30 acid-induced lipid accumulation in hepatoma cells.

31 and dedifferentiated phenotypes in hepatoma cells.

32 ghtforward identification of innate lymphoid cell 2 progenitor populations.

33 he high levels of Env on the surface of MT-4 cells, 2-fold less Env is incorporated into virus partic

34 -matched late erythroblast F cells and non-F cells (A cells) from the human HUDEP2 erythroid cell lin

35 A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infec

36 nocytosis that increases in magnitude upon T cell activation to support T cell growth even under amin

37 Inhibiting IRE1alpha blocked stellate cell activation, which then decreased proliferation and

38 ctional analysis were mainly associated with cell adhesion, inflammatory response, and extracellular

39 involved in their reorganization to sites of cell adhesion.

40 D regimen favors persistence of functional B cells after the third dose.

41 Rationale: A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mi

42 A major challenge in cell and developmental biology is the automated identifi

43 g primary human retinal vascular endothelial cells and an established human endothelial cell line, we

44 hy brains, spatially tuned hippocampal place cells and entorhinal grid cells exhibit distinct spike p

45 ption and pore formation in HeLa and BE(2)-C cells and inhibition and eradication of C. albicans biof

46 rentiation stage-matched late erythroblast F cells and non-F cells (A cells) from the human HUDEP2 er

47 ing and priming for both CD4(+) and CD8(+) T cells and of the direct orchestration of their cross-tal

48 s redistribution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreases AMPAR-

49 ribed a method to introduce DELs into living cells and recover conjugates that bind to an intracellul

50 that depletes eosinophils and inhibits mast cells and that has shown potential in animal models as a

51 In this manner, intact cells and their antigens were separated and independentl

52 fitness in cancer cell lines, primary cancer cells, and fibroblasts under unhindered growth condition

53 igate the impact of cross-talk between tumor cell- and endothelial cell (EC)-secreted IL6 on HNSCC gr

54 T(H)17 cells are believed to orchestrate MS pathology, in part,

55 ce that primary FCRL4-bearing human memory B cells are constitutively bound to IgA.

56 ed, when preimplantation endometrial stromal cells are exposed to hypoxic conditions in vitro, we obs

57 Our data suggest that MAIT cells are highly activated and become dysfunctional duri

58 Expanded GPA33(high) Treg cells are suppressive, unable to produce proinflammatory

59 , relative frequencies of CXCR5(-) memory Th cells as well as regulatory T and B cells were increased

60 cerebellar cortical output neurons, Purkinje cells, attenuated seizures.

61 s of microalgae in the context of evolution, cell biology, and metabolic adaptations.

62 number of flagella, their arrangement on the cell body and their sense of rotation hypothetically det

63 ing, strengthening tissues: CXE in xylem and cells bordering intercellular canals and MXE in sclerenc

64 veloped in the absence of NOD-PerIg CD8(+) T cells but required CD4(+) T cells.

65 g patterns not only in the CS network of CLL cells, but also of healthy cells.

66 ngly upregulated on renal tubular epithelial cells by acute cell-mediated rejection (ACR.

67 ) after chimeric antigen receptor-modified T-cell (CAR-T-cell) therapy are limited.

68 upport the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extremely lethal form of skin c

69 y of the cadherin family of Ca(2+)-dependent cell-cell adhesion proteins, which play essential roles

70 lular compositions within functional niches, cell-cell signaling in homeostatic health, the responses

71 identical intact sequences, suggestive of a cell clone harboring a replication-competent provirus.

72 n Tph1 deficient ILC2s including inducible T cell co-stimulator (Icos).

73 ment and activation of lymphatic endothelial cells.Conclusions: A unique population of LAM(CORE) cell

74 odels for a discoidal or an ellipsoidal stem cell confinement respectively.

75 fic cytokines produced by autoreactive CD4 T cells contribute to the pathogenesis of MS.

76 Tumor and stromal cells cooperated in forming niches; stromal cells produc

77 T6GAL-I and SOX9 in human gastric epithelial cells correlated positively with one another through the

78 ut differed in terms of myeloid and lymphoid cell counts.

79 Cancer stem cells (CSCs) are a small subpopulation of quiescent cell

80 of the Kunjin virus helicase on infection in cell culture and in vivo This work provides new insight

81 es and potential mispaired side products, in cell culture media, or other complex matrices.

82 hat do not compromise replicative fitness in cell culture.

