ライフサイエンスコーパス: cell cluster

1 hen sink under the surface to form a compact cell cluster.

2 regulation of dendritic cell/natural killer cell cluster.

3 or and interfacial deflection in a simulated cell cluster.

4 a lack of directional movement by the border cell cluster.

5 evation in a CXCR5/CCR6(high) transitional B-cell cluster.

6 y heterogeneous ILC1, ILC3, and NK precursor cell cluster.

7 duced from human embryonic cell-derived beta-cell clusters.

8 e text] T cells from infiltrating into tumor cell clusters.

9 served only when NP cells form CDH2 positive cell clusters.

10 loss of CDH2 expression and ability to form cell clusters.

11 reductions in the frequency of these AMY(-) cell clusters.

12 induced changes in the proportions of some B cell clusters.

13 ctable in most chondrocytes, particularly in cell clusters.

14 bronectin matrix disruption and dispersal of cell clusters.

15 nfined spaces such as the medium surrounding cell clusters.

16 ution, the dynamics of force transmission in cell clusters.

17 y mapping glaucoma-relevant genes to outflow cell clusters.

18 actions determine the emergent properties of cell clusters.

19 ng of cell functions in isolated and grouped cell clusters.

20 y and reliably to formation of proliferating cell clusters.

21 ible, and ordered envelopes that encased the cell clusters.

22 ng both types of data to accurately identify cell clusters.

23 mipara but with a greater propensity to form cell clusters.

24 3 proteins were strongly expressed in the OA cell clusters.

25 the failure to detect viral genomes in the T-cell clusters.

26 ue to the emergence of periportal islet-like cell clusters.

27 rns in cell cycle activity within epithelial cell clusters.

28 ization algorithms produce a fixed number of cell clusters.

29 show that GiniClust3 could robustly identify cell clusters.

30 ration and metastasis of multicellular tumor cell clusters.

31 D1), suggesting these were proliferative FLC cell clusters.

32 by a loss of cell-cell contacts within tumor cell clusters.

33 evels of eDNA and a concomitant reduction in cell clustering.

34 ulations, like confluent cell monolayers and cell clustering.

35 taining, imaging noise, cell morphology, and cell clustering.

36 core-Vangl2 PCP axis to control mesenchymal cell clustering.

37 tasets, where it also improves resolution of cell clustering.

38 ng-controlled phenotypes as a consequence of cell clustering.

39 coinhibitory receptor expression in the Tc17 cell clusters, a comparison of these cells with melanoma

40 ies are concentrated in the A1 and caudal C1 cell cluster (A1/C1) in the ventrolateral medulla, a reg

41 ltifocal aberrant crypt-containing endocrine cell clusters (ACECs) that contain crypt EC cell microtu

42 We directly observed multicolored tumor cell clusters across major stages of metastasis, includi

43 velopment in culture, also forms embryogenic cell clusters after TSA treatment.

44 ility of pharmacological interventions on 3D cell clusters against both suspension cells and adherent

45 ly score gene expression profiles of unknown cell clusters against mouse or human references, or a cu

46 Here, we describe scHiCluster, a single-cell clustering algorithm for Hi-C contact matrices that

47 mainly expressed by the vascular endothelial cell cluster almost exclusively in DFU, indicating a pot

48 The directed migration of the cell cluster along the path of Sdf1a chemokine requires

49 innata sequestered Se in localized epidermal cell clusters along leaf margins and tips, concentrated

50 To survive, cancer cells cluster amplified extra centrosomes and achieve ps

51 novel subtypes, pseudo-temporal ordering of cells, clustering analysis, etc.

52 blishes a boundary between the motile border cell cluster and its non-invasive epithelial neighbors t

53 its in calcium-dependent N-cadherin-mediated cell clustering and cell-substratum adhesion, and primar

54 t in AML cell lines facilitated T cell-tumor cell clustering and enhanced CD3 bsAb-mediated AML cell

55 s of the original expression matrix, and for cell clustering and lineage reconstruction in terms of t

56 litate many downstream analyses that include cell clustering and lineage reconstruction.

57 senchymal PCP induced by Hh signaling drives cell clustering and subsequent epithelial remodeling.

58 lets compared with sub-islet-sized endocrine cell clusters and among pancreatic lobes.

59 horizontal cells reveals novel morphological cell clusters and axonal maturation patterns.

60 y also showed upregulation of VLA-4-positive cell clusters and BMD cells at the metastatic sites, pro

61 urately predict the identity of a variety of cell clusters and can be used in various experimental co

62 mo retinal organoids identified cone and rod cell clusters and confirmed the cone enrichment initiall

63 ranscriptome, we identified five distinct NK cell clusters and define their relative developmental ma

64 nrich can assign tissue identities to single cell clusters and differentiated embryonic stem cells.

65 central nervous system reduced pathogenic B cell clusters and disease severity.

66 hymal transition (EMT) enables scattering of cell clusters and disseminates motile cells to distant l

67 direct contact of mouse submandibular (mSMG) cell clusters and hHF-MSCs was not required for mSMG cel

68 quencing analysis showed multiple fibroblast cell clusters and increased inflammation in the dorsal s

69 Silencing hnRNP A2/B1 induced formation of cell clusters and increased proliferation.

70 particle-based simulation model for adhesive cell clusters and monolayers.

71 pressure that leads to clonality of these B-cell clusters and opens the possibility that infection a

72 e provides a purification step by entrapping cell clusters and other impurities within its fibers.

73 1+ embryonic precursors also results in stem cell clusters and paracrine tumours.

74 he graph enables identification of recurrent cell clusters and propagation of information between dat

75 n, PanoView will identify the most confident cell clusters and repeat the clustering with the remaini

76 hen moving in from the boundary of the tumor cell clusters and then rises again when approaching the

77 the superior raphe, an intermediate 5-HT-ir cell cluster, and an extensive inferior raphe population

78 ced proplatelet formation from cultured MKs, cell clustering, and abnormal cortical filamentous actin

79 ils preceded the accumulation of meningeal B cell clusters, and inhibition of CXCR2-mediated granuloc

80 carotenoid-enriched oil, chromoplasts, small cell clusters, and large cell clusters) were isolated fr

81 lly disseminated clusters, circulating tumor cell clusters, and lung micrometastases frequently expre

82 ion, intravascular emboli, circulating tumor cell clusters, and micrometastases.

83 nd glycosaminoglycan-expressing interstitial cell clusters, and prevalent ECM gene expression.

84 cell transport studies, guided formation of cell clusters, and tissue engineering.

85 Recently, aldosterone-producing cell clusters (APCCs) with high expression of aldosteron

86 Merkel cell clusters appear to have direct access to Fz6-based

87 e of the age of the donor hepatocytes, large cell clusters appeared in juvenile, but only small clust

88 Current approaches for single cell clustering are often sensitive to the input paramet

89 At P30, four interstitial cell clusters are apparent with leaflet specificity and

90 that preserve their integrity, and even two-cell clusters are captured efficiently.

91 ng metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clusterin

92 The B-cell clusters are in close proximity to peripheral node

93 01), whereas the total aldosterone-producing cell cluster area was positively correlated with age (r=

94 In addition, CXCR3 is also necessary for T cell clustering around APCs and T cell bystander activat

95 We present the Single-Cell Clustering Assessment Framework, a method for the a

96 sa cells, our analyses identified 5 distinct cell clusters associated with germ cells and 6 with gran

97 In general, CD8 T-cell clusters associated with poorly controlled HCMV vir

98 A cell cluster at the anterior tip of planarian head blast

99 -cell compartment (CD3CD19) revealed 2 CD4 T-cell clusters at higher frequency among those with SLD (

100 or-intact BXD2 mouse spleens, MZ precursor B cells clustered at the T cell-B cell border.

101 can be coloured by different features or by cell clusters based on gene expression.

102 chemoattractant gradients, the speed of the cell cluster becomes non-monotonic in the cluster's size

103 scle-induced physical forces and mesenchymal cell clustering beneath emerging villi are implicated in

104 rms the existing methods for integrating the cell clusters between scRNA-seq and scATAC-seq.

105 or Cas function retinal neurons form ectopic cell clusters beyond the inner-limiting membrane (ILM),

106 led to the formation of warty lesions, with cell clusters bulging from the epidermal layer, and some

107 cell flexibility values, can align and form cell clusters but only when periodic reversals of cell d

108 ution of integrin CD49d to the periphery and cell clustering, but inhibited ERK(1/2) activation and e

109 we have focused on recapitulating endocrine cell clustering by isolating and reaggregating immature

110 n the other hand, manually annotating single cell clusters by examining the expression of marker gene

111 of RNA-modifying enzymes in a given neuronal cell cluster can be characterized and simultaneously cor

112 affected, transcriptional profile of several cell clusters changed.

113 strongly responding cell is at one end of a cell cluster, cluster motion is biased toward that cell.

114 The time-activity curves for tumor cell clusters, comprising fewer than 10 cells, were deri

115 Hox gene expression, features three lateral cell clusters connected to ducts.

116 We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy

117 Circulating tumor cell clusters (CTC clusters) are potent initiators of me

118 Circulating tumor cell clusters (CTC clusters) are present in the blood of

119 tected, whereas neither were observed within cell clusters (CTM), implicating both protection from an

120 Dynamic regulation of cell clustering depends on the balance between contracti

121 In vivo, expanding cell clusters derived from transplanted FLSPCs had lower

122 B-cell clusters develop late after infection.

123 lowing the initial influx of immune cells, T cell clusters develop, accelerating the pathology in the

124 ALDH(+)/CD49f(+)/EpCAM(+) tumor and normal cells clustered differently compared with unselected tum

125 e that proliferating keratinocyte epithelial cell clusters display waves of oscillatory extracellular

126 ish the concept that K14(+) epithelial tumor cell clusters disseminate collectively to colonize dista

127 al where PGCs arise as paired endomesodermal cell clusters during early development.

128 At this leaflet/annulus junction, CD44(+) cells clustered during elongation (11 weeks), extending

129 We found cell clusters embedded in the 3D ECM can exert translati

130 hile not readily apparent at birth, discrete cell clusters emerge over the first postnatal week, yiel

131 We found that ICAM-1-mediated cell clustering enabled CD8(+) T cells to collectively r

132 bit the T cell-dendritic cell contacts and T cell clustering essential for sustained T cell activatio

133 pression and increased aldosterone-producing cell cluster expression.

134 To survive, cancer cells cluster extra centrosomes during mitosis, avoiding

135 le NP matrix synthesis patterns by promoting cell clustering for controlled microenvironment conditio

136 rnating direction method of multipliers with cell clustering for DGRN reconstruction.

137 minin 1 (L1) is critical for intact salivary cell cluster formation and organization.

138 A combination of cell cluster formation and subsequent cross-linking with

139 lthough all MWCNT-alginates lead to enhanced cell cluster formation compared to alginate alone.

140 gated to fibrin hydrogel (L(1p)M-FH) promote cell cluster formation in vitro and salivary gland regen

141 into SCID mice resulted in a homogenous germ cell cluster formation in vivo.

142 Consistently, cell cluster formation per unit area on 5 mum wide line

143 Prior to cell division, CD8 T cell-dendritic cell clusters formed in the spleen after live L. monocyt

144 er 7 days, the PECs formed self-regenerating cell clusters, forming villi that resemble intestinal ep

145 ration: (1) initial detachment of the border cell cluster from the follicular epithelium and (2) the

146 s about 7 h to identify both common and rare cell clusters from a dataset that contains more than one

147 subtractive process involving the release of cell clusters from a thick, unstructured biofilm.

148 Tumor cell clusters from basal-like 2, but not mesenchymal-lik

149 Here we report that switching preformed cell clusters from procontractile to promigratory cultur

150 Analysis of cell clusters from single NG2 cells revealed that more t

151 lude regular distributions of cells, dynamic cell clusters, gel-like networks, collectively migrating

152 The current solutions for annotating single cell clusters generally lack a graphical user interface,

153 ehaviours that contribute to alveologenesis: cell clustering, hollowing and cell extension.

154 Neonatal islet cell clusters (ICCs) from INSLEA29Y transgenic (LEA-tg)

155 Here, we report single-cell clustering, immune phenotyping, and risk gene analy

156 usion protein resulted in enhanced in vivo T cell clustering in draining lymph nodes and IL-2 product

157 photon imaging reveals enhanced hue-specific cell clustering in V2 compared with V1.

158 bed endocrine cell differentiation and islet cell clustering in VEGF-A overexpressing embryos.

159 hat exhibited extensive individual cells and cell clusters in a perivascular and subpial cellular inf

160 controls directed cell protrusions of border cell clusters in a Scar-dependent manner.

161 d provides accurate predictions for multiple cell clusters in a scRNAseq experiment involving tumor-i

162 scRNAseq data analysis by annotating unknown cell clusters in an objective and efficient manner.

163 While alpha and beta cells formed islet cell clusters in control embryos at E16.5, the increased

164 atrix platform to culture mammary epithelial cell clusters in ECMs of tunable stiffness and confineme

165 We identified larger B-cell clusters in epicardial AT of human patients with co

166 yte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chr

167 nd that this cell population surrounds tumor cell clusters in M-LN.

168 rogenous population of lymphatic endothelial cell clusters in mouse and human embryonic kidneys.

169 re, we investigate the role of CDH2 positive cell clusters in preserving healthy, biosynthetically ac

170 d with the occurrence of abnormal basal/stem cell clusters in prostate epithelium of prostate-specifi

171 ove the quality and efficiency of annotating cell clusters in scRNAseq data, we present a web-based R

172 is the presence of a germinal center like B-cell clusters in the allograft.

173 ed for the extraction of RNA from individual cell clusters in the central nervous system of the marin

174 , we observed the rapid formation of large B cell clusters in the spinal cord subarachnoid space.

175 pread infection of individual cells or small cell clusters in the subepithelial lamina propria of mon

176 in, and reside in N-cadherin (CDH2) positive cell clusters in vivo.

177 HIV RNA(+) cells clustered in cerebellum tissue but were dispersed

178 for the first time that infiltrating myeloid cells clustered in damaged areas of dystrophic skeletal

179 Single-cell RNA sequencing identified 16 cell clusters, including gastrodermal cells and cnidocyt

180 We identified 22 CD4(+) T cell clusters, including naive-like, regulatory-like and

181 ease from PC12 cell clusters is presented at cell clusters incubated with the dopamine precursor and

182 agent, L-3,4-dihydroxyphenylalanine, and at cell clusters incubated with the vesicular monoamine tra

183 gle oocytes are lineage-labeled, rather than cell clusters indicative of new oocyte formation.

184 Notably, endocrine cell clustering induces metabolic maturation by driving

185 varian tumors involves the invasion of tumor cell clusters into the mesothelial cell lining of perito

186 ividually infected cells and show that these cells cluster into transcriptionally distinct sub-popula

187 Based on STRF shape, cells clustered into functional groups that divided the

188 The cells clustered into populations of alpha-cells (5%), be

189 Germ cells clustered into six meiotic substages, as well as d

190 PVL cells clustered into two states consistent with a differ

191 Insulin-producing cell clusters (IPCCs) have recently been generated in vi

192 The GABA-sensitive cell cluster is centered on a tegmental (reticular) fiel

193 Here we show that the border cell cluster is compact and round throughout their entir

194 a P2RY8 orthologue, we show that mouse GC B cell clustering is also dependent on FDCs acting to supp

195 Cell clustering is one of the most common routines in si

196 Formation of cell clusters is a common morphogenic cell behavior obse

197 ng to demonstrate that polyclonal seeding by cell clusters is a frequent mechanism in a common mouse

198 data, annotating the biological identity of cell clusters is an important step before downstream ana

199 ing demonstrate that the drug effect on PC12 cell clusters is consistent with previous single-cell ex

200 The integrity of cell clusters is dictated by cell-cell junctions, which

201 single vesicle exocytotic release from PC12 cell clusters is presented at cell clusters incubated wi

202 , we examine how the integrity of epithelial cell clusters is regulated by subcellular forces, protru

203 measuring and sorting particles, cells, and cell-clusters, is a potential solution to this bottlenec

204 lso suppressed in ex vivo cultures of acinar cell clusters isolated from mouse pancreas bearing targe

205 Taking bam/sam files and cell cluster labels as inputs, scDAPA detects APA dynami

206 At the cell cluster level, low intensities of thermal processin

207 onitors TCR signal strength indicates that T cell clustering limits T cell exposure to Ag during acti

208 A majority of these AMY(-) cell clusters localized proximal to islets (i.e., peri-i

209 earlier phenotype observed was that the two cell clusters lose direction and converge at the midline

210 that the sum of forces generated by multiple cell clusters may result in macroscopic deformation.

211 regulates the growth and morphology of these cell clusters; MCAs grow larger and faster in the more r

212 neurons with cell bodies in the moth medial cell cluster (mcPNs) predominantly have dendritic arbori

213 n neurons with cell bodies in the AL lateral cell cluster (MGC lcPNs) of two closely related moth spe

214 ing in enlarged and densely packed bacterial cell-clusters (microcolonies).

215 This result suggests that circulating tumor cell clusters might be able to better survive chemothera

216 Within these cell clusters, motor neurons receive afferent input and

217 VNC in the avian model, revealing three VNC cell clusters (neural, neurogenic and mesenchymal), each

218 dominant tolerance to porcine neonatal islet cell cluster (NICC) xenografts in mice.

219 roperties of the ECM to predict the state of cell clusters of defined shapes and sizes.

220 uce invasion of either single cells or small cell clusters of N-type cells.

221 sential for induction of dermal condensates, cell clusters of precursors for the hair follicle dermal

222 o pancreas, with formation of many endocrine cell clusters of the type found in normal islets of Lang

223 Bacteria cooperated by aggregating in cell clusters of ~10 to 20 um, in which cells were able

224 ages resulted in increased priming of OT-I T cells [cluster of differentiation 8-positive (CD8(+))] b

225 ree distinct levels of spatial organization: cells, clusters of cells, and collections of clusters.

226 7 markers, we characterized 293 nasal immune cell clusters, of which 7 were associated with Spn colon

227 blasts functioned as a nucleation center for cell clustering on three-dimensional collagen matrices.

228 in-resistant clones were identified as green cell clusters on a spectinomycin medium.

229 oduced by multiple isolated cells as well as cell clusters on soft substrates.

230 ors at an intermediate, mesoscopic, level of cell clusters or domains.

231 Abnormal cell clusters or heterotopias were detected in the margi

232 chick embryonic ventricular CM (3.5 x 10(4) cell clusters per cell chamber) were cultured for 4 days

233 In summary, replicating aspects of endocrine cell clustering permits the generation of stem-cell-deri

234 p)T-FH induced similar levels of acinar-like cell clustering, polarization, lumen formation, and calc

235 -photon microscopy revealed that recipient T cells cluster predominantly around lung-resident, donor-

236 that there is no spatial structure, such as cell clustering, present.

237 We show that tumor cell clusters produce the growth factor epigen and conce

238 Furthermore, T cell clustering promotes the upregulation of the CTLA-4

239 mechanism underlying this synergy within NK cell clusters remains unclear.

240 c map of the visual field, in which adjacent cell clusters represent adjacent points of visual space.

241 is realized by individual cells, rather than cell clusters, representing an alternative to the lobula

242 These results suggest that T cell clustering represents a mechanism that allows conti

243 re, Durdu et al. (2014) show that epithelial cell clusters secrete FGFs into a microlumen, restrictin

244 Hence, cell cluster size can be larger than substrate thickness

245 ities, donor-to-recipient ratios and initial cell cluster size, and are therefore flawed as universal

246 any morphogenetic behaviors, which depend on cell cluster size.

247 fails and cells proliferate to intermediate cell cluster sizes.

248 We argue that the cell cluster speed is a crucial readout of how the clust

249 Maintenance of mitotic cell clusters such as meristematic cells depends on thei

250 ntify a collective signal generated by tumor cell clusters supporting metastatic colonization.

251 isingly, confinement induces EMT even in the cell clusters surrounded by a soft matrix, which otherwi

252 Encapsulated human islet-like cell clusters survived, replicated, and acquired a level

253 tegy for the mechanical stimulation of large cell clusters, taking advantage of dielectrophoresis.

254 methodology is complimentary to other single cell clustering techniques and adds to a growing palette

255 er 5 identifies a transcriptomically-defined cell cluster that contained VENs, but also fork cells an

256 We identified neurons of this cell cluster that suppress mating, but not feeding behav

257 c rejection is the infiltration of ectopic B-cell clusters that are clonal into the transplanted kidn

258 loid parental strain led to slow-sedimenting cell clusters that consisted of just a few cells, thus r

259 erate within distinct islands, forming large cell clusters that eventually fuse during metamorphosis

260 duced here to explicitly detect and quantify cell clusters that move coordinately in a monolayer.

261 Our data revealed three major cell clusters that represent the epimastigote, and pre-

262 We show that biologically meaningful cell clusters that were manually identified in previousl

263 ulation of Myo-II activity within the border cell cluster through localized inhibition of myosin phos

264 By imaging HEK-293 cell clusters through 4.5 mm thick ex vivo rat brain tis

265 of [Formula: see text] T cells around tumor cell clusters (tightly connected tumor cells) in the cor

266 he integrated ratio of aldosterone-producing cell cluster to CYP11B2-expressing area was most strongl

267 on at the outer edge of the migrating border cell cluster to resist compressive forces from nurse cel

268 f ADAM15 isoforms in MDA-MB-231 cells led to cell clustering to varying degree, without changes in EM

269 o account in a systematic way when assigning cell clusters to cell types.

270 the colonies where newly divided (smallest) cells cluster together in patches, separated from larger

271 ure selection, batch correction, imputation, cell clustering, trajectory/pseudotime analysis, and net

272 t migratory forces is sufficient to disperse cell clusters under physiological settings and present a

273 Consequently, velocity of border cell clusters undergoing guided migration was reduced in

274 We present single-cell clustering using bifurcation analysis (SCUBA), a no

275 nd contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model (CPM) in a

276 ation growth, such as the formation of tight cell clusters versus dispersed colonies, alter the effic

277 and primordial germ cells, Drosophila border cell clusters, vertebrate neural crest migration and ang

278 ial distribution of hyperexcitable pyramidal cells (clustered vs uniform), and firing patterns (weakl

279 Formation of B cell clusters was assessed using immunohistochemistry.

280 Furthermore, intravasation of cancer cell clusters was observed following the formation of a

281 to spontaneously-forming adherent epithelial cell clusters, we found that basal force fluctuations we

282 found the top enriched pathways in the CK5+ cell cluster were cell junction remodeling and signaling

283 islets and human fetal pancreatic islet-like cell clusters were encapsulated in polytetrafluorethylen

284 taining HBMSCs and HUVECs, and CD31-positive cell clusters were prominent within HUVEC-implanted defe

285 B cell and CD8+CD161+ T cell clusters were significantly lower in colonized than

286 adherin-coated surfaces and the formation of cell clusters were slower for zyxin-deficient cells than

287 chromoplasts, small cell clusters, and large cell clusters) were isolated from different types of car

288 pressing cells, called aldosterone-producing cell clusters, were analyzed.

289 postulate that quorum sensing occurs within cell clusters, where signal dispersion might be signific

290 xists a possible chemorepellent inside tumor cell clusters, which prevents [Formula: see text] T cell

291 Cross-species alignment of this cell cluster with a well-annotated mouse classification

292 Increased expression of SPN impeded tumor cell clustering with T cells, thereby limiting CD3 bsAb-

293 ressed gene expression matrix and identifies cell clusters with a graph-based clustering strategy.

294 Deletion of the enzyme results in large cell clusters with disordered division patterns, indicat

295 Cell clusters with excess Vangl2 could induce non-autono

296 by enabling high-content sorting of cells or cell clusters with unique spatial chemical and morpholog

297 re scattered in the tissue, CD103(-)CD8(+) T cells clustered with CD4(+) T cells and CX3CR1(+) macrop

298 We also detected a few novel or rare cell clusters within the amygdala, medial septum, and in

299 conversion, and during viral infection, ILC2 cells clustered within inflamed areas and acquired an IL

300 diabetic patients receiving fetal pig islet cell clusters xenograft together with a kidney allograft