ライフサイエンスコーパス: cell biological

1 r polyglutamine-associated developmental and cell biological abnormalities, particularly those with e

2 ub-circuits of the GRN control five distinct cell biological activities, each part of the complex EMT

3 tream targets that participate in a range of cell biological activities.

4 inary insight into potential windows of stem cell biological activity and identified clinical assessm

5 Genetic, biochemical, and cell biological analyses demonstrate that the ECH/YIP4 c

6 Biochemical and cell biological analyses demonstrate these mutations inf

7 h that included structural, biochemical, and cell biological analyses revealed two distinct chemotype

8 tive band in prion-infected mice, subsequent cell biological analyses uncovered a surprisingly coordi

9 Cell biological analyses, genetics and chemical interfer

10 Using biochemical, molecular modeling and cell biological analyses, we have investigated the inter

11 Complementary proteomic and cell biological analysis demonstrate that the spindle ch

12 Biochemical and cell biological analysis indicate that the Zn1 and Zn2 d

13 Cell biological analysis indicates that MAP7 promotes br

14 hnical challenges associated with performing cell biological analysis of the delicate filopodial stru

15 Cell biological analysis revealed that ALIX and AMSH3 co

16 Here, using an array of biophysical, cell biological and behavioural assays we have character

17 Here, we use human and mouse genetics and cell biological and biochemical approaches to elucidate

18 In combination with other cell biological and biochemical approaches, a robust and

19 nowledge related to the genetic, epigenetic, cell biological and biochemical aspects of BDNF biology

20 A variety of cell biological and biochemical assays was employed to d

21 In this Review, we present the molecular, cell biological and biochemical bases of NLRP3 activatio

22 Our data reveal the cell biological and biochemical basis of the obligate re

23 Here we integrate optical tweezers with cell biological and biochemical methods to test the prev

24 By cell biological and biochemical methods, we demonstrate

25 Cell biological and biophysical experiments with primary

26 ep understanding of the viral mechanisms and cell biological and biophysical principles will continue

27 nin signaling mechanisms in beta cells using cell biological and electrophysiological approaches.

28 n described that confer a range of molecular cell biological and functional phenotypes.

29 Cell biological and genetic analyses of these SH3 partne

30 To address this question, we applied cell biological and genetic analyses to investigate guar

31 y of open and closed mitosis will complement cell biological and genetic approaches aimed at decipher

32 und accumulation-we applied a combination of cell biological and genetic approaches.

33 Cell biological and genetic evidence has implicated the

34 Fusarium graminearum was investigated using cell biological and genetic methods.

35 physical autonomy from the nucleus has both cell biological and genetic ramifications.

36 ordial germ cells), and their analysis using cell biological and genetic tools is straightforward.

37 Next, we cover the cell biological and molecular aspects of PIN function, i

38 Here, we have used biochemical, cell biological and molecular genetic approaches to demo

39 Here we use genetics, cell biological and pharmacological tools to demonstrate

40 Based on important cell-biological and biochemical results concerning the s

41 Cell-biological and molecular evidence is consistent wit

42 d employ Ca2+ imaging, electrophysiological, cell biological, and biochemical approaches to describe

43 regates based on morphological, biophysical, cell biological, and biochemical criteria, suggesting th

44 Based upon genetic, cell biological, and biochemical data, we propose that O

45 These results provide genetic, cell biological, and biochemical evidence that a princip

46 In sum, this study utilizes computational, cell biological, and biochemical methods to present a mo

47 Genetic, cell biological, and biochemical studies suggest that re

48 oach that includes biophysical, biochemical, cell biological, and bioinformatics methods to study the

49 Employing biochemical, cell biological, and biophysical approaches, we demonstr

50 ypes are not equivalent, and recent genetic, cell biological, and biophysical evidence suggests how t

51 In addition, we combine genetic, cell biological, and evolutionary perspectives so that w

52 Emerging studies of the structural, cell biological, and functional defects caused by rare m

53 Using multidisciplinary epidemiological, cell biological, and gene expression profiling approache

54 Using biochemical, cell biological, and genetic approaches we demonstrate t

55 By combining molecular, cell biological, and genetic approaches, we show that ST

56 Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein

57 Gene disruption, cell biological, and immunolocalization studies show tha

58 Based on a combination of biochemical, cell biological, and molecular dynamics simulation appro

59 Here, biochemical, cell biological, and organismal analysis was used to det

60 tional profiling, combined with biochemical, cell biological, and physiological phenotyping, identifi

61 ts in significantly different developmental, cell biological, and signaling phenotypes from those see

62 Here, we develop a cell biological approach to characterize the spatiotempo

63 Using a cell biological approach, we show that the two Streptomy

64 conundrum using genetic, physiological, and cell biological approaches and identified the operation

65 Using a combination of cell biological approaches and in vitro reconstitution o

66 rt outlook into how combined biophysical and cell biological approaches might lead to the identificat

67 Genetic, genomic, biochemical, and cell biological approaches possible in the powerful Sacc

68 omain, we used biophysical, biochemical, and cell biological approaches to examine the two major prod

69 At the same time, our aim has been to employ cell biological approaches to expand the fundamental und

70 tor Rfx2, we used bioinformatics and in vivo cell biological approaches to gain insights into the mol

71 We used genetic, physiological and cell biological approaches to show that reorganisation o

72 mutations, a combination of biophysical and cell biological approaches were applied to evaluate the

73 he central role of morphology comparisons in cell biological approaches, few statistical tools are av

74 erse genetics, complementation analyses, and cell biological approaches, we assessed the in vivo func

75 Using pharmacological and cell biological approaches, we demonstrate that IRAP lig

76 combination of transcriptomic, genomic, and cell biological approaches.

77 combination of structural, biochemical, and cell biological approaches.

78 Here, using cell-biological approaches, we have dissected basic prin

79 Although genetic and cell biological aspects have been elucidated, the molecu

80 ew findings provide fundamental insight into cell biological aspects of AQP2 function and may be rele

81 Cell biological assays in C. elegans neurons show that N

82 This system enables many types of cell biological assays that have been performed with imm

83 mining modalities alongside biochemical and cell biological assays to show that CX-5461 exerts its p

84 By combining cell biological assays with cross-linking mass spectrome

85 characterized by a range of biochemical and cell biological assays, including a novel high-throughpu

86 In cell biological assays, the actin cross-linking domain (

87 bined this with biochemical measurements and cell biological assays.

88 ated by flow cytometry analysis and in vitro cell biological assays.

89 Recent advances highlight important cell biological atherogenic processes, including mechano

90 ey inherited developmental, biochemical, and cell biological attributes.

91 The cell biological basis for the formation of rods is well

92 Taken together, our results provide a cell biological basis for the role of PKCtheta clusterin

93 Our findings provide a biochemical and cell biological basis for the understanding of the patho

94 tion in some cases, though the mechanism and cell biological basis for this requirement remain unknow

95 y mammalian embryos, although the underlying cell biological basis is still incompletely understood.

96 They also provide a cell biological basis of centromere drive and karyotype

97 ganglion cells as a model to investigate the cell biological basis of radial migration and the conseq

98 ues has enabled investigators to explore the cell biological basis of the inhibitory response.

99 CD133 has been linked on a cell biological basis to stem cell-fate decisions in hum

100 ar basis of XIAP in the regulation of cancer cell biological behavior remains largely unknown.

101 however, it is also involved in other cancer cell biological behavior.

102 Here, we use cell biological, biochemical, and computational techniqu

103 We show using cell biological, biochemical, and genetic analyses that

104 consequences of these mutations by genetic, cell biological, biochemical, and spectroscopic approach

105 CRISPRi/a-based chemical-genetic screens and cell biological, biochemical, and structural assays to d

106 and use of a wealth of experimental data in cell biological calculations.

107 t of HER2 overexpression on disease-relevant cell biological changes in these BC.

108 esfahr, and Wickstrom illustrate the complex cell biological changes observed in cells of patients wi

109 ment, offering a link between structural and cell biological characterisation.

110 t supergroups lack defining morphological or cell-biological characteristics, making the supergroup l

111 Here, we report the biochemical and cell biological characterization of the rest of the yeas

112 However, the range of substrates and cell biological consequences of AMPylation remain poorly

113 r bending membranes are evident in different cell biological contexts across eukaryotic phyla.

114 ta has been documented in various tissue and cell biological contexts, yet the underlying mechanisms

115 ates that toxicity arises only in particular cell biological contexts.

116 e and determine microtubule orientation, the cell biological correlate of neurite polarization.

117 In this review, we focus on the cell biological course of autophagy in neurons, from bio

118 Here, we integrate genetic, structural, and cell biological data into an updated overview of yeast s

119 Complementary biochemical and cell biological data refine and consolidate the interact

120 Although a vast body of genetic and cell biological data regarding Mlh1-Mlh3 is available, m

121 llectively, our structural, biochemical, and cell biological data suggest that multiple anillin-actin

122 Genetic, biochemical, and cell biological data suggest that UCN suppresses ectopic

123 This study presents biochemical and cell biological data that further elucidate the mechanis

124 hatase oxidation in signal transduction, the cell biological details of reactive oxygen species-catal

125 ious entry process of MCPyV, we analyzed the cell biological determinants of MCPyV entry into A549 ce

126 man stem cells can also drive biomedical and cell biological discoveries in a human model system, whi

127 verload, diabetes mellitus, and obesity, the cell biological effectors mediating ECM remodeling are p

128 gnitive experience importantly regulates the cell biological effects of HDACi administration, however

129 in disease pathogenesis, we investigated the cell biological effects of increased TMEM106B expression

130 COSAN elicits a range of cell biological effects, including altered cell morpholo

131 thogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, t

132 ocess that requires the coordination of many cell biological events.

133 se platelets through a series of fascinating cell biological events.

134 We provide genetic and cell biological evidence for the role of ADP-ribosylatio

135 Genetics and cell biological evidence indicate that ZapD requires Fts

136 Genetic, biochemical, and cell biological evidence suggests that MYB2 functions as

137 Here we provide biochemical, genetic, and cell biological evidence that the microtubule-bundling p

138 hat have been discovered through genetic and cell biological examination of this pathway.

139 Genetic and cell biological experiments indicate a critical role of

140 Biochemical and cell biological experiments revealed that trehalose alte

141 of tractable transformed T cell systems for cell biological experiments that may not correctly repre

142 he data for this model come from genetic and cell biological experiments.

143 ct motility parameters from a diverse set of cell-biological experiments in an automated and user-fri

144 associated disorders are unified by a common cell biological feature: the deposition of the culprit p

145 r, the resulting neurogenic progenitors show cell biological features different from multipotent prog

146 This study reveals novel cell biological features that may contribute to the mech

147 models, we are still learning much about the cell biological features that regulate melanogenesis, me

148 mportant pathogens and symbionts with unique cell biological features.

149 e be a thorough understanding of the general cell biological function of inclusions and their potenti

150 ngs indicate that gamma-RIMs are involved in cell biological functions distinct from the regulation o

151 To better apprehend gamma/delta T cell biological functions in the periphery, it appears c

152 T cells use the endocytic pathway for key cell biological functions, including receptor turnover a

153 roteins tasked with the execution of crucial cell biological functions.

154 ole of GOLPH3 in N-glycosylation to regulate cell biological functions.

155 ulated genes that can be related to specific cell biological functions.

156 e targets and then correlated these with the cell biological impact.

157 binds to and destabilizes microtubules using cell biological, in vitro, and structural approaches.

158 is of coupled variables is a core concept of cell biological inference, with co-localization of two m

159 What is the minimal set of cell-biological ingredients needed to generate a Golgi a

160 Therefore, to gain genetic and cell biological insight into FXTAS, we examined the effe

161 Two recent studies provide important cell biological insights into the subcellular sites of N

162 generated large datasets, contributing many cell biological insights.

163 ew, we propose that as a result of the tight cell biological interconnection of axons and myelin, dam

164 rabbit an excellent model for gene therapy, cell biological intervention, progenitor cell transplant

165 of the ontology to the continuously growing cell biological knowledge.

166 ains physiological operation within inherent cell biological limitations.

167 The early cell biological literature is the resting place of false

168 cells that are adapted to the use of certain cell biological machinery, but also of highlighting the

169 compartments makes the use of decentralized cell biological machines necessary.

170 ed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials.

171 tructure of the mitotic spindle, providing a cell biological mechanism for its aneugenic activity, an

172 To elucidate the molecular and cell biological mechanism for trans-enhancement, we perf

173 This cell-biological mechanism may mediate such cell transiti

174 y regulation of axonal mitochondria as a new cell-biological mechanism that helps determine the regen

175 rent vulnerabilities to OGD recruit distinct cell biological mechanisms in response to insult, and th

176 tional decay during aging in humans, but the cell biological mechanisms responsible for this process

177 rent understanding of developmental cues and cell biological mechanisms that establish polarity in ne

178 Genetic and cell biological mechanisms that regulate stomatal develo

179 * Genetic and cell biological mechanisms that regulate stomatal develo

180 Membrane trafficking is key to the cell biological mechanisms underlying development.

181 Several studies have identified cell biological mechanisms underlying extrusion of cells

182 Cell-biological mechanisms mediating delamination are, h

183 f clot formation are well characterized, the cell-biological mechanisms of platelet recruitment to in

184 Given the impressive developments in cell biological methodologies at the structural and func

185 ce of genetic, biochemical, biophysical, and cell biological methods has uncovered several fundamenta

186 We have used various biochemical and cell biological methods to study the dynamics of clamp a

187 Based on these and previous cell biological observations, we suggest that Pch2 impac

188 ut my scientific journey to the synapse, the cell biological one, but also a metaphorical synapse-my

189 Autophagy is a cell biological pathway affecting immune responses.

190 not only increases our appreciation of basic cell biological pathways but also may lead to more effec

191 d our understanding of the developmental and cell biological pathways that contribute to palate closu

192 processes that play important roles in many cell biological pathways, including intracellular transp

193 Despite distinct patterns of biochemical and cell-biological perturbations, V60L and I90M each attenu

194 this Perspective, I provide a broad view of cell biological phenomena in bacteria, the technical cha

195 in vitro and in vivo study of these classic cell biological phenomena.

196 a lack internal organization and interesting cell biological phenomena.

197 cellular components and of cell volume, is a cell biological phenomenon experienced by many unicellul

198 In this review, we discuss the cell biological principles of endosomal trafficking, the

199 The cell biological principles that govern innate immune res

200 ng with the clonable SNAP tag, a widely used cell biological probe to visualize fusion proteins by fl

201 le reaction may be useful for creating novel cell biological probes, diagnostics, or therapeutics tha

202 e-organizing center, as an early step in the cell biological process underlying NK cell cytotoxicity.

203 Autophagy is a fundamental cell biological process whereby eukaryotic cells form me

204 tributions of Innexins and microtubules to a cell-biological process important in development and can

205 es represent the end products of a multistep cell-biological process termed the invasion-metastasis c

206 Metastasis is a multistep cell-biological process, which is orchestrated by many f

207 ecent studies have advanced our views of the cell biological processes and crucial proteins that driv

208 sis can be used to deconvolve highly complex cell biological processes and identify new biochemical p

209 ontraction in nonmuscle cells underlies many cell biological processes and is based on contractility

210 ay, overt or covert mechanical forces govern cell biological processes and produce sensations.

211 ghlighting parallels to the control of other cell biological processes by biomolecular condensates th

212 ndance can profoundly limit the precision of cell biological processes from secretion to metabolism.

213 uman evolution has impacted even fundamental cell biological processes generally assumed to be highly

214 w the protocol can be adapted to study other cell biological processes in aging neurons.

215 evel programs of gene expression to discrete cell biological processes in vivo remain poorly understo

216 They are involved in key cell biological processes including vesicle trafficking,

217 transcription factors participate in myriad cell biological processes including: the cell cycle, DNA

218 Our understanding of cell biological processes involved in regulating aging h

219 ighlighting examples wherein the fundamental cell biological processes of protein synthesis and degra

220 of the cancers by altering the molecular and cell biological processes of the cells.

221 Several cell biological processes play a role in the regulation

222 are fundamentally important for a variety of cell biological processes ranging from cytoskeletal dyna

223 ,5)P2 production may be coupled to important cell biological processes such as membrane trafficking o

224 that have previously shed light on critical cell biological processes that are perturbed by single-g

225 SRC and ERK kinases control many cell biological processes that promote tumorigenesis by

226 aradigm for understanding genomic control of cell biological processes that span from early cell morp

227 made towards understanding how the distinct cell biological processes that together drive apical con

228 usion is essential in a myriad of eukaryotic cell biological processes, including the synaptic transm

229 one of the preferred metazoans for studying cell biological processes, such as ERAD.

230 orylation of Cdk targets involved in several cell biological processes.

231 coordinate the timing and execution of these cell biological processes.

232 ans to discover small molecules that perturb cell biological processes.

233 rstood, despite its clear importance in many cell biological processes.

234 ms by which motors contribute to fundamental cell biological processes.

235 imulation technique to provide insights into cell biological processes.

236 that regulate and execute developmental and cell biological processes.

237 ns that play important roles in a variety of cell biological processes.

238 tools may transform our view of fundamental cell biological processes.

239 advances made specifically in the following cell biological processes: (1) cytoskeletal-related proc

240 our current understanding of the underlying cell-biological processes in the Golgi.

241 thelial-to-mesenchymal transition (EMT) is a cell biological program that confers mesenchymal traits

242 e compared the biochemical, biophysical, and cell biological properties of C. albicans SOD4 and SOD5.

243 basis for this observation, we examined the cell biological properties of sacsin.

244 he Hippo pathway is regulated by fundamental cell biological properties, such as polarity and adhesio

245 re invisible to contemporary haploid-centric cell biological, proteomic, and functional genomics appr

246 lated relative to cell size is a fundamental cell biological question.

247 w nuclear size is regulated is a fundamental cell-biological question with relevance to cancers, whic

248 used computational approaches for exploring cell biological questions and provide a framework for de

249 hodology that can be applied to a variety of cell biological questions or used within a clinical sett

250 spectrometry-based lipidomics in addressing cell biological questions.

251 olution investigations of a broad variety of cell biological questions.

252 utational models for application to specific cell biological questions.

253 scopy ultrastructure, which can help address cell biological questions.

254 exchange, selective ion exchange, and whole-cell biological reduction) and emerging (catalysis) perc

255 lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions

256 microscopy, has become an important tool in cell biological research.

257 ted to find applications in diverse areas of cell biological research.

258 pplications of biochemical, biophysical, and cell biological research.

259 th applications in nutritional, medical, and cell-biological research.

260 strate, for the first time, that neural stem cell biological responses to laminin are dependent on to

261 mes have long been proposed to play multiple cell biological roles in cancer.

262 s within the body, extending its function to cell biological roles such as mediating cellular recepto

263 ng a series of mutants to examine Abl's many cell biological roles.

264 nd diagnostic platform for identification of cell biological signatures specific for the LRRK2 G2019S

265 last decade has enabled researchers to image cell biological structures at unprecedented resolution.

266 Mitotic chromosomes were one of the first cell biological structures to be described, yet their mo

267 ries, an activity that has been suggested by cell biological studies but had not been directly measur

268 Cell biological studies confirmed OCTN1-mediated transpo

269 Genetic and cell biological studies have revealed that mechanisms un

270 A recent series of genetic and cell biological studies have shed light on the question-

271 Cell biological studies have shown that even though KTN1

272 Cell biological studies in mouse and rat neurons have sh

273 d N-terminal RXLR motif, has meant that most cell biological studies into Phytophthora diseases have

274 Biochemical and cell biological studies of how bacteria and other microo

275 opy (cryo-EM), biophysical, biochemical, and cell biological studies of the interaction between the C

276 Mutant TIA1 was characterized by cell biological studies on HeLa cells, including quantif

277 Genetic and cell biological studies over almost 2 decades have revea

278 In the case of cilia and flagella, multiple cell biological studies show that microtubule diversity

279 rmatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa

280 ide range of bioanalytical, biophysical, and cell biological studies where individual DNA strands are

281 We performed both clinical and cell biological studies, aimed at clarifying rotatin fun

282 key findings from previous mouse genetic and cell biological studies, we suggest a cytoskeleton-based

283 f both cell types has hampered molecular and cell biological studies, which often require large quant

284 r pathway that may be of interest for future cell biological studies.

285 ther proteins with genetic, biochemical, and cell biological studies.

286 d model for developmental, physiological and cell biological studies.

287 Biochemical, molecular, and cell-biological studies reveal that PITPNC1 promotes mal

288 sors for a variety of applications including cell-biological studies, substance detection, and diseas

289 ticipation of TBK1 in a myriad of additional cell biological systems in normal and pathophysiologic c

290 ve and chemically characterize molecular and cell biological systems under physiological conditions.

291 ng and elucidating the complex mechanisms of cell biological systems.

292 oscopy, single-molecule assays, genetic, and cell biological techniques to show that autoinhibition i

293 with electrophysiological, biochemical, and cell biological techniques, to identify a clinically rel

294 gation of cytoneme regulation using standard cell biological techniques.

295 comprehensive synthesis of evolutionary and cell-biological thinking is lacking.

296 d C3H mice using proteomic, biochemical, and cell biological tools.

297 genetic basis of differences in fundamental cell biological traits, such as organelle size.

298 ttings facilitates an accurate evaluation of cell biological variability.

299 tumor-suppressor inactivation and reveals a cell-biological vulnerability for TNBCs lacking therapeu

300 Biochemical and cell biological work indicated that SPRTN is a nonspecif