83 Annexin A5 addition to choroid plexus cell cultures restored the Abeta-induced impairments on

84 d with and counteracted EZH2 and SOX2 during cell-cycle and self-renewal regulation to restrain tumor

85 hen, the ubiquitous entry gate to within the cells' cytoplasm is macropinocytosis.

86 w that NVP was readily taken up by dendritic cells (DCs) and promoted DC maturation and antigen prese

87 DDH cartilage, with no evidence of augmented cell death by activation of caspase 3.

88 s that NPR1 is centrally integrated into the cell death or survival decisions in plant immunity by mo

89 pic brain slices we found that D(1)R-induced cell death signaling and neuronal degeneration, are miti

90 of genetic lesions drives the activation of cell death to eliminate cells with defective genome.

91 nfolded protein response (UPR) signaling and cell death upon ER stress induction.

92 significantly affecting cell proliferation, cell death, or UPR induction in murine myeloblast 32D an

93 -alpha)-induced signalling and prevention of cell death.

94 s (34%; P < 0.001), and increased epithelial cell density (13%; P < 0.001).

95 bust clinical responsiveness of IgG4-RD to B cell depletion and by the identification of multiple sel

96 80(-)) NKDIs promoted non-NK innate lymphoid cell differentiation at the expense of NK cell different

97 id cell differentiation at the expense of NK cell differentiation.

98 This can complement existing T cell-directed immunotherapy, providing a promising appro

99 virus (EBV) is associated with a number of T-cell diseases, including some peripheral T-cell lymphoma

100 In vitro, VE-cadDEE mutant cells displayed defects in polarization and cell migrati

101 s involved in transcription, DNA repair, and cell division.

102 y the spindle, which then guides the axis of cell division.

103 A disproportionate number of germ cell divisions were observed at the DTC-Sh1 interface.

104 predisposition, epidermal dysfunction, and T-cell driven inflammation.

105 the SPB that is delivered into the daughter cell (dSPB) during anaphase and the SPB that remains in

106 ells for metabolic resources often renders T cells dysfunctional.

107 oss-talk between tumor cell- and endothelial cell (EC)-secreted IL6 on HNSCC growth and the CSC fract

108 Endothelial cells (ECs) display remarkable plasticity during develop

109 vaccinia virus (VV) stimulation to measure T cells elicited after childhood smallpox vaccination.

110 MARS uses deep learning to learn a cell embedding function as well as a set of landmarks in

111 unction as well as a set of landmarks in the cell embedding space.

112 pathways, whereas OXPHOS(low) BAP1 mutant UM cells employ fatty acid oxidation.

113 Here we show that primary mouse and human T cells engage in macropinocytosis that increases in magni

114 Day 4 Th17 cells engrafted, induced release of multiple cytokines i

115 MUC1 knockdown in pancreatic cancer cells enhanced unfolded protein response (UPR) signaling

116 In both C. elegans and human cancer cells, ether-lipid synthesis protects against ferroptosi

117 hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different envir

118 Furthermore, ARDKO cells exhibited several electrophysiological changes suc

119 ion of multiple self-antigens that promote B cell expansion.

120 Here we show that beta-cells express abundant Kindlin-2 and deleting its expres

121 2C protein allowed for robust replication in cells expressing mSTING, suggesting a role for 2C in rec

122 ascade, indicating that increased epithelial cell expression of ST6Gal-I is associated with premalign

123 of the Th1/Th2 paradigm ignited the CD4(+) T cell field.

124 tion, as well as the length and stability of cell filopodia.

125 DynaFit revealed that cell fitness in cancer cell lines, primary cancer cells,

126 he pneumococcal competence cycle, preserving cell fitness.

127 or-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysf

128 eir affinity to PIPs we have developed a new cell free assay based on the ability of the receptor to

129 ing and whole-genome bisulfite sequencing of cell free DNA (cfDNA) and of matched metastatic tumor bi

130 B cells led to greater tissue like memory B cell frequencies.

131 ctly or indirectly excluding effector CD8+ T cells from the tumor microenvironment.

132 late erythroblast F cells and non-F cells (A cells) from the human HUDEP2 erythroid cell line and pri

133 ptor; however, its impact on pancreatic beta-cell function is unknown.

134 g glucose, insulin, insulin resistance, beta-cell function, and adiponectin at age 11.5 years.

135 milar levels of insulin sensitivity and beta-cell function.

136 recurrence in the genome or essentiality for cell function.

137 ion by RNA polymerase (Pol) II and regulates cell growth and differentiation.

138 phosphoprotein that plays a critical role in cell growth control as the central regulator of RNA poly

139 agnitude upon T cell activation to support T cell growth even under amino acid (AA) replete condition

140 ations important to tumorigenesis and cancer cell growth, here we report a chemoproteomic analysis of

141 on-making with a few molecules in artificial cells has remained a challenge.

142 Mammalian cells have the ability to incorporate thymidine analogs

143 nd how burst propensity relates to pyramidal cell heterogeneity.

144 ronment for the growth of hepatic progenitor cells (HPCs) at the periportal area and subsequent devel

145 ited greater potency in drug-resistant NSCLC cells (IC(50) = 17 nM) and in mice with H1975 xenograft

146 tors of gene silencing that establish immune cell identity and function.

147 eta that controls the differentiation of Th2 cells important for AD pathogenesis.

148 that ensures homeostasis and survival of the cell in the face of stressors as different as starvation

149 ase sputum eosinophils and inhibit lung mast cells in asthma.

150 is highly expressed on eosinophils and mast cells in asthmatic sputum and targeting Siglec-8 with an

151 automated identification and quantitation of cells in complex multilayered tissues.

152 e findings reveal how an interaction between cells in different EMT states confers properties that ar

153 creased proliferation and migration of tumor cells in different in vitro 2D and 3D co-cultures.

154 This study supports an important role for B cells in indirect T cell priming and further emphasizes

155 vestigated how excitatory and VIP inhibitory cells in layer 2/3 of mouse visual cortex were impacted

156 uman cancer cells, killing SW48 colon cancer cells in particular with a submicromolar half maximum in

157 While hair cells in the cochlea are established targets of cisplati

158 emodeling machinery in intestinal epithelial cells in the colitis response and shows how a highly con

159 In particular, the central role of B cells in the disease has been demonstrated by both the r

160 We have examined the priming of naive CD4 T cells in vitro at fever temperatures, and we report nota

161 ss B type 1 (SR-B1) and CD15 on brain SHH MB cells in vitro, ex vivo, and in vivo.

162 D8(-)TCRalphabeta(+), double-negative (DN) T cells, in mouse secondary lymphoid organs.

163 neoantigen load) and the degree of CD8(+) T cell infiltration were not associated with clinical resp

164 ng noncoding RNA (lncRNA) that we named Stem Cell Inhibitory RNA Transcript (SCIRT), which was marked

165 This review focuses on tumor cell-intrinsic alterations that blunt productive anti-tu

166 triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the

167 mportant regulator of cell migration, cancer cell invasion, and vesicular content release, we sought

168 In this study, induced pluripotent stem cells (iPSC)-derived neuronal stem cell lines were gener

169 is study used models allowing the convenient cell isolation from Ccl17(E/+) reporter mice; it also ex

170 otoxic activity against various human cancer cells, killing SW48 colon cancer cells in particular wit

171 n of the catalytic domain of PDE3A in cancer cells lacking PDE3A is sufficient to confer sensitivity

172 atures to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plast

173 ction model of primary lymphatic endothelial cells (LECs) infected with a lytically replicating KSHV

174 Culture of MAIT cell supernatants with B cells led to greater tissue like memory B cell frequenci

175 tween active and inactive bacteria at single cell level is urgently needed in many fields including c

176 ls (A cells) from the human HUDEP2 erythroid cell line and primary human erythroid cultures.

177 21-plex quantification of labeled K562 human cell line protein digests via single-shot nanoLC-MS/MS a

178 l cells and an established human endothelial cell line, we investigated the role of AMP-activated pro

179 proteomic analysis of a kidney-derived HLRCC cell line.

180 micromolar range among various tested cancer cell lines such as A2780 (0.23 muM), PC3 (0.48 muM), and

181 tent stem cells (iPSC)-derived neuronal stem cell lines were generated from individuals with MDD.

182 DynaFit revealed that cell fitness in cancer cell lines, primary cancer cells, and fibroblasts under

183 n isogenic TP53-WT and TP53-null (TP53(-/-)) cell lines.

184 n several Ewing sarcoma and multiple myeloma cell lines.

185 y of miR-21-5p isolated from human non-small cell lung cancer (NSCLC) tissue possesses 3'-terminal 2'

186 T-cell diseases, including some peripheral T-cell lymphomas, hemophagocytic lymphohistiocytosis, and

187 wt % of the total protein from breast cancer cell lysates.

188 inantly entered lytic replication, underwent cell lysis, and released new virus.

189 man olfactory neurosphere-derived stem (ONS) cell matrix.

190 ization are important determinants of CD8+ T cell-mediated efficacy against SIV.

191 d on renal tubular epithelial cells by acute cell-mediated rejection (ACR.

192 el cyclotides interact with and permeabilize cell membranes.

193 YO7A's essential role in tensioning the hair cell MET complex.

194 ng high spatial and temporal resolution live-cell microscopy, we identified a role for mitochondria-l

195 , we found that during this adaptation tumor cells might present unique, temporally restricted collat

196 cells displayed defects in polarization and cell migration that were rescued by uncoupling VE-cadDEE

197 now recognized as an important regulator of cell migration, cancer cell invasion, and vesicular cont

198 months, not acutely ill, CD4 count not <200 cells/mm3) and willingness to participate in an AC.

199 Using an HD mouse striatal cell model and HD mouse organotypic brain slices we foun

200 end, we used the well-characterized iSLK.219 cell model of KSHV infection and established a new infec

201 rent specialized cell types in the root stem cell niche.

202 sidered an integral component of neural stem cells (NSCs) niches.

203 rare somatic mutations, suggesting a shared cell of origin.

204 an be found in the peripheral blood CD4(+) T cells of patients at all stages of HIV-1 infection.

205 tant for neuronal maturation and function in cells of the SC and dLGN.

206 dynamically assemble filamentous polymers in cells, often in response to changes in physiological con

207 cytes with limbal epithelial stem/progenitor cells on fibrin hydrogels pre-incubated with LN-511-E8 r

208 We performed whole-cell patch-clamp recordings of medium spiny neurons (MSN

209 f I/LnJ BMDMs with C57BL/6J CD300LF made the cells permissible to MNV infection, suggesting that the

210 of injury, C4d positivity, and inflammatory cell phenotyping.

211 etains target protein dosages in gene-edited cell populations and expands gene editing to chromosomal

212 Image analysis of motile cell populations, both primary and cultured, typically r

213 an important role for B cells in indirect T cell priming and further emphasizes the advantage of com

214 ntly core, structural ECM proteins and tumor cells produced a diverse array of ECM-associated protein

215 cells cooperated in forming niches; stromal cells produced predominantly core, structural ECM protei

216 The Hippo pathway regulates cell proliferation and organ size through control of the

217 Interestingly, MNT was required for cell proliferation even in the absence of MAX.

218 ferentiation without significantly affecting cell proliferation, cell death, or UPR induction in muri

219 Cytokines that stimulate T cell proliferation, such as interleukin (IL)-15, have be

220 enhanced Akt activity and increased rate of cell proliferation.

221 ng genes expressed in peripheral white blood cells (PWBCs), and circulating micro RNAs in plasma, are

222 tially enhance our understanding of CD4(+) T cell recognition.

223 esents the main opiate receptor of skin mast cells remains unknown.

224 Total and spike-specific T cell responses correlated with spike-specific antibody r

225 Total memory T-cell responses were measured after anti-CD3 or vaccinia

226 te immune responses and adaptive cytotoxic T cell responses.

227 robiome shifts and enhanced intestinal CD8 T cell responses.

228 Paired TCRalphabeta analyses of MAIT cells revealed large clonal expansions in older adults a

229 FBN1+ FAP cell type was also found in single cell RNA-seq analysis in mouse.

230 expression from different tissues in single-cell RNA-sequencing data.

231 s derived from DCLK1-overexpressing hepatoma cells showed high level expression of active beta-cateni

232 served correlations attributed to particular cell size control mechanisms, we identify dependencies t

233 n tau/tau(D) and can be much larger than the cell size.

234 erotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodel

235 stacles cause Pol II stalling or arrest, the cell somehow distinguishes between them and invokes diff

236 This study utilised cell sorting and immunohistochemistry to identify a phen

237 Cell-specific deletion reveals a requirement for GATA6 i

238 and nhr-67 (NR2E1/TLX), that mediate anchor cell specification and/or invasive behavior.

239 ifferential AQP-1 levels affect neural crest cell speed and direction, as well as the length and stab

240 Spermatogonial stem cells (SSCs) are generally characterized by excellent DN

241 The discovery of CD4(+) T cell subset-defining master transcription factors and fr

242 The human FBN1+ FAP cell subtype is novel and a corresponding FBN1+ FAP cell

243 , absent in therapy naive or fully resistant cells, suggesting the potential for new therapeutic inte

244 Culture of MAIT cell supernatants with B cells led to greater tissue lik

245 ncreasing incorporation of GalNAzMe into the cell surface glycoproteome.

246 gment holoreceptors that remain bound at the cell surface.

247 owever, many NF-kappaB-mediated pathways for cell survival and apoptosis signaling in cancer remain t

248 global profile of mitochondrial salvage and cell survival was observed in the EVLP lung tissue compa

249 lar mechanisms (tissue recovery and variable cell susceptibility to infection), using our software mo

250 These drawbacks can be circumvented by CAR-T cells targeting tumour-specific driver gene mutations, s

251 A group of cells that can become adipocytes controls the formation

252 After applying PT-TPA into perovskite solar cells, the doping-induced band bending in perovskite eff

253 eric antigen receptor-modified T-cell (CAR-T-cell) therapy are limited.

254 ctrolyte protected Zn anode enables a Zn||Ti cell to achieve a high average Coulombic efficiency of 9

255 cancer and depleting BRD9 sensitizes cancer cells to olaparib and cisplatin.

256 -specific progeny of individual naive CD8+ T cells to the T effector (TEFF), T circulating memory (TC

257 and TRM pools by lineage-tracing and single-cell transcriptome analysis.

258 e diminished upon the same treatment of A549 cells transfected with either p53 siRNA or acetylcholine

259 is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited b

260 effective generally become dependent on red-cell transfusions.

261 included: infant ALL, relapsed ALL, and stem cell transplant recipients.

262 ndergoing chemotherapy or hematopoietic stem cell transplantation for hematological malignancy at St.

263 NF2-null cells treated with an ERBB3-neutralizing antibody partia

264 tive was to develop macaque trophoblast stem cells (TSCs) as an in vitro platform for future assessme

265 nt integration scheme compared with the same cell type in somatosensory cortex, which has important i

266 btype is novel and a corresponding FBN1+ FAP cell type was also found in single cell RNA-seq analysis

267 proach to help identify the CCL17 responding cell type(s) and the mediators downstream of CCL17 in th

268 of regulatory effects per variant on several cell type-specific chromatin features.

269 t beginning to catalog the vast diversity of cell types in the cerebral cortex.

270 division timing of two different specialized cell types in the root stem cell niche.

271 Effects of LAM on resident pulmonary cell types indicated recruitment and activation of lymph

272 cells with their capacity to generate mature cell types.

273 flux may play a role in the survival of N2a cells upon prion infection.

274 d to models of early life in which the first cells used simpler types of membrane building blocks and

275 They target eukaryotic cells using different mechanisms, but all require the pr

276 yses showed that OXPHOS(high) BAP1 mutant UM cells utilize glycolytic and nucleotide biosynthesis pat

277 tive transfer of labeled bone marrow-derived cells validated the results in a murine Leishmania ear i

278 r five days through continuous perfusion and cell viability was analysed on-chip at different time po

279 To envisage potential applications, cell wall sequential extraction performed on dry plant y

280 valent cellulose-xyloglucan bonding in plant cell walls and showed that CXE and MXE action was up to

281 of minor polysaccharide components of plant cell walls that are particularly difficult to assign by

282 ment by mechanical feedback within the inner cell walls, not the outer epidermal wall, in guiding org

283 onclusions: A unique population of LAM(CORE) cells was identified in lung and uterus of patients with

284 ed on recent experimental results for single cells, we derive a minimal length scale for the patterns

285 B, T, and myeloid cells were analyzed before anti-CD20 administration and

286 Signaling pathways in cells were analyzed by immunoblots.

287 emory Th cells as well as regulatory T and B cells were increased.

288 Th17 cells were required to promote depressive-like behaviors

289 as the principal acid 5' exonuclease in HeLa cells, where it showed a markedly higher specific activi

290 highly plastic hybrid epithelial/mesenchymal cells, which display invasive features and alterations i

291 ion through FcepsilonRI on allergic effector cells, while IgE-ICs were noninflammatory because of red

292 duced features of ER stress in renal tubular cells with ATF3/ATF4 activation.

293 CD29 also marked T cells with cytotoxic gene expression from different tiss

294 es the activation of cell death to eliminate cells with defective genome.

295 d that ischemia induces addiction to NRF2 in cells with NRF2 alterations.

296 vel viral gene expression strategy to target cells with specific miRNA expression using miRNA-guided

297 CSCs) are a small subpopulation of quiescent cells with the potential to differentiate into tumor cel

298 ciate molecular differences among progenitor cells with their capacity to generate mature cell types.

299 In eukaryotic cells, with the exception of the specialized genomes of

300 -specific expression of GCaMP3 and imaged zG cells within their native rosette structure